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Volumn 13, Issue 5, 2011, Pages 508-519

Treatment of apathy in Huntington's disease and other movement disorders

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; AMFEBUTAMONE; ATOMOXETINE; BENSERAZIDE; BROMOCRIPTINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; DOPAMINE RECEPTOR STIMULATING AGENT; GALANTAMINE; LEVODOPA; METHYLPHENIDATE; MODAFINIL; PLACEBO; RIVASTIGMINE; SELEGILINE;

EID: 80755128156     PISSN: 10928480     EISSN: 15343138     Source Type: Journal    
DOI: 10.1007/s11940-011-0140-y     Document Type: Article
Times cited : (35)

References (47)
  • 1
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group
    • Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell. 1993;72:971-83.
    • (1993) Cell. , vol.72 , pp. 971-983
  • 2
    • 0027737645 scopus 로고
    • A clinico-genetic study of psychiatric disorder in Huntington's chorea
    • Watt DC, Seller A: A clinico-genetic study of psychiatric disorder in Huntington's chorea. Psychol Med Monogr SUPPL. 1993:23.
    • (1993) Psychol Med Monogr SUPPL. , pp. 23
    • Watt, D.C.1    Seller, A.2
  • 3
    • 0029183627 scopus 로고
    • Behavioral and psychiatric symptoms associated with Huntington's disease
    • Weiner WJ, Lang AE, editors, New York: Raven
    • Cummings JL. Behavioral and psychiatric symptoms associated with Huntington's disease. In: Weiner WJ, Lang AE, editors. Behavioral neurology of movement disorders. New York: Raven; 1995. p. 179-86.
    • (1995) Behavioral Neurology of Movement Disorders. , pp. 179-186
    • Cummings, J.L.1
  • 7
    • 70349635120 scopus 로고    scopus 로고
    • Apathy is not depression in Huntington's disease
    • This article highlights the prevalence of depression and apathy in HD, and points out that these are different phenomena in HD. The authors have used standardized measures for diagnosing apathy and depression
    • Naarding P, Janzing JG, Eling P, van der Werf S, Kremer B. Apathy is not depression in Huntington's disease. J Neuropsychiatry Clin Neurosci. 2009;21(3):266-70. This article highlights the prevalence of depression and apathy in HD, and points out that these are different phenomena in HD. The authors have used standardized measures for diagnosing apathy and depression.
    • (2009) J Neuropsychiatry Clin Neurosci. , vol.21 , Issue.3 , pp. 266-270
    • Naarding, P.1    Janzing, J.G.2    Eling, P.3    Van Der Werf, S.4    Kremer, B.5
  • 10
    • 0033880915 scopus 로고    scopus 로고
    • Apathy and withdrawal
    • Starkstein SE. Apathy and withdrawal. Int Psychogeriatr. 2000;12 SUPPL. 1:135-8.
    • (2000) Int Psychogeriatr. , vol.12 , Issue.1 SUPPL. , pp. 135-138
    • Starkstein, S.E.1
  • 12
    • 53149124795 scopus 로고    scopus 로고
    • The nosological position of apathy in clinical practice
    • In this article, the author describes diagnostic criteria for apathy, differential diagnosis, its relationship to cognitive disorders and depression, and the use of assessment scales
    • Starkstein SE, Leentjens AF. The nosological position of apathy in clinical practice. J Neurol Neurosurg Psychiatry. 2008;79(10):1088-92. In this article, the author describes diagnostic criteria for apathy, differential diagnosis, its relationship to cognitive disorders and depression, and the use of assessment scales.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , Issue.10 , pp. 1088-1092
    • Starkstein, S.E.1    Leentjens, A.F.2
  • 13
    • 33745595886 scopus 로고    scopus 로고
    • Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits
    • DOI 10.1093/cercor/bhj043
    • Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex. 2006;16(7):916-28. (Pubitemid 43992442)
    • (2006) Cerebral Cortex , vol.16 , Issue.7 , pp. 916-928
    • Levy, R.1    Dubois, B.2
  • 16
    • 33749861388 scopus 로고    scopus 로고
    • Effect of donepezil on motor and cognitive function in Huntington disease
    • DOI 10.1212/01.wnl.0000238106.10423.00, PII 0000611420061010000034
    • Cubo E, Shannon KM, Tracy D, Jaglin JA, Bernard BA, Wuu J, et al. Effect of donepezil on motor and cognitive function in Huntington disease. Neurology. 2006;67(7):1268-71. (Pubitemid 44563842)
    • (2006) Neurology , vol.67 , Issue.7 , pp. 1268-1271
    • Cubo, E.1    Shannon, K.M.2    Tracy, D.3    Jaglin, J.A.4    Bernard, B.A.5    Wuu, J.6    Leurgans, S.E.7
  • 17
    • 77951087900 scopus 로고    scopus 로고
    • EXPLORE investigators. Effects of rivastigmine on common symptomatology of Alzheimer's disease (EX-PLORE)
    • Gauthier S, Juby A, Dalziel W, Réhel B, Schecter R. EXPLORE investigators. Effects of rivastigmine on common symptomatology of Alzheimer's disease (EX-PLORE). CurrMed Res Opin. 2010;26(5):1149-60.
