메뉴 건너뛰기




Volumn 17, Issue 4, 2017, Pages

Huntington’s Disease—Update on Treatments

Author keywords

Behavioral; Chorea; Cognitive; Huntington; Neurodegeneration; Treatment

Indexed keywords

AMANTADINE; ARIPIPRAZOLE; BENZODIAZEPINE; BOTULINUM TOXIN; CARBAMAZEPINE; CLOMIPRAMINE; CLOZAPINE; DEUTETRABENAZINE; DONEPEZIL; DOPAMINE RECEPTOR STIMULATING AGENT; FLUPHENAZINE; HALOPERIDOL; LAMOTRIGINE; LEVODOPA; MEMANTINE; OLANZAPINE; PERPHENAZINE; PIMOZIDE; PRIDOPIDINE; QUETIAPINE; RILUZOLE; RISPERIDONE; RIVASTIGMINE; SEROTONIN UPTAKE INHIBITOR; TETRABENAZINE; TOPIRAMATE; UNINDEXED DRUG; VALPROIC ACID; VENLAFAXINE; ZIPRASIDONE;

EID: 85015826786     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-017-0739-9     Document Type: Review
Times cited : (114)

References (128)
  • 1
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes
    • Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell. 1993;72(6):971–83.
    • (1993) Cell , vol.72 , Issue.6 , pp. 971-983
  • 2
    • 2942625910 scopus 로고    scopus 로고
    • Differential loss of striatal projection systems in Huntington’s disease: a quantitative immunohistochemical study
    • COI: 1:STN:280:DC%2BD2c3otl2jsQ%3D%3D, PID: 15183201
    • Deng YP, et al. Differential loss of striatal projection systems in Huntington’s disease: a quantitative immunohistochemical study. J Chem Neuroanat. 2004;27(3):143–64.
    • (2004) J Chem Neuroanat , vol.27 , Issue.3 , pp. 143-164
    • Deng, Y.P.1
  • 3
    • 0001589776 scopus 로고
    • Differential loss of striatal projection neurons in Huntington disease
    • COI: 1:STN:280:DyaL1c3ovFOqsw%3D%3D, PID: 2456581
    • Reiner A, et al. Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci. 1988;85(15):5733–7.
    • (1988) Proc Natl Acad Sci , vol.85 , Issue.15 , pp. 5733-5737
    • Reiner, A.1
  • 4
    • 58149189835 scopus 로고    scopus 로고
    • Tetrabenazine
    • COI: 1:CAS:528:DC%2BD1cXhsFCku7zO, PID: 19116624
    • Hayden MR, et al. Tetrabenazine. Nat Rev Drug Discov. 2009;8(1):17–8.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.1 , pp. 17-18
    • Hayden, M.R.1
  • 5
    • 84874201382 scopus 로고    scopus 로고
    • Analysis of CYP2D6 genotype and response to tetrabenazine
    • COI: 1:CAS:528:DC%2BC3sXktlCgsLg%3D, PID: 23280482
    • Mehanna R, et al. Analysis of CYP2D6 genotype and response to tetrabenazine. Mov Disord. 2013;28(2):210–5.
    • (2013) Mov Disord , vol.28 , Issue.2 , pp. 210-215
    • Mehanna, R.1
  • 6
    • 33847731495 scopus 로고    scopus 로고
    • Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders
    • PID: 17133512
    • Kenney C, Hunter C, Jankovic J. Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders. Mov Disord. 2007;22(2):193–7.
    • (2007) Mov Disord , vol.22 , Issue.2 , pp. 193-197
    • Kenney, C.1    Hunter, C.2    Jankovic, J.3
  • 7
    • 33645798913 scopus 로고    scopus 로고
    • Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial
    • Huntington Study Group. Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial. Neurology. 2006;66(3):366–72.
    • (2006) Neurology , vol.66 , Issue.3 , pp. 366-372
  • 9
    • 59849086625 scopus 로고    scopus 로고
    • The long-term effect of tetrabenazine in the management of Huntington disease
    • COI: 1:CAS:528:DC%2BD1cXhsVCrsL%2FO, PID: 19050408
    • Fasano A, et al. The long-term effect of tetrabenazine in the management of Huntington disease. Clin Neuropharmacol. 2008;31(6):313–8.
    • (2008) Clin Neuropharmacol , vol.31 , Issue.6 , pp. 313-318
    • Fasano, A.1
  • 10
    • 41249090997 scopus 로고    scopus 로고
    • A study of chorea after tetrabenazine withdrawal in patients with Huntington disease
    • COI: 1:CAS:528:DC%2BD1cXmsFymu7k%3D, PID: 18520979
    • Frank S, et al. A study of chorea after tetrabenazine withdrawal in patients with Huntington disease. Clin Neuropharmacol. 2008;31(3):127–33.
    • (2008) Clin Neuropharmacol , vol.31 , Issue.3 , pp. 127-133
    • Frank, S.1
  • 11
    • 84907929491 scopus 로고    scopus 로고
    • Safety and efficacy of tetrabenazine and use of concomitant medications during long-term, open-label treatment of chorea associated with Huntington’s and other diseases
    • Shen V, et al. Safety and efficacy of tetrabenazine and use of concomitant medications during long-term, open-label treatment of chorea associated with Huntington’s and other diseases. Tremor Other Hyperkinet Mov. 2013;3
    • (2013) Tremor Other Hyperkinet Mov , pp. 3
    • Shen, V.1
  • 12
    • 84906923097 scopus 로고    scopus 로고
    • Depressed mood and suicidality in individuals exposed to tetrabenazine in a large Huntington disease observational study
    • COI: 1:CAS:528:DC%2BC2cXosFSl, PID: 25062735
    • Dorsey ER, et al. Depressed mood and suicidality in individuals exposed to tetrabenazine in a large Huntington disease observational study. J Huntingtons Dis. 2013;2(4):509–15.
    • (2013) J Huntingtons Dis , vol.2 , Issue.4 , pp. 509-515
    • Dorsey, E.R.1
  • 13
    • 84977592334 scopus 로고    scopus 로고
    • Effect of deutetrabenazine on chorea among patients with Huntington disease: a randomized clinical trial
    • COI: 1:CAS:528:DC%2BC28XhtlOlu77M, PID: 27380342, A recent trial testing a novel molecule containing deuterium bound to tetrabenazine (TBZ), used to prolong the half-life of TBZ and decrease the side effects. This new medication could potentially allow for better control of chorea with fewer side effects
    • •• Frank S, et al. Effect of deutetrabenazine on chorea among patients with Huntington disease: a randomized clinical trial. JAMA. 2016;316(1):40–50. A recent trial testing a novel molecule containing deuterium bound to tetrabenazine (TBZ), used to prolong the half-life of TBZ and decrease the side effects. This new medication could potentially allow for better control of chorea with fewer side effects
    • (2016) JAMA , vol.316 , Issue.1 , pp. 40-50
    • Frank, S.1
  • 14
    • 0016276793 scopus 로고
    • Letter: double-blind trial of lithium carbonate and haloperidol in Huntington’s chorea
    • COI: 1:STN:280:DyaE2M%2FksVGgsA%3D%3D, PID: 4139622
    • Leonard DP, et al. Letter: double-blind trial of lithium carbonate and haloperidol in Huntington’s chorea. Lancet. 1974;2(7890):1208–9.
    • (1974) Lancet , vol.2 , Issue.7890 , pp. 1208-1209
    • Leonard, D.P.1
  • 15
    • 0019444436 scopus 로고
    • Huntington disease: functional capacities in patients treated with neuroleptic and antidepressant drugs
    • COI: 1:STN:280:DyaL383nt12nug%3D%3D, PID: 6125919
    • Shoulson I. Huntington disease: functional capacities in patients treated with neuroleptic and antidepressant drugs. Neurology. 1981;31(10):1333–5.
