BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage

Oxidative Medicine and Cellular Longevity

Volumn 2017, Issue , 2017, Pages

  Qin, Li Xia ^a   Tan, Jie Qiong ^b   Zhang, Hai Nan ^a   Rizwana, Kousar ^c   Lu, Jia Hong ^d   Tang, Jian Guang ^a   Jiang, Bo ^a   Shen, Xiang Min ^a   Guo, Ji Feng ^b,e   Tang, Bei Sha ^b,e   Tan, Li Ming ^a   Wang, Chun Yu ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c ALLAMA IQBAL OPEN UNIVERSITY   (Pakistan)

^d University of Macau   (Macao)

^e CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; MAMMALS;

CO-IMMUNOPRECIPITATIONS; FUNCTIONAL INTERACTION; IMMUNOFLUORESCENCE METHODS; MITOCHONDRIAL DAMAGE; MULTIFUNCTIONAL PROTEIN; NEUROPROTECTIVE EFFECTS; PARKINSON'S DISEASE; STRESS CONDITION;

GENE ENCODING;

BCL 2 ASSOCIATED ATHANOGENE 5; CARRIER PROTEINS AND BINDING PROTEINS; COMPLEMENTARY DNA; CYCLOHEXIMIDE; LIPOCORTIN 5; PROTEIN DEGLYCASE DJ-1; ROTENONE; UNCLASSIFIED DRUG; BAG5 PROTEIN, HUMAN; HEAT SHOCK PROTEIN 70; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOPLASM; DIMERIZATION; FLOW CYTOMETRY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR CLONING; NEUROPROTECTION; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; RNA INTERFERENCE;

DISEASES; GENETIC ENGINEERING; STRESSES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PROTEIN DEGLYCASE DJ-1; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; ROTENONE;

EID: 85015737491     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2017/5094934     Document Type: Article

References (44)