    • (2010) CurrMed Res Opin. , vol.26 , Issue.5 , pp. 1149-1160
    • Gauthier, S.1    Juby, A.2    Dalziel, W.3    Réhel, B.4    Schecter, R.5
  • 18
    • 0036834904 scopus 로고    scopus 로고
    • Rivastigmine in the treatment of Huntington's disease
    • Rot U, Kobal J, Sever A, Pirtosek Z, Mesec A. Rivastigmine in the treatment of Huntington's disease. Eur J Neurol. 2002;9(6):689-90.
    • (2002) Eur J Neurol. , vol.9 , Issue.6 , pp. 689-690
    • Rot, U.1    Kobal, J.2    Sever, A.3    Pirtosek, Z.4    Mesec, A.5
  • 19
    • 33846815309 scopus 로고    scopus 로고
    • Two years' follow-up of rivastigmine treatment in Huntington disease
    • DOI 10.1097/01.wnf.0000240945.44370.f0, PII 0000282620070100000007
    • deTommaso M, Difruscolo O, Sciruicchio V, Specchio N, Livrea P. Two years' follow-up of rivastigmine treatment in Huntington disease. Clin Neuropharmacol. 2007;30(1):43-6. (Pubitemid 46204317)
    • (2007) Clinical Neuropharmacology , vol.30 , Issue.1 , pp. 43-46
    • De Tommaso, M.1    Difruscolo, O.2    Sciruicchio, V.3    Specchio, N.4    Livrea, P.5
  • 20
    • 33750327234 scopus 로고    scopus 로고
    • A naturalistic study of galantamine for Alzheimer's disease
    • DOI 10.2165/00023210-200620110-00006
    • Brodaty H, Woodward M, Boundy K, Barnes N, Allen G, NATURE Investigators. A naturalistic study of galantamine for Alzheimer's disease. CNS Drugs. 2006;20(11):935-43. (Pubitemid 44612715)
    • (2006) CNS Drugs , vol.20 , Issue.11 , pp. 935-943
    • Brodaty, H.1    Woodward, M.2    Boundy, K.3    Barnes, N.4    Allen, G.5
  • 21
    • 51449084071 scopus 로고    scopus 로고
    • Methylphenidate for the treatment of apathy in Alzheimer disease: Prediction of response using dextroamphetamine challenge
    • Herrmann N, Rothenburg LS, Black SE, Ryan M, Liu BA, Busto UE, et al. Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. J Clin Psychopharmacol. 2008;28(3):296-301.
    • (2008) J Clin Psychopharmacol. , vol.28 , Issue.3 , pp. 296-301
    • Herrmann, N.1    Rothenburg, L.S.2    Black, S.E.3    Ryan, M.4    Liu, B.A.5    Busto, U.E.6
  • 22
    • 77949502907 scopus 로고    scopus 로고
    • Methylphenidate for apathy and functional status in dementia of the Alzheimer type
    • This is one of the very few trials open-label with apathy as a primary outcome measure. This study shows improvement in AES scores using methylphenidate over a 12-week period in Alzheimer's disease
    • Padala PR, Burke WJ, Shostrom VK, Bhatia SC, Wengel SP, Potter JF, et al. Methylphenidate for apathy and functional status in dementia of the Alzheimer type. Am J Geriatr Psychiatry. 2010;18(4):371-4. This is one of the very few trials (open-label) with apathy as a primary outcome measure. This study shows improvement in AES scores using methylphenidate over a 12-week period in Alzheimer's disease.