    • (1981) Neurology , vol.31 , Issue.10 , pp. 1333-1335
    • Shoulson, I.1
  • 16
    • 0018878029 scopus 로고
    • Huntington’s disease: clinical effects of a short-term treatment with pimozide
    • COI: 1:STN:280:DyaL3c3mt1CmtA%3D%3D, PID: 6447434
    • Arena R, et al. Huntington’s disease: clinical effects of a short-term treatment with pimozide. Adv Biochem Psychopharmacol. 1980;24:573–5.
    • (1980) Adv Biochem Psychopharmacol , vol.24 , pp. 573-575
    • Arena, R.1
  • 17
    • 0017067441 scopus 로고
    • Fluphenazine decanoate in the treatment of chorea: a double-blind study
    • COI: 1:STN:280:DyaE283ls1Gmug%3D%3D, PID: 133787
    • Terrence CF. Fluphenazine decanoate in the treatment of chorea: a double-blind study. Curr Ther Res Clin Exp. 1976;20(2):177–83.
    • (1976) Curr Ther Res Clin Exp , vol.20 , Issue.2 , pp. 177-183
    • Terrence, C.F.1
  • 18
    • 0030790234 scopus 로고    scopus 로고
    • Clozapine versus placebo in Huntington’s disease: a double blind randomised comparative study
    • PID: 9221965
    • van Vugt JP, et al. Clozapine versus placebo in Huntington’s disease: a double blind randomised comparative study. J Neurol Neurosurg Psychiatry. 1997;63(1):35–9.
    • (1997) J Neurol Neurosurg Psychiatry , vol.63 , Issue.1 , pp. 35-39
    • van Vugt, J.P.1
  • 19
    • 0028341579 scopus 로고
    • Clozapine in Huntington’s chorea
    • COI: 1:STN:280:DyaK2c3kslKmsg%3D%3D, PID: 8190281
    • Bonuccelli U, et al. Clozapine in Huntington’s chorea. Neurology. 1994;44(5):821–3.
    • (1994) Neurology , vol.44 , Issue.5 , pp. 821-823
    • Bonuccelli, U.1
  • 20
    • 0036709253 scopus 로고    scopus 로고
    • Olanzapine for Huntington’s disease: an open label study
    • COI: 1:CAS:528:DC%2BD38XovFShsr0%3D, PID: 12410058
    • Bonelli RM, Mahnert FA, Niederwieser G. Olanzapine for Huntington’s disease: an open label study. Clin Neuropharmacol. 2002;25(5):263–5.
    • (2002) Clin Neuropharmacol , vol.25 , Issue.5 , pp. 263-265
    • Bonelli, R.M.1    Mahnert, F.A.2    Niederwieser, G.3
  • 21
    • 0036276160 scopus 로고    scopus 로고
    • Olanzapine in Huntington’s disease
    • COI: 1:CAS:528:DC%2BD38Xlt1Cms7Y%3D, PID: 12027832
    • Paleacu D, Anca M, Giladi N. Olanzapine in Huntington’s disease. Acta Neurol Scand. 2002;105(6):441–4.
    • (2002) Acta Neurol Scand , vol.105 , Issue.6 , pp. 441-444
    • Paleacu, D.1    Anca, M.2    Giladi, N.3
  • 22
    • 0035118773 scopus 로고    scopus 로고
    • Short-term effects of olanzapine in Huntington disease
    • COI: 1:STN:280:DC%2BD3M3lvVKhsQ%3D%3D, PID: 11234911
    • Squitieri F, et al. Short-term effects of olanzapine in Huntington disease. Neuropsychiatry Neuropsychol Behav Neurol. 2001;14(1):69–72.
    • (2001) Neuropsychiatry Neuropsychol Behav Neurol , vol.14 , Issue.1 , pp. 69-72
    • Squitieri, F.1
  • 23
    • 61449249292 scopus 로고    scopus 로고
    • Treatment of the symptoms of Huntington’s disease: preliminary results comparing aripiprazole and tetrabenazine
    • PID: 19170197
    • Brusa L, et al. Treatment of the symptoms of Huntington’s disease: preliminary results comparing aripiprazole and tetrabenazine. Mov Disord. 2009;24(1):126–9.
    • (2009) Mov Disord , vol.24 , Issue.1 , pp. 126-129
    • Brusa, L.1
  • 24
    • 33746687898 scopus 로고    scopus 로고
    • Clinical experience with risperidone and memantine in the treatment of Huntington’s disease
    • PID: 16916137
    • Cankurtaran ES, et al. Clinical experience with risperidone and memantine in the treatment of Huntington’s disease. J Natl Med Assoc. 2006;98(8):1353–5.
    • (2006) J Natl Med Assoc , vol.98 , Issue.8 , pp. 1353-1355
    • Cankurtaran, E.S.1
  • 25
    • 0036038875 scopus 로고    scopus 로고
    • Risperidone in chorea and psychosis of Huntington’s disease
    • PID: 11882064
    • Erdemoglu AK, Boratav C. Risperidone in chorea and psychosis of Huntington’s disease. Eur J Neurol. 2002;9(2):182–3.
    • (2002) Eur J Neurol , vol.9 , Issue.2 , pp. 182-183
    • Erdemoglu, A.K.1    Boratav, C.2
  • 26
    • 0030938246 scopus 로고    scopus 로고
    • Risperidone in treatment of choreoathetosis of Huntington’s disease
    • COI: 1:STN:280:DC%2BD3cvitFWmtw%3D%3D, PID: 10950488
    • Parsa MA, et al. Risperidone in treatment of choreoathetosis of Huntington’s disease. J Clin Psychopharmacol. 1997;17(2):134–5.
    • (1997) J Clin Psychopharmacol , vol.17 , Issue.2 , pp. 134-135
    • Parsa, M.A.1
  • 27
    • 0036041559 scopus 로고    scopus 로고
    • Quetiapine in Huntington’s disease: a first case report
    • PID: 12420714
    • Bonelli RM, Niederwieser G. Quetiapine in Huntington’s disease: a first case report. J Neurol. 2002;249(8):1114–5.
    • (2002) J Neurol , vol.249 , Issue.8 , pp. 1114-1115
    • Bonelli, R.M.1    Niederwieser, G.2
  • 28
    • 0347285447 scopus 로고    scopus 로고
    • Ziprasidone in Huntington’s disease: the first case reports
    • PID: 14870962
    • Bonelli RM, et al. Ziprasidone in Huntington’s disease: the first case reports. J Psychopharmacol. 2003;17(4):459–60.
    • (2003) J Psychopharmacol , vol.17 , Issue.4 , pp. 459-460
    • Bonelli, R.M.1
  • 29
    • 77957986360 scopus 로고    scopus 로고
    • Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington’s disease
    • COI: 1:CAS:528:DC%2BC3cXht1WisrbF, PID: 20616707
    • Lundin A, et al. Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington’s disease. Clin Neuropharmacol. 2010;33(5):260–4.
    • (2010) Clin Neuropharmacol , vol.33 , Issue.5 , pp. 260-264
    • Lundin, A.1
  • 30
    • 81255195330 scopus 로고    scopus 로고
    • Pridopidine for the treatment of motor function in patients with Huntington’s disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
    • PID: 22071279
    • de Yebenes JG, et al. Pridopidine for the treatment of motor function in patients with Huntington’s disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2011;10(12):1049–57.
    • (2011) Lancet Neurol , vol.10 , Issue.12 , pp. 1049-1057
    • de Yebenes, J.G.1
  • 31
    • 84884724757 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington’s disease
    • Huntington Study Group. A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington’s disease. Mov Disord. 2013;28(10):1407–15.
