Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variants in vivo

International Journal of Cancer

Volumn 66, Issue 4, 1996, Pages 470-476

  Jäger, Elke ^a   Ringhoffer, Mark ^a   Karbach, Julia ^a   Arand, Michael ^b   Oesch, Franz ^b   Knuth, Alexander ^a  

^a KRANKENHAUS NORDWEST   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; DIFFERENTIATION ANTIGEN; MONOPHENOL MONOOXYGENASE; PEPTIDE ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; MELANOCYTE; MELANOMA; PRIORITY JOURNAL; TUMOR REGRESSION;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOTOXICITY, IMMUNOLOGIC; DNA PRIMERS; EPITOPES; HUMANS; IMMUNITY, CELLULAR; MELANOCYTES; MELANOMA; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; NEOPLASM PROTEINS; PROTEINS; TUMOR CELLS, CULTURED;

EID: 0030000146     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960516)66:4<470::AID-IJC10>3.0.CO;2-C     Document Type: Article

References (30)

1. ANICHINI, A., MACCALLI, C., MOTARINI, R., SALVI, S., MAZZOCCHI, A., SQUARCINA, P., HERLYN, M. and PARMIANI, G., Melanoma cells and normal melanocytes share antigens recognized by HLA-A2-restricted cytotoxic T-cell clones from melanoma patients. J. exp. Med., 177, 989-998 (1993).
2. BAKKER, A.B., SCHREURS, M.W., DEBOER, A.J., KAWAKAMI, Y., ROSENBERG, S.A., ADEMA, G.J. and FIGDOR, C.G., Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumorinfiltrating lymphocytes. J. exp. Med., 179, 1005-1009 (1994).
3. BAKKER, A.B.H., SCHREURS, M.W.J., TAFAZZUL, G., DE BOER, A.J., KAWAKAMI, Y., ADEMA, G.J. and FIGDOR, C.G., Identification of a novel peptide derived from the melanocyte-specific GP100 antigen as the dominant epitope recognized by an HLA-A2.1-restricted antimelanoma CTL line. Int. J. Cancer, 62, 97-102 (1995).
4. BERNHARD, H., KARBACH, J., WÖLFEL, T., BUSCH, P., STÖRKEL, S., STÖCKLE, M., WÖLFEL, C., SELIGER, B., HUBER, C., MEYER ZUM BÜSCHENFELDE, K.-H. and KNUTH, A., Cellular immune response to human renal-cell carcinomas: definition of a common antigen recognized by HLA-A2-restricted cytotoxic T lymphocytes. Int. J. Cancer, 59, 1-6 (1994).
5. BODMER, H., OGG, G., GOTCH, F. and MCMICHAEL, A., Anti-HLA-A2-antibody enhancement of peptide association with HLA-A2 as detected by cytotoxic T lymphocytes. Nature (Lond.), 342, 443-446 (1989).
6. BOON, T., GAJEWSKI, T.F. and COULIE, P., From defined human tumor antigens to effective immunization? Immunol. Today, 16, 334-336 (1995).
7. BRICHARD, V., VAN PEL, A., WÖLFEL, T., DEPLAEN, E., LETHE, B., COULIE, P. and BOON, T., The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. exp. Med., 178, 489-495 (1993).
8. CHEN, Y.T., STOCKERT, E., TSANG, S., COPLAN, K.A. and OLD, L.J., Immunophenotyping of melanomas for tyrosinase: implications for vaccine development. Proc. nat. Acad. Sci. (Wash.), (1996). (In press).
9. COULIE, P.G., BRICHARD, V., VAN PEL, A., WÖLFEL, T., SCHNEIDER, J., TRAVERSARI, C., MATTEI, S., DEPLAEN, E., LURQUIN, C., SZIKORA, J.-P., RENAULD, J.-C. and BOON, T., A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. exp. Med., 180, 35-42 (1994).
10. COX, A.L., SKIPPER, J., CHEN, Y., HENDERSON, R.A., DARROW, T.L., SHABANOWITZ, J., ENGELHARD, V.H., HUNT, D.F. and SLINGLUFF, C.L.S., Identification of a peptide recognized by five melanoma-specific human cytotoxic T-cell lines. Science, 264, 716-719 (1994).
11. GAUGLER, B., VAN DEN EYNDE, B., VAN DER BRUGGEN, P., ROMERO, P., GAFORIO, J.J., DEPLAEN, E., LETHE, B., BRASSEUR, F. and BOON, T., Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J. exp. Med., 179, 921-930 (1994).
12. HÉRIN, M., LEMOINE, C., WEYNANTS, P., VESSIERE, F., VANPEL, A., KNUTH, A., DEVOS, R. and BOON, T., Production of stable cytolytic T-cell clones directed against autologous human melanoma. Int. J. Cancer, 39, 390-396 (1987).
