Metformin suppresses systemic autoimmunity in Roquinsan/san mice through inhibiting B cell differentiation into plasma cells via regulation of AMPK/mTOR/STAT3

Journal of Immunology

Volumn 198, Issue 7, 2017, Pages 2661-2670

  Lee, Seon Yeong ^a,b   Moon, Su Jin ^b   Kim, Eun Kyung ^a   Seo, Hyeon Beom ^a   Yang, Eun Ji ^a   Son, Hye Jin ^a   Kim, Jae Kyung ^a   Min, Jun Ki ^b   Park, Sung Hwan ^b   Cho, Mi La ^a,b  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; DNA ANTIBODY; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PROTEIN P53; STAT3 PROTEIN; ANTIDIABETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MTOR PROTEIN, MOUSE; RC3H1 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; DRUG MECHANISM; ENZYME INHIBITION; GERMINAL CENTER; GLUCOSE BLOOD LEVEL; HELPER CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TISSUE; LIVER TISSUE; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS; TH17 CELL; ANIMAL; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL SEPARATION; CONFOCAL MICROSCOPY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOIMMUNITY; B-LYMPHOCYTES; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL SEPARATION; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GERMINAL CENTER; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; METFORMIN; MICE; MICROSCOPY, CONFOCAL; PLASMA CELLS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES; UBIQUITIN-PROTEIN LIGASES;

EID: 85016262208     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1403088     Document Type: Article

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