    • (2013) Mov Disord , vol.28 , Issue.10 , pp. 1407-1415
  • 32
    • 0037700247 scopus 로고    scopus 로고
    • IV amantadine improves chorea in Huntington,s disease: an acute randomized, controlled study
    • COI: 1:CAS:528:DC%2BD3sXksVGisrc%3D, PID: 12821751
    • Lucetti C, et al. IV amantadine improves chorea in Huntington,s disease: an acute randomized, controlled study. Neurology. 2003;60(12):1995–7.
    • (2003) Neurology , vol.60 , Issue.12 , pp. 1995-1997
    • Lucetti, C.1
  • 33
    • 0036757043 scopus 로고    scopus 로고
    • Amantadine in Huntington’s disease: open-label video-blinded study
    • PID: 12548355
    • Lucetti C, et al. Amantadine in Huntington’s disease: open-label video-blinded study. Neurol Sci. 2002;23(Suppl 2):S83–4.
    • (2002) Neurol Sci , vol.23 , pp. S83-S84
    • Lucetti, C.1
  • 34
    • 0037056392 scopus 로고    scopus 로고
    • Huntington’s disease: a randomized, controlled trial using the NMDA-antagonist amantadine
    • Verhagen ML, et al. Huntington’s disease: a randomized, controlled trial using the NMDA-antagonist amantadine. Neurology. 2002;59(5):694–9.
    • (2002) Neurology , vol.59 , Issue.5 , pp. 694-699
    • Verhagen, M.L.1
  • 35
    • 0038375825 scopus 로고    scopus 로고
    • A randomized trial of amantadine in Huntington disease
    • PID: 12873857
    • O’Suilleabhain P, Dewey RB. A randomized trial of amantadine in Huntington disease. Arch Neurol. 2003;60(7):996–8.
    • (2003) Arch Neurol , vol.60 , Issue.7 , pp. 996-998
    • O’Suilleabhain, P.1    Dewey, R.B.2
  • 36
    • 34948838383 scopus 로고    scopus 로고
    • Riluzole in Huntington’s disease: a 3-year, randomized controlled study
    • COI: 1:CAS:528:DC%2BD2sXht1CntrvO, PID: 17702031
    • Landwehrmeyer GB, et al. Riluzole in Huntington’s disease: a 3-year, randomized controlled study. Ann Neurol. 2007;62(3):262–72.
    • (2007) Ann Neurol , vol.62 , Issue.3 , pp. 262-272
    • Landwehrmeyer, G.B.1
  • 37
    • 0345600893 scopus 로고    scopus 로고
    • Dosage effects of riluzole in Huntington’s disease: a multicenter placebo-controlled study
    • Huntington Study Group. Dosage effects of riluzole in Huntington’s disease: a multicenter placebo-controlled study. Neurology. 2003;61(11):1551–6.
    • (2003) Neurology , vol.61 , Issue.11 , pp. 1551-1556
  • 38
    • 84866131013 scopus 로고    scopus 로고
    • Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology
    • PID: 22815556
    • Armstrong MJ, Miyasaki JM. Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2012;79(6):597–603.
    • (2012) Neurology , vol.79 , Issue.6 , pp. 597-603
    • Armstrong, M.J.1    Miyasaki, J.M.2
  • 39
    • 84957844104 scopus 로고    scopus 로고
    • Deep brain stimulation of the internal pallidum in Huntington’s disease patients: clinical outcome and neuronal firing patterns
    • PID: 26568561
    • Delorme C, et al. Deep brain stimulation of the internal pallidum in Huntington’s disease patients: clinical outcome and neuronal firing patterns. J Neurol. 2016;263(2):290–8.
    • (2016) J Neurol , vol.263 , Issue.2 , pp. 290-298
    • Delorme, C.1
  • 40
    • 84903892559 scopus 로고    scopus 로고
    • Deep brain stimulation for Huntington’s disease: long-term results of a prospective open-label study
    • PID: 24702329, Longitudinal case series of bilateral GPi DBS in patients with pharmacologically resistant chorea secondary to HD. Provides information about long-term outcomes of DBS therapy for chorea in HD
    • • Gonzalez V, et al. Deep brain stimulation for Huntington’s disease: long-term results of a prospective open-label study. J Neurosurg. 2014;121(1):114–22. Longitudinal case series of bilateral GPi DBS in patients with pharmacologically resistant chorea secondary to HD. Provides information about long-term outcomes of DBS therapy for chorea in HD
    • (2014) J Neurosurg , vol.121 , Issue.1 , pp. 114-122
    • Gonzalez, V.1
  • 41
    • 79951814028 scopus 로고    scopus 로고
    • Long-term follow-up of pallidal deep brain stimulation in two cases of Huntington’s disease
    • PID: 20974647
    • Kang GA, et al. Long-term follow-up of pallidal deep brain stimulation in two cases of Huntington’s disease. J Neurol Neurosurg Psychiatry. 2011;82(3):272–7.
    • (2011) J Neurol Neurosurg Psychiatry , vol.82 , Issue.3 , pp. 272-277
    • Kang, G.A.1
  • 42
    • 3843077481 scopus 로고    scopus 로고
    • Bilateral globus pallidus stimulation for Huntington’s disease
    • PID: 15293283
    • Moro E, et al. Bilateral globus pallidus stimulation for Huntington’s disease. Ann Neurol. 2004;56(2):290–4.
    • (2004) Ann Neurol , vol.56 , Issue.2 , pp. 290-294
    • Moro, E.1
  • 43
    • 84872786004 scopus 로고    scopus 로고
    • Differential and better response to deep brain stimulation of chorea compared to dystonia in Huntington’s disease
    • PID: 23343665
    • Velez-Lago FM, et al. Differential and better response to deep brain stimulation of chorea compared to dystonia in Huntington’s disease. Stereotact Funct Neurosurg. 2013;91(2):129–33.
    • (2013) Stereotact Funct Neurosurg , vol.91 , Issue.2 , pp. 129-133
    • Velez-Lago, F.M.1
  • 44
    • 84893636639 scopus 로고    scopus 로고
    • A 5-year follow-up of deep brain stimulation in Huntington’s disease
    • PID: 24300048
    • Lopez-Sendon Moreno JL, et al. A 5-year follow-up of deep brain stimulation in Huntington’s disease. Parkinsonism Relat Disord. 2014;20(2):260–1.
    • (2014) Parkinsonism Relat Disord , vol.20 , Issue.2 , pp. 260-261
    • Lopez-Sendon Moreno, J.L.1
  • 45
    • 84861706912 scopus 로고    scopus 로고
    • Deep brain stimulation in Huntington’s disease: a 4-year follow-up case report
    • PID: 22451258, author reply 807-8
    • Spielberger S, et al. Deep brain stimulation in Huntington’s disease: a 4-year follow-up case report. Mov Disord. 2012;27(6):806–7. author reply 807-8
    • (2012) Mov Disord , vol.27 , Issue.6 , pp. 806-807
    • Spielberger, S.1
  • 46
    • 0031785792 scopus 로고    scopus 로고
    • Levodopa responsive parkinsonism in an adult with Huntington’s disease
    • COI: 1:STN:280:DyaK1cvkt1Ogtg%3D%3D, PID: 9771791
    • Racette BA, Perlmutter JS. Levodopa responsive parkinsonism in an adult with Huntington’s disease. J Neurol Neurosurg Psychiatry. 1998;65(4):577–9.
    • (1998) J Neurol Neurosurg Psychiatry , vol.65 , Issue.4 , pp. 577-579
    • Racette, B.A.1    Perlmutter, J.S.2
  • 47
    • 0034057350 scopus 로고    scopus 로고
    • Late onset levodopa responsive Huntington’s disease with minimal chorea masquerading as Parkinson plus syndrome
    • COI: 1:STN:280:DC%2BD3c7ht12msA%3D%3D, PID: 10644798
    • Reuter I, et al. Late onset levodopa responsive Huntington’s disease with minimal chorea masquerading as Parkinson plus syndrome. J Neurol Neurosurg Psychiatry. 2000;68(2):238–41.