    • (2010) Am J Geriatr Psychiatry , vol.18 , Issue.4 , pp. 371-374
    • Padala, P.R.1    Burke, W.J.2    Shostrom, V.K.3    Bhatia, S.C.4    Wengel, S.P.5    Potter, J.F.6
  • 23
    • 67749089224 scopus 로고    scopus 로고
    • Apathy due to cerebrovascular accidents successfully treated with methylphenidate: A case series
    • Spiegel DR Kim J, Greene K, Conner C, Zamfir D. Apathy due to cerebrovascular accidents successfully treated with methylphenidate: a case series. J Neuropsychiatry Clin Neurosci. 2009;21(2):216-9.
    • (2009) J Neuropsychiatry Clin Neurosci. , vol.21 , Issue.2 , pp. 216-219
    • Spiegel, D.R.1    Kim, J.2    Greene, K.3    Conner, C.4    Zamfir, D.5
  • 24
    • 20444460226 scopus 로고    scopus 로고
    • Effects of methylphenidate on cognition and apathy in normal pressure hydrocephalus: A case study and review
    • DOI 10.1080/02688690500080893
    • Keenan S, Mavaddat N, Iddon J, Pickard JD, Sahakian BJ. Effects of methylphenidate on cognition and apathy in normal pressure hydrocephalus: a case study and review. Br J Neurosurg. 2005;19(1):46-50. (Pubitemid 40824373)
    • (2005) British Journal of Neurosurgery , vol.19 , Issue.1 , pp. 46-50
    • Keenan, S.1    Mavaddat, N.2    Iddon, J.3    Pickard, J.D.4    Sahakian, B.J.5
  • 26
    • 47349132531 scopus 로고    scopus 로고
    • Juvenile Huntington disease exacerbated by methylphenidate: Case report
    • DOI 10.1177/0883073808314152
    • Waugh JL, Miller VS, Chudnow RS, Dowling MM. Juvenile Huntington disease exacerbated by methylphenidate: case report. J Child Neurol. 2008;23(7):807-9. (Pubitemid 351998170)
    • (2008) Journal of Child Neurology , vol.23 , Issue.7 , pp. 807-809
    • Waugh, J.L.1    Miller, V.S.2    Chudnow, R.S.3    Dowling, M.M.4
  • 27
    • 61649118193 scopus 로고    scopus 로고
    • Atomoxetine for the treatment of executive dysfunction in Parkinson's disease: A pilot open-label study
    • Marsh L, Biglan K, Gerstenhaber M, Williams JR. Atomoxetine for the treatment of executive dysfunction in Parkinson's disease: a pilot open-label study. Mov Disord. 2009;24(2):277-82.
