Prioritizing Functional Capacity as a Principal End Point for Therapies Oriented to Older Adults with Cardiovascular Disease: A Scientific Statement for Healthcare Professionals from the American Heart Association

Circulation

Volumn 135, Issue 16, 2017, Pages e894-e918

  Forman, Daniel E ^a   Arena, Ross ^a   Boxer, Rebecca ^a   Dolansky, Mary A ^a   Eng, Janice J ^a   Fleg, Jerome L ^a   Haykowsky, Mark ^a   Jahangir, Arshad ^a   Kaminsky, Leonard A ^a   Kitzman, Dalane W ^a   Lewis, Eldrin F ^a   Myers, Jonathan ^a   Reeves, Gordon R ^a   Shen, Win Kuang ^a  

^a NONE

Author keywords

aged; AHA Scientific Statements; cardiopulmonary exercise test; cardiorespiratory fitness; exercise tolerance; frail older adults; physical activity; sarcopenia

Indexed keywords

AEROBIC CAPACITY; AEROBIC EXERCISE; ATHEROSCLEROSIS; BODY EQUILIBRIUM; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR DISEASE; COGNITION; COMORBIDITY; EXERCISE; FRAILTY; FUNCTIONAL STATUS; HEALTH CARE PERSONNEL; HEART; HEART FAILURE; HUMAN; INFLAMMATION; LUNG; MEDICAL SOCIETY; MITOCHONDRIAL RESPIRATION; MUSCLE EXERCISE; MUSCLE STRENGTH; NURSING HOME; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; SENESCENCE; SKILL; SLEEP; STRENGTH; VASCULARIZATION; CARDIOVASCULAR DISEASES; CARDIOVASCULAR FUNCTION; GENETICS; RISK FACTOR; UNITED STATES;

AMERICAN HEART ASSOCIATION; CARDIOVASCULAR DISEASES; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; HUMANS; RISK FACTORS; UNITED STATES;

EID: 85016020610     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIR.0000000000000483     Document Type: Review

References (241)

1. Centers for Disease Control and Prevention. Table 22: life expectancy at birth, at 65 years of age, and at 75 years of age, by race and sex: United States, selected years 1900-2007. http:// www.cdc.gov/nchs/data/hus/2010/022.pdf. Accessed May 15, 2016.
2. Ortman JM, Velkoff VA, Hogan H. An aging nation: the older population in the United States. 2014. https://www.census.gov/ prod/2014pubs/p25-1140.pdf. Accessed January 14, 2017.
3. Forman DE, Rich MW, Alexander KP, Zieman S, Maurer MS, Naj-jar SS, Cleveland JC Jr, Krumholz HM, Wenger NK. Cardiac care for older adults: time for a new paradigm. J Am Coll Cardiol. 2011;57:1801-1810. doi: 10.1016/j.jacc.2011.02.014.
4. Covinsky KE, Pierluissi E, Johnston CB. Hospitalization-associated disability: "She was probably able to ambulate, but I'm not sure." JAMA. 2011;306:1782-1793. doi: 10.1001/jama.2011.1556.
5. Fried TR, McGraw S, Agostini JV, Tinetti ME. Views of older persons with multiple morbidities on competing outcomes and clinical decision-making. J Am Geriatr Soc. 2008;56:1839-1844. doi: 10.1111/j.1532-5415.2008.01923.x.
6. Lavie CJ, Arena R, Swift DL, Johannsen NM, Sui X, Lee DC, Earnest CP, Church TS, O'Keefe JH, Milani RV, Blair SN. Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circ Res. 2015;117:207-219. doi: 10.1161/CIRCRESAHA. 117.305205.
7. Arena R, Myers J, Williams MA, Gulati M, Kligfield P, Balady GJ, Collins E, Fletcher G. Assessment of functional capacity in clinical and research settings: a scientific statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing. Circulation. 2007;116:329-343. doi: 10.1161/CIRCULATIONAHA.106.184461.
8. Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, Forman D, Franklin B, Guazzi M, Gulati M, Keteyian SJ, Lavie CJ, Macko R, Mancini D, Milani RV; on behalf of the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Interdisciplinary Council on Quality of Care and Outcomes Research. Clinician's guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation. 2010;122:191-225. doi: 10.1161/ CIR.0b013e3181e52e69.
9. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801. doi: 10.1056/ NEJMoa011858.
10. Fleg JL, Morrell CH, Bos AG, Brant LJ, Talbot LA, Wright JG, Lakatta EG. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005;112:674-682. doi: 10.1161/CIRCULATIONAHA.105.545459.
11. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schul-man SP, Lakatta EG. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol (1985). 1995;78:890-900.
12. Kaye DM, Esler MD. Autonomic control of the aging heart. Neuro-molecular Med. 2008;10:179-186. doi: 10.1007/s12017-008-8034-1.
13. Gouspillou G, Bourdel-Marchasson I, Rouland R, Calmettes G, Biran M, Deschodt-Arsac V, Miraux S, Thiaudiere E, Pasdois P, Detaille D, Franconi JM, Babot M, Trézéguet V, Arsac L, Diolez P. Mitochondrial energetics is impaired in vivo in aged skeletal muscle. Aging Cell. 2014;13:39-48. doi: 10.1111/acel.12147.
14. Bean JF, Kiely DK, LaRose S, Leveille SG. Which impairments are most associated with high mobility performance in older adults? Implications for a rehabilitation prescription. Arch Phys Med Reha-bil. 2008;89:2278-2284. doi: 10.1016/j.apmr.2008.04.029.
15. Kallman DA, Plato CC, Tobin JD. The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives. J Gerontol. 1990;45:M82-M88.
16. Deschenes MR. Effects of aging on muscle fibre type and size. Sports Med. 2004;34:809-824.
17. Manologas S. Aging and the musculoskeletal system. In: Beers MH, and Berkow. R, eds. The Merck Manual of Geriatrics, Third Edition. Whitehouse Station, NJ: Merck Research Laboratories; 2000:467-472.
18. Forman DE, Fleg JL. Exercise in older adults. In: Ehrman JK, Gordon PM, Visich PS, Keteyian SJ, eds. Clinical Exercise Physiology. Champaign, IL: Human Kinetics; 2013;589-604.
19. Fleg JL, Aronow WS, Frishman WH. Cardiovascular drug therapy in the elderly: benefits and challenges. Nat Rev Cardiol. 2011;8:13-28. doi: 10.1038/nrcardio.2010.162.
20. Whitson HE, Cousins SW, Burchett BM, Hybels CF, Pieper CF, Cohen HJ. The combined effect of visual impairment and cognitive impairment on disability in older people. J Am Geriatr Soc. 2007;55:885-891. doi: 10.1111/j.1532-5415.2007.01093.x.
21. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cush-man M, Das SR, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jimenez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER, 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB; on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2016 update: a report from the American Heart Association [published correction appears in Circulation. 2016;133:e599]. Circulation. 2016;133:e38-e360. doi: 10.1161/CIR.0000000000000350.
22. Lichtman JH, Bigger JT Jr, Blumenthal JA, Frasure-Smith N, Kaufmann PG, Lespérance F, Mark DB, Sheps DS, Taylor CB, Fro-elicher ES. Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation. 2008;118:1768-1775. doi: 10.1161/CIRCULATIONAHA. 108.190769.
23. Sin NL, Kumar AD, Gehi AK, Whooley MA. Direction of association between depressive symptoms and lifestyle behaviors in patients with coronary heart disease: the Heart and Soul Study. Ann Behav Med. 2016;50:523-532. doi: 10.1007/s12160-016-9777-9.
