Impaired aerobic capacity and physical functional performance in older heart failure patients with preserved ejection fraction: Role of lean body mass

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 8, 2013, Pages 968-975

  Haykowsky, Mark J ^a   Brubaker, Peter H ^b   Morgan, Timothy M ^b   Kritchevsky, Stephen ^b   Eggebeen, Joel ^b   Kitzman, Dalane W ^c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Health and Exercise Sciences ^*  (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular; Exercise; Functional performance; Muscle; Physical function; Sarcopenia

Indexed keywords

AGED; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CARDIOVASCULAR; CASE CONTROL STUDY; EXERCISE; EXERCISE TOLERANCE; FEMALE; FUNCTIONAL PERFORMANCE; HEART FAILURE; HEART STROKE VOLUME; HUMAN; LEG; MALE; MIDDLE AGED; MUSCLE; OXYGEN CONSUMPTION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSICAL FUNCTION; PHYSIOLOGY; SARCOPENIA; SEX DIFFERENCE; SKELETAL MUSCLE;

CARDIOVASCULAR; EXERCISE; FUNCTIONAL PERFORMANCE; MUSCLE; PHYSICAL FUNCTION; SARCOPENIA;

AGED; BODY COMPOSITION; BODY WEIGHT; CASE-CONTROL STUDIES; EXERCISE; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HUMANS; LEG; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; SEX FACTORS; STROKE VOLUME;

EID: 84880517296     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt011     Document Type: Article

References (33)

1. Kitzman DW, Gardin JM, Gottdiener JS, et al., Cardiovascular Health Study Research Group. Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study. Am J Cardiol. 2001;87:413-419. (Pubitemid 32149998)
2. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355:251-259. (Pubitemid 44079340)
3. Kitzman DW, Higginbotham MB, Cobb FR, Sheikh KH, Sullivan MJ. Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism. J Am Coll Cardiol. 1991;17:1065-1072.
4. Kitzman DW, Little WC, Brubaker PH, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA. 2002;288:2144-2150. (Pubitemid 35265382)
5. Haykowsky MJ, Brubaker PH, John JM, Stewart KP, Morgan TM, Kitzman DW. Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol. 2011;58:265-274.
6. Borlaug BA, Melenovsky V, Russell SD, et al. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006;114:2138-2147. (Pubitemid 44747894)
7. Borlaug BA, Olson TP, Lam CS, et al. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2010;56:845-854.
8. Bhella PS, Prasad A, Heinicke K, et al. Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction. Eur J Heart Fail. 2011;13:1296-1304.
9. Maeder MT, Thompson BR, Brunner-La Rocca HP, Kaye DM. Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction. J Am Coll Cardiol. 2010;56:855-863.
10. Katz SD, Maskin C, Jondeau G, Cocke T, Berkowitz R, LeJemtel T. Near-maximal fractional oxygen extraction by active skeletal muscle in patients with chronic heart failure. J Appl Physiol. 2000;88:2138-2142. (Pubitemid 30453920)
11. Haykowsky MJ, Brubaker PH, Stewart KP, Morgan TM, Eggebeen J, Kitzman DW. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol. 2012;60:120-128.
12. Haykowsky M, Brubaker P, Kitzman D. Role of physical training in heart failure with preserved ejection fraction. Curr Heart Fail Rep. 2012;9:101-106.
13. Buford TW, Lott DJ, Marzetti E, et al. Age-related differences in lower extremity tissue compartments and associations with physical function in older adults. Exp Gerontol. 2012;47:38-44.
14. Lang CC, Chomsky DB, Rayos G, yeoh TK, Wilson JR. Skeletal muscle mass and exercise performance in stable ambulatory patients with heart failure. J Appl Physiol. 1997;82:257-261. (Pubitemid 27052069)
15. Mancini DM, Walter G, Reichek N, et al. Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure. Circulation. 1992;85:1364-1373.
16. Minotti JR, Pillay P, Oka R, Wells L, Christoph I, Massie BM. Skeletal muscle size: relationship to muscle function in heart failure. J Appl Physiol. 1993;75:373-381. (Pubitemid 23221999)
17. Cicoira M, Zanolla L, Franceschini L, et al. Skeletal muscle mass independently predicts peak oxygen consumption and ventilatory response during exercise in noncachectic patients with chronic heart failure. J Am Coll Cardiol. 2001;37:2080-2085. (Pubitemid 32548001)
18. Harrington D, Anker SD, Chua TP, et al. Skeletal muscle function and its relation to exercise tolerance in chronic heart failure. J Am Coll Cardiol. 1997;30:1758-1764. (Pubitemid 27521259)
19. Kitzman DW, Brubaker PH, Morgan TM, Stewart KP, Little WC. Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail. 2010;3:659-667.
20. Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med. 1995;333:1190-1195.
21. Schocken DD, Arrieta MI, Leaverton PE, Ross EA. Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol. 1992;20:301-306.
22. John JM, Haykowsky M, Brubaker P, Stewart K, Kitzman DW. Decreased left ventricular distensibility in response to postural change in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2010;299:H883-H889.
23. Haykowsky MJ, Herrington DM, Brubaker PH, Morgan TM, Hundley WG, Kitzman DW. Relationship of flow-mediated arterial dilation and exercise capacity in older patients with heart failure and preserved ejection fraction. J Gerontol A Biol Sci Med Sci. 2013;68:161-167.
24. Marburger CT, Brubaker PH, Pollock WE, Morgan TM, Kitzman DW. Reproducibility of cardiopulmonary exercise testing in elderly patients with congestive heart failure. Am J Cardiol. 1998;82:905-909. (Pubitemid 28467369)
25. Chen Z, Wang Z, Lohman T, et al. Dual-energy x-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women. J Nutr. 2007;137:2775-2780. (Pubitemid 350255312)
26. Schoeller DA, Tylavsky FA, Baer DJ, et al. QDR 4500A dual-energy x-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults. Am J Clin Nutr. 2005;81:1018-1025. (Pubitemid 41724942)
27. Newman AB, Kupelian V, Visser M, et al., Health ABC Study Investigators. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51:1602-1609. (Pubitemid 37409595)
28. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85-M94. (Pubitemid 24100267)
29. Ogawa T, Spina RJ, Martin WH 3rd, et al. Effects of aging, sex, and physical training on cardiovascular responses to exercise. Circulation. 1992;86:494-503.
30. Drexler H, Riede U, Münzel T, König H, Funke E, Just H. Alterations of skeletal muscle in chronic heart failure. Circulation. 1992;85:1751-1759.
31. Koster A, Ding J, Stenholm S, et al. Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults? J Gerontol A Biol Sci Med Sci. 2011;66:888-895.
32. Visser M, Kritchevsky SB, Goodpaster BH, et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc. 2002;50:897-904. (Pubitemid 34496688)
33. Sergi G, Lupoli L, Volpato S, et al. Body fluid distribution in elderly subjects with congestive heart failure. Ann Clin Lab Sci. 2004;34:416-422. (Pubitemid 40040963)