    • (2000) J Neurol Neurosurg Psychiatry , vol.68 , Issue.2 , pp. 238-241
    • Reuter, I.1
  • 48
    • 0019254352 scopus 로고
    • Seven cases of Huntington’s disease in childhood and levodopa induced improvement in the hypokinetic—rigid form
    • COI: 1:STN:280:DyaL3M3htVOrug%3D%3D, PID: 6165509
    • Jongen PJ, Renier WO, Gabreels FJ. Seven cases of Huntington’s disease in childhood and levodopa induced improvement in the hypokinetic—rigid form. Clin Neurol Neurosurg. 1980;82(4):251–61.
    • (1980) Clin Neurol Neurosurg , vol.82 , Issue.4 , pp. 251-261
    • Jongen, P.J.1    Renier, W.O.2    Gabreels, F.J.3
  • 49
    • 46449134291 scopus 로고    scopus 로고
    • Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus
    • PID: 18590443
    • Biolsi B, et al. Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus. J Neurosurg. 2008;109(1):130–2.
    • (2008) J Neurosurg , vol.109 , Issue.1 , pp. 130-132
    • Biolsi, B.1
  • 50
    • 33645461836 scopus 로고    scopus 로고
    • Cabergoline in Huntington’s disease: the first case report
    • COI: 1:STN:280:DC%2BD283it1Wgtw%3D%3D, PID: 16629775
    • Magnet MK, Kapfhammer HP, Bonelli RM. Cabergoline in Huntington’s disease: the first case report. Acta Neurol Scand. 2006;113(5):355–6.
    • (2006) Acta Neurol Scand , vol.113 , Issue.5 , pp. 355-356
    • Magnet, M.K.1    Kapfhammer, H.P.2    Bonelli, R.M.3
  • 51
    • 0036182828 scopus 로고    scopus 로고
    • Pramipexole ameliorates neurologic and psychiatric symptoms in a Westphal variant of Huntington’s disease
    • PID: 11852299
    • Bonelli RM, et al. Pramipexole ameliorates neurologic and psychiatric symptoms in a Westphal variant of Huntington’s disease. Clin Neuropharmacol. 2002;25(1):58–60.
    • (2002) Clin Neuropharmacol , vol.25 , Issue.1 , pp. 58-60
    • Bonelli, R.M.1
  • 52
    • 84905174777 scopus 로고    scopus 로고
    • Bilateral globus pallidus stimulation in Westphal variant of Huntington disease
    • PID: 24024832
    • Cislaghi G, et al. Bilateral globus pallidus stimulation in Westphal variant of Huntington disease. Neuromodulation. 2014;17(5):502–5.
    • (2014) Neuromodulation , vol.17 , Issue.5 , pp. 502-505
    • Cislaghi, G.1
  • 53
    • 0033693353 scopus 로고    scopus 로고
    • Internal globus pallidotomy in dystonia secondary to Huntington’s disease
    • COI: 1:STN:280:DC%2BD3MzgsVagtg%3D%3D, PID: 11104214
    • Cubo E, et al. Internal globus pallidotomy in dystonia secondary to Huntington’s disease. Mov Disord. 2000;15(6):1248–51.
    • (2000) Mov Disord , vol.15 , Issue.6 , pp. 1248-1251
    • Cubo, E.1
  • 54
    • 33645216173 scopus 로고    scopus 로고
    • Dose-dependent improvement of myoclonic hyperkinesia due to valproic acid in eight Huntington’s disease patients: a case series
    • PID: 16507108
    • Saft C, et al. Dose-dependent improvement of myoclonic hyperkinesia due to valproic acid in eight Huntington’s disease patients: a case series. BMC Neurol. 2006;6:11.
    • (2006) BMC Neurol , vol.6 , pp. 11
    • Saft, C.1
  • 55
    • 0028077467 scopus 로고
    • Cortical myoclonus in Huntington’s disease
    • COI: 1:STN:280:DyaK2M7ksl2jsg%3D%3D, PID: 7845404
    • Thompson PD, et al. Cortical myoclonus in Huntington’s disease. Mov Disord. 1994;9(6):633–41.
    • (1994) Mov Disord , vol.9 , Issue.6 , pp. 633-641
    • Thompson, P.D.1
  • 56
    • 0025965356 scopus 로고
    • Myoclonus in adult Huntington’s disease
    • COI: 1:STN:280:DyaK3M7ovFKltg%3D%3D, PID: 1826419
    • Vogel CM, et al. Myoclonus in adult Huntington’s disease. Ann Neurol. 1991;29(2):213–5.
    • (1991) Ann Neurol , vol.29 , Issue.2 , pp. 213-215
    • Vogel, C.M.1
  • 57
    • 84885649254 scopus 로고    scopus 로고
    • Cognitive decline in prodromal Huntington disease: implications for clinical trials
    • PID: 23911948
    • Paulsen JS, Smith MM, Long JD. Cognitive decline in prodromal Huntington disease: implications for clinical trials. J Neurol Neurosurg Psychiatry. 2013;84(11):1233–9.
    • (2013) J Neurol Neurosurg Psychiatry , vol.84 , Issue.11 , pp. 1233-1239
    • Paulsen, J.S.1    Smith, M.M.2    Long, J.D.3
  • 58
    • 0029043634 scopus 로고
    • Distinct cognitive profiles of cortical and subcortical dementia in advanced illness
    • COI: 1:STN:280:DyaK2M3msFajsA%3D%3D, PID: 7746413
    • Paulsen JS, et al. Distinct cognitive profiles of cortical and subcortical dementia in advanced illness. Neurology. 1995;45(5):951–6.
    • (1995) Neurology , vol.45 , Issue.5 , pp. 951-956
    • Paulsen, J.S.1
  • 59
    • 34248560852 scopus 로고    scopus 로고
    • Patients with Huntington’s disease have impaired awareness of cognitive, emotional, and functional abilities
    • Hoth KF, et al. Patients with Huntington’s disease have impaired awareness of cognitive, emotional, and functional abilities. J Clin Exp Neuropsychol. 2007;9(4):365–76.
    • (2007) J Clin Exp Neuropsychol , vol.9 , Issue.4 , pp. 365-376
    • Hoth, K.F.1
  • 60
    • 33846815309 scopus 로고    scopus 로고
    • Two years’ follow-up of rivastigmine treatment in Huntington disease
    • PID: 17272969
    • de Tommaso M, et al. Two years’ follow-up of rivastigmine treatment in Huntington disease. Clin Neuropharmacol. 2007;30(1):43–6.
    • (2007) Clin Neuropharmacol , vol.30 , Issue.1 , pp. 43-46
    • de Tommaso, M.1
  • 61
    • 0036834904 scopus 로고    scopus 로고
    • Rivastigmine in the treatment of Huntington’s disease
    • COI: 1:STN:280:DC%2BD38npt1GisA%3D%3D, PID: 12453090
    • Rot U, et al. Rivastigmine in the treatment of Huntington’s disease. Eur J Neurol. 2002;9(6):689–90.
    • (2002) Eur J Neurol , vol.9 , Issue.6 , pp. 689-690
    • Rot, U.1
  • 62
    • 84907167457 scopus 로고    scopus 로고
    • Cognitive function in early clinical phase Huntington disease after rivastigmine treatment
    • COI: 1:CAS:528:DC%2BC2cXhvFejtLfM, PID: 25191771
    • Sesok S, et al. Cognitive function in early clinical phase Huntington disease after rivastigmine treatment. Psychiatr Danub. 2014;26(3):239–48.