24. Sherwood A, Blumenthal JA, Hinderliter AL, Koch GG, Adams KF Jr, Dupree CS, Bensimhon DR, Johnson KS, Trivedi R, Bowers M, Christenson RH, O'Connor CM. Worsening depressive symptoms are associated with adverse clinical outcomes in patients with heart failure. J Am Coll Cardiol. 2011;57:418-423. doi: 10.1016/j.jacc.2010.09.031.
25. Crane PB. Fatigue and physical activity in older women after myo-cardial infarction. Heart Lung. 2005;34:30-38. doi: 10.1016/j. hrtlng.2004.08.007.
26. Olivieri F, Recchioni R, Marcheselli F, Abbatecola AM, Santini G, Borghetti G, Antonicelli R, Procopio AD. Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment. Curr Pharm Des. 2013;19: 1710-1719.
27. Preston CC, Oberlin AS, Holmuhamedov EL, Gupta A, Sagar S, Syed RH, Siddiqui SA, Raghavakaimal S, Terzic A, Jahangir A. Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart. Mech Ageing Dev. 2008;129:304-312. doi: 10.1016/j. mad.2008.02.010.
28. Gonzalez-Freire M, de Cabo R, Bernier M, Sollott SJ, Fabbri E, Navas P, Ferrucci L. Reconsidering the role of mitochondria in aging. J Gerontol A Biol Sci Med Sci. 2015;70:1334-1342. doi: 10.1093/gerona/glv070.
29. Tepp K, Timohhina N, Puurand M, Klepinin A, Chekulayev V, Shev-chuk I, Kaambre T. Bioenergetics of the aging heart and skeletal muscles: modern concepts and controversies. Ageing Res Rev. 2016;28:1-14. doi: 10.1016/j.arr.2016.04.001.
30. Di Lisa F, Bernardi P. Mitochondrial function and myocardial aging: a critical analysis of the role of permeability transition. Cardiovasc Res. 2005;66:222-232. doi: 10.1016/j.cardiores.2005.02.009.
31. Wohlgemuth SE, Calvani R, Marzetti E. The interplay between au-tophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology. J Mol Cell Cardiol. 2014;71:62-70. doi: 10.1016/j.yjmcc.2014.03.007.
32. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-270. doi: 10.1146/annurev.med.51.1.245.
33. Brüünsgaard H, Pedersen BK. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003;23:15-39.
34. Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014;2:4172. doi: 10.1038/ncomms5172.
35. Kalogeropoulos A, Georgiopoulou V, Psaty BM, Rodondi N, Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Newman AB, Kritchevsky SB, Harris TB, Butler J; Health ABC Study Investigators. Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol. 2010;55:2129-2137. doi: 10.1016/j. jacc.2009.12.045.
36. Liu CK, Lyass A, Larson MG, Massaro JM, Wang N, D'Agostino RB Sr, Benjamin EJ, Murabito JM. Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study. Age (Dordr). 2016;38:1. doi: 10.1007/s11357-015-9864-z.
37. Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, Launer L, Kuller L, Rubin S, Harris T. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003;61:76-80.
38. DiMaria-Ghalili RA, Sullivan-Marx EM, Compher C. Inflammation, functional status, and weight loss during recovery from cardiac surgery in older adults: a pilot study. Biol Res Nurs. 2014;16:344-352. doi: 10.1177/1099800413503489.
39. Forman DE, Alexander KP. Frailty: a vital sign for older adults with cardiovascular disease. Can J Cardiol. 2016;32:1082-1087. doi: 10.1016/j.cjca.2016.05.015.
40. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991-1001.
41. Afilalo J, Alexander KP, Mack MJ, Maurer MS, Green P, Allen LA, Popma JJ, Ferrucci L, Forman DE. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol. 2014;63:747-762. doi: 10.1016/j.jacc.2013.09.070.
42. Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12:29-37.
43. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-M156.
44. Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009;103:1616-1621. doi: 10.1016/j.amjcard. 2009.01.375.
45. Partridge JS, Fuller M, Harari D, Taylor PR, Martin FC, Dhesi JK. Frailty and poor functional status are common in arterial vascular surgical patients and affect postoperative outcomes. Int J Surg. 2015;18:57-63. doi: 10.1016/j.ijsu.2015.04.037.
46. Afilalo J, Eisenberg MJ, Morin JF, Bergman H, Monette J, Noiseux N, Perrault LP, Alexander KP, Langlois Y, Dendukuri N, Chamoun P, Kasparian G, Robichaud S, Gharacholou SM, Boivin JF. Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol. 2010;56:1668-1676. doi: 10.1016/j.jacc.2010.06.039.
47. Pinsky JL, Jette AM, Branch LG, Kannel WB, Feinleib M. The Fram-ingham Disability Study: relationship of various coronary heart disease manifestations to disability in older persons living in the community. Am J Public Health. 1990;80:1363-1367.
48. ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemp Clin Trials. 2013;36:555-564.
49. Myers J, Arena R, Cahalin LP, Labate V, Guazzi M. Cardiopul-monary exercise testing in heart failure. Curr Probl Cardiol. 2015;40:322-372. doi: 10.1016/j.cpcardiol.2015.01.009.
50. Scardovi A, De Maria R, Ferraironi A, Renzi M, Turi F, Parolini M, Di Giacomo T, Ricci R. Prognostic value of cardiopulmonary exercise test in elderly women with heart failure and reduced or preserved ejection fraction. World J Cardiovasc Dis. 2014;4:341-349.
51. Reeves GR, Gupta S, Forman DE. Evolving role of exercise testing in contemporary cardiac rehabilitation. J Cardiopulm Rehabil Prev. 2016;36:309-319. doi: 10.1097/HCR.0000000000000176.
52. Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, Coke LA, Fleg JL, Forman DE, Gerber TC, Gulati M, Madan K, Rhodes J, Thompson PD, Williams MA; on behalf of the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology, Council on Nutrition, Physical Activity and Metabolism, Council on Cardiovascular and Stroke Nursing, and Council on Epidemiology and Prevention. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128:873-934. doi: 10.1161/CIR.0b013e31829b5b44.
53. Skinner J. Aging for exercise testing and prescription. In: Skinner J., ed. Exercise Testing and Prescription for Special Cases: Theoretical Basis and Clinical Applications. Philadelphia, PA: Lippincott, Williams & Wilkins; 2005:85-99.
54. Forman DE. Diagnostic testing in the elderly: imaging is great, but it's not the whole story. Am J Geriatr Cardiol. 2007;16:340-342.
55. Myers J, Forman DE, Balady GJ, Franklin BA, Nelson-Worel J, Martin BJ, Herbert WG, Guazzi M, Arena R; on behalf of the American Heart Association Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention of the Council on Clinical Cardiology, Council on Lifestyle and Cardiometabolic Health, Council on Epidemiology and Prevention, and Council on Cardiovascular and Stroke Nursing. Supervision of exercise testing by non-physicians: a scientific statement from the American Heart Association. Circulation. 2014;130:1014-1027. doi: 10.1161/ CIR.0000000000000101.
56. McArdle W, Katch F. Exercise Physiology: Nutrition, Energy, and Human Performance. 7th ed. Baltimore, MD: Wolters Kluwer; 2010.
57. Arena R, Myers J, Kaminsky LA. Revisiting age-predicted maximal heart rate: can it be used as a valid measure of effort? Am Heart J. 2016;173:49-56. doi: 10.1016/j.ahj.2015.12.006.
58. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test [published correction appears in Am J Respir Crit Care Med. 2016;193:1185]. Am J Respir Crit Care Med. 2002;166:111-117.
59. Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest. 2001;119:256-270.
60. Ross RM, Murthy JN, Wollak ID, Jackson AS. The six minute walk test accurately estimates mean peak oxygen uptake. BMC Pulm Med. 2010;10:31. doi: 10.1186/1471-2466-10-31.
61. Myers J, Zaheer N, Quaglietti S, Madhavan R, Froelicher V, Heiden-reich P. Association of functional and health status measures in heart failure. J Card Fail. 2006;12:439-445. doi: 10.1016/ j.cardfail.2006.04.004.
62. Rantanen T, Guralnik JM, Ferrucci L, Penninx BW, Leveille S, Sipilä S, Fried LP. Coimpairments as predictors of severe walking disability in older women. J Am Geriatr Soc. 2001;49:21-27.
63. Legrand D, Vaes B, Matheï C, Adriaensen W, Van Pottelbergh G, Degryse JM. Muscle strength and physical performance as predictors of mortality, hospitalization, and disability in the oldest old. J Am Geriatr Soc. 2014;62:1030-1038. doi: 10.1111/jgs.12840.
64. Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB. Strength, but not muscle mass, is associated with mortality in the Health, Aging and Body Composition Study Cohort. J Gerontol A Biol Sci Med Sci. 2006;61:72-77.
65. Metter EJ, Talbot LA, Schrager M, Conwit R. Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002;57:B359-B365.
66. Katzmarzyk PT, Craig CL. Musculoskeletal fitness and risk of mortality. Med Sci Sports Exerc. 2002;34:740-744.
67. Hurley BF, Redmond RA, Pratley RE, Treuth MS, Rogers MA, Goldberg AP. Effects of strength training on muscle hypertrophy and muscle cell disruption in older men. Int J Sports Med. 1995;16:378-384. doi: 10.1055/s-2007-973024.
68. Shaw CE, McCully KK, Posner JD. Injuries during the one repetition maximum assessment in the elderly. J Cardiopulm Rehabil. 1995;15:283-287.
69. Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330:1769-1775. doi: 10.1056/NEJM199406233302501.
70. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians: effects on skeletal muscle. JAMA. 1990;263:3029-3034.
71. Rantanen T, Era P, Heikkinen E. Maximal isometric strength and mobility among 75-year-old men and women. Age Ageing. 1994;23:132-137.
72. Norman K, Stobäus N, Gonzalez MC, Schulzke JD, Pirlich M. Hand grip strength: outcome predictor and marker of nutritional status. Clin Nutr. 2011;30:135-142. doi: 10.1016/j.clnu.2010.09.010.
73. Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, Seron P, Ahmed SH, Rosengren A, Kelishadi R, Rahman O, Swaminathan S, Iqbal R, Gupta R, Lear SA, Oguz A, Yusoff K, Zatonska K, Chifamba J, Igumbor E, Mohan V, Anjana RM, Gu H, Li W, Yusuf S; Prospective Urban Rural Epidemiology (PURE) Study investigators. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015;386:266-273. doi: 10.1016/S0140-6736(14)62000-6.
74. Gale CR, Martyn CN, Cooper C, Sayer AA. Grip strength, body composition, and mortality. Int J Epidemiol. 2007;36:228-235.
75. Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40:423-429. doi: 10.1093/ageing/afr051.
76. Lindström B, Lexell J, Gerdle B, Downham D. Skeletal muscle fatigue and endurance in young and old men and women. J Gerontol A Biol Sci Med Sci. 1997;52:B59-B66.
77. Jubrias SA, Odderson IR, Esselman PC, Conley KE. Decline in isokinetic force with age: muscle cross-sectional area and specific force. Pflugers Arch. 1997;434:246-253. doi: 10.1007/ s004240050392.
78. Hicks AL, Cupido CM, Martin J, Dent J. Muscle excitation in elderly adults: the effects of training. Muscle Nerve. 1992;15:87-93. doi: 10.1002/mus.880150115.
79. Hunter S, White M, Thompson M. Techniques to evaluate elderly human muscle function: a physiological basis. J Gerontol A Biol Sci Med Sci. 1998;53:B204-B216.
80. Power GA, Dalton BH, Rice CL. Human neuromuscular structure and function in old age: a brief review. J Sport Health Sci. 2013;2:215-226. doi: 10.1016/j.jshs.2013.07.001.
81. Cooper R, Kuh D, Cooper C, Gale CR, Lawlor DA, Matthews F, Hardy R; FALCon and HALCyon Study Teams. Objective measures of physical capability and subsequent health: a systematic review. Age Ageing. 2011;40:14-23. doi: 10.1093/ageing/afq117.
82. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332:556-561. doi: 10.1056/NEJM199503023320902.
83. Callahan D, Phillips E, Carabello R, Frontera WR, Fielding RA. Assessment of lower extremity muscle power in functionally-limited elders. Aging Clin Exp Res. 2007;19:194-199.
84. Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Fer-rucci L, Guralnik J. Gait speed and survival in older adults. JAMA. 2011;305:50-58. doi: 10.1001/jama.2010.1923.
85. Abellan van Kan G, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, Cesari M, Donini LM, Gillette Guyonnet S, Inzitari M, Nourhashemi F, Onder G, Ritz P, Salva A, Visser M, Vellas B. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people: an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging. 2009;13:881-889.
86. Karlsson MK, Magnusson H, von Schewelov T, Rosengren BE. Prevention of falls in the elderly: a review. Osteoporos Int. 2013;24:747-762. doi: 10.1007/s00198-012-2256-7.
87. Alamgir H, Muazzam S, Nasrullah M. Unintentional falls mortality among elderly in the United States: time for action. Injury. 2012;43:2065-2071. doi: 10.1016/j.injury.2011.12.001.
88. Noohu MM, Dey AB, Hussain ME. Relevance of balance measurement tools and balance training for fall prevention in older adults. J Clin Gerontol Geriatr. 2014;5:31-35.
89. Mancini M, Horak FB. The relevance of clinical balance assessment tools to differentiate balance deficits. Eur J Phys Rehabil Med. 2010;46:239-248.
90. Berg KO, Wood-Dauphinee SL, Williams JI, Maki B. Measuring balance in the elderly: validation of an instrument. Can J Public Health. 1992;83(suppl 2):S7-S11.
91. Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc. 1986;34:119-126.
92. Brito LB, Ricardo DR, Araújo DS, Ramos PS, Myers J, Araújo CG. Ability to sit and rise from the floor as a predictor of all-cause mortality. Eur J Prev Cardiol. 2014;21:892-898. doi: 10.1177/2047487312471759.
93. Weiner DK, Duncan PW, Chandler J, Studenski SA. Functional reach: a marker of physical frailty. J Am Geriatr Soc. 1992;40:203-207.
94. Katz-Leurer M, Fisher I, Neeb M, Schwartz I, Carmeli E. Reliability and validity of the modified functional reach test at the sub-acute stage post-stroke. Disabil Rehabil. 2009;31:243-248. doi: 10.1080/09638280801927830.
95. Perera S, Mody SH, Woodman RC, Studenski SA. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc. 2006;54:743-749. doi: 10.1111/j.1532-5415.2006.00701.x.
96. Schoene D, Wu SM, Mikolaizak AS, Menant JC, Smith ST, Delbaere K, Lord SR. Discriminative ability and predictive validity of the timed up and go test in identifying older people who fall: systematic review and meta-analysis. J Am Geriatr Soc. 2013;61:202-208. doi: 10.1111/jgs.12106.
