Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 3, 2016, Pages E348-E357

  Tufariello, JoAnn M ^a   Chapman, Jessica R ^b   Kerantzas, Christopher A ^a   Wong, Ka Wing ^c   Vilchèze, Catherine ^a   Jones, Christopher M ^d   Cole, Laura E ^a   Tinaztepe, Emir ^b   Thompson, Victor ^b   Fenyö, David ^b   Niederweis, Michael ^d   Ueberheide, Beatrix ^b   Philips, Jennifer A ^b,e   Jacobs, William R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FUDAN UNIVERSITY   (China)

^d University of Alabama at Birmingham   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ESX 3; Mycobacterium tuberculosis; Mycobactin; Siderophore; Type VII secretion system

Indexed keywords

BACTERIAL PROTEIN; GLUTAMIC ACID; IRON; PE5 PROTEIN; PPE4 PROTEIN; PROLINE; PROTEIN ESX 3; PROTEIN ESXG; PROTEIN ESXH; SIDEROPHORE; UNCLASSIFIED DRUG; AEROSOL; HEMIN; HOMEODOMAIN PROTEIN; MYCOBACTINS; OXAZOLE DERIVATIVE; RAG-1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENOTYPE; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; IRON METABOLISM; IRON TRANSPORT; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEOMICS; TUBERCULOSIS; AEROSOL; ANIMAL; C57BL MOUSE; CELL POLARITY; CYTOLOGY; DRUG EFFECTS; ENZYME SPECIFICITY; GENETICS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; MACROPHAGE; MASS SPECTROMETRY; METABOLISM; MICROBIOLOGY; MUTATION; PATHOGENICITY; PHENOTYPE; SCID MOUSE; VIRULENCE;

AEROSOLS; ANIMALS; BACTERIAL PROTEINS; CELL POLARITY; GENOTYPE; HEMIN; HOMEODOMAIN PROTEINS; HOST-PATHOGEN INTERACTIONS; HUMANS; IRON; MACROPHAGES; MASS SPECTROMETRY; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXAZOLES; PHENOTYPE; PROTEOMICS; SIDEROPHORES; SUBSTRATE SPECIFICITY; VIRULENCE;

EID: 84955084428     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523321113     Document Type: Article

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