Capsicum spp in vitro liquid cell suspensions: A useful system for the production of capsaicinoids and polyphenols

Plant Biosystems

Volumn 152, Issue 3, 2018, Pages 436-444

  Ferri, Maura ^a   Gruarin, Nicolò ^a   Barbieri, Federica ^a   Tassoni, Annalisa ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

antioxidant activity; capsaicinoids; cell cultures; chili pepper; elicitors; polyphenols

Indexed keywords

EID: 85016319220     PISSN: 11263504     EISSN: 17245575     Source Type: Journal    
DOI: 10.1080/11263504.2017.1305998     Document Type: Article

References (38)

1. Bajaj KL. 1980. Colorimetric determination of capsaicin in Capsicum fruits. J Assoc Off Anal Chem 63: 1314–1316.
2. Bartnicki-Garcia S. 1970. Cell wall composition and other biochemical markers in fungal phylogeny. In: Harborne JB, editor. Phytochemical phylogeny. San Francisco, CA: Academic Press. pp. 81–103.
3. Dong HD, Zhong JJ. 2001. Significant improvement of taxane production in suspension cultures of Taxus chinensis by combining elicitation with sucrose feed. Biochem Eng J 8: 145–150.10.1016/S1369-703X(01)00096-1
4. Ferri M, Gianotti A, Tassoni A. 2013. Optimisation of assay conditions for the determination of antioxidant capacity and polyphenols in cereal food components. J Food Comp Anal 30: 94–101.10.1016/j.jfca.2013.02.004
5. Ferri M, Tassoni A, Franceschetti M, Righetti L, Naldrett MJ, Bagni N. 2009. Chitosan treatment induces changes of protein expression profile and stilbene distribution in Vitis vinifera cell suspensions. Proteomics 9: 610–624.10.1002/pmic.v9:3
6. Gibbs HAA, O’Garro LW. 2004. Capsaicin content of West Indies hot pepper cultivars using colorimetric and chromatographic techniques. HortSci 39: 132–135.
7. Gutiérrez-Carbajal MG, Monforte-González M, Miranda-Ham MD, Godoy-Hernández G, Vázquez-Flota F. 2010. Induction of capsaicinoid synthesis in Capsicum chinense cell cultures by salicylic acid or methyl jasmonate. Biol Plant 54: 430–434.10.1007/s10535-010-0078-z
8. Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, et al. 2004. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 64: 1071–1078.10.1158/0008-5472.CAN-03-1670
9. Kang BC, Nahm SH, Huh JH, Yoo HS, Yu JW, Lee MH, et al. 2001. An interspecific (Capsicum annuum × Capsicum chinese) F-2 linkage map in pepper using RFLP and AFLP markers. Theor Appl Genet 102: 531–539.10.1007/s001220051678
10. Kantar MB, Anderson JE, Lucht SA, Mercer K, Bernau V, Case KA, et al. 2016. Vitamin variation in Capsicum Spp. provides opportunities to improve nutritional value of human diets. PLoS One 11: e0161464.10.1371/journal.pone.0161464
11. Kehie M, Kumaria S, Tandon P. 2014. Manipulation of culture strategies to enhance capsaicin biosynthesis in suspension and immobilized cell cultures of Capsicum chinense Jacq. cv. Naga King Chili. Bioprocess Biosyst Eng 37: 1055–1063.10.1007/s00449-013-1076-2
12. Kehie M, Kumaria S, Tandon P, Ramchiary N. 2015. Biotechnological advances on in vitro capsaicinoids biosynthesis in capsicum: a review. Phytochem Rev 14: 189–201.10.1007/s11101-014-9344-6
13. Kothari SL, Joshi A, Kachhwaha S, Ochoa-Alejo N. 2010. Chili peppers–A review on tissue culture and transgenesis. Biotechnol Adv 28: 35–48.10.1016/j.biotechadv.2009.08.005
14. Materska M, Perucka I. 2005. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.). J Agric Food Chem 53: 1750–1756.10.1021/jf035331k
15. Mazzone SB, Geraghty DP. 1999. Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors. Br J Pharmacol 127: 473–481.
16. Murashige T, Skoog F. 1962. A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiol Plant 15: 473–497.10.1111/ppl.1962.15.issue-3
17. Nuñez-Palenius HG, Ochoa-Alejo N. 2005. Effect of phenylalanine and phenylpropanoids on the accumulation of capsaicinoids and lignin in cell cultures of chili pepper (capsicum annuum L.). In Vitro Cell Dev Plant 41: 801–805.10.1079/IVP2005708
