메뉴 건너뛰기




Volumn 5, Issue 1, 2017, Pages 17-28

Angiopoietin-2 as a biomarker and target for immune checkpoint therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; BEVACIZUMAB; CD163 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IPILIMUMAB; PROGRAMMED DEATH 1 LIGAND 1; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CTLA4 PROTEIN, HUMAN; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; PROGRAMMED DEATH 1 RECEPTOR; TUMOR MARKER; VASCULOTROPIN A;

EID: 85016109280     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-16-0206     Document Type: Article
Times cited : (124)

References (57)
  • 2
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Weber, J.5    Garbe, C.6
  • 5
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 6
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014;32:1020-30.
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 8
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3    Braiteh, F.S.4    Loriot, Y.5    Cruz, C.6
  • 13
    • 84926516814 scopus 로고    scopus 로고
    • Intertwined regulation of angiogenesis and immunity by myeloid cells
    • Rivera LB, Bergers G. Intertwined regulation of angiogenesis and immunity by myeloid cells. Trends Immunol 2015;36:240-9.
    • (2015) Trends Immunol , vol.36 , pp. 240-249
    • Rivera, L.B.1    Bergers, G.2
  • 14
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • Ohm JE, Carbone DP. VEGF as a mediator of tumor-associated immunodeficiency. Immunol Res 2001;23:263-72.
    • (2001) Immunol Res , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 15
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells
    • Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol 1998;160:1224-32.
    • (1998) J Immunol , vol.160 , pp. 1224-1232
    • Oyama, T.1    Ran, S.2    Ishida, T.3    Nadaf, S.4    Kerr, L.5    Carbone, D.P.6
  • 16
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 2012;12:237-51.
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 17
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res 2010;70:6171-80.
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 18
    • 84928705533 scopus 로고    scopus 로고
    • VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-kappaB-induced endothelial activation
    • Huang H, Langenkamp E, Georganaki M, Loskog A, Fuchs PF, Dieterich LC, et al. VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-kappaB-induced endothelial activation. FASEB J 2015;29:227-38.
    • (2015) FASEB J , vol.29 , pp. 227-238
    • Huang, H.1    Langenkamp, E.2    Georganaki, M.3    Loskog, A.4    Fuchs, P.F.5    Dieterich, L.C.6
  • 19
    • 84996525854 scopus 로고    scopus 로고
    • Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab
    • Yuan J, Zhou J, Dong Z, Tandon S, Kuk D, Panageas KS, et al. Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab. Cancer Immunol Res 2014;2:127-32.
    • (2014) Cancer Immunol Res , vol.2 , pp. 127-132
    • Yuan, J.1    Zhou, J.2    Dong, Z.3    Tandon, S.4    Kuk, D.5    Panageas, K.S.6
  • 20
    • 33751225092 scopus 로고    scopus 로고
    • Angiopoietins: A link between angiogenesis and inflammation
    • Fiedler U, Augustin HG. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol 2006;27:552-8.
    • (2006) Trends Immunol , vol.27 , pp. 552-558
    • Fiedler, U.1    Augustin, H.G.2
  • 21
  • 22
    • 4544290590 scopus 로고    scopus 로고
    • Angiopoietins in tumours: The angiogenic switch
    • Tait CR, Jones PF. Angiopoietins in tumours: the angiogenic switch. J Pathol 2004;204:1-10.
    • (2004) J Pathol , vol.204 , pp. 1-10
    • Tait, C.R.1    Jones, P.F.2
  • 23
    • 84875807200 scopus 로고    scopus 로고
    • The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway
    • Thurston G, Daly C. The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway. Cold Spring Harb Perspect Med 2012;2: a006550.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006550
    • Thurston, G.1    Daly, C.2
  • 24
    • 63149188174 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with disease progression inmetastatic malignant melanoma
    • Helfrich I, Edler L, Sucker A, Thomas M, Christian S, Schadendorf D, et al. Angiopoietin-2 levels are associated with disease progression inmetastatic malignant melanoma. Clin Cancer Res 2009;15:1384-92.
