Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

BMC Medicine

Volumn 15, Issue 1, 2017, Pages

  Witney, Adam A ^a   Bateson, Anna L E ^b   Jindani, Amina ^a   Phillips, Patrick P J ^c   Coleman, David ^a   Stoker, Neil G ^a   Butcher, Philip D ^a   McHugh, Timothy D ^b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c MRC CLINICAL TRIALS UNIT   (United Kingdom)

Author keywords

Clinical trial; Tuberculosis; Whole genome sequencing

Indexed keywords

ETHAMBUTOL; ISONIAZID; MOXIFLOXACIN; PYRAZINAMIDE; RIFAMPICIN; RIFAPENTINE; BACTERIAL DNA; TUBERCULOSTATIC AGENT;

AFRICA SOUTH OF THE SAHARA; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EPIDEMIOLOGICAL DATA; GENE LOCUS; GENOTYPING TECHNIQUE; HUMAN; MAJOR CLINICAL STUDY; MYCOBACTERIAL INTERSPERSED REPETITIVE UNITS VARIABLE NUMBER TANDEM REPEAT TYPING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYLOGENY; RANDOMIZED CONTROLLED TRIAL; REINFECTION; RELAPSE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; TUBERCULOSIS; WHOLE GENOME SEQUENCING; BACTERIAL GENOME; BACTERIUM IDENTIFICATION; CLASSIFICATION; DNA SEQUENCE; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; MICROBIOLOGY; POLYMERASE CHAIN REACTION; PROCEDURES; RECURRENT DISEASE; VARIABLE NUMBER OF TANDEM REPEAT;

ANTIBIOTICS, ANTITUBERCULAR; BACTERIAL TYPING TECHNIQUES; DNA, BACTERIAL; GENOME, BACTERIAL; GENOTYPE; HUMANS; MINISATELLITE REPEATS; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECURRENCE; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS;

EID: 85016488115     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-017-0834-4     Document Type: Article

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