Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

Frontiers in Aging Neuroscience

Volumn 6, Issue MAY, 2014, Pages

  Chen, Yanxing ^a,b,d   Run, Xiaoqin ^b   Liang, Zhihou ^b   Zhao, Yang ^a,c   Dai, Chun ling ^a   Iqbal, Khalid ^a   Liu, Fei ^a   Gong, Cheng Xin ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^d THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Alzheimer's disease; Anesthesia; Brain insulin signaling; Hyperphosphorylation of tau; Intranasal insulin; Propofol; Protein phosphatase 2A; Tau protein kinases

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIN DEPENDENT KINASE 5; PHOSPHOPROTEIN PHOSPHATASE 2A; PROPOFOL; RECOMBINANT HUMAN INSULIN; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; ENZYME INHIBITION; FEMALE; GENERAL ANESTHESIA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; RISK FACTOR; SIGNAL TRANSDUCTION; TAU HYPERPHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

EID: 84987652765     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00100     Document Type: Article

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