97. Beauchet O, Fantino B, Allali G, Muir SW, Montero-Odasso M, Annweiler C. Timed Up and Go test and risk of falls in older adults: a systematic review. J Nutr Health Aging. 2011;15:933-938.
98. Clegg A, Rogers L, Young J. Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. Age Ageing. 2015;44:148-152. doi: 10.1093/ageing/afu157.
99. Katz S. Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc. 1983;31:721-727.
100. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179-186.
101. Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J. 1965;14:61-65.
102. Cohen ME, Marino RJ. The tools of disability outcomes research functional status measures. Arch Phys Med Rehabil. 2000;81(suppl 2):S21-S29.
103. Gloth FM 3rd, Walston J, Meyer J, Pearson J. Reliability and validity of the Frail Elderly Functional Assessment questionnaire. Am J Phys Med Rehabil. 1995;74:45-53.
104. Gloth FM 3rd, Scheve AA, Shah S, Ashton R, McKinney R. The Frail Elderly Functional Assessment questionnaire: its responsiveness and validity in alternative settings. Arch Phys Med Rehabil. 1999;80:1572-1576.
105. Strath SJ, Kaminsky LA, Ainsworth BE, Ekelund U, Freedson PS, Gary RA, Richardson CR, Smith DT, Swartz AM; on behalf of the American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health and Cardiovascular, Exercise, Cardiac Rehabilitation and Prevention Committee of the Council on Clinical Cardiology, and Council on Cardiovascular and Stroke Nursing. Guide to the assessment of physical activity: clinical and research applications: a scientific statement from the American Heart Association. Circulation. 2013;128:2259-2279. doi: 10.1161/01.cir.0000435708.67487.da.
106. Hlatky MA, Boineau RE, Higginbotham MB, Lee KL, Mark DB, Califf RM, Cobb FR, Pryor DB. A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). Am J Cardiol. 1989;64:651-654.
107. Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis. 1978;31:741-755.
108. Loprinzi PD, Davis RE. Daily movement patterns and predicted 10-yr risk for a first atherosclerotic cardiovascular disease (ASCVD) event using the pooled cohort risk equations among US adults. Prev Med. 2015;81:78-81. doi: 10.1016/j. ypmed.2015.08.008.
109. Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E; NHLBI Heart Failure Clinical Research Network. Isosorbide mononitrate in heart failure with preserved ejection fraction. N Engl J Med. 2015;373:2314-2324. doi: 10.1056/NEJMoa1510774.
110. Lewis EF. Activities worth living for: call to action beyond prognosis. Circ Heart Fail. 2015;8:231-232. doi: 10.1161/ CIRCHEARTFAILURE.115.002064.
111. Burke LB, Kennedy DL, Miskala PH, Papadopoulos EJ, Trentacosti AM. The use of patient-reported outcome measures in the evaluation of medical products for regulatory approval. Clin Pharmacol Ther. 2008;84:281-283. doi: 10.1038/clpt.2008.128.
112. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), and Center for Devices and Radiological Health (CDRH). Guidance for industry. Patient-reported outcome measures: use in medical product development to support labeling claims. December 2009. http:// www.fda.gov/downloads/Drugs/Guidances/UCM193282.pdf. Accessed May 15, 2016.
113. Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic value of health status in patients with heart failure after acute myocardial infarction. Circulation. 2004;110:546-551. doi: 10.1161/01.CIR.0000136991.85540.A9.
114. Vaishnava P, Lewis EF. Assessment of quality of life in severe heart failure. Curr Heart Fail Rep. 2007;4:170-177.
115. Guyatt GH. Measurement of health-related quality of life in heart failure. J Am Coll Cardiol. 1993;22(suppl A):185A-191A.
116. Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000;35:1245-1255.
117. Gottlieb SS, Kop WJ, Ellis SJ, Binkley P, Howlett J, O'Connor C, Blumenthal JA, Fletcher G, Swank AM, Cooper L; HF-ACTION Investigators. Relation of depression to severity of illness in heart failure (from Heart Failure And a Controlled Trial Investigating Outcomes of Exercise Training [HF-ACTION]). Am J Cardiol. 2009;103:1285-1289. doi: 10.1016/j.amjcard.2009.01.025.
118. Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev. 1977;84:191-215.
119. White SM, Wójcicki TR, McAuley E. Physical activity and quality of life in community dwelling older adults. Health Qual Life Outcomes. 2009;7:10. doi: 10.1186/1477-7525-7-10.
120. McAuley E, Morris KS, Doerksen SE, Motl RW, Liang H, White SM, Wójcicki TR, Rosengren K. Effects of change in physical activity on physical function limitations in older women: mediating roles of physical function performance and self-efficacy. J Am Geriatr Soc. 2007;55:1967-1973. doi: 10.1111/j.1532-5415. 2007.01469.x.
121. Elavsky S, McAuley E, Motl RW, Konopack JF, Marquez DX, Hu L, Jerome GJ, Diener E. Physical activity enhances long-term quality of life in older adults: efficacy, esteem, and affective influences. Ann Behav Med. 2005;30:138-145. doi: 10.1207/ s15324796abm3002-6.
122. McAuley E, Blissmer B, Katula J, Duncan TE, Mihalko SL. Physical activity, self-esteem, and self-efficacy relationships in older adults: a randomized controlled trial. Ann Behav Med. 2000;22:131-139.
123. Gnanasakthy A, Mordin M, Clark M, DeMuro C, Fehnel S, Copley-Merriman C. A review of patient-reported outcome labels in the United States: 2006 to 2010. Value Health. 2012;15:437-442. doi: 10.1016/j.jval.2011.11.032.
124. Arena R, Williams M, Forman DE, Cahalin LP, Coke L, Myers J, Hamm L, Kris-Etherton P, Humphrey R, Bittner V, Lavie CJ; on behalf of the American Heart Association Exercise, Cardiac Rehabilitation and Prevention Committee of the Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Council on Nutrition, Physical Activity and Metabolism. Increasing referral and participation rates to outpatient cardiac rehabilitation: the valuable role of healthcare professionals in the inpatient and home health settings: a science advisory from the American Heart Association. Circulation. 2012;125:1321-1329. doi: 10.1161/CIR.0b013e318246b1e5.
125. Morey MC, Pieper CF, Cornoni-Huntley J. Is there a threshold between peak oxygen uptake and self-reported physical functioning in older adults? Med Sci Sports Exerc. 1998;30:1223-1229.
126. Kortebein P. Rehabilitation for hospital-associated decondition-ing. Am J Phys Med Rehabil. 2009;88:66-77. doi: 10.1097/ PHM.0b013e3181838f70.
127. Kortebein P, Bopp MM, Granger CV, Sullivan DH. Outcomes of inpatient rehabilitation for older adults with debility. Am J Phys Med Rehabil. 2008;87:118-125. doi: 10.1097/PHM. 0b013e3181588429.
128. Berg HE, Eiken O, Miklavcic L, Mekjavic IB. Hip, thigh and calf muscle atrophy and bone loss after 5-week bedrest inactivity. Eur J Appl Physiol. 2007;99:283-289. doi: 10.1007/s00421-006-0346-y.
129. Bloomfield SA. Changes in musculoskeletal structure and function with prolonged bed rest. Med Sci Sports Exerc. 1997;29:197-206.
130. Brown CJ, Redden DT, Flood KL, Allman RM. The underrec-ognized epidemic of low mobility during hospitalization of older adults. J Am Geriatr Soc. 2009;57:1660-1665. doi: 10.1111/j.1532-5415.2009.02393.x.