    • (2014) Psychiatr Danub , vol.26 , Issue.3 , pp. 239-248
    • Sesok, S.1
  • 63
    • 33749861388 scopus 로고    scopus 로고
    • Effect of donepezil on motor and cognitive function in Huntington disease
    • COI: 1:CAS:528:DC%2BD28XhtFyqtb7M, PID: 17030764
    • Cubo E, et al. Effect of donepezil on motor and cognitive function in Huntington disease. Neurology. 2006;67(7):1268–71.
    • (2006) Neurology , vol.67 , Issue.7 , pp. 1268-1271
    • Cubo, E.1
  • 64
    • 34548814154 scopus 로고    scopus 로고
    • A pilot study of the clinical efficacy and safety of memantine for Huntington’s disease
    • PID: 17046312
    • Ondo WG, Mejia NI, Hunter CB. A pilot study of the clinical efficacy and safety of memantine for Huntington’s disease. Parkinsonism Relat Disord. 2007;13(7):453–4.
    • (2007) Parkinsonism Relat Disord , vol.13 , Issue.7 , pp. 453-454
    • Ondo, W.G.1    Mejia, N.I.2    Hunter, C.B.3
  • 65
    • 4544335687 scopus 로고    scopus 로고
    • The N-methyl-D-aspartate antagonist memantine retards progression of Huntington’s disease
    • COI: 1:CAS:528:DC%2BD2MXht1CgurfK
    • Beister A, et al. The N-methyl-D-aspartate antagonist memantine retards progression of Huntington’s disease. J Neural Transm Suppl. 2004;68:117–22.
    • (2004) J Neural Transm Suppl , vol.68 , pp. 117-122
    • Beister, A.1
  • 66
    • 0034881096 scopus 로고    scopus 로고
    • Neuropsychiatric aspects of Huntington’s disease
    • COI: 1:STN:280:DC%2BD3Mvms12hsQ%3D%3D, PID: 11511702
    • Paulsen JS, et al. Neuropsychiatric aspects of Huntington’s disease. J Neurol Neurosurg Psychiatry. 2001;71(3):310–4.
    • (2001) J Neurol Neurosurg Psychiatry , vol.71 , Issue.3 , pp. 310-314
    • Paulsen, J.S.1
  • 67
    • 0031849018 scopus 로고    scopus 로고
    • Apathy is not depression
    • COI: 1:STN:280:DyaK1czntFyhug%3D%3D, PID: 9706539
    • Levy ML, et al. Apathy is not depression. J Neuropsychiatry Clin Neurosci. 1998;10(3):314–9.
    • (1998) J Neuropsychiatry Clin Neurosci , vol.10 , Issue.3 , pp. 314-319
    • Levy, M.L.1
  • 68
    • 36549036813 scopus 로고    scopus 로고
    • Psychiatric symptoms in Huntington’s disease before diagnosis: the predict-HD study
    • PID: 17481592
    • Duff K, et al. Psychiatric symptoms in Huntington’s disease before diagnosis: the predict-HD study. Biol Psychiatry. 2007;62(12):1341–6.
    • (2007) Biol Psychiatry , vol.62 , Issue.12 , pp. 1341-1346
    • Duff, K.1
  • 69
    • 0346502764 scopus 로고    scopus 로고
    • Cognitive and psychiatric aspects of Huntington disease contribute to functional capacity
    • PID: 14718780
    • Nehl C, Paulsen JS. Cognitive and psychiatric aspects of Huntington disease contribute to functional capacity. J Nerv Ment Dis. 2004;192(1):72–4.
    • (2004) J Nerv Ment Dis , vol.192 , Issue.1 , pp. 72-74
    • Nehl, C.1    Paulsen, J.S.2
  • 70
    • 84900376687 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms in a European Huntington’s disease cohort (REGISTRY)
    • PID: 24828898
    • van Duijn E, et al. Neuropsychiatric symptoms in a European Huntington’s disease cohort (REGISTRY). J Neurol Neurosurg Psychiatry. 2014;85(12):1411–8.
    • (2014) J Neurol Neurosurg Psychiatry , vol.85 , Issue.12 , pp. 1411-1418
    • van Duijn, E.1
  • 72
    • 84927518627 scopus 로고    scopus 로고
    • Systematic review of pharmacological treatments for depressive symptoms in Huntington’s disease
    • COI: 1:CAS:528:DC%2BC2cXhslajsrbN, PID: 25111961
    • Moulton CD, Hopkins CW, Bevan-Jones WR. Systematic review of pharmacological treatments for depressive symptoms in Huntington’s disease. Mov Disord. 2014;29(12):1556–61.
    • (2014) Mov Disord , vol.29 , Issue.12 , pp. 1556-1561
    • Moulton, C.D.1    Hopkins, C.W.2    Bevan-Jones, W.R.3
  • 73
    • 16744362352 scopus 로고    scopus 로고
    • A controlled trial of fluoxetine in nondepressed patients with Huntington’s disease
    • COI: 1:STN:280:DyaK2szgtlCisg%3D%3D, PID: 9159735
    • Como PG, et al. A controlled trial of fluoxetine in nondepressed patients with Huntington’s disease. Mov Disord. 1997;12(3):397–401.
    • (1997) Mov Disord , vol.12 , Issue.3 , pp. 397-401
    • Como, P.G.1
  • 74
    • 84896110683 scopus 로고    scopus 로고
    • Results of the citalopram to enhance cognition in Huntington disease trial
    • COI: 1:CAS:528:DC%2BC2cXktlChu7s%3D, PID: 24375941
    • Beglinger LJ, et al. Results of the citalopram to enhance cognition in Huntington disease trial. Mov Disord. 2014;29(3):401–5.
    • (2014) Mov Disord , vol.29 , Issue.3 , pp. 401-405
    • Beglinger, L.J.1
  • 75
    • 73449100113 scopus 로고    scopus 로고
    • Combating depression in Huntington’s disease: effective antidepressive treatment with venlafaxine XR
    • PID: 19996754
    • Holl AK, et al. Combating depression in Huntington’s disease: effective antidepressive treatment with venlafaxine XR. Int Clin Psychopharmacol. 2010;25(1):46–50.
    • (2010) Int Clin Psychopharmacol , vol.25 , Issue.1 , pp. 46-50
    • Holl, A.K.1
  • 76
    • 39749165003 scopus 로고    scopus 로고
    • Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington’s disease
    • PID: 18297579
    • Duff K, et al. Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington’s disease. Ann Clin Psychiatry. 2008;20(1):1–3.
    • (2008) Ann Clin Psychiatry , vol.20 , Issue.1 , pp. 1-3
    • Duff, K.1
  • 77
    • 70449710919 scopus 로고    scopus 로고
    • Aripiprazole in the treatment of Huntington’s disease: a case series
    • COI: 1:CAS:528:DC%2BD1MXitFWls7k%3D, PID: 19557093
    • Ciammola A, et al. Aripiprazole in the treatment of Huntington’s disease: a case series. Neuropsychiatr Dis Treat. 2009;5:1–4.
    • (2009) Neuropsychiatr Dis Treat , vol.5 , pp. 1-4
    • Ciammola, A.1
  • 78
    • 0025977935 scopus 로고
    • Clozapine treatment of psychiatric symptoms resistant to neuroleptic treatment in patients with Huntington’s chorea
    • COI: 1:STN:280:DyaK3M%2FovVSktg%3D%3D, PID: 1670739
    • Sajatovic M, et al. Clozapine treatment of psychiatric symptoms resistant to neuroleptic treatment in patients with Huntington’s chorea. Neurology. 1991;41(1):156.