13. JÄGER, E., BERNHARD, H., ROMERO, P., RINGHOFFER, M., ARAND, M., KARBACH, J., ILSEMANN, C., HAGEDORN, M. and KNUTH, A., Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptides in vivo: implications for tumor vaccines with melanoma associated antigens. Int. J. Cancer 66, 162-169 (1996).
14. KANG, X.Q., KAWAKAMI, Y., EL-GAMIL, M., WANG, R., SAKAGUCHI, K., YANNELLI, J.R., APPELLA, E. and ROSENBERG, S.A., Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes. J. Immunol., 155, 1343-1348 (1995).
15. KAWAKAMI, Y., ELIYAHU, S., DELGADO, C.H., ROBBINS, P.F., RIVOLTINI, L., TOPALIAN, S.L., MIKI, T. and ROSENBERG, S.A., Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. nat. Acad. Sci. (Wash.), 91, 3525-3519 (1994a).
16. KAWAKAMI, Y., ELIYAHU, S., DELGADO, C.H., ROBBINS, P.F., SAKAGUCHI, K., APPELLA, E., YANNELLI, J.R., ADEMA, G.J., MIKI, T. and ROSENBERG, S.A., Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. nat. Acad. Sci. (Wash.), 91, 6458-6462 (1994b).
17. KAWAKAMI, Y., ELIYAHU, S., JENNINGS, C., SAKAGUCHI, K., KANG, X.Q., SOUTHWOOD, S., ROBBINS, P.P., SETTE, A., APPELLA, E. and ROSENBERG, S.A., Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating lymphocytes associated with in vivo tumor regression. J. Immunol., 154, 3961-3968 (1995).
18. KNUTH, A., DANOWSKI, B., OETTGEN, H.F. and OLD, L.J., T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin-2-dependent T-cell cultures. Proc. not. Acad. Sci. (Wash.), 81, 3511-3515 (1984).
19. KNUTH, A., WÖLFEL, T., KLEHMANN, E., BOON, T. and MEYER ZUM BÜSCHENFELDE, K.-H., Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection. Proc. nat. Acad. Sci. (Wash.), 86, 2804-2808 (1989).
20. KNUTH, A., WÖLFEL, T. and MEYER ZUM BÜSCHENFELDE, K.-H., T-cell responses to human malignant tumours. Cancer Surveys, 13, 39-52 (1992).
21. NANDA, N.K. and SERCARZ, E.E., Induction of anti-self-immunity to cure cancer. Cell, 82, 13-17 (1995).
22. RIVOLTINI, L., KAWAKAMI, Y., SAKAGUCHI, K., SOUTHWOOD, S., SETTE, A., ROBBINS, P.F., MARINCOLA, F.M., SALGALLER, M.L., YANNELLI, J.R., APPELLA, E. and ROSENBERG, S.A., Induction of tumor-reactive CTL from peripheral-blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. J. Immunol., 154, 2257-2265 (1995).
23. ROBBINS, P.F., ELGAMIL, M., KAWAKAMI, Y. and ROSENBERG, S.A., Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy. Cancer Res., 54, 3124-3126 (1994).
24. SLOAN-LANCASTER, J. and ALLEN, P.M., Significance of T-cell stimulation by altered peptide ligands in T-cell biology. Curr. Opin. Immunol., 7, 103-109 (1995).
25. STORKUS, W.J., ZEH, H.J.Z., MAEURER, M.J., SALTER, R.D. and LOTZE, M.T., Identification of human melanoma peptides recognized by class-I-restricted tumor-infiltrating T lymphocytes. J. Immunol., 151, 3719-3727 (1993).
26. VAN DER BRUGGEN, P., SZIKORA, J.-P., BOEL, P., WILDMANN, C., SOMVILLE, M., SENSI, M. and BOON, T., Autologous cytolytic T lymphocytes recognize a MAGE-1 nonapeptide on melanomas expressing HLA-Cw*1601*. Europ. J. Immunol., 24, 2134-2140 (1994).
27. VAN DER BRUGGEN, P., TRAVERSARI, C., CHOMEZ, P., LURQUIN, C., DE PLAEN, E., VAN DEN EYNDE, B., KNUTH, A. and BOON, T., A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science, 254, 1643-1647 (1991).
28. VISSEREN, M.J.W., VAN ELSAS, A., VAN DER VOORT, E.I.H., RESSING, M.E., KAST, W.M., SCHRIER, P.I. and MELIEF, C.J.M., CTL specific for the tyrosinase auto-antigen can be induced from healthy donor blood to lyse melanoma cells. J Immunol., 154, 3991-3998 (1995).
29. WANG, R.-F., ROBBINS, P.F., KAWAKAMI, Y., KANG, X.-Q. and ROSENBERG, S.A., Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J. exp. Med., 181, 799-804 (1995).
30. WÖLFEL, T., HAUER, M., KLEHMANN, E., BRICHARD, V., ACKERMANN, B., KNUTH, A., BOON, T. and MEYER ZUM BÜSCHENFELDE, K.-H., Analysis of antigens recognized on human melanoma cells by A2-restricted cytolytic T lymphocytes (CTL). Int. J. Cancer, 55, 237-244 (1993).