131. Convertino VA, Bloomfield SA, Greenleaf JE. An overview of the issues: physiological effects of bed rest and restricted physical activity. Med Sci Sports Exerc. 1997;29:187-190.
132. Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans WJ. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA. 2007;297:1772-1774. doi: 10.1001/ jama.297.16.1772-b.
133. Hruda KV, Hicks AL, McCartney N. Training for muscle power in older adults: effects on functional abilities. Can J Appl Physiol. 2003;28:178-189.
134. Kalapotharakos VI, Diamantopoulos K, Tokmakidis SP. Effects of resistance training and detraining on muscle strength and functional performance of older adults aged 80 to 88 years. Aging Clin Exp Res. 2010;22:134-140.
135. Rantanen T, Guralnik JM, Izmirlian G, Williamson JD, Simonsick EM, Ferrucci L, Fried LP. Association of muscle strength with maximum walking speed in disabled older women. Am J Phys Med Rehabil. 1998;77:299-305.
136. Boyd CM, Landefeld CS, Counsell SR, Palmer RM, Fortinsky RH, Kresevic D, Burant C, Covinsky KE. Recovery of activities of daily living in older adults after hospitalization for acute medical illness. J Am Geriatr Soc. 2008;56:2171-2179. doi: 10.1111/j.1532-5415.2008.02023.x.
137. Brown CJ, Friedkin RJ, Inouye SK. Prevalence and outcomes of low mobility in hospitalized older patients. J Am Geriatr Soc. 2004;52:1263-1270. doi: 10.1111/j.1532-5415. 2004.52354.x.
138. Depalma G, Xu H, Covinsky KE, Craig BA, Stallard E, Thomas J 3rd, Sands LP. Hospital readmission among older adults who return home with unmet need for ADL disability. Gerontologist. 2013;53:454-461. doi: 10.1093/geront/gns103.
139. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59:255-263.
140. Gill TM, Allore HG, Holford TR, Guo Z. Hospitalization, restricted activity, and the development of disability among older persons. JAMA. 2004;292:2115-2124. doi: 10.1001/ jama.292.17.2115.
141. Dolansky MA, Moore SM. Older adults' early disability following a cardiac event. West J Nurs Res. 2008;30:163-180. doi: 10.1177/0193945907303061.
142. Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. Am Heart J. 2012;163:790-796. doi: 10.1016/j.ahj.2012.02.024.
143. Hagberg JM, Graves JE, Limacher M, Woods DR, Leggett SH, Cononie C, Gruber JJ, Pollock ML. Cardiovascular responses of 70- to 79-yr-old men and women to exercise training. J Appl Physiol (1985). 1989;66:2589-2594.
144. Huang G, Gibson CA, Tran ZV, Osness WH. Controlled endurance exercise training and VO2max changes in older adults: a meta-analysis. Prev Cardiol. 2005;8:217-225.
145. Beere PA, Russell SD, Morey MC, Kitzman DW, Higginbotham MB. Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. Circulation. 1999;100:1085-1094.
146. Konopka AR, Harber MP. Skeletal muscle hypertrophy after aerobic exercise training. Exerc Sport Sci Rev. 2014;42:53-61. doi: 10.1249/JES.0000000000000007.
147. Hakim AA, Curb JD, Petrovitch H, Rodriguez BL, Yano K, Ross GW, White LR, Abbott RD. Effects of walking on coronary heart disease in elderly men: the Honolulu Heart Program. Circulation. 1999;100:9-13.
148. Bensimhon DR, Leifer ES, Ellis SJ, Fleg JL, Keteyian SJ, Piña IL, Kitzman DW, McKelvie RS, Kraus WE, Forman DE, Kao AJ, Whellan DJ, O'Connor CM, Russell SD; HF-ACTION Trial Investigators. Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing). Am J Cardiol. 2008;102:712-717. doi: 10.1016/j.amjcard.2008.04.047.
149. Keteyian SJ, Brawner CA, Ehrman JK, Ivanhoe R, Boehmer JP, Abraham WT; PEERLESS-HF Trial Investigators. Reproducibility of peak oxygen uptake and other cardiopulmonary exercise parameters: implications for clinical trials and clinical practice. Chest. 2010;138:950-955. doi: 10.1378/chest.09-2624.
150. Tinetti ME. Clinical practice. preventing falls in elderly persons. N Engl J Med. 2003;348:42-49. doi: 10.1056/NEJMcp020719.
151. Smith SC Jr, Benjamin EJ, Bonow RO, Braun LT, Creager MA, Franklin BA, Gibbons RJ, Grundy SM, Hiratzka LF, Jones DW, Lloyd-Jones DM, Minissian M, Mosca L, Peterson ED, Sacco RL, Spertus J, Stein JH, Taubert KA. AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation [published correction appears in Circulation. 2015;131:e408]. Circulation. 2011;124:2458-2473.
152. Janssen V, De Gucht V, Dusseldorp E, Maes S. Lifestyle modification programmes for patients with coronary heart disease: a systematic review and meta-analysis of randomized controlled trials. Eur J Prev Cardiol. 2013;20:620-640. doi: 10.1177/2047487312462824.
153. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJV, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WHW, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128:e240-e327.
154. Fleg JL, Cooper LS, Borlaug BA, Haykowsky MJ, Kraus WE, Levine BD, Pfeffer MA, Piña IL, Poole DC, Reeves GR, Whellan DJ, Kitzman DW; National Heart, Lung, and Blood Institute Working Group. Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail. 2015;8:209-220. doi: 10.1161/CIRCHEARTFAILURE.113.001420.
155. Anderson L, Oldridge N, Thompson DR, Zwisler AD, Rees K, Martin N, Taylor RS. Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane systematic review and meta-analysis. J Am Coll Cardiol. 2016;67:1-12. doi: 10.1016/j.jacc.2015.10.044.
156. Taylor RS, Dalal H, Jolly K, Zawada A, Dean SG, Cowie A, Norton RJ. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev. 2015:CD007130. doi: 10.1002/14651858.CD007130.pub3.
157. Rawstorn JC, Gant N, Direito A, Beckmann C, Maddison R. Telehealth exercise-based cardiac rehabilitation: a systematic review and meta-analysis. Heart. 2016;102:1183-1192. doi: 10.1136/heartjnl-2015-308966.
158. Lager KE, Mistri AK, Khunti K, Haunton VJ, Sett AK, Wilson AD. Interventions for improving modifiable risk factor control in the secondary prevention of stroke. Cochrane Database Syst Rev. 2014:CD009103. doi: 10.1002/14651858.CD009103.pub2.
159. Winstein CJ, Stein J, Arena R, Bates B, Cherney LR, Cramer SC, Deruyter F, Eng JJ, Fisher B, Harvey RL, Lang CE, MacKay-Lyons M, Ottenbacher KJ, Pugh S, Reeves MJ, Richards LG, Stiers W, Zorowitz RD; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association [published correction appears in Stroke. 2017;48:e78]. Stroke. 2016;47:e98-e169. doi: 10.1161/STR.0000000000000098.
160. Fearon P, Langhorne P; Early Supported Discharge Trialists. Services for reducing duration of hospital care for acute stroke patients. Cochrane Database Syst Rev. 2012:CD000443. doi: 10.1002/14651858.CD000443.pub3.
161. Lohse KR, Lang CE, Boyd LA. Is more better? Using metadata to explore dose-response relationships in stroke rehabilitation. Stroke. 2014;45:2053-2058. doi: 10.1161/STROKEAHA. 114.004695.