    • (1991) Neurology , vol.41 , Issue.1 , pp. 156
    • Sajatovic, M.1
  • 79
    • 79951513261 scopus 로고    scopus 로고
    • Risperidone long-acting injection and Huntington’s disease: case series with significant psychiatric and behavioural symptoms
    • PID: 21119522
    • Johnston TG. Risperidone long-acting injection and Huntington’s disease: case series with significant psychiatric and behavioural symptoms. Int Clin Psychopharmacol. 2011;26(2):114–9.
    • (2011) Int Clin Psychopharmacol , vol.26 , Issue.2 , pp. 114-119
    • Johnston, T.G.1
  • 80
    • 0029875455 scopus 로고    scopus 로고
    • ECT in genetically confirmed Huntington’s disease
    • COI: 1:STN:280:DyaK2s7htVyktg%3D%3D, PID: 9081559
    • Lewis CF, DeQuardo JR, Tandon R. ECT in genetically confirmed Huntington’s disease. J Neuropsychiatry Clin Neurosci. 1996;8(2):209–10.
    • (1996) J Neuropsychiatry Clin Neurosci , vol.8 , Issue.2 , pp. 209-210
    • Lewis, C.F.1    DeQuardo, J.R.2    Tandon, R.3
  • 81
    • 0028349632 scopus 로고
    • ECT as a treatment for depression in Huntington’s disease
    • COI: 1:STN:280:DyaK2czhvFWktA%3D%3D, PID: 8044037
    • Ranen NG, Peyser CE, Folstein SE. ECT as a treatment for depression in Huntington’s disease. J Neuropsychiatry Clin Neurosci. 1994;6(2):154–9.
    • (1994) J Neuropsychiatry Clin Neurosci , vol.6 , Issue.2 , pp. 154-159
    • Ranen, N.G.1    Peyser, C.E.2    Folstein, S.E.3
  • 82
    • 84887032790 scopus 로고    scopus 로고
    • Rapid improvement of depression and psychotic symptoms in Huntington’s disease: a retrospective chart review of seven patients treated with electroconvulsive therapy
    • PID: 23541803, e3-5
    • Cusin C, et al. Rapid improvement of depression and psychotic symptoms in Huntington’s disease: a retrospective chart review of seven patients treated with electroconvulsive therapy. Gen Hosp Psychiatry. 2013;35(6):678. e3-5
    • (2013) Gen Hosp Psychiatry , vol.35 , Issue.6 , pp. 678
    • Cusin, C.1
  • 83
    • 29044431699 scopus 로고    scopus 로고
    • Depression and stages of Huntington’s disease
    • PID: 16387989
    • Paulsen JS, et al. Depression and stages of Huntington’s disease. J Neuropsychiatry Clin Neurosci. 2005;17(4):496–502.
    • (2005) J Neuropsychiatry Clin Neurosci , vol.17 , Issue.4 , pp. 496-502
    • Paulsen, J.S.1
  • 84
    • 0027467546 scopus 로고
    • Suicide risk in Huntington’s disease
    • COI: 1:STN:280:DyaK3s3ltlOntg%3D%3D, PID: 8487273
    • Di Maio L, et al. Suicide risk in Huntington’s disease. J Med Genet. 1993;30(4):293–5.
    • (1993) J Med Genet , vol.30 , Issue.4 , pp. 293-295
    • Di Maio, L.1
  • 85
    • 0027134654 scopus 로고
    • Risk factors for suicide in Huntingtons disease: a retrospective case controlled study
    • COI: 1:STN:280:DyaK2c7ot1Kktw%3D%3D, PID: 8135306
    • Lipe H, Schultz A, Bird TD. Risk factors for suicide in Huntingtons disease: a retrospective case controlled study. Am J Med Genet. 1993;48(4):231–3.
    • (1993) Am J Med Genet , vol.48 , Issue.4 , pp. 231-233
    • Lipe, H.1    Schultz, A.2    Bird, T.D.3
  • 86
    • 79960696876 scopus 로고    scopus 로고
    • Suicidal ideation in Huntington disease: the role of comorbidity
    • PID: 21605914
    • Wetzel HH, et al. Suicidal ideation in Huntington disease: the role of comorbidity. Psychiatry Res. 2011;188(3):372–6.
    • (2011) Psychiatry Res , vol.188 , Issue.3 , pp. 372-376
    • Wetzel, H.H.1
  • 87
    • 80755128156 scopus 로고    scopus 로고
    • Treatment of apathy in Huntington’s disease and other movement disorders
    • PID: 21800056
    • Krishnamoorthy A, Craufurd D. Treatment of apathy in Huntington’s disease and other movement disorders. Curr Treat Options Neurol. 2011;13(5):508–19.
    • (2011) Curr Treat Options Neurol , vol.13 , Issue.5 , pp. 508-519
    • Krishnamoorthy, A.1    Craufurd, D.2
  • 88
    • 0035140902 scopus 로고    scopus 로고
    • Fluoxetine in the treatment of Huntington’s disease
    • COI: 1:CAS:528:DC%2BD3MXhtlGiurg%3D, PID: 11205429
    • De Marchi N, Daniele F, Ragone MA. Fluoxetine in the treatment of Huntington’s disease. Psychopharmacology. 2001;153(2):264–6.
    • (2001) Psychopharmacology , vol.153 , Issue.2 , pp. 264-266
    • De Marchi, N.1    Daniele, F.2    Ragone, M.A.3
  • 89
    • 0036713657 scopus 로고    scopus 로고
    • Obsessive compulsive disorder in Huntington disease: a case of isolated obsessions successfully treated with sertraline
    • PID: 12218715
    • Patzold T, Brune M. Obsessive compulsive disorder in Huntington disease: a case of isolated obsessions successfully treated with sertraline. Neuropsychiatry Neuropsychol Behav Neurol. 2002;15(3):216–9.
    • (2002) Neuropsychiatry Neuropsychol Behav Neurol , vol.15 , Issue.3 , pp. 216-219
    • Patzold, T.1    Brune, M.2
  • 90
    • 84863702589 scopus 로고    scopus 로고
    • An international survey-based algorithm for the pharmacologic treatment of obsessive-compulsive behaviors in Huntington’s disease
    • PID: 21947193
    • Anderson K, et al. An international survey-based algorithm for the pharmacologic treatment of obsessive-compulsive behaviors in Huntington’s disease. PLoS Curr. 2011;3:Rrn1261.
    • (2011) PLoS Curr , vol.3 , pp. Rrn1261
    • Anderson, K.1
  • 91
    • 0029793158 scopus 로고    scopus 로고
    • Sertraline in the treatment of severe aggressiveness in Huntington’s disease
    • COI: 1:STN:280:DyaK2s%2FgslSgsA%3D%3D, PID: 8854307
    • Ranen NG, et al. Sertraline in the treatment of severe aggressiveness in Huntington’s disease. J Neuropsychiatry Clin Neurosci. 1996;8(3):338–40.
    • (1996) J Neuropsychiatry Clin Neurosci , vol.8 , Issue.3 , pp. 338-340
    • Ranen, N.G.1
  • 92
    • 84865652676 scopus 로고    scopus 로고
    • An international survey-based algorithm for the pharmacologic treatment of irritability in Huntington’s disease
    • PID: 21975525
    • Groves M, et al. An international survey-based algorithm for the pharmacologic treatment of irritability in Huntington’s disease. PLoS Curr. 2011;3:Rrn1259.
    • (2011) PLoS Curr , vol.3 , pp. Rrn1259
    • Groves, M.1
  • 93
    • 0031708158 scopus 로고    scopus 로고
    • Use of risperidone in psychosis associated with Huntington’s disease
    • COI: 1:STN:280:DyaK1M%2FgvF2rsg%3D%3D, PID: 9793585
    • Madhusoodanan S, Brenner R. Use of risperidone in psychosis associated with Huntington’s disease. Am J Geriatr Psychiatry. 1998;6(4):347–9.
