MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2)

Biochemical and Biophysical Research Communications

Volumn 486, Issue 3, 2017, Pages 759-766

  Wu, Rihan ^a   He, Qinyu ^b   Chen, Haitao ^a   Xu, Miao ^a   Zhao, Ning ^a   Xiao, Ying ^a   Tu, Qian qian ^a   Zhang, Wenjun ^a   Bi, Xiaoying ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

IL 1 ; miR 448; Multiple sclerosis; PTPN2; Th17

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 1BETA; MICRORNA; MICRORNA 448; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; UNCLASSIFIED DRUG; IL1B PROTEIN, HUMAN; LUCIFERASE; MIRN448 MICRORNA, HUMAN; PTPN2 PROTEIN, HUMAN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, HUMAN;

ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH17 CELL; UPREGULATION; B LYMPHOCYTE; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NEUTROPHIL; PATHOLOGY; PRIMARY CELL CULTURE; REMISSION; REPORTER GENE; SEVERITY OF ILLNESS INDEX;

B-LYMPHOCYTES; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; INTERLEUKIN-17; INTERLEUKIN-1BETA; LUCIFERASES; MICRORNAS; MULTIPLE SCLEROSIS; NEUTROPHILS; NF-KAPPA B; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PRIMARY CELL CULTURE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; REMISSION INDUCTION; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TH17 CELLS;

EID: 85016056536     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2017.03.115     Document Type: Article

References (26)

1. [1] Baxter, A.G., The origin and application of experimental autoimmune encephalomyelitis. Nat. Rev. Immunol. 7 (2007), 904–912.
2. [2] Goverman, J., Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9 (2009), 393–407.
3. [3] Cua, D.J., Sherlock, J., Chen, Y., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003), 744–748.
4. [4] Langrish, C.L., Chen, Y., Blumenschein, W.M., et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201 (2005), 233–240.
5. [5] Elson, C.O., Cong, Y., Weaver, C.T., et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132 (2007), 2359–2370.
6. [6] Baumjohann, D., Ansel, K.M., MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat. Rev. Immunol. 13 (2013), 666–678.
7. [7] Zhang, L., Ke, F., Liu, Z., et al. MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. Nat. Commun., 6, 2015, 7639.
8. [8] Murugaiyan, G., da Cunha, A.P., Ajay, A.K., et al. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J. Clin. Invest 125 (2015), 1069–1080.
9. [9] Li, B., Ge, L., Li, M., et al. miR-448 suppresses proliferation and invasion by regulating IGF1R in colorectal cancer cells. Am. J. Transl. Res. 8 (2016), 3013–3022.
10. [10] Hong, X., Xu, Y., Qiu, X., et al. MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B. Oncotarget 7 (2016), 22092–22102.
11. [11] Spalinger, M.R., Kasper, S., Chassard, C., et al. PTPN2 controls differentiation of CD4(+) T cells and limits intestinal inflammation and intestinal dysbiosis. Mucosal Immunol. 8 (2015), 918–929.
12. [12] Liu, Z., Colpaert, S., D'Haens, G.R., et al. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J. Immunol. 163 (1999), 4049–4057.
13. [13] He, C., Shi, Y., Wu, R., et al. miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-alpha in IBD. Gut 65:12 (2016 Dec), 1938–1950.
14. [14] Xue, X., Feng, T., Yao, S., et al. Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40. J. Immunol. 187 (2011), 5879–5886.
15. [15] Bergman, J., Dring, A., Zetterberg, H., et al. Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS. Neurol. Neuroimmunol. Neuroinflamm, 3, 2016, e271.
16. [16] Novakova, L., Axelsson, M., Khademi, M., et al. Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis. Mult. Scler. 23 (2017), 62–71.
17. [17] Kuhle, J., Barro, C., Disanto, G., et al. Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity. Mult. Scler. 22 (2016), 1550–1559.
18. [18] Modvig, S., Degn, M., Roed, H., et al. Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis. Mult. Scler. 21 (2015), 1761–1770.
19. [19] Weber, A., Wasiliew, P., Kracht, M., Interleukin-1 (IL-1) pathway. Sci. Signal, 3, 2010 cm1.
20. [20] Wu, W., Song, Y., He, C., et al. Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease. Sci. Rep., 5, 2015, 16344.
21. [21] Ifergan, I., Chen, S., Zhang, B., et al. Cutting edge: MicroRNA-223 regulates myeloid dendritic cell-driven Th17 responses in experimental autoimmune encephalomyelitis. J. Immunol. 196 (2016), 1455–1459.
22. [22] Zhu, E., Wang, X., Zheng, B., et al. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3. J. Immunol. 192 (2014), 5599–5609.
23. [23] Mycko, M.P., Cichalewska, M., Machlanska, A., et al. MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination. Proc. Natl. Acad. Sci.U. S. A 109 (2012), E1248–E1257.
24. [24] Spalinger, M.R., McCole, D.F., Rogler, G., et al. Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease. World. J. Gastroenterol. 22 (2016), 1034–1044.
25. [25] Tonks, N.K., Protein tyrosine phosphatases: from genes, to function, to disease. Nat. Rev. Mol. Cell Biol. 7 (2006), 833–846.
26. [26] Heinonen, K.M., Nestel, F.P., Newell, E.W., et al. T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood 103 (2004), 3457–3464.