162. Pollock A, Baer G, Campbell P, Choo PL, Forster A, Morris J, Pomeroy VM, Langhorne P. Physical rehabilitation approaches for the recovery of function and mobility following stroke. Cochrane Database Syst Rev. 2014:CD001920. doi: 10.1002/14651858. CD001920.pub3.
163. Saunders DH, Sanderson M, Hayes S, Kilrane M, Greig CA, Brazzelli M, Mead GE. Physical fitness training for stroke patients. Cochrane Database Syst Rev. 2016:CD003316. doi: 10.1002/14651858.CD003316.pub6.
164. Eng JJ, Reime B. Exercise for depressive symptoms in stroke patients: a systematic review and meta-analysis. Clin Rehabil. 2014;28:731-739. doi: 10.1177/0269215514523631.
165. Cumming TB, Tyedin K, Churilov L, Morris ME, Bernhardt J. The effect of physical activity on cognitive function after stroke: a systematic review. Int Psychogeriatr. 2012;24:557-567. doi: 10.1017/S1041610211001980.
166. Conte MS, Pomposelli FB. Society for Vascular Surgery Practice guidelines for atherosclerotic occlusive disease of the lower extremities management of asymptomatic disease and clau-dication: introduction. J Vasc Surg. 2015;61(suppl):1S. doi: 10.1016/j.jvs.2014.12.006.
167. Lane R, Ellis B, Watson L, Leng GC. Exercise for intermittent claudication. Cochrane Database Syst Rev. 2014:CD000990. doi: 10.1002/14651858.CD000990.pub3.
168. Vemulapalli S, Dolor RJ, Hasselblad V, Schmit K, Banks A, Heidenfelder B, Patel MR, Jones WS. Supervised vs unsuper-vised exercise for intermittent claudication: a systematic review and meta-analysis. Am Heart J. 2015;169:924-937.e3. doi: 10.1016/j.ahj.2015.03.009.
169. Bedenis R, Stewart M, Cleanthis M, Robless P, Mikhailidis DP, Stansby G. Cilostazol for intermittent claudication. Cochrane Database Syst Rev. 2014:CD003748. doi: 10.1002/14651858. CD003748.pub4.
170. Katsanos K, Spiliopoulos S, Saha P, Diamantopoulos A, Karunanithy N, Krokidis M, Modarai B, Karnabatidis D. Comparative efficacy and safety of different antiplatelet agents for prevention of major cardiovascular events and leg amputations in patients with peripheral arterial disease: a systematic review and network meta-analysis. PLoS One. 2015;10:e0135692. doi: 10.1371/journal. pone.0135692.
171. Malgor RD, Alahdab F, Elraiyah TA, Rizvi AZ, Lane MA, Prokop LJ, Phung OJ, Farah W, Montori VM, Conte MS, Murad MH. A systematic review of treatment of intermittent claudication in the lower extremities [published correction appears in J Vasc Surg. 2015;61:1382]. J Vasc Surg. 2015;61(suppl):54S-73S. doi: 10.1016/j.jvs.2014.12.007.
172. Abu Dabrh AM, Steffen MW, Asi N, Undavalli C, Wang Z, Elamin MB, Conte MS, Murad MH. Bypass surgery versus endovascular interventions in severe or critical limb ischemia. J Vasc Surg. 2016;63:244-253.e11. doi: 10.1016/j.jvs.2015.07.068.
173. Pattyn N, Vanhees L, Cornelissen VA, Coeckelberghs E, De Maeyer C, Goetschalckx K, Possemiers N, Wuyts K, Van Craenenbroeck EM, Beckers PJ. The long-term effects of a randomized trial comparing aerobic interval versus continuous training in coronary artery disease patients: 1-year data from the SAINTEX-CAD study. Eur J Prev Cardiol. 2016;23:1154-1164. doi: 10.1177/2047487316631200.
174. Swardfager W, Herrmann N, Cornish S, Mazereeuw G, Marzolini S, Sham L, Lanctôt KL. Exercise intervention and inflammatory markers in coronary artery disease: a meta-analysis. Am Heart J. 2012;163:666-676.e1-3. doi: 10.1016/j.ahj.2011.12.017.
175. Gardner AW, Parker DE, Montgomery PS, Blevins SM. Step-monitored home exercise improves ambulation, vascular function, and inflammation in symptomatic patients with peripheral artery disease: a randomized controlled trial. J Am Heart Assoc. 2014;3:e001107. doi: 10.1161/JAHA.114.001107.
176. Phillips SA, Mahmoud AM, Brown MD, Haus JM. Exercise interventions and peripheral arterial function: implications for cardio-metabolic disease. Prog Cardiovasc Dis. 2015;57:521-534. doi: 10.1016/j.pcad.2014.12.005.
177. Tang A, Eng JJ, Krassioukov AV, Madden KM, Mohammadi A, Tsang MY, Tsang TS. Exercise-induced changes in cardiovascular function after stroke: a randomized controlled trial. Int J Stroke. 2014;9:883-889. doi: 10.1111/ijs.12156.
178. Takatori K, Matsumoto D, Okada Y, Nakamura J, Shomoto K. Effect of intensive rehabilitation on physical function and arterial function in community-dwelling chronic stroke survivors. Top Stroke Rehabil. 2012;19:377-383. doi: 10.1310/tsr1905-377.
179. Ades PA, Waldmann ML, Gillespie C. A controlled trial of exercise training in older coronary patients. J Gerontol A Biol Sci Med Sci. 1995;50A:M7-M11.
180. Lavie CJ, Milani RV. Effects of cardiac rehabilitation programs on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in a large elderly cohort. Am J Cardiol. 1995;76:177-179.
181. Harwood AE, Cayton T, Sarvanandan R, Lane R, Chetter I. A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication. Ann Vasc Surg. 2016;30:312-320. doi: 10.1016/j.avsg.2015.05.043.
182. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S; on behalf of the American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:2672-2713. doi: 10.1161/ STR.0b013e3182299496.
183. McLennan SN, Mathias JL, Brennan LC, Russell ME, Stewart S. Cognitive impairment predicts functional capacity in dementia-free patients with cardiovascular disease. J Cardiovasc Nurs. 2010;25:390-397. doi: 10.1097/JCN.0b013e3181dae445.
184. Swardfager W, Herrmann N, Marzolini S, Saleem M, Kiss A, Shammi P, Oh PI, Lanctôt KL. Cardiopulmonary fitness is associated with cognitive performance in patients with coronary artery disease. J Am Geriatr Soc. 2010;58:1519-1525. doi: 10.1111/j.1532-5415.2010.02966.x.
185. Bhella PS, Prasad A, Heinicke K, Hastings JL, Arbab-Zadeh A, Adams-Huet B, Pacini EL, Shibata S, Palmer MD, Newcomer BR, Levine BD. Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction. Eur J Heart Fail. 2011;13:1296-1304. doi: 10.1093/eurjhf/hfr133.
186. Kitzman DW, Little WC, Brubaker PH, Anderson RT, Hundley WG, Marburger CT, Brosnihan B, Morgan TM, Stewart KP. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA. 2002;288:2144-2150.
187. Savage PA, Shaw AO, Miller MS, VanBuren P, LeWinter MM, Ades PA, Toth MJ. Effect of resistance training on physical disability in chronic heart failure. Med Sci Sports Exerc. 2011;43:1379-1386. doi: 10.1249/MSS.0b013e31820eeea1.
188. Pu CT, Johnson MT, Forman DE, Hausdorff JM, Roubenoff R, Foldvari M, Fielding RA, Singh MA. Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. J Appl Physiol (1985). 2001;90:2341-2350.
189. Haykowsky MJ, Brubaker PH, Morgan TM, Kritchevsky S, Eggebeen J, Kitzman DW. Impaired aerobic capacity and physical functional performance in older heart failure patients with preserved ejection fraction: role of lean body mass. J Gerontol A Biol Sci Med Sci. 2013;68:968-975. doi: 10.1093/gerona/glt011.
190. Keteyian SJ, Patel M, Kraus WE, Brawner CA, McConnell TR, Piña IL, Leifer ES, Fleg JL, Blackburn G, Fonarow GC, Chase PJ, Piner L, Vest M, O'Connor CM, Ehrman JK, Walsh MN, Ewald G, Bensimhon D, Russell SD; HF-ACTION Investigators. Variables measured during cardiopulmonary exercise testing as predictors of mortality in chronic systolic heart failure [published correction appears in J Am Coll Cardiol. 2016;67:1979-1980]. J Am Coll Cardiol. 2016;67:780-789. doi: 10.1016/j.jacc.2015.11.050.
191. Shafiq A, Brawner CA, Aldred HA, Lewis B, Williams CT, Tita C, Schairer JR, Ehrman JK, Velez M, Selektor Y, Lanfear DE, Keteyian SJ. Prognostic value of cardiopulmonary exercise testing in heart failure with preserved ejection fraction: the Henry Ford HospITal CardioPulmonary EXercise Testing (FIT-CPX) project. Am Heart J. 2016;174:167-172. doi: 10.1016/j.ahj.2015.12.020.
192. Guazzi M, Adams V, Conraads V, Halle M, Mezzani A, Vanhees L, Arena R, Fletcher GF, Forman DE, Kitzman DW, Lavie CJ, Myers J. EACPR/AHA scientific statement: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation. 2012;126:2261-2274. doi: 10.1161/CIR.0b013e31826fb946.
193. Chiarantini D, Volpato S, Sioulis F, Bartalucci F, Del Bianco L, Mangani I, Pepe G, Tarantini F, Berni A, Marchionni N, Di Bari M. Lower extremity performance measures predict long-term prognosis in older patients hospitalized for heart failure. J Card Fail. 2010;16:390-395. doi: 10.1016/j.cardfail.2010.01.004.
194. McKelvie RS, Teo KK, Roberts R, McCartney N, Humen D, Montague T, Hendrican K, Yusuf S. Effects of exercise training in patients with heart failure: the Exercise Rehabilitation Trial (EXERT). Am Heart J. 2002;144:23-30.
195. Austin J, Williams R, Ross L, Moseley L, Hutchison S. Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure. Eur J Heart Fail. 2005;7:411-417. doi: 10.1016/j. ejheart.2004.10.004.
196. Fleg JL. Exercise therapy for elderly heart failure patients. Heart Fail Clin. 2007;3:529-537. doi: 10.1016/j.hfc.2007.07.016.
197. O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Piña IL; HF-ACTION Investigators. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301:1439-1450. doi: 10.1001/ jama.2009.454.
198. Flynn KE, Piña IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP; HF-ACTION Investigators. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial [published correction appears in JAMA. 2009;302:2322]. JAMA. 2009;301:1451-1459. doi: 10.1001/ jama.2009.457.
199. Blumenthal JA, Babyak MA, O'Connor C, Keteyian S, Landzberg J, Howlett J, Kraus W, Gottlieb S, Blackburn G, Swank A, Whellan DJ. Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial [published correction appears in JAMA. 2012;308:1742]. JAMA. 2012;308:465-474. doi: 10.1001/jama.2012.8720.
200. Haykowsky MJ, Brubaker PH, Stewart KP, Morgan TM, Eggebeen J, Kitzman DW. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol. 2012;60:120-128. doi: 10.1016/j. jacc.2012.02.055.
201. Kitzman DW, Brubaker PH, Herrington DM, Morgan TM, Stewart KP, Hundley WG, Abdelhamed A, Haykowsky MJ. Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol. 2013;62:584-592. doi: 10.1016/j.jacc.2013.04.033.
202. Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115:3086-3094. doi: 10.1161/ CIRCULATIONAHA.106.675041.
203. Sandri M, Kozarez I, Adams V, Mangner N, Höllriegel R, Erbs S, Linke A, Möbius-Winkler S, Thiery J, Kratzsch J, Teupser D, Mende M, Hambrecht R, Schuler G, Gielen S. Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. Eur Heart J. 2012;33:1758-1768. doi: 10.1093/eurheartj/ehr469.
204. Hambrecht R, Niebauer J, Fiehn E, Kälberer B, Offner B, Hauer K, Riede U, Schlierf G, Kübler W, Schuler G. Physical training in patients with stable chronic heart failure: effects on car-diorespiratory fitness and ultrastructural abnormalities of leg muscles. J Am Coll Cardiol. 1995;25:1239-1249. doi: 10.1016/0735-1097(94)00568-B.
205. Esposito F, Reese V, Shabetai R, Wagner PD, Richardson RS. Isolated quadriceps training increases maximal exercise capacity in chronic heart failure: the role of skeletal muscle convective and diffusive oxygen transport. J Am Coll Cardiol. 2011;58:1353-1362. doi: 10.1016/j.jacc.2011.06.025.
206. Sullivan MJ, Higginbotham MB, Cobb FR. Exercise training in patients with severe left ventricular dysfunction: hemodynamic and metabolic effects. Circulation. 1988;78:506-515.
207. Thomas RJ, King M, Lui K, Oldridge N, Piña IL, Spertus J; ACC/ AHA Task Force Members. AACVPR/ACC/AHA 2007 performance measures on cardiac rehabilitation for referral to and delivery of cardiac rehabilitation/secondary prevention services. J Cardiopulm Rehabil Prev. 2007;27:260-290. doi: 10.1097/01. HCR.0000291295.24776.7b.
208. Jolliffe JA, Rees K, Taylor RS, Thompson D, Oldridge N, Ebrahim S. Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2000:CD001800.
209. Strong PC, Lee SH, Chou YC, Wu MJ, Hung SY, Chou CL. Relationship between quality of life and aerobic capacity of patients entering phase II cardiac rehabilitation after coronary artery bypass graft surgery. J Chin Med Assoc. 2012;75:121-126. doi: 10.1016/j.jcma.2012.02.005.
210. Gunstad J, Macgregor KL, Paul RH, Poppas A, Jefferson AL, Todaro JF, Cohen RA. Cardiac rehabilitation improves cognitive performance in older adults with cardiovascular disease. J Cardiopulm Rehabil. 2005;25:173-176.
211. Schopfer DW, Forman DE. Cardiac rehabilitation in older adults. Can J Cardiol. 2016;32:1088-1096. doi: 10.1016/j. cjca.2016.03.003.
212. Balady GJ, Ades PA, Bittner VA, Franklin BA, Gordon NF, Thomas RJ, Tomaselli GF, Yancy CW. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond: a presidential advisory from the American Heart Association. Circulation. 2011;124:2951-2960. doi: 10.1161/CIR.0b013e31823b21e2.
213. Suaya JA, Stason WB, Ades PA, Normand SL, Shepard DS. Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol. 2009;54:25-33. doi: 10.1016/j.jacc.2009.01.078.
214. Dolansky MA, Moore SM. Older adults' use of postacute and cardiac rehabilitation services after hospitalization for a cardiac event. Rehabil Nurs. 2008;33:73-81.
215. Menezes AR, Lavie CJ, Forman DE, Arena R, Milani RV, Franklin BA. Cardiac rehabilitation in the elderly. Prog Cardiovasc Dis. 2014;57:152-159. doi: 10.1016/j.pcad.2014.01.002.