    • (1998) Am J Geriatr Psychiatry , vol.6 , Issue.4 , pp. 347-349
    • Madhusoodanan, S.1    Brenner, R.2
  • 94
    • 3042733763 scopus 로고    scopus 로고
    • Quetiapine in the management of psychosis secondary to Huntington’s disease: a case report
    • Seitz DP, Millson RC. Quetiapine in the management of psychosis secondary to Huntington’s disease: a case report. Can J Psychiatr. 2004;49(6):413.
    • (2004) Can J Psychiatr , vol.49 , Issue.6 , pp. 413
    • Seitz, D.P.1    Millson, R.C.2
  • 95
    • 29544445190 scopus 로고    scopus 로고
    • Quetiapine in the treatment of behavioral disturbances in patients with Huntington’s disease
    • PID: 16384811
    • Alpay M, Koroshetz WJ. Quetiapine in the treatment of behavioral disturbances in patients with Huntington’s disease. Psychosomatics. 2006;47(1):70–2.
    • (2006) Psychosomatics , vol.47 , Issue.1 , pp. 70-72
    • Alpay, M.1    Koroshetz, W.J.2
  • 96
    • 84961752080 scopus 로고    scopus 로고
    • The genetic modifiers of motor onsetAge (GeM MOA) website: genome-wide association analysis for genetic modifiers of Huntington’s disease
    • COI: 1:CAS:528:DC%2BC2MXhs1WqsrrF, PID: 26444025
    • Correia K, et al. The genetic modifiers of motor onsetAge (GeM MOA) website: genome-wide association analysis for genetic modifiers of Huntington’s disease. J Huntingtons Dis. 2015;4(3):279–84.
    • (2015) J Huntingtons Dis , vol.4 , Issue.3 , pp. 279-284
    • Correia, K.1
  • 97
    • 84938389137 scopus 로고    scopus 로고
    • Identification of genetic factors that modify clinical onset of Huntington’s disease
    • Genetic Modifiers of Huntington’s Disease Consortium. Identification of genetic factors that modify clinical onset of Huntington’s disease. Cell. 2015;162(3):516–26.
    • (2015) Cell , vol.162 , Issue.3 , pp. 516-526
  • 98
    • 84922460332 scopus 로고    scopus 로고
    • Delivering a disease-modifying treatment for Huntington’s disease
    • COI: 1:CAS:528:DC%2BC2cXhs1KgtrrK, PID: 25256777
    • Godinho BM, et al. Delivering a disease-modifying treatment for Huntington’s disease. Drug Discov Today. 2015;20(1):50–64.
    • (2015) Drug Discov Today , vol.20 , Issue.1 , pp. 50-64
    • Godinho, B.M.1
  • 99
    • 84941569159 scopus 로고    scopus 로고
    • Therapeutic advances in Huntington’s disease
    • PID: 26226924
    • Shannon KM, Fraint A. Therapeutic advances in Huntington’s disease. Mov Disord. 2015;30(11):1539–46.
    • (2015) Mov Disord , vol.30 , Issue.11 , pp. 1539-1546
    • Shannon, K.M.1    Fraint, A.2
  • 100
    • 84918574081 scopus 로고    scopus 로고
    • Huntington disease: pathogenesis and treatment
    • PID: 25432725
    • Dayalu P, Albin RL. Huntington disease: pathogenesis and treatment. Neurol Clin. 2015;33(1):101–14.
    • (2015) Neurol Clin , vol.33 , Issue.1 , pp. 101-114
    • Dayalu, P.1    Albin, R.L.2
  • 103
    • 84918785958 scopus 로고    scopus 로고
    • H.D.I. Safety, tolerability, and efficacy of PBT2 in Huntington’s disease: a phase 2, randomised, double-blind, placebo-controlled trial
    • Huntington Study Group Reach. H.D.I. Safety, tolerability, and efficacy of PBT2 in Huntington’s disease: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015;14(1):39–47.
    • (2015) Lancet Neurol , vol.14 , Issue.1 , pp. 39-47
  • 104
    • 84930012088 scopus 로고    scopus 로고
    • An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington’s disease
    • PID: 25223731
    • Sussmuth SD, et al. An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington’s disease. Br J Clin Pharmacol. 2015;79(3):465–76.
    • (2015) Br J Clin Pharmacol , vol.79 , Issue.3 , pp. 465-476
    • Sussmuth, S.D.1
  • 107
    • 84930189896 scopus 로고    scopus 로고
    • Disease modifying potential of glatiramer acetate in Huntington’s disease
    • COI: 1:CAS:528:DC%2BC2cXhs12ku7bP, PID: 25300334
    • Corey-Bloom J, et al. Disease modifying potential of glatiramer acetate in Huntington’s disease. J Huntingtons Dis. 2014;3(3):311–6.
    • (2014) J Huntingtons Dis , vol.3 , Issue.3 , pp. 311-316
    • Corey-Bloom, J.1
  • 108
    • 80053937926 scopus 로고    scopus 로고
    • Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington’s disease and other neurodegenerative disorders
    • COI: 1:CAS:528:DC%2BC3MXht12jt7nE, PID: 21907197
    • Pasinetti GM, et al. Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington’s disease and other neurodegenerative disorders. Exp Neurol. 2011;232(1):1–6.
    • (2011) Exp Neurol , vol.232 , Issue.1 , pp. 1-6
    • Pasinetti, G.M.1
  • 109
    • 84938718400 scopus 로고    scopus 로고
    • Sirtuins: double players in Huntington’s disease
    • COI: 1:CAS:528:DC%2BC2MXhtFKis7zF, PID: 26163995
    • Naia L, Rego AC. Sirtuins: double players in Huntington’s disease. Biochim Biophys Acta. 2015;1852(10 Pt A):2183–94.
    • (2015) Biochim Biophys Acta , vol.1852 , Issue.10 , pp. 2183-2194
    • Naia, L.1    Rego, A.C.2
  • 110
    • 0033595502 scopus 로고    scopus 로고
    • Influence of lamotrigine on progression of early Huntington disease: a randomized clinical trial
    • COI: 1:CAS:528:DyaK1MXmsFers7c%3D, PID: 10496259
    • Kremer B, et al. Influence of lamotrigine on progression of early Huntington disease: a randomized clinical trial. Neurology. 1999;53(5):1000–11.
    • (1999) Neurology , vol.53 , Issue.5 , pp. 1000-1011
    • Kremer, B.1
  • 111
    • 78649369122 scopus 로고    scopus 로고
    • A futility study of minocycline in Huntington’s disease
    • Huntington Study Group DOMINO Investigators. A futility study of minocycline in Huntington’s disease. Mov Disord. 2010;25(13):2219–24.
    • (2010) Mov Disord , vol.25 , Issue.13 , pp. 2219-2224
  • 112
    • 33745211255 scopus 로고    scopus 로고
    • Antisense oligonucleotides: from design to therapeutic application
    • COI: 1:CAS:528:DC%2BD28XlvFCmt70%3D, PID: 16700890
    • Chan JH, Lim S, Wong WS. Antisense oligonucleotides: from design to therapeutic application. Clin Exp Pharmacol Physiol. 2006;33(5–6):533–40.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , Issue.5-6 , pp. 533-540
    • Chan, J.H.1    Lim, S.2    Wong, W.S.3
  • 113
    • 84901688904 scopus 로고    scopus 로고
    • Personalized gene silencing therapeutics for Huntington disease
    • COI: 1:CAS:528:DC%2BC2cXpsVelt7g%3D, PID: 24646433
    • Kay C, et al. Personalized gene silencing therapeutics for Huntington disease. Clin Genet. 2014;86(1):29–36.