    • (2009) Clin Cancer Res , vol.15 , pp. 1384-1392
    • Helfrich, I.1    Edler, L.2    Sucker, A.3    Thomas, M.4    Christian, S.5    Schadendorf, D.6
  • 25
    • 84927743238 scopus 로고    scopus 로고
    • Prognostic value of angiopoietin-2 for death risk stratification in patients with metastatic colorectal carcinoma
    • Jary M, Vernerey D, Lecomte T, Dobi E, Ghiringhelli F, Monnien F, et al. Prognostic value of angiopoietin-2 for death risk stratification in patients with metastatic colorectal carcinoma. Cancer Epidemiol Biomarkers Prev 2015;24:603-12.
    • (2015) Cancer Epidemiol Biomarkers Prev , vol.24 , pp. 603-612
    • Jary, M.1    Vernerey, D.2    Lecomte, T.3    Dobi, E.4    Ghiringhelli, F.5    Monnien, F.6
  • 27
    • 78049268477 scopus 로고    scopus 로고
    • Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy
    • Goede V, Coutelle O, Neuneier J, Reinacher-Schick A, Schnell R, Koslowsky TC, et al. Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy. Br J Cancer 2010;103:1407-14.
    • (2010) Br J Cancer , vol.103 , pp. 1407-1414
    • Goede, V.1    Coutelle, O.2    Neuneier, J.3    Reinacher-Schick, A.4    Schnell, R.5    Koslowsky, T.C.6
  • 28
    • 80855133511 scopus 로고    scopus 로고
    • Angiopoietin-2 promotes myeloid cell infiltration in a beta(2)-integrindependent manner
    • Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, et al. Angiopoietin-2 promotes myeloid cell infiltration in a beta(2)-integrindependent manner. Blood 2011;118:5050-9.
    • (2011) Blood , vol.118 , pp. 5050-5059
    • Scholz, A.1    Lang, V.2    Henschler, R.3    Czabanka, M.4    Vajkoczy, P.5    Chavakis, E.6
  • 29
    • 84944686465 scopus 로고    scopus 로고
    • Angiopoietin-2: A multifaceted cytokine that functions in both angiogenesis and inflammation
    • Scholz A, Plate KH, Reiss Y. Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation. Ann NY Acad Sci 2015;1347:45-51.
    • (2015) Ann NY Acad Sci , vol.1347 , pp. 45-51
    • Scholz, A.1    Plate, K.H.2    Reiss, Y.3
  • 30
    • 78650385895 scopus 로고    scopus 로고
    • Active immunotherapy induces antibody responses that target tumor angiogenesis
    • Schoenfeld J, Jinushi M, Nakazaki Y, Wiener D, Park J, Soiffer R, et al. Active immunotherapy induces antibody responses that target tumor angiogenesis. Cancer Res 2010;70:10150-60.
    • (2010) Cancer Res , vol.70 , pp. 10150-10160
    • Schoenfeld, J.1    Jinushi, M.2    Nakazaki, Y.3    Wiener, D.4    Park, J.5    Soiffer, R.6
  • 31
    • 79952271693 scopus 로고    scopus 로고
    • Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth
    • Huang H, Lai JY, Do J, Liu D, Li L, Del Rosario J, et al. Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth. Clin Cancer Res 2011;17:1001-11.
    • (2011) Clin Cancer Res , vol.17 , pp. 1001-1011
    • Huang, H.1    Lai, J.Y.2    Do, J.3    Liu, D.4    Li, L.5    Del Rosario, J.6
  • 33
    • 84871989305 scopus 로고    scopus 로고
    • Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    • Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, et al. Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res 2013;73:108-18.
    • (2013) Cancer Res , vol.73 , pp. 108-118
    • Daly, C.1    Eichten, A.2    Castanaro, C.3    Pasnikowski, E.4    Adler, A.5    Lalani, A.S.6
  • 34
    • 84994097105 scopus 로고    scopus 로고
    • VEGF neutralization plus CTLA-4 blockade alters soluble and cellular factors associated with enhancing lymphocyte infiltration and humoral recognition in Melanoma
    • Wu X, Giobbie-Hurder A, Liao X, Lawrence D, McDermott D, Zhou J, et al. VEGF Neutralization Plus CTLA-4 Blockade Alters Soluble and Cellular Factors Associated with Enhancing Lymphocyte Infiltration and Humoral Recognition in Melanoma. Cancer Immunol Res 2016;4:858-68.
