Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1

Nanotoxicology

Volumn 11, Issue 4, 2017, Pages 434-442

  Kreyling, Wolfgang G ^a   Holzwarth, Uwe ^b   Haberl, Nadine ^a   Kozempel, Ján ^b   Hirn, Stephanie ^a   Wenk, Alexander ^a   Schleh, Carsten ^a   Schäffler, Martin ^a   Lipka, Jens ^a   Semmler Behnke, Manuela ^a   Gibson, Neil ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b JOINT RESEARCH CENTRE   (Italy)

Author keywords

accumulation in organs and tissues; hepato biliary nanoparticle clearance; intravenous injection; Size selected, radiolabeled titanium dioxide nanoparticles; translocation across organ membranes

Indexed keywords

TITANIUM DIOXIDE NANOPARTICLE; NANOPARTICLE; POLLUTANT; RADIOISOTOPE; TITANIUM; TITANIUM DIOXIDE; VANADIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCASS; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG RETENTION; FEMALE; ISOTOPE LABELING; LIVER; NONHUMAN; PARTICLE SIZE; PHARMACOKINETICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOACTIVITY; RAT; SINGLE DRUG DOSE; SKELETON; SPLEEN; URINARY EXCRETION; ADMINISTRATION AND DOSAGE; ANIMAL; ANTIBODY SPECIFICITY; BILIARY EXCRETION; BLOOD; DOSE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; POLLUTANT; TIME FACTOR; TISSUE DISTRIBUTION; URINE; WISTAR RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; HEPATOBILIARY ELIMINATION; INJECTIONS, INTRAVENOUS; METABOLIC CLEARANCE RATE; NANOPARTICLES; ORGAN SPECIFICITY; PARTICLE SIZE; RADIOISOTOPES; RATS; RATS, WISTAR; TIME FACTORS; TISSUE DISTRIBUTION; TITANIUM; VANADIUM;

EID: 85016970654     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.1080/17435390.2017.1306892     Document Type: Article

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