메뉴 건너뛰기




Volumn 292, Issue 2, 2007, Pages

Acute modulation of PP2a and troponin I phosphorylation in ventricular myocytes: Studies with a novel PP2a peptide inhibitor

Author keywords

adrenergic receptor; Hydrogen peroxide; Peptide inhibition; Protein phosphatase 2a

Indexed keywords

HYDROGEN PEROXIDE; OKADAIC ACID; PEPTIDE DERIVATIVE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN PHOSPHATASE 2A INHIBITOR; THREONYLPROLYLASPARTYLTYROSYLPHENYLALANYLLEUCINE; TROPONIN I; UNCLASSIFIED DRUG;

EID: 33846963541     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00225.2006     Document Type: Article
Times cited : (27)

References (36)
  • 2
    • 13444274308 scopus 로고    scopus 로고
    • A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways
    • Boehning D, van Rossum DB, Patterson RL, Snyder SH. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci USA 102: 1466-1471, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1466-1471
    • Boehning, D.1    van Rossum, D.B.2    Patterson, R.L.3    Snyder, S.H.4
  • 3
    • 0033560729 scopus 로고    scopus 로고
    • Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit
    • Bryant JC, Westphal RS, Wadzinski BE. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. Biochem J 339: 241-246, 1999.
    • (1999) Biochem J , vol.339 , pp. 241-246
    • Bryant, J.C.1    Westphal, R.S.2    Wadzinski, B.E.3
  • 4
    • 0026786471 scopus 로고
    • Regulation of protein serinethreonine phosphatase type-2A by tyrosine phosphorylation
    • Chen J, Martin BL, Brautigan DL. Regulation of protein serinethreonine phosphatase type-2A by tyrosine phosphorylation. Science 257: 1261-1264, 1992.
    • (1992) Science , vol.257 , pp. 1261-1264
    • Chen, J.1    Martin, B.L.2    Brautigan, D.L.3
  • 5
    • 0038482115 scopus 로고    scopus 로고
    • Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130
    • Cicchillitti L, Fasanaro P, Biglioli P, Capogrossi MC, Martelli F. Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. J Biol Chem 278: 19509-19517, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 19509-19517
    • Cicchillitti, L.1    Fasanaro, P.2    Biglioli, P.3    Capogrossi, M.C.4    Martelli, F.5
  • 6
    • 31044435283 scopus 로고    scopus 로고
    • A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A
    • Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Mol Pharmacol 69: 608-617, 2006.
    • (2006) Mol Pharmacol , vol.69 , pp. 608-617
    • Crossthwaite, A.J.1    Ciruela, A.2    Rayner, T.F.3    Cooper, D.M.4
  • 7
    • 0036196195 scopus 로고    scopus 로고
    • Intracellular transport mechanisms of signal transducers
    • Dorn GW 2nd, Mochly-Rosen D. Intracellular transport mechanisms of signal transducers. Annu Rev Physiol 64: 407-429, 2002.
    • (2002) Annu Rev Physiol , vol.64 , pp. 407-429
    • Dorn 2nd, G.W.1    Mochly-Rosen, D.2
  • 8
    • 0036032442 scopus 로고    scopus 로고
    • Okadaic acid: The archetypal serine/threonine protein phosphatase inhibitor
    • Dounay AB, Forsyth CJ. Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor. Curr Med Chem 9: 1939-1980, 2002.
    • (2002) Curr Med Chem , vol.9 , pp. 1939-1980
    • Dounay, A.B.1    Forsyth, C.J.2
  • 9
    • 0028361380 scopus 로고
    • The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo
    • Favre B, Zolnierowicz S, Turowski P, Hemmings BA. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. J Biol Chem 269: 16311-16317, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 16311-16317
    • Favre, B.1    Zolnierowicz, S.2    Turowski, P.3    Hemmings, B.A.4
  • 10
    • 0028241574 scopus 로고
    • Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid
    • Floer M, Stock J. Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid. Biochem Biophys Res Commun 198: 372-379, 1994.
    • (1994) Biochem Biophys Res Commun , vol.198 , pp. 372-379
