Gene Therapy for Heart Failure: Back to the Bench

Molecular Therapy

Volumn 23, Issue 10, 2015, Pages 1551-1552

  Ylä Herttuala, Seppo ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADENYLYL CYCLASE TYPE 6; PARVOVIRUS VECTOR; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PLACEBO; PROTEIN PHOSPHATASE 1 INHIBITOR; PROTEIN S 100; PROTEIN S100A1; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG;

CALCIUM HOMEOSTASIS; CONGESTIVE HEART FAILURE; DRUG EFFICACY; DRUG TREATMENT FAILURE; EDITORIAL; ENZYME INACTIVATION; ENZYME REPLACEMENT; GENE EXPRESSION; GENE THERAPY; HEART FAILURE; HOSPITALIZATION; HUMAN; INCIDENCE; NONHUMAN; OUTCOME ASSESSMENT; TRANSGENE; TREATMENT RESPONSE; VIRAL GENE DELIVERY SYSTEM; CLINICAL TRIAL (TOPIC); GENE VECTOR; GENETICS; PROCEDURES;

CLINICAL TRIALS AS TOPIC; GENETIC THERAPY; GENETIC VECTORS; HEART FAILURE; HUMANS; TRANSGENES;

EID: 84943549038     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2015.158     Document Type: Editorial

References (3)

1. Celladon. Celladon reports negative results for CUPID2 trial of MYDICAR® in advanced heart failure. Press release, 26 April 2015 .
2. Jessup, M, Greenberg, B, Mancini, D, Cappola, T, Pauly, DF, Jaski, B et al. (2011). Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 124: 304-313.
3. Gruchala, M, Bhardwaj, S, Pajusola, K, Roy, H, Rissanen, TT, Kokina, I et al. (2004). Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors. J Gene Med 6: 545-554.