    • (2014) Clin Genet , vol.86 , Issue.1 , pp. 29-36
    • Kay, C.1
  • 114
    • 84926687571 scopus 로고    scopus 로고
    • Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients
    • PID: 25207939, Article describing development of stable ASOs targeting SNPs found on a majority of mutant alleles to stop production of mhtt
    • • Skotte NH, et al. Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients. PLoS One. 2014;9(9):e107434. Article describing development of stable ASOs targeting SNPs found on a majority of mutant alleles to stop production of mhtt
    • (2014) PLoS One , vol.9 , Issue.9
    • Skotte, N.H.1
  • 115
    • 78649379362 scopus 로고    scopus 로고
    • Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat
    • COI: 1:CAS:528:DC%2BC3cXhtlynsb3O, PID: 21028906
    • Gagnon KT, et al. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry. 2010;49(47):10166–78.
    • (2010) Biochemistry , vol.49 , Issue.47 , pp. 10166-10178
    • Gagnon, K.T.1
  • 116
    • 70349469318 scopus 로고    scopus 로고
    • Allele-selective inhibition of mutant huntingtin by peptide nucleic acid-peptide conjugates, locked nucleic acid, and small interfering RNA
    • COI: 1:CAS:528:DC%2BD1MXhtlGgu7zJ, PID: 19796074
    • Hu J, Matsui M, Corey DR. Allele-selective inhibition of mutant huntingtin by peptide nucleic acid-peptide conjugates, locked nucleic acid, and small interfering RNA. Ann N Y Acad Sci. 2009;1175:24–31.
    • (2009) Ann N Y Acad Sci , vol.1175 , pp. 24-31
    • Hu, J.1    Matsui, M.2    Corey, D.R.3
  • 117
    • 84937251574 scopus 로고    scopus 로고
    • Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity
    • COI: 1:CAS:528:DC%2BC28XhtFOntL3K, PID: 25035419
    • Sun X, et al. Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity. Hum Mol Genet. 2014;23(23):6302–17.
    • (2014) Hum Mol Genet , vol.23 , Issue.23 , pp. 6302-6317
    • Sun, X.1
  • 118
    • 84862663712 scopus 로고    scopus 로고
    • Sustained therapeutic reversal of Huntington’s disease by transient repression of huntingtin synthesis
    • COI: 1:CAS:528:DC%2BC38XptVKgtbs%3D, PID: 22726834
    • Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington’s disease by transient repression of huntingtin synthesis. Neuron. 2012;74(6):1031–44.
    • (2012) Neuron , vol.74 , Issue.6 , pp. 1031-1044
    • Kordasiewicz, H.B.1
  • 119
    • 82955237522 scopus 로고    scopus 로고
    • Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene/allele-specific silencing of mutant huntingtin
    • COI: 1:CAS:528:DC%2BC3MXht1GqsLzM, PID: 21971427
    • Carroll JB, et al. Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene/allele-specific silencing of mutant huntingtin. Mol Ther. 2011;19(12):2178–85.
    • (2011) Mol Ther , vol.19 , Issue.12 , pp. 2178-2185
    • Carroll, J.B.1
  • 120
    • 84907924586 scopus 로고    scopus 로고
    • Targets for future clinical trials in Huntington’s disease: what’s in the pipeline?
    • COI: 1:CAS:528:DC%2BC2cXhsFGhtrfF, PID: 25155142
    • Wild EJ, Tabrizi SJ. Targets for future clinical trials in Huntington’s disease: what’s in the pipeline? Mov Disord. 2014;29(11):1434–45.
    • (2014) Mov Disord , vol.29 , Issue.11 , pp. 1434-1445
    • Wild, E.J.1    Tabrizi, S.J.2
  • 121
    • 84876466100 scopus 로고    scopus 로고
    • An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study
    • COI: 1:CAS:528:DC%2BC3sXltVynsrY%3D, PID: 23541756
    • Miller TM, et al. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study. Lancet Neurol. 2013;12(5):435–42.
    • (2013) Lancet Neurol , vol.12 , Issue.5 , pp. 435-442
    • Miller, T.M.1
  • 122
    • 85015850311 scopus 로고    scopus 로고
    • Inc. Safety, tolerability, pharmacokinetics, and pharmacodynamics of IONIS-HTTRx in patients with early manifest Huntington's disease
    • Ionis Pharmaceuticals, Inc. Safety, tolerability, pharmacokinetics, and pharmacodynamics of IONIS-HTTRx in patients with early manifest Huntington's disease. Bethesda: National Library of Medicine (US); 2000. https://clinicaltrials.gov/ct2/show/NCT02519036.
    • (2000) Bethesda: National Library of Medicine (US)
    • Pharmaceuticals, I.1
  • 123
    • 84907920445 scopus 로고    scopus 로고
    • Huntingtin-lowering strategies in Huntington’s disease: antisense oligonucleotides, small RNAs, and gene editing
    • COI: 1:CAS:528:DC%2BC2cXhsFGhtrfE, PID: 25164989, Review article describing in greater detail the function and limitations of various genetic approaches at gene silencing for HD
    • • Aronin N, DiFiglia M. Huntingtin-lowering strategies in Huntington’s disease: antisense oligonucleotides, small RNAs, and gene editing. Mov Disord. 2014;29(11):1455–61. Review article describing in greater detail the function and limitations of various genetic approaches at gene silencing for HD
    • (2014) Mov Disord , vol.29 , Issue.11 , pp. 1455-1461
    • Aronin, N.1    DiFiglia, M.2
  • 124
    • 84919622781 scopus 로고    scopus 로고
    • Huntington’s disease: an update of therapeutic strategies
    • COI: 1:CAS:528:DC%2BC2cXhvFantLjJ, PID: 25447911
    • Kumar A, et al. Huntington’s disease: an update of therapeutic strategies. Gene. 2015;556(2):91–7.
    • (2015) Gene , vol.556 , Issue.2 , pp. 91-97
    • Kumar, A.1
  • 125
    • 84901195245 scopus 로고    scopus 로고
    • Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington’s disease
    • COI: 1:CAS:528:DC%2BC2cXotlWhsrw%3D, PID: 24484067
    • Stanek LM, et al. Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington’s disease. Hum Gene Ther. 2014;25(5):461–74.
    • (2014) Hum Gene Ther , vol.25 , Issue.5 , pp. 461-474
    • Stanek, L.M.1
  • 126
    • 77953700445 scopus 로고    scopus 로고
    • Promising human brain tumors therapy with interference RNA intervention (iRNAi)
    • PID: 20118657
    • Rolle K, et al. Promising human brain tumors therapy with interference RNA intervention (iRNAi). Cancer Biol Ther. 2010;9(5):396–406.
    • (2010) Cancer Biol Ther , vol.9 , Issue.5 , pp. 396-406
    • Rolle, K.1
  • 127
    • 84891834550 scopus 로고    scopus 로고
    • Phase I clinical trial of SYL040012, a small interfering RNA targeting beta-adrenergic receptor 2, for lowering intraocular pressure
    • COI: 1:CAS:528:DC%2BC3sXhs1WmsLjE, PID: 24025752
    • Moreno-Montanes J, et al. Phase I clinical trial of SYL040012, a small interfering RNA targeting beta-adrenergic receptor 2, for lowering intraocular pressure. Mol Ther. 2014;22(1):226–32.
    • (2014) Mol Ther , vol.22 , Issue.1 , pp. 226-232
    • Moreno-Montanes, J.1
  • 128
    • 84868538087 scopus 로고    scopus 로고
    • Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
    • COI: 1:CAS:528:DC%2BC38Xhslyiu7fP, PID: 23054839
    • Garriga-Canut M, et al. Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proc Natl Acad Sci. 2012;109(45):E3136–45.
    • (2012) Proc Natl Acad Sci , vol.109 , Issue.45 , pp. E3136-E3145
    • Garriga-Canut, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.