Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy

European Heart Journal

Volumn 32, Issue 13, 2011, Pages 1664-1672

  Korpisalo, Petra ^a   Hytnen, Jarkko P ^a   Laitinen, Johannes T T ^a   Laidinen, Svetlana ^a   Parviainen, Henna ^a   Karvinen, Henna ^a   Siponen, Jaana ^a   Marjomki, Varpu ^b   Vajanto, Ismo ^a,c   Rissanen, Tuomas T ^a   Yl Herttuala, Seppo ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Angiogenesis; Gene therapy; Side effects; Vascular endothelial growth factor

Indexed keywords

ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; AMYLASE; BETA GALACTOSIDASE; CALCIUM; CREATINE; POTASSIUM; SODIUM; VASCULOTROPIN A;

AEROBIC METABOLISM; ANGIOGENESIS; ANGIOGENIC GENE THERAPY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; BLOOD FLOW; CAPILLARY; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; ECHOCARDIOGRAPHY; EDEMA; ELECTROCARDIOGRAM; EXERCISE; EXPERIMENTAL RABBIT; GENE CONSTRUCT; HINDLIMB; HYPERKALEMIA; HYPOCALCEMIA; HYPONATREMIA; INFLAMMATION; METABOLIC ACIDOSIS; METABOLIC RATE; MICROSCOPY; MUSCLE PERFUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOVIRIDAE; ANIMALS; CAPILLARIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HINDLIMB; INJECTIONS, INTRAMUSCULAR; LAC OPERON; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; RABBITS; ULTRASONOGRAPHY, INTERVENTIONAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79960019666     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq433     Document Type: Article

References (15)

1. Gowdak LH, Poliakova L, Wang X, Kovesdi I, Fishbein KW, Zacheo A, Palumbo R, Straino S, Emanueli C, Marrocco-Trischitta M, Lakatta EG, Anversa P, Spencer RG, Talan M, Capogrossi MC. Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia. Circulation 2000;102:565-571. (Pubitemid 30639975)
2. Rissanen TT, Korpisalo P, Markkanen JE, Liimatainen T, Orden MR, Kholova I, de Goede A, Heikura T, Grohn OH, Yla-Herttuala S. Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis. Circulation 2005;112:3937-3946. (Pubitemid 43739492)
3. Richardson TP, Peters MC, Ennett AB, Mooney DJ. Polymeric system for dual growth factor delivery. Nat Biotechnol 2001;19:1029-1034. (Pubitemid 33041886)
4. Zacchigna S, Tasciotti E, Kusmic C, Arsic N, Sorace O, Marini C, Marzullo P, Pardini S, Petroni D, Pattarini L, Moimas S, Giacca M, Sambuceti G. In vivo imaging shows abnormal function of vascular endothelial growth factor-induced vasculature. Hum Gene Ther 2007;18:515-524. (Pubitemid 47036045)
5. Yla-Herttuala S, Rissanen TT, Vajanto I, Hartikainen J. Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol 2007;49:1015-1026. (Pubitemid 46349500)
6. Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Grohn OH, Yla-Herttuala S. Therapeutic angiogenesis with placen-tal growth factor improves exercise tolerance of ischaemic rabbit hindlimbs. Cardiovasc Res 2008;80:263-270.
7. Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomaki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Yla-Herttuala S. Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels. Circ Res 2008;103:1092-1099.
8. Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn O, Ylä-Herttuala S. High-resolution ultrasound perfusion imaging of therapeutic angiogenesis. J Am Coll Cardiol: Cardiovasc Imaging 2008;1:83-91. (Pubitemid 351445390)
9. Karvinen H, Rutanen J, Leppanen O, Lach R, Levonen AL, Eriksson U, Yla-Herttuala S. PDGF-C and-D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries. Eur J Clin Invest 2009;39:320-327.
10. Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald DM, Blau HM. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest 2004;113:516-527. (Pubitemid 38542501)
11. Isner JM, Vale PR, Symes JF, Losordo DW. Assessment of risks associated with cardiovascular gene therapy in human subjects. Circ Res 2001;89:389-400. (Pubitemid 34132654)
12. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med 1999;77:527-543. (Pubitemid 29426311)
13. Vajanto I, Rissanen TT, Rutanen J, Hiltunen MO, Tuomisto TT, Arve K, Narvanen O, Manninen H, Rasanen H, Hippelainen M, Alhava E, Yla-Herttuala S. Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ. J Gene Med 2002;4:371-380. (Pubitemid 40277174)
14. Rajagopalan S, Mohler ER III, Lederman RJ, Mendelsohn FO, Saucedo JF, Goldman CK, Blebea J, Macko J, Kessler PD, Rasmussen HS, Annex BH. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 2003;108:1933-1938. (Pubitemid 37296537)
15. Wirth T, Hedman M, Mäkinen K, Manninen H, Immonen A, Vapalahti M, Ylä-Herttuala S. Safety Profile of plasmid/liposomes and virus vectors in clinical gene therapy. Curr Drug Saf 2006;1:253-257.