MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B

Oncotarget

Volumn 7, Issue 16, 2016, Pages 22092-22102

  Hong, Xuehui ^a,b   Xu, Yang ^c   Qiu, Xingfeng ^a   Zhu, Yuekun ^c   Feng, Xing ^d   Ding, Zhijie ^a   Zhang, Shifeng ^a   Zhong, Lifeng ^a   Zhuang, Yifan ^a   Su, Chen ^a   Hong, Xinya ^a   Cai, Jianchun ^a,b  

^a ZHONGSHAN HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b XIAMEN UNIVERSITY   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Gastric cancer; Glucose metabolism; Lysine (K) specific demethylase 2B; MiR 448; Mitochondria respira

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 448; MYC PROTEIN; ONCOPROTEIN; PROTEIN KDM2B; UNCLASSIFIED DRUG; F BOX PROTEIN; HISTONE DEMETHYLASE; KDM2A PROTEIN, HUMAN; MIRN448 MICRORNA, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CANCER TISSUE; CELL PROLIFERATION; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; DOWN REGULATION; FEMALE; GASTRIC CANCER CELL LINE; GENE OVEREXPRESSION; GENE REPRESSION; GENE SWITCHING; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KDM2B GENE; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE MYC; OXIDATIVE PHOSPHORYLATION; STOMACH CANCER; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; METABOLISM; NUDE MOUSE; PATHOLOGY; STOMACH TUMOR; XENOGRAFT;

ANIMALS; DOWN-REGULATION; F-BOX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HETEROGRAFTS; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; KAPLAN-MEIER ESTIMATE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; STOMACH NEOPLASMS;

EID: 84965074856     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8020     Document Type: Article

References (19)

1. Justus CR, Sanderlin EJ, Yang LV. Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment. Int J Mol Sci. 2015; 16:11055-11086.
2. Courtnay R, Ngo DC, Malik N, Ververis K, Tortorella SM, Karagiannis TC. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol Biol Rep. 2015; 42:841-851.
3. Lee S-H, Kim I-H, Kim I-H, Kwak S-G, Chae H-D. Comparison of short-term outcomes and acute inflammatory response between laparoscopy-assisted and totally laparoscopic distal gastrectomy for early gastric cancer. Ann Surg Treat Res. 2015; 89:176-182.
4. Choi AH, Nelson RA, Merchant SJ, Kim JY, Chao J, Kim J. Rates of Lymph Node Metastasis and Survival in T1a Gastric Adenocarcinoma in Western Populations. Gastrointest Endosc. 2015.
5. Subhash VV, Yeo MS, Tan WL, Yong WP. Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy. J Immunol Res. 2015; 2015:308574.
6. Mo D, Gu B, Gong X, Wu L, Wang H, Jiang Y, Zhang B, Zhang M, Zhang Y, Xu J, Pan S. miR-1290 is a potential prognostic biomarker in non-small cell lung cancer. J Thorac Dis. 2015; 7:1570-1579.
7. Pérez-García EI, Meza-Sosa KF, López-Sevilla Y, Camacho-Concha N, Sánchez NC, Pérez-Martínez L, Pedraza-Alva G. Merlin negative regulation by miR-146a promotes cell transformation. Biochem Biophys Res Commun. 2015.
8. Sher YP, Wang LJ, Chuang LL, Tsai MH, Kuo TT, Huang CC5, Chuang EY, Lai LC. ADAM9 upregulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells. PLoS One. 2014; 9:e94065.
9. Aguer C, Gambarotta D, Mailloux RJ, Moffat C, Dent R, McPherson R, Harper M-E. Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells. PLoS One. 2011; 6:e28536-e28536.
10. Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, WolffL, Honda Z, Wu X, et al. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood. 2015; 125:3437-3446.
11. Wahlström T, Henriksson MA. Impact of MYC in regulation of tumor cell metabolism. Biochim Biophys Acta. 2015; 1849:563-569.
12. Safe S. MicroRNA-Specificity Protein (Sp) Transcription Factor Interactions and Significance in Carcinogenesis. Curr Pharmacol Rep. 2015;1:73-78.
13. Lv Y, Lei Y, Hu Y, Ding W, Zhang C, Fang C. miR-448 negatively regulates ovarian cancer cell growth and metastasis by targeting CXCL12. Clin Transl Oncol. 2015; 17:903-909.
14. Zhu H, Zhou X, Ma C, Chang H, Li H, Liu F, Lu J. Low Expression of miR-448 Induces EMT and Promotes Invasion by Regulating ROCK2 in Hepatocellular Carcinoma. Cell Physiol Biochem. 2015; 36:487-498.
15. Li Q, Chen Z, Cao X, Xu J, Xu J, Chen Y, Wang W, Chen Q, Tang F, Liu X, Xu Z. Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ. 2011; 18:16-25.
16. Xu C, Zheng Y, Lian D, Ye S, Yang J, Zeng Z. Analysis of MicroRNA expression profile identifies novel biomarkers for non-small cell lung cancer. Tumori. 2014; 101:104-110.
17. Mikawa T, LLeonart ME, Takaori-Kondo A, Inagaki N, Yokode M, Kondoh H. Dysregulated glycolysis as an oncogenic event. Cell Mol Life Sci. 2015; 72:1881-1892.
18. Huang SW, Kao JK, Wu CY, Wang ST, Lee HC, Liang SM, Chen YJ, Shieh JJ. Targeting Aerobic Glycolysis and HIF-1aα Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells. Oncotarget. 2014; 5:1363-1381. doi: 10.18632/oncotarget.1734.
19. Dal Bo M, Bomben R, Hernández L, Gattei V. The MYC/miR-17-92 axis in lymphoproliferative disorders: A common pathway with therapeutic potential. Oncotarget. 2015; 6:19381-19392. doi: 10.18632/oncotarget.4574.