Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Frederick, Dennie T ^a   Salas Fragomeni, Roberto A ^a,b   Schalck, Aislyn ^c   Ferreiro Neira, Isabel ^a   Hoff, Taylor ^a   Cooper, Zachary A ^d   Haq, Rizwan ^b,c   Panka, David J ^b,e   Kwong, Lawrence N ^d   Davies, Michael A ^d   Cusack, James C ^a,b   Flaherty, Keith T ^b,c   Fisher, David E ^a,b   Mier, James W ^b,e   Wargo, Jennifer A ^d   Sullivan, Ryan J ^b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BH3 PROTEIN; DABRAFENIB; MESSENGER RNA; N [3 (5 CHLORO 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONYL) 2,4 DIFLUOROPHENYL]PROPANESULFONAMIDE; NAVITOCLAX; PROTEIN BCL 2; TRAMETINIB; VEMURAFENIB; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; BRAF PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; OXIME; PYRIDONE DERIVATIVE; PYRIMIDINONE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BCL XL GENE; BCL2 W GENE; BIM GENE; CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER PROGNOSIS; CELL VIABILITY; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG TARGETING; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MELANOMA CELL; MONOTHERAPY; MOUSE; MOUSE MODEL; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTO ONCOGENE; RNA GENE; TUMOR REGRESSION; TUMOR XENOGRAFT; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; DRUG RESISTANCE; GENETICS; METABOLISM; METASTASIS; MIDDLE AGED; MISSENSE MUTATION; PATHOLOGY; TUMOR CELL LINE;

ADULT; AGED; ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; IMIDAZOLES; INDOLES; MELANOMA; MICE; MIDDLE AGED; MUTATION, MISSENSE; NEOPLASM METASTASIS; OXIMES; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDONES; PYRIMIDINONES; SULFONAMIDES;

EID: 84903740769     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101286     Document Type: Article

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