Molecular chaperone targeting and regulation by BAG family proteins

Nature Cell Biology

Volumn 3, Issue 10, 2001, Pages

  Takayama, S ^a   Reed, J C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BAG; UNCLASSIFIED DRUG;

CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL MIGRATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; LABORATORY TEST; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN PROCESSING; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 0034790768     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1001-e237     Document Type: Review

References (53)

1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators
2. BAG-1 modulates the chaperone activity of Hsp70/Hsc70
3. Mammalian protein RAP46: An interaction partner and modulator of 70 kDa heat shock proteins
4. The ubiquitin-related bag-1 provides a link between the molecular chaperones hsc70/hsp70 and the proteasome
5. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines
6. A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity
7. Function of WW domains as phosphoserine- or phosphothreonine-binding modules
8. Folding of newly translated proteins in vivo: The role of molecular chaperones
9. Molecular chaperone interactions with steroid receptors: An update
10. Stress management - Heat shock protein-70 and the regulation of apoptosis
11. Cloning and functional analysis of BAG-1: A novel Bcl-2 binding protein with anti-cell death activity
12. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1
13. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-21/ERK and cell growth
14. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: Suppression by BAG-1
15. Siah-1, SIP, and Ebi collaborate in a novel pathway for ?-catenin degradation linked to p53 responses
16. Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2
17. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death
18. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation
19. Human BAG-1 / RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells
20. The hsp70-associating protein Hap46 binds to DNA and stimulates transcription
21. Transcriptional activation by the human Hsp70-associating protein Hap50
22. A protein that interacts with members of the nuclear hormone receptor family: Identification and cDNA cloning
23. BAG-1L protein enhances androgen receptor function
24. Structure-function analysis of Bag1 proteins: Effects on androgen receptor transcriptional activity
25. BAG1L enhances trans-activation function of the vitamin D receptor
26. RAP46 is a negative regulator of glucocorticoid receptor action and hormone induced apoptosis
27. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
28. High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers
29. BAG-1: A novel biomaker predicting long term survival in early-stage breast cancer
30. Expression of BAG-1 in invasive breast carcinomas
31. Nuclear BAG-1 localization and the risk of recurrence after radiation therapy in laryngeal carcinoma
32. CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-? and hsp70/hsc70
33. Bis, a bcl-2 binding protein that synergizes with bcl-2 in preventing cell death
34. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
35. Apoptosis: Silencing the death receptors
36. Enhanced expression of Silencer of Death Domains (SODD/BAG-4) in pancreatic cancer
37. Scythe: A novel reaper-binding apoptotic regulator
38. Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper
39. GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1
40. Bag-1, a negative regulator of HSP70 chaperone activity, uncouples nucleotide hydrolysis from substrate release
41. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70
42. Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration dependent as positive and negative cofactor
43. Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones
44. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange
45. Chaperones get in touch: The hip-hop connection
46. Molecular chaperones and the art of recognizing a lost cause
47. Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK
48. Structure of a Bag/Hsc70 complex: Convergent functional evolution of Hsp70 nucleotide exchange factors
49. Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein
50. A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE
51. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
52. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A
53. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis