Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease

Human Molecular Genetics

Volumn 25, Issue 24, 2016, Pages 5365-5382

  Islam, Md Shariful ^a,b,c   Nolte, Hendrik ^b   Jacob, Wright ^d   Ziegler, Anna B ^e,f   Pütz, Stefanie ^d   Grosjean, Yael ^e,f   Szczepanowska, Karolina ^g   Trifunovic, Aleksandra ^b,g   Braun, Thomas ^h   Heumann, Hermann ^a   Heumann, Rolf ^d   Hovemann, Bernhard ^d   Moore, Darren J ^c   Krüger, Marcus ^b,g,h  

^a Silantes GmbH   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c VAN ANDEL RESEARCH INSTITUTE   (United States)

^d RUHR UNIVERSITY BOCHUM   (Germany)

^e CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^f UNIVERSITÉ BOURGOGNE FRANCHE COMTÉ   (France)

^g UNIVERSITY OF COLOGNE   (Germany)

^h MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPHILIN; ENDOPHILIN A; LEUCINE RICH REPEAT KINASE 2; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHOPROTEIN; PHOSPHOPROTEOME; PROTEOME; RAB PROTEIN; SYNAPTOJANIN; SYNAPTOTAGMIN I; SYNTAXIN 1A; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; NERVE PROTEIN; PHOSPHATASE; RAB3 PROTEIN, DROSOPHILA; SYNTAXIN 1;

ADULT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DROSOPHILA STRAIN; FEMALE; FRUIT FLY MODEL; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOPRECIPITATION; LOCOMOTION; MALE; MASS SPECTROMETRY; MOTOR DYSFUNCTION; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; PARKINSON DISEASE; PATHOPHYSIOLOGY; PHOSPHOPROTEOMICS; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; RETINA DEGENERATION; SCREENING; SYNAPSE VESICLE; WILD TYPE; ANIMAL; BIOSYNTHESIS; BRAIN; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; PHOSPHORYLATION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LEUCINE-RICH REPEAT SERINE-THREONINE PROTEIN KINASE-2; MUTATION; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN INTERACTION MAPS; PROTEOME; RAB3 GTP-BINDING PROTEINS; SYNAPTIC VESICLES; SYNAPTOTAGMIN I; SYNTAXIN 1;

EID: 85015987506     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw352     Document Type: Article

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