    • (2009) Mov Disord. , vol.24 , Issue.2 , pp. 277-282
    • Marsh, L.1    Biglan, K.2    Gerstenhaber, M.3    Williams, J.R.4
  • 30
    • 33847346003 scopus 로고    scopus 로고
    • Modafinil therapy for apathy in an elderly patient
    • DOI 10.1345/aph.1H302
    • Padala PR Burke WJ, Bhatia SC. Modafinil therapy for apathy in an elderly patient. Ann Pharmacother. 2007;41(2):346-9. (Pubitemid 46340067)
    • (2007) Annals of Pharmacotherapy , vol.41 , Issue.2 , pp. 346-349
    • Padala, P.R.1    Burke, W.J.2    Bhatia, S.C.3
  • 31
    • 0036412603 scopus 로고    scopus 로고
    • Motivation, reward, and Parkinson's disease: Influence of dopatherapy
    • DOI 10.1016/S0028-3932(02)00108-2, PII S0028393202001082
    • Czernecki V, Pillon B, Houeto JL, Pochon JB, Levy R, Dubois B. Motivation, reward, and Parkinson's disease: influence of dopatherapy. Neuropsychologia. 2002;40(13):2257-67. (Pubitemid 35303365)
    • (2002) Neuropsychologia , vol.40 , Issue.13 , pp. 2257-2267
    • Czernecki, V.1    Pillon, B.2    Houeto, J.L.3    Pochon, J.B.4    Levy, R.5    Dubois, B.6
  • 32
    • 13844314242 scopus 로고    scopus 로고
    • Selegiline in the management of apathy following traumatic brain injury
    • DOI 10.1080/02699050410001719989
    • Newburn G, Newburn D. Selegiline in the management of apathy following traumatic brain injury. Brain Inj. 2005;19(2):149-54. (Pubitemid 40259752)
    • (2005) Brain Injury , vol.19 , Issue.2 , pp. 149-154
    • Newburn, G.1    Newburn, D.2
  • 33
    • 70450241116 scopus 로고    scopus 로고
    • Severe apathy following head injury: Improvement with selegiline treatment
    • Moutaouakil F, El Otmani H, Fadel H, Slassi I. Severe apathy following head injury: improvement with selegiline treatment. Neurochirurgie. 2009;55(6):551-4.
    • (2009) Neurochirurgie , vol.55 , Issue.6 , pp. 551-554
    • Moutaouakil, F.1    El Otmani, H.2    Fadel, H.3    Slassi, I.4
  • 34
    • 0028955521 scopus 로고
    • N of 1 study: Amantadine for the amotivational syndrome in a patient with traumatic brain injury
    • Van Reekum R, Bayley M, Garner S, Burke IM, Fawcett S, Hart A, et al. N of 1 study: amantadine for the amotivational syndrome in a patient with traumatic brain injury. Brain Inj. 1995;9(1):49-53.
    • (1995) Brain Inj. , vol.9 , Issue.1 , pp. 49-53
    • Van Reekum, R.1    Bayley, M.2    Garner, S.3    Burke, I.M.4    Fawcett, S.5    Hart, A.6
  • 35
    • 20744442879 scopus 로고    scopus 로고
    • Effects of the dopaminergenic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: A study using positron emission tomography (PET)
    • DOI 10.1080/02699050400025059
    • Kraus MF, Smith GS, Butters M, Donnell AJ, Dixon E, Yilong C, et al. Effects of the dopaminergic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: a study using positron emission tomography (PET). Brain Inj. 2005;19(7):471-9. (Pubitemid 40852596)
    • (2005) Brain Injury , vol.19 , Issue.7 , pp. 471-479
    • Kraus, M.F.1    Smith, G.S.2    Butters, M.3    Donnell, A.J.4    Dixon, E.5    Yilong, C.6    Marion, D.7
  • 36
    • 0038375825 scopus 로고    scopus 로고
    • A randomized trial of amantadine in Huntington disease
    • DOI 10.1001/archneur.60.7.996
    • O'Suilleabhain P, Dewey Jr RB. A randomized trial of amantadine in Huntington disease. Arch Neurol. 2003;60:996-8. (Pubitemid 36858360)
    • (2003) Archives of Neurology , vol.60 , Issue.7 , pp. 996-998
    • O'Suilleabhain, P.1    Dewey Jr., R.B.2
  • 37
    • 0037056392 scopus 로고    scopus 로고
    • Huntington's disease: A randomized, controlled trial using the NMDA-antagonist amantadine
    • Verhagen Metman L, Morris MJ, Farmer C, Gillespie M, Mosby K, Wuu J, et al. Huntington's disease: a randomized, controlled trial using the NMDA-antagonist amantadine. Neurology. 2002;59(5):694-9.