1. T. M. Dawson and V. L. Dawson, "Molecular pathways of neurodegeneration in Parkinson's disease," Science, vol. 302, no. 5646, pp. 819-822, 2003.
2. A. J. Lees, J. Hardy, and T. Revesz, "Parkinson's disease," The Lancet, vol. 373, no. 9680, pp. 2055-2066, 2009.
3. M. H. Polymeropoulos, C. Lavedan, E. Leroy et al., "Mutation in the -synuclein gene identified in families with Parkinson's disease," Science, vol. 276, no. 5321, pp. 2045-2047, 1997.
4. M.-C. Chartier-Harlin, J. Kachergus, C. Roumier et al., "-synuclein locus duplication as a cause of familial Parkinson's disease," Lancet, vol. 364, no. 9440, pp. 1167-1169, 2004.
5. T. Kitada, S. Asakawa,N.Hattori et al., "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism," Nature, vol. 392, no. 6676, pp. 605-608, 1998.
6. E. M. Valente, P. M. Abou-Sleiman, V. Caputo et al., "Hereditary early-onset Parkinson's disease caused by mutations in PINK1," Science, vol. 304, no. 5674, pp. 1158-1160, 2004.
7. V. Bonifati, P. Rizzu, M. J. Van Baren et al., "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism," Science, vol. 299, no. 5604, pp. 256-259, 2003.
8. P. M. Abou-Sleiman, D. G. Healy, N. Quinn, A. J. Lees, and N. W.Wood, "The role of pathogenicDJ-1mutations in Parkinson's disease," Annals of Neurology, vol. 54, no. 3, pp. 283-286, 2003.
9. W. Yang, L. Chen, Y. Ding, X. Zhuang, and U. J. Kang, "Paraquat induces dopaminergic dysfunction and proteasome impairment inDJ-1-deficient mice," HumanMolecular Genetics, vol. 16, no. 23, pp. 2900-2910, 2007.
10. M. P. Van Der Brug, J. Blackinton, J. Chandran et al., "RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement inmultiple cellular pathways," Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 29, pp. 10244-10249, 2008.
11. H. Aleyasin, M. W. C. Rousseaux, P. C. Marcogliese et al., "DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway," Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 7, pp. 3186-3191, 2010.
12. H. Ariga, K. Takahashi-Niki, I. Kato, H. Maita, T. Niki, and S. M. M. Iguchi-Ariga, "Neuroprotective function of dj-1 in Parkinson's disease," OxidativeMedicine and Cellular Longevity, vol. 2013, Article ID 683920, 9 pages, 2013.
13. D. J.Moore, L. Zhang, J. Troncoso et al., "AssociationofDJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress," HumanMolecular Genetics, vol. 14, no. 1, pp. 71-84, 2005.
14. B. Tang, H. Xiong, P. Sun et al., "Association of PINK1 andDJ-1 confers digenic inheritance of early-onset Parkinson's disease," Human Molecular Genetics, vol. 15, no. 11, pp. 1816-1825, 2006.
15. S. K. Kalia, S. Lee, P. D. Smith et al., "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration," Neuron, vol. 44, no. 6, pp. 931-945, 2004.
16. E. Elliott, O. Laufer, and I. Ginzburg, "BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins," Journal of Neurochemistry, vol. 109, no. 4, pp. 1168-1178, 2009.
17. S. Takayama and J.C. Reed, "Molecular chaperone targeting and regulation by BAG family proteins," Nature Cell Biology, vol. 3, no. 10, pp. E237-E241, 2001.
18. J. Song,M. Takeda, andR. I.Morimoto, "Bag1-Hsp70mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth," Nature Cell Biology, vol. 3, no. 3, pp. 276-282, 2001.
19. M. Kabbage and M. B. Dickman, "The BAG proteins: A ubiquitous family of chaperone regulators," Cellular andMolecular Life Sciences, vol. 65, no. 9, pp. 1390-1402, 2008.
20. A. Arakawa, N. Handa, N. Ohsawa et al., "The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain forADP-ATP exchange," Structure, vol. 18, no. 3, pp. 309-319, 2010.
21. X.Wang, J. Guo, E. Fei et al., "BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation," PLOS ONE, vol. 9, Article IDe86276, 2014.
22. Z. Zhang, H. Hartmann, V. M. Do et al., "Destabilization of -catenin by mutations in presenilin-1 potentiates neuronal apoptosis," Nature, vol. 395, no. 6703, pp. 698-702, 1998.
23. X.-Q. Che, B.-S. Tang, H.-F.Wang et al., "The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q," International Journal of Neuroscience, vol. 125, no. 5, pp. 390-394, 2015.
24. P. K. Smith, R. I. Krohn, G. T. Hermanson et al., "Measurement of protein using bicinchoninic acid," Analytical Biochemistry, vol. 150, no. 1, pp. 76-85, 1985.
25. V. Zinchuk, O. Zinchuk, and T. Okada, "Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: pushing pixels to explore biological phenomena," Acta Histochemica et Cytochemica, vol. 40, no. 4, pp. 101-111, 2007.
26. X.-L. Yuan, J.-F. Guo, Z.-H. Shi et al., "R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress," Brain Research, vol. 1351, pp. 229-237, 2010.
27. Y.-F. Zhou, S.-S. Liao, Y.-Y. Luo et al., "SUMO-1 modification on K166 of PolyQ-expanded aTaxin-3 strengthens its stability and increases its cytotoxicity," PLoS ONE, vol. 8, no. 1, Article ID e54214, 2013.
28. E. Junn,W. H. Jang, X. Zhao, B. S. Jeong, and M. M.Mouradian, "Mitochondrial localization of DJ-1 leads to enhanced neuroprotection," Journal of Neuroscience Research, vol. 87, no. 1, pp. 123-129, 2009.
29. S. J. Mullett, R. Di Maio, J. T. Greenamyre, and D. A. Hinkle, "DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stress," Journal of Molecular Neuroscience, vol. 49, no. 3, pp. 507-511, 2013.
30. S. K. Kalia, L. V. Kalia, and P. J.McLean, "Molecular chaperones as rational drug targets for parkinson's disease therapeutics," CNS & Neurological Disorders-Drug Targets, vol. 9, no. 6, pp. 741-753, 2010.
31. P. Kermer, A. Köhn, M. Schnieder et al., "BAG1 is neuroprotective in in vivo and in vitro models of Parkinson's disease," Journal of Molecular Neuroscience, vol. 55, no. 3, pp. 587-595, 2015.
32. Z. Song, S. Xu, B. Song, andQ. Zhang, "Bcl-2-associatedathanogene 2 prevents the neurotoxicity ofMPP+ via interaction with DJ-1," Journal of Molecular Neuroscience, vol. 55, no. 3, pp. 798-802, 2015.
33. K. Görner, E. Holtorf, S. Odoy et al., "Differential effects of Parkinson's Disease-associated mutations on stability and folding of DJ-1," Journal of Biological Chemistry, vol. 279, no. 8, pp. 6943-6951, 2004.
34. K. Honbou, N. N. Suzuki, M. Horiuchi et al., "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease," Journal of Biological Chemistry, vol. 278, no. 33, pp. 31380-31384, 2003.
35. M. A.Wilson, J. L. Collins, Y. Hod, D. Ringe, and G. A. Petsko, "The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease," Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 16, pp. 9256-9261, 2003.
36. S. Deeg, M. Gralle, K. Sroka, M. Bähr, F. S. Wouters, and P. Kermer, "BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity," Journal of Cell Biology, vol. 188, no. 4, pp. 505-513, 2010.
37. H. M. Li, T. Niki, T. Taira, S. M. M. Iguchi-Ariga, and H. Ariga, "Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress," Free Radical Research, vol. 39, no. 10, pp. 1091-1099, 2005.
38. T. Hayashi, C. Ishimori, K. Takahashi-Niki et al., "DJ-1 binds to mitochondrial complex I andmaintains its activity," Biochemical and Biophysical Research Communications, vol. 390, no. 3, pp. 667-672, 2009.
39. S. Tada-Oikawa, Y. Hiraku, M. Kawanishi, and S. Kawanishi, "Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis," Life Sciences, vol. 73, no. 25, pp. 3277-3288, 2003.
40. T. Tatsuta and T. Langer, "Quality control ofmitochondria: protection against neurodegeneration and ageing," EMBO Journal, vol. 27, no. 2, pp. 306-314, 2008.
41. I. Kim, S. Rodriguez-Enriquez, and J. J. Lemasters, "Selective degradation of mitochondria by mitophagy," Archives of Biochemistry and Biophysics, vol. 462, no. 2, pp. 245-253, 2007.
42. A. M. Tolkovsky, "Mitophagy," Biochimica et Biophysica Acta- Molecular Cell Research, vol. 1793, no. 9, pp. 1508-1515, 2009.
43. F. Gao, D. Chen, J. Si et al., "The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway," Human Molecular Genetics, vol. 24, no. 9, pp. 2528-2538, 2015.
44. H. Deng, M.W. Dodson, H. Huang, and M. Guo, "The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila," Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 38, pp. 14503-14508, 2008.