    • Floer, M.1    Stock, J.2
  • 11
    • 1242272862 scopus 로고    scopus 로고
    • Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain
    • Foley TD, Armstrong JJ, Kupchak BR. Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain. Biochem Biophys Res Commun 315: 568-574, 2004.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 568-574
    • Foley, T.D.1    Armstrong, J.J.2    Kupchak, B.R.3
  • 12
    • 1642559254 scopus 로고    scopus 로고
    • Microcystin-LR and okadaic acid-induced cellular effects: A dualistic response
    • Gehringer MM. Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Lett 557: 1-8, 2004.
    • (2004) FEBS Lett , vol.557 , pp. 1-8
    • Gehringer, M.M.1
  • 13
    • 20444485337 scopus 로고    scopus 로고
    • A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers
    • Gentry MS, Li Y, Wei H, Syed FF, Patel SH, Hallberg RL, Pallas DC. A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers. Eukaryot Cell 4: 1029-1040, 2005.
    • (2005) Eukaryot Cell , vol.4 , pp. 1029-1040
    • Gentry, M.S.1    Li, Y.2    Wei, H.3    Syed, F.F.4    Patel, S.H.5    Hallberg, R.L.6    Pallas, D.C.7
  • 14
    • 21244473309 scopus 로고    scopus 로고
    • Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation
    • Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem 280: 24135-24142, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 24135-24142
    • Itoh, S.1    Ding, B.2    Bains, C.P.3    Wang, N.4    Takeishi, Y.5    Jalili, T.6    King, G.L.7    Walsh, R.A.8    Yan, C.9    Abe, J.10
  • 15
    • 0035252894 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
    • Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353: 417-439, 2001.
    • (2001) Biochem J , vol.353 , pp. 417-439
    • Janssens, V.1    Goris, J.2
  • 17
    • 0027184102 scopus 로고
    • Protein phosphatase 2A catalytic subunit is methylesterified at its carboxyl terminus by a novel methyltransferase
    • Lee J, Stock J. Protein phosphatase 2A catalytic subunit is methylesterified at its carboxyl terminus by a novel methyltransferase. J Biol Chem 268: 19192-19195, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 19192-19195
    • Lee, J.1    Stock, J.2
  • 18
    • 0029952559 scopus 로고    scopus 로고
    • A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
    • Lee J, Chen Y, Tolstykh T, Stock J. A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci USA 93: 6043-6047, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6043-6047
    • Lee, J.1    Chen, Y.2    Tolstykh, T.3    Stock, J.4
  • 20
    • 0027939868 scopus 로고
    • Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferase
    • Li M, Damuni Z. Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferase. Biochem Biophys Res Commun 202: 1023-1030, 1994.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 1023-1030
    • Li, M.1    Damuni, Z.2
  • 21
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270: 14255-14258, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 22
    • 0029999551 scopus 로고    scopus 로고
    • Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs
    • Liu KY, Timmons S, Lin YZ, Hawiger J. Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs. Proc Natl Acad Sci USA 93: 11819-11824, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11819-11824
    • Liu, K.Y.1    Timmons, S.2    Lin, Y.Z.3    Hawiger, J.4
  • 23
    • 0036783558 scopus 로고    scopus 로고
    • 1 receptormediated protein phosphatase 2a activation in the heart
    • 1 receptormediated protein phosphatase 2a activation in the heart. Am J Physiol Heart Circ Physiol 283: H1314-H1321, 2002.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Liu, Q.1    Hofmann, P.A.2
  • 25
    • 2542433090 scopus 로고    scopus 로고
    • Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes
    • Liu Q, Hofmann PA. Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol 286: H2204-H2212, 2004.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Liu, Q.1    Hofmann, P.A.2
  • 26
    • 1042302791 scopus 로고    scopus 로고
    • Covalent and noncovalent modification of thin filament action: The essential role of troponin in cardiac muscle regulation
    • Metzger JM, Westfall MV. Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation. Circ Res 94: 146-158, 2004.
    • (2004) Circ Res , vol.94 , pp. 146-158
    • Metzger, J.M.1    Westfall, M.V.2
  • 27
    • 0000714961 scopus 로고    scopus 로고
    • Regulation of protein kinase cascades by protein phosphatase 2A
    • Millward TA, Zolnierowicz S, Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 24: 186-191, 1999.
    • (1999) Trends Biochem Sci , vol.24 , pp. 186-191
    • Millward, T.A.1    Zolnierowicz, S.2    Hemmings, B.A.3
  • 29
    • 0030821233 scopus 로고    scopus 로고
    • Protein phosphatase 2A subunit assembly: The catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen
    • Ogris E, Gibson DM, Pallas DC. Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene 15: 911-917, 1997.
    • (1997) Oncogene , vol.15 , pp. 911-917
    • Ogris, E.1    Gibson, D.M.2    Pallas, D.C.3
  • 30
    • 0022871110 scopus 로고
    • Rapid microassay for protein kinase C translocation in Swiss 3T3 cells
    • Pelech SL, Meier KE, Krebs EG. Rapid microassay for protein kinase C translocation in Swiss 3T3 cells. Biochemistry 25: 8348-8353, 1986.
    • (1986) Biochemistry , vol.25 , pp. 8348-8353
    • Pelech, S.L.1    Meier, K.E.2    Krebs, E.G.3
  • 31
    • 0036291166 scopus 로고    scopus 로고
    • Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation
    • Rao RK, Clayton LW. Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation. Biochem Biophys Res Commun 293: 610-616, 2002.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 610-616
    • Rao, R.K.1    Clayton, L.W.2
  • 32
    • 0028274544 scopus 로고
    • Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons
    • Rosenmund C, Carr DW, Bergeson SE, Nilaver G, Scott JD, Westbrook GL. Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature 368: 853-856, 1994.
    • (1994) Nature , vol.368 , pp. 853-856
    • Rosenmund, C.1    Carr, D.W.2    Bergeson, S.E.3    Nilaver, G.4    Scott, J.D.5    Westbrook, G.L.6
  • 33
    • 0025647113 scopus 로고
    • Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes
    • Sneddon AA, Cohen PT, Stark MJ. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. EMBO J 9: 4339-4346, 1990.
    • (1990) EMBO J , vol.9 , pp. 4339-4346
    • Sneddon, A.A.1    Cohen, P.T.2    Stark, M.J.3
  • 34
    • 0035100658 scopus 로고    scopus 로고
    • Protein phosphatase 2A: The Trojan Horse of cellular signaling
    • Sontag E. Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell Signal 13: 7-16, 2001.
    • (2001) Cell Signal , vol.13 , pp. 7-16
    • Sontag, E.1
  • 35
    • 0029074550 scopus 로고
    • Sublethal levels of oxidant stress stimulate multiple serine/threonine kinases and suppress protein phosphatases in Jurkat T cells
    • Whisler RL, Goyette MA, Grants IS, Newhouse YG. Sublethal levels of oxidant stress stimulate multiple serine/threonine kinases and suppress protein phosphatases in Jurkat T cells. Arch Biochem Biophys 319: 23-35, 1995.
    • (1995) Arch Biochem Biophys , vol.319 , pp. 23-35
    • Whisler, R.L.1    Goyette, M.A.2    Grants, I.S.3    Newhouse, Y.G.4
  • 36
    • 0028154020 scopus 로고
    • Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain
    • Xie H, Clarke S. Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain. J Biol Chem 269: 1981-1984, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 1981-1984
    • Xie, H.1    Clarke, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.