βAdrenergic stimulation induces histone deacetylase 5 (HDAC5) nuclear accumulation in cardiomyocytes by B55α-PP2A-mediated dephosphorylation

Journal of the American Heart Association

Volumn 6, Issue 4, 2017, Pages

  Weeks, Kate L ^a,b   Ranieri, Antonella ^a   Karaś, Agnieszka ^a   Bernardo, Bianca C ^b   Ashcroft, Alexandra S ^a   Molenaar, Chris ^a   McMullen, Julie R ^b   Avkiran, Metin ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Adrenergic stimulation; B adrenergic signaling; B55a; Confocal imaging; Histone deacetylase 5; Hypertrophy remodeling; Microscopy; Phosphatase; Phosphorylation; PP2A; Three dimensional

Indexed keywords

5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ALANINE; B55ALPHA PROTEIN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE DEACETYLASE 5; ISOPRENALINE; MYOCYTE ENHANCER FACTOR 2; PP2A PROTEIN; SERINE; TROPONIN I; UNCLASSIFIED DRUG; ADRB1 PROTEIN, RAT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; HDAC5 PROTEIN, RAT; HISTONE DEACETYLASE; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2R2A PROTEIN, RAT; PROTEIN BINDING;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA ADRENERGIC STIMULATION; CARDIAC MUSCLE CELL; CELL ADHESION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; NEWBORN; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL NUCLEUS; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; MALE; METABOLISM; MUTATION; NUCLEOCYTOPLASMIC TRANSPORT; PHOSPHORYLATION; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; TIME FACTOR; WISTAR RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ADRENERGIC BETA-AGONISTS; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HISTONE DEACETYLASES; ISOPROTERENOL; MALE; MUTATION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PHOSPHATASE 2; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-1; RNA INTERFERENCE; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 85016614772     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.116.004861     Document Type: Article

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