    • (2016) Cancer Immunol Res , vol.4 , pp. 858-868
    • Wu, X.1    Giobbie-Hurder, A.2    Liao, X.3    Lawrence, D.4    McDermott, D.5    Zhou, J.6
  • 35
    • 84873911646 scopus 로고    scopus 로고
    • Activity of the heat shock protein 90 inhibitor ganetespib in melanoma
    • Wu X, Marmarelis ME, Hodi FS. Activity of the heat shock protein 90 inhibitor ganetespib in melanoma. PLoS One 2013;8:e56134.
    • (2013) PLoS One , vol.8 , pp. e56134
    • Wu, X.1    Marmarelis, M.E.2    Hodi, F.S.3
  • 36
    • 0032626964 scopus 로고    scopus 로고
    • An application of changepoint methods in studying the effect of age on survival in breast cancer
    • Contal C, O'Quigley J. An application of changepoint methods in studying the effect of age on survival in breast cancer. Comput Stat Data Anal 1999;30:253-70.
    • (1999) Comput Stat Data Anal , vol.30 , pp. 253-270
    • Contal, C.1    O'Quigley, J.2
  • 37
    • 84896745708 scopus 로고    scopus 로고
    • Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype
    • Garcia S, Krausz S, Ambarus CA, Fernandez BM, Hartkamp LM, van Es IE, et al. Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. PLoS One 2014;9:e82088.
    • (2014) PLoS One , vol.9 , pp. e82088
    • Garcia, S.1    Krausz, S.2    Ambarus, C.A.3    Fernandez, B.M.4    Hartkamp, L.M.5    Van Es, I.E.6
  • 38
    • 84902456985 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer
    • Forget MA, Voorhees JL, Cole SL, Dakhlallah D, Patterson IL, Gross AC, et al. Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer. PLoS One 2014;9:e98623.
    • (2014) PLoS One , vol.9 , pp. e98623
    • Forget, M.A.1    Voorhees, J.L.2    Cole, S.L.3    Dakhlallah, D.4    Patterson, I.L.5    Gross, A.C.6
  • 39
    • 84919466750 scopus 로고    scopus 로고
    • Postsurgical adjuvant tumor therapy by combining anti-angiopoietin- 2 and metronomic chemotherapy limits metastatic growth
    • Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, et al. Postsurgical adjuvant tumor therapy by combining anti-angiopoietin- 2 and metronomic chemotherapy limits metastatic growth. Cancer Cell 2014;26:880-95.
    • (2014) Cancer Cell , vol.26 , pp. 880-895
    • Srivastava, K.1    Hu, J.2    Korn, C.3    Savant, S.4    Teichert, M.5    Kapel, S.S.6
  • 40
    • 84893487976 scopus 로고    scopus 로고
    • Angiogenic capacity of M1-and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9
    • Zajac E, Schweighofer B, Kupriyanova TA, Juncker-Jensen A, Minder P, Quigley JP, et al. Angiogenic capacity of M1-and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9. Blood 2013;122:4054-67.
    • (2013) Blood , vol.122 , pp. 4054-4067
    • Zajac, E.1    Schweighofer, B.2    Kupriyanova, T.A.3    Juncker-Jensen, A.4    Minder, P.5    Quigley, J.P.6
  • 41
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 2014;6:13.
    • (2014) F1000Prime Rep , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 42
    • 84904016151 scopus 로고    scopus 로고
    • Human macrophage polarization in vitro: Maturation and activation methods compared
    • Vogel DY, Glim JE, Stavenuiter AW, Breur M, Heijnen P, Amor S, et al. Human macrophage polarization in vitro: maturation and activation methods compared. Immunobiology 2014;219:695-703.
    • (2014) Immunobiology , vol.219 , pp. 695-703
    • Vogel, D.Y.1    Glim, J.E.2    Stavenuiter, A.W.3    Breur, M.4    Heijnen, P.5    Amor, S.6
  • 43
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-7.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 44
    • 84937759727 scopus 로고    scopus 로고
    • The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma
    • Mahoney KM, Freeman GJ, McDermott DF. The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma. Clin Ther 2015;37:764-82.