216. Leggett LE, Hauer T, Martin BJ, Manns B, Aggarwal S, Arena R, Austford LD, Meldrum D, Ghali W, Knudtson ML, Norris CM, Stone JA, Clement F. Optimizing value from cardiac rehabilitation: a cost-utility analysis comparing age, sex, and clinical subgroups. Mayo Clin Proc. 2015;90:1011-1020. doi: 10.1016/j. mayocp.2015.05.015.
217. Dennis SM, Harris M, Lloyd J, Powell Davies G, Faruqi N, Zwar N. Do people with existing chronic conditions benefit from telephone coaching? A rapid review. Aust Health Rev. 2013;37:381-388. doi: 10.1071/AH13005.
218. Dolansky MA, Xu F, Zullo M, Shishehbor M, Moore SM, Rimm AA. Post-acute care services received by older adults following a cardiac event: a population-based analysis. J Cardiovasc Nurs. 2010;25:342-349. doi: 10.1097/JCN.0b013e3181c9fbca.
219. Cowie A, Thow MK, Granat MH, Mitchell SL. A comparison of home and hospital-based exercise training in heart failure: immediate and long-term effects upon physical activity level. Eur J Cardiovasc Prev Rehabil. 2011;18:158-166. doi: 10.1177/1741826710389389.
220. Kraal JJ, Peek N, Van den Akker-Van Marle ME, Kemps HM. Effects of home-based training with telemonitoring guidance in low to moderate risk patients entering cardiac rehabilitation: short-term results of the FIT@Home study. Eur J Prev Cardiol. 2014;21(suppl):26-31. doi: 10.1177/2047487314552606.
221. Ramadi A, Haennel RG, Stone JA, Arena R, Threlfall TG, Hitt E, Aggarwal SG, Haykowsky M, Martin BJ. The sustainability of exercise capacity changes in home versus center-based cardiac rehabilitation. J Cardiopulm Rehabil Prev. 2015;35:21-28. doi: 10.1097/HCR.0000000000000084.
222. Scane K, Alter D, Oh P, Brooks D. Adherence to a cardiac rehabilitation home program model of care: a comparison to a well-established traditional on-site supervised program. Appl Physiol Nutr Metab. 2012;37:206-213. doi: 10.1139/h11-151.
223. Corazza I, Bianchini D, Urbinati S, Zannoli R. REHAL®, a tele-medicine platform for home cardiac rehabilitation. Minerva Cardioangiol. 2014;62:399-405.
224. Forman DE, LaFond K, Panch T, Allsup K, Manning K, Sattelmair J. Utility and efficacy of a smartphone application to enhance the learning and behavior goals of traditional cardiac rehabilitation: a feasibility study. J Cardiopulm Rehabil Prev. 2014;34:327-334. doi: 10.1097/HCR.0000000000000058.
225. Maddison R, Pfaeffli L, Whittaker R, Stewart R, Kerr A, Jiang Y, Kira G, Leung W, Dalleck L, Carter K, Rawstorn J. A mobile phone intervention increases physical activity in people with cardiovascular disease: results from the HEART randomized controlled trial. Eur J Prev Cardiol. 2015;22:701-709. doi: 10.1177/2047487314535076.
226. Dale LP, Whittaker R, Jiang Y, Stewart R, Rolleston A, Maddison R. Improving coronary heart disease self-management using mobile technologies (Text4Heart): a randomised controlled trial protocol. Trials. 2014;15:71. doi: 10.1186/1745-6215-15-71.
227. Varnfield M, Karunanithi M, Lee CK, Honeyman E, Arnold D, Ding H, Smith C, Walters DL. Smartphone-based home care model improved use of cardiac rehabilitation in postmyo-cardial infarction patients: results from a randomised controlled trial. Heart. 2014;100:1770-1779. doi: 10.1136/ heartjnl-2014-305783.
228. Allen LA, Hernandez AF, Peterson ED, Curtis LH, Dai D, Masoudi FA, Bhatt DL, Heidenreich PA, Fonarow GC. Discharge to a skilled nursing facility and subsequent clinical outcomes among older patients hospitalized for heart failure. Circ Heart Fail. 2011;4:293-300.
229. Mehr DR, Williams BC, Fries BE. Predicting discharge outcomes of VA nursing home residents. J Aging Health. 1997;9:244-265.
230. Harris-Kojetin L, Sengupta M, Park-Lee E, Valverde R. Long-Term Care Services in the United States: 2013 Overview. Hyattsville, MD: National Center for Health Statistics; 2013.
231. Skilled Nursing Facility Services. 2013:157-184. http://www. medpac.gov/docs/default-source/reports/chapter-8-skilled-nursing-facility-services-march-2015-report-.pdf?sfvrsn=0. Accessed May 15, 2016.
232. Portegijs E, Buurman BM, Essink-Bot ML, Zwinderman AH, de Rooij SE. Failure to regain function at 3 months after acute hospital admission predicts institutionalization within 12 months in older patients. J Am Med Dir Assoc. 2012;13:569.e1-569.e7. doi: 10.1016/j.jamda.2012.04.003.
233. Hoyer EH, Needham DM, Atanelov L, Knox B, Friedman M, Brotman DJ. Association of impaired functional status at hospital discharge and subsequent rehospitalization. J Hosp Med. 2014;9:277-282. doi: 10.1002/jhm.2152.
234. Hoyer EH, Needham DM, Miller J, Deutschendorf A, Friedman M, Brotman DJ. Functional status impairment is associated with unplanned readmissions. Arch Phys Med Rehabil. 2013;94:1951-1958. doi: 10.1016/j.apmr.2013.05.028.
235. Baztán JJ, Gálvez CP, Socorro A. Recovery of functional impairment after acute illness and mortality: one-year follow-up study. Gerontology. 2009;55:269-274. doi: 10.1159/ 000193068.
236. Peiris CL, Taylor NF, Shields N. Additional Saturday allied health services increase habitual physical activity among patients receiving inpatient rehabilitation for lower limb orthopedic conditions: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:1365-1370. doi: 10.1016/j.apmr.2012.03.004.
237. Peiris CL, Taylor NF, Shields N. Patients receiving inpatient rehabilitation for lower limb orthopaedic conditions do much less physical activity than recommended in guidelines for healthy older adults: an observational study. J Physiother. 2013;59:39-44. doi: 10.1016/S1836-9553(13)70145-0.
238. Grant PM, Granat MH, Thow MK, Maclaren WM. Analyzing free-living physical activity of older adults in different environments using body-worn activity monitors. J Aging Phys Act. 2010;18:171-184.
239. Lenze EJ, Host HH, Hildebrand MW, Morrow-Howell N, Carpenter B, Freedland KE, Baum CA, Dixon D, Doré P, Wendleton L, Binder EF. Enhanced medical rehabilitation increases therapy intensity and engagement and improves functional outcomes in postacute rehabilitation of older adults: a randomized-controlled trial. J Am Med Dir Assoc. 2012;13:708-712. doi: 10.1016/j. jamda.2012.06.014.
240. Fritz S, Lusardi M. White paper: "walking speed: the sixth vital sign" [published correction appears in J Geriatr Phys Ther. 2009;32:110]. J Geriatr Phys Ther. 2009;32:46-49.
241. Dolansky MA, Zullo MD, Hassanein S, Schaefer JT, Murray P, Boxer R. Cardiac rehabilitation in skilled nursing facilities: a missed opportunity. Heart Lung. 2012;41:115-124. doi: 10.1016/j.hrtlng.2011.08.006.