Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity

Human molecular genetics

Volumn 23, Issue 23, 2014, Pages 6302-6317

  Sun, Xin ^a   Marque, Leonard O ^a   Cordner, Zachary ^a   Pruitt, Jennifer L ^a   Bhat, Manik ^a   Li, Pan P ^a   Kannan, Geetha ^a   Ladenheim, Ellen E ^a   Moran, Timothy H ^a   Margolis, Russell L ^a   Rudnicki, Dobrila D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; HTT PROTEIN, HUMAN; MESSENGER RNA; MORPHOLINO OLIGONUCLEOTIDE; NERVE PROTEIN;

ANIMAL; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION; GENE TARGETING; GENETICS; HUMAN; HUNTINGTON CHOREA; METABOLISM; MOUSE; MUTATION; NERVE CELL; NUCLEOTIDE SEQUENCE; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION; GENE KNOCK-IN TECHNIQUES; HUMANS; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; MORPHOLINOS; MUTATION; NERVE TISSUE PROTEINS; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84937251574     PISSN: None     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu349     Document Type: Article

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