    • (2015) Clin Ther , vol.37 , pp. 764-782
    • Mahoney, K.M.1    Freeman, G.J.2    McDermott, D.F.3
  • 45
    • 77954369555 scopus 로고    scopus 로고
    • Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions
    • Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, et al. Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions. Cancer Res 2010; 70:5270-80.
    • (2010) Cancer Res , vol.70 , pp. 5270-5280
    • Coffelt, S.B.1    Tal, A.O.2    Scholz, A.3    De Palma, M.4    Patel, S.5    Urbich, C.6
  • 46
    • 84956829295 scopus 로고    scopus 로고
    • Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatmentnaive and bevacizumab-resistant glioblastoma
    • Scholz A, Harter PN, Cremer S, Yalcin BH, Gurnik S, Yamaji M, et al. Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatmentnaive and bevacizumab-resistant glioblastoma. EMBO Mol Med 2015; 8:39-57.
    • (2015) EMBO Mol Med , vol.8 , pp. 39-57
    • Scholz, A.1    Harter, P.N.2    Cremer, S.3    Yalcin, B.H.4    Gurnik, S.5    Yamaji, M.6
  • 47
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014;41:49-61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 48
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013;23:277-86.
    • (2013) Cancer Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 50
    • 84926523845 scopus 로고    scopus 로고
    • Macrophages and cancer: From mechanisms to therapeutic implications
    • Ostuni R, Kratochvill F, Murray PJ, Natoli G. Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol 2015; 36:229-39.
    • (2015) Trends Immunol , vol.36 , pp. 229-239
    • Ostuni, R.1    Kratochvill, F.2    Murray, P.J.3    Natoli, G.4
  • 51
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009;206:1327-37.
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5    Wu, C.6
  • 52
    • 84964402874 scopus 로고    scopus 로고
    • Ang-2/VEGF bispecific antibody reprograms macrophages and residentmicroglia to anti-tumor phenotype and prolongs glioblastoma survival
    • Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and residentmicroglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci USA 2016;113:4476-81.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 4476-4481
    • Kloepper, J.1    Riedemann, L.2    Amoozgar, Z.3    Seano, G.4    Susek, K.5    Yu, V.6
  • 53
    • 84964409623 scopus 로고    scopus 로고
    • Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
    • Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci USA 2016;113: 4470-5.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 4470-4475
    • Peterson, T.E.1    Kirkpatrick, N.D.2    Huang, Y.3    Farrar, C.T.4    Marijt, K.A.5    Kloepper, J.6
  • 54
    • 84890667775 scopus 로고    scopus 로고
    • Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
    • Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, et al. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin Cancer Res 2013;19: 6730-40.
    • (2013) Clin Cancer Res , vol.19 , pp. 6730-6740
    • Kienast, Y.1    Klein, C.2    Scheuer, W.3    Raemsch, R.4    Lorenzon, E.5    Bernicke, D.6
  • 55
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patientswith advanced solid tumors
    • Herbst RS, Hong D, Chap L, Kurzrock R, Jackson E, Silverman JM, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patientswith advanced solid tumors. JClin Oncol 2009;27:3557-65.
    • (2009) JClin Oncol , vol.27 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2    Chap, L.3    Kurzrock, R.4    Jackson, E.5    Silverman, J.M.6
  • 56
    • 84873545836 scopus 로고    scopus 로고
    • A novel angiopoietin-2 selective fully human antibody with potent antitumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors
    • Thomas M, Kienast Y, Scheuer W, Bahner M, Kaluza K, Gassner C, et al. A novel angiopoietin-2 selective fully human antibody with potent antitumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors. PLoS One 2013;8: e54923.
    • (2013) PLoS One , vol.8 , pp. e54923
    • Thomas, M.1    Kienast, Y.2    Scheuer, W.3    Bahner, M.4    Kaluza, K.5    Gassner, C.6
  • 57
    • 79953750307 scopus 로고    scopus 로고
    • Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
    • Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, et al. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell 2011;19:512-26.
    • (2011) Cancer Cell , vol.19 , pp. 512-526
    • Mazzieri, R.1    Pucci, F.2    Moi, D.3    Zonari, E.4    Ranghetti, A.5    Berti, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.