18. Ochoa-Alejo N. (2006) Capsaicin accumulation in Capsicum spp. suspension cultures. In: Loyola-Vergas VM, Vásquez-Flota F, editors. Plant cell culture protocols, vol 138. Methods in molecular biology. 2nd ed. Totowa, NJ: Humana Press Inc. pp 327–334.
19. Ochoa-Alejo N, Gómez-Peralta JE. 1993. Activity of enzymes involved in capsaicin biosynthesis in callus tissue and fruits of chili pepper (Capsicum annuum L.). J Plant Physiol 141: 147–152.10.1016/S0176-1617(11)80751-0
20. Ochoa-Alejo N, Ramirez-Malagon R. 2001. In vitro chili pepper biotechnology. In Vitro Cell Dev Plant 37: 701–729.10.1007/s11627-001-0121-z
21. Oksman-Caldentey KM, Inzé D. 2004. Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites. Trends Plant Sci 9: 433–440.10.1016/j.tplants.2004.07.006
22. Prasad BC, Gururaj HB, Kumar V, Giridhar P, Ravishankar GA. 2006. Valine pathway is more crucial than phenyl propanoid pathway in regulating capsaicin biosynthesis in Capsicum frutescens Mill. J Agric Food Chem 54: 6660–6666.10.1021/jf061040a
23. Prasad NBC, Shrivastava R, Ravishankar GA. 2005. Capsaicin: a promising multifaceted drug from Capsicum species. Evid Based Integrative Med 2: 147–166.10.2165/01197065-200502030-00006
24. Rabea EI, Badawy MET, Stevens C, Smagghe G, Steurbaut W. 2003. Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules 4: 1457–1465.10.1021/bm034130m
25. Radwan DEM, Fayez KA, Mahmoud SY, Hamad A, Lu G. 2007. Physiological and metabolic changes of Cucurbita pepo leaves in response to zucchini yellow mosaic virus (ZYMV) infection and salicylic acid treatments. Plant Physiol Biochem 45: 480–489.10.1016/j.plaphy.2007.03.002
26. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol Med 26: 1231–1237.10.1016/S0891-5849(98)00315-3
27. Salgado-Garciglia R, Ochoa-Alejo N. 1990. Increased capsaicin content in PFP-resistant cells of chili pepper (Capsicum annuum L.). Plant Cell Rep 8: 617–620.10.1007/BF00270067
28. Shahidi F. 1997. Natural antioxidants: chemistry, health effects, and applications. Champaign, IL: AOCS Press.
29. Singleton VL, Orthofer R, Lamuela-Raventós RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152–178.10.1016/S0076-6879(99)99017-1
30. Stewart CJ, Mazourek M, Stellari GM, O’Connell M, Jahn M. 2007. Genetic control of pungency in C. chinense via the Pun1 locus. J Exp Bot 58: 979–991.10.1093/jxb/erl243
31. Sudha G, Ravishankar GA. 2003. Influence of methyl jasmonate and salicylic acid in the enhancement of capsaicin production in cell suspension cultures of Capsicum frutescens Mill. Curr Sci 85: 1212–1217.
32. Sudhakar Johnson T, Ravishankar GA, Venkataraman LV. 1990. In vitro capsaicin production by immobilized cells and placental tissues of Capsicum annuum L. grown in liquid medium. Plant Sci 70: 223–229.10.1016/0168-9452(90)90137-D
33. Tai A, Sawano T, Yazama F, Ito H. 2011. Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays. Biochim Biophys Acta 1810: 170–177.10.1016/j.bbagen.2010.11.004
34. Tassoni A, Fornalè S, Franceschetti M, Musiani F, Michael AJ, Perry B, et al. 2005. Jasmonates and Na-orthovanadate promote resveratrol production in Vitis vinifera cv. barbera cell cultures. New Phytol 166: 895–905.10.1111/j.1469-8137.2005.01383.x
35. Wang J, Qian J, Yao L, Lu Y. 2015. Enhanced production of flavonoids by methyl jasmonate elicitation in cell suspension culture of Hypericum perforatum. Bioresourc Bioprocess 2: 5–14.10.1186/s40643-014-0033-5
36. Weathers PJ, Towler MJ, Xu J. 2010. Bench to batch: advances in plant cell culture for producing useful products. App Microbiol Biot 85: 1339–1351.10.1007/s00253-009-2354-4
37. Wong GY, Gavva NR. 2009. Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: recent advances and setbacks. Brain Res Rev 60: 267–277.10.1016/j.brainresrev.2008.12.006
38. Zhishen J, Mengcheng T, Jianming W. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem 64: 555–559.10.1016/S0308-8146(98)00102-2