Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response

Bioscience Reports

Volumn 37, Issue 2, 2017, Pages

  Poothong, Juthakorn ^a,b   Tirasophon, Witoon ^a   Kaufman, Randal J ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN IRE1; RNA LIGASE; X BOX BINDING PROTEIN 1; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; HAC1 PROTEIN, S CEREVISIAE; IRE1 PROTEIN, S CEREVISIAE; LIGASE; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARABIDOPSIS THALIANA; ARTICLE; BIOACCUMULATION; CATALYSIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ESCHERICHIA COLI; EXON; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; HAC1 GENE; HUMAN; HUMAN CELL; INTRON; MAMMAL; NONHUMAN; RNA CLEAVAGE; RNA SPLICING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ESCHERICHIA COLI; EXONS; HUMANS; INTRONS; LIGASES; MAMMALS; MEMBRANE GLYCOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; RNA SPLICING; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; X-BOX BINDING PROTEIN 1;

EID: 85015919449     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20160574     Document Type: Article

References (30)

1. Schroder, M. and Kaufman, R.J. (2005) The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789
2. Bernales, S., Papa, F.R. and Walter, P. (2006) Intracellular signaling by the unfolded protein response. Annu. Rev. Cell Dev. Biol. 22, 487-508
3. Wang, M. and Kaufman, R.J. (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529, 326-335
4. Walter, P. and Ron, D. (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334, 1081-1086
5. Cox, J.S. and Walter, P. (1996) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87, 391-404
6. Sidrauski, C. and Walter, P. (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031-1039
7. Culver, G.M., McCraith, S.M., Consaul, S.A., Stanford, D.R. and Phizicky, E.M. (1997) A 2′-phosphotransferase implicated in tRNA splicing is essential in Saccharomyces cerevisiae. J. Biol. Chem. 272, 13203-13210
8. Gonzalez, T.N., Sidrauski, C., Dörfler, S. and Walter, P. (1999) Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J. 18, 3119-3132
9. Popow, J., Englert, M., Weitzer, S., Schleiffer, A., Mierzwa, B., Mechtler, K. et al. (2011) HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331, 760-764
10. Tanaka, N., Meineke, B. and Shuman, S. (2011) RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J. Biol. Chem. 286, 30253-30257
11. Englert, M., Sheppard, K., Aslanian, A., Yates, III, J.R. and Soll, D. (2011) Archaeal 3′-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation. Proc. Natl. Acad. Sci. U.S.A. 108, 1290-1295
12. Jurkin, J., Henkel, T., Nielsen, A.F., Minnich, M., Popow, J., Kaufmann, T. et al. (2014) The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 33, 2922-2936
13. Kosmaczewski, S.G., Edwards, T.J., Han, S.M., Eckwahl, M.J., Meyer, B.I., Peach, S. et al. (2014) The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. EMBO Rep. 15, 1278-1285
14. Lu, Y., Liang, F.X. and Wang, X. (2014) A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol. Cell 55, 758-770
15. Englert, M. and Beier, H. (2005) Plant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic origins. Nucleic Acids Res. 33, 388-399
16. Sidrauski, C., Cox, J.S. and Walter, P. (1996) tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87, 405-413
17. Desai, K.K., Cheng, C.L., Bingman, C.A., Phillips, Jr, G.N. and Raines, R.T. (2014) A tRNA splicing operon: archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Res. 42, 3931-3942
18. Desai, K.K., Beltrame, A.L. and Raines, R.T. (2015) Coevolution of RtcB and archease created a multiple-turnover RNA ligase. RNA 21, 1866-1872
19. Poothong, J., Sopha, P., Kaufman, R.J. and Tirasophon, W. (2010) Domain compatibility in Ire1 kinase is critical for the unfolded protein response. FEBS Lett. 584, 3203-3208
20. Poothong, J., Sopha, P., Kaufman, R.J. and Tirasophon, W. (2016) IRE1α nucleotide sequence cleavage specificity in the unfolded protein response. FEBS lett. doi:10.1002/1873-3468.12546
21. Aragon, T., van Anken, E., Pincus, D., Serafimova, I.M., Korennykh, A.V., Rubio, C.A. et al. (2009) Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature 457, 736-740
22. Plongthongkum, N., Kullawong, N., Panyim, S. and Tirasophon, W. (2007) Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 354, 789-794
23. Wu, S. and Letchworth, G.J. (2004) High efficiency transformation by electroporation of Pichia pastoris pretreated with lithium acetate and dithiothreitol. Biotechniques 36, 152-154
24. Kushnirov, V.V. (2000) Rapid and reliable protein extraction from yeast. Yeast 16, 857-860
25. Tirosh, B., Iwakoshi, N.N., Glimcher, L.H. and Ploegh, H.L. (2006) Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J. Biol. Chem. 281, 5852-5860.
26. Perez-Gonzalez, A., Pazo, A., Navajas, R., Ciordia, S., Rodriguez-Frandsen, A. and Nieto, A. (2014) hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. PLoS ONE 9, e90957
27. Popow, J., Jurkin, J., Schleiffer, A. and Martinez, J. (2014) Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Nature 511, 104-107
28. Iwawaki, T. and Tokuda, M. (2011) Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing. Biochem. Biophys. Res. Commun. 413, 527-531
29. Baltz, A.G., Munschauer, M., Schwanhausser, B., Vasile, A., Murakawa, Y., Schueler, M. et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46, 674-690
30. Hollien, J., Lin, J.H., Li, H., Stevens, N., Walter, P. and Weissman, J.S. (2009) Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J. Cell Biol. 186, 323-331