    • (2002) Neurology , vol.59 , Issue.5 , pp. 694-699
    • Metman, L.V.1    Morris, M.J.2    Farmer, C.3    Gillespie, M.4    Mosby, K.5    Wuu, J.6
  • 38
    • 0037005408 scopus 로고    scopus 로고
    • Levodopa and bromocriptine in hypoxic brain injury
    • DOI 10.1007/s00415-002-0903-1
    • Debette S, Kozlowski O, Steinling M, Rousseaux M. Levodopa and bromocriptine in hypoxic brain injury. J Neurol. 2002;249(12):1678-82. (Pubitemid 36269260)
    • (2002) Journal of Neurology , vol.249 , Issue.12 , pp. 1678-1682
    • Debette, S.1    Kozlowski, O.2    Steinling, M.3    Rousseaux, M.4
  • 40
  • 42
    • 78649534298 scopus 로고    scopus 로고
    • Open, uncontrolled, nonrandomized, 9-month, off-label use of bupropion to treat fatigue in a single patient with multiple sclerosis
    • Siniscalchi A, Gallelli L, Tolotta GA, Loiacono D, De Sarro G. Open, uncontrolled, nonrandomized, 9-month, off-label use of bupropion to treat fatigue in a single patient with multiple sclerosis. Clin Ther. 2010;32(12):2030-4.
    • (2010) Clin Ther. , vol.32 , Issue.12 , pp. 2030-2034
    • Siniscalchi, A.1    Gallelli, L.2    Tolotta, G.A.3    Loiacono, D.4    De Sarro, G.5
  • 43
    • 0032809441 scopus 로고    scopus 로고
    • The effects of a psychomotor activation programme for use in groups of cognitively impaired people in homes for the elderly
    • DOI 10.1002/(SICI)1099-1166(199908)14:8<633::AID-GPS996>3.0.CO;2-W
    • Hopman-Rock M, Staats PG, Tak EC, Dröes RM. The effects of a psychomotor activation programme for use in groups of cognitively impaired people in homes for the elderly. Int J Geriatr Psychiatry. 1999;14(8):633-42. (Pubitemid 29403282)
    • (1999) International Journal of Geriatric Psychiatry , vol.14 , Issue.8 , pp. 633-642
    • Hopman-Rock, M.1    Staats, P.G.M.2    Tak, E.C.P.M.3    Droes, R.-M.4
  • 45
    • 41549119352 scopus 로고    scopus 로고
    • The effects of snoezelen (multi-sensory behavior therapy) and psychiatric care on agitation, apathy, and activities of daily living in dementia patients on a short term geriatric psychiatric inpatient unit
    • DOI 10.2190/PM.37.4.a
    • Staal JA, Sacks A, Matheis R, Collier L, Calia T, Hanif H, et al. The effects of Snoezelen (multi-sensory behavior therapy) and psychiatric care on agitation, apathy, and activities of daily living in dementia patients on a short term geriatric psychiatric inpatient unit. Int J Psychiatry Med. 2007;37(4):357-70. (Pubitemid 351468860)
    • (2007) International Journal of Psychiatry in Medicine , vol.37 , Issue.4 , pp. 357-370
    • Staal, J.A.1    Sacks, A.2    Matheis, R.3    Collier, L.4    Calia, T.5    Hanif, H.6    Kofman, E.S.7
  • 47
    • 78650137357 scopus 로고    scopus 로고
    • Cognitive stimulation therapy in the treatment of neuropsychiatric symptoms in Alzheimer's disease: A randomized controlled trial
    • This trial of cognitive stimulation therapy for mild to moderate dementia specifically addressed outcomes of neuropsychiatric symptoms and found that only apathy and depression showed improvement. This study highlights the need for more studies of psychosocial interventions for apathy
    • Niu YX, Tan JP, Guan JQ, Zhang ZQ, Wang LN. Cognitive stimulation therapy in the treatment of neuropsychiatric symptoms in Alzheimer's disease: a randomized controlled trial. Clin Rehabil. 2010;24(12):1102-11. This trial of cognitive stimulation therapy for mild to moderate dementia specifically addressed outcomes of neuropsychiatric symptoms and found that only apathy and depression showed improvement. This study highlights the need for more studies of psychosocial interventions for apathy.
    • (2010) Clin Rehabil. , vol.24 , Issue.12 , pp. 1102-1111
    • Niu, Y.X.1    Tan, J.P.2    Guan, J.Q.3    Zhang, Z.Q.4    Wang, L.N.5


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