메뉴 건너뛰기




Volumn 141, Issue 2, 2017, Pages 195-207

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

Author keywords

cellular energetics; glycolysis; hippocampus; ketone bodies; mitochondria

Indexed keywords

1,3 BUTANEDIOL; 3 HYDROXYBUTYRIC ACID; 4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; AMINO ACID; ASPARTIC ACID; ESTER DERIVATIVE; GLUCOSE; GLUTAMIC ACID; KETONE ESTER; LIPID; N ACETYLASPARTIC ACID; PERCHLORIC ACID; UNCLASSIFIED DRUG; BUTANE; HYDROXYBUTYRIC ACID; KETONE BODY;

EID: 85015368086     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13958     Document Type: Article
Times cited : (82)

References (43)
  • 1
    • 61949363966 scopus 로고    scopus 로고
    • Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor
    • Andrews M. T., Russeth K. P., Drewes L. R. and Henry P. G. (2009) Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R383–R393.
    • (2009) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.296 , pp. R383-R393
    • Andrews, M.T.1    Russeth, K.P.2    Drewes, L.R.3    Henry, P.G.4
  • 2
    • 84875226541 scopus 로고    scopus 로고
    • A ketogenic diet improves motor performance but does not affect beta-amyloid levels in a mouse model of Alzheimer's disease
    • Beckett T. L., Studzinski C. M., Keller J. N., Paul Murphy M. and Niedowicz D. M. (2013) A ketogenic diet improves motor performance but does not affect beta-amyloid levels in a mouse model of Alzheimer's disease. Brain Res. 1505, 61–67.
    • (2013) Brain Res. , vol.1505 , pp. 61-67
    • Beckett, T.L.1    Studzinski, C.M.2    Keller, J.N.3    Paul Murphy, M.4    Niedowicz, D.M.5
  • 3
    • 78650151883 scopus 로고    scopus 로고
    • 2+ on ATP linked enzymes and the calculation of Gibbs free energy of ATP hydrolysis
    • 2+ on ATP linked enzymes and the calculation of Gibbs free energy of ATP hydrolysis. J. Phys. Chem. B 114, 16137–16146.
    • (2010) J. Phys. Chem. B , vol.114 , pp. 16137-16146
    • Bergman, C.1    Kashiwaya, Y.2    Veech, R.L.3
  • 4
    • 0034722108 scopus 로고    scopus 로고
    • Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
    • Bretillon L., Siden A., Wahlund L. O. et al. (2000) Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. Neurosci. Lett. 293, 87–90.
    • (2000) Neurosci. Lett. , vol.293 , pp. 87-90
    • Bretillon, L.1    Siden, A.2    Wahlund, L.O.3
  • 5
    • 84884177253 scopus 로고    scopus 로고
    • Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology
    • Brownlow M. L., Benner L., D'Agostino D., Gordon M. N. and Morgan D. (2013) Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PLoS ONE 8, e75713.
    • (2013) PLoS ONE , vol.8
    • Brownlow, M.L.1    Benner, L.2    D'Agostino, D.3    Gordon, M.N.4    Morgan, D.5
  • 6
    • 84949256198 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology
    • Burlot M. A., Braudeau J., Michaelsen-Preusse K. et al. (2015) Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. Hum. Mol. Genet. 24, 5965–5976.
    • (2015) Hum. Mol. Genet. , vol.24 , pp. 5965-5976
    • Burlot, M.A.1    Braudeau, J.2    Michaelsen-Preusse, K.3
  • 7
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B., Sies H. and Boveris A. (1979) Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59, 527–605.
    • (1979) Physiol. Rev. , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 8
    • 84862236426 scopus 로고    scopus 로고
    • Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects
    • Clarke K., Tchabanenko K., Pawlosky R. et al. (2012) Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul. Toxicol. Pharmacol. 63, 401–408.
    • (2012) Regul. Toxicol. Pharmacol. , vol.63 , pp. 401-408
    • Clarke, K.1    Tchabanenko, K.2    Pawlosky, R.3
  • 9
    • 78649962844 scopus 로고    scopus 로고
    • Brain fuel metabolism, aging, and Alzheimer's disease
    • Cunnane S., Nugent S., Roy M. et al. (2011) Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition 27, 3–20.
    • (2011) Nutrition , vol.27 , pp. 3-20
    • Cunnane, S.1    Nugent, S.2    Roy, M.3
  • 10
    • 84893200583 scopus 로고    scopus 로고
    • Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention
    • Ding F., Yao J., Rettberg J. R., Chen S. and Brinton R. D. (2013a) Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. PLoS ONE 8, e79977.
    • (2013) PLoS ONE , vol.8
    • Ding, F.1    Yao, J.2    Rettberg, J.R.3    Chen, S.4    Brinton, R.D.5
  • 11
    • 84875423210 scopus 로고    scopus 로고
    • Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's
    • Ding F., Yao J., Zhao L., Mao Z., Chen S. and Brinton R. D. (2013b) Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. PLoS ONE 8, e59825.
    • (2013) PLoS ONE , vol.8
    • Ding, F.1    Yao, J.2    Zhao, L.3    Mao, Z.4    Chen, S.5    Brinton, R.D.6
  • 12
    • 0019783428 scopus 로고
    • Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography
    • Frackowiak R. S., Pozzilli C., Legg N. J., Du Boulay G. H., Marshall J., Lenzi G. L. and Jones T. (1981) Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain 104, 753–778.
    • (1981) Brain , vol.104 , pp. 753-778
    • Frackowiak, R.S.1    Pozzilli, C.2    Legg, N.J.3    Du Boulay, G.H.4    Marshall, J.5    Lenzi, G.L.6    Jones, T.7
  • 13
    • 84860170321 scopus 로고    scopus 로고
    • A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons
    • Ghosh D., LeVault K. R., Barnett A. J. and Brewer G. J. (2012) A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J. Neurosci. 32, 5821–5832.
    • (2012) J. Neurosci. , vol.32 , pp. 5821-5832
    • Ghosh, D.1    LeVault, K.R.2    Barnett, A.J.3    Brewer, G.J.4
  • 14
    • 84905008400 scopus 로고    scopus 로고
    • Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons
    • Ghosh D., Levault K. R. and Brewer G. J. (2014) Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell 13, 631–640.
    • (2014) Aging Cell , vol.13 , pp. 631-640
    • Ghosh, D.1    Levault, K.R.2    Brewer, G.J.3
  • 15
    • 0015898203 scopus 로고
    • Equilibrium constants of the malate dehydrogenase, citrate synthase, citrate lyase, and acetyl coenzyme A hydrolysis reactions under physiological conditions
    • Guynn R. W., Gelberg H. J. and Veech R. L. (1973) Equilibrium constants of the malate dehydrogenase, citrate synthase, citrate lyase, and acetyl coenzyme A hydrolysis reactions under physiological conditions. J. Biol. Chem. 248, 6957–6965.
    • (1973) J. Biol. Chem. , vol.248 , pp. 6957-6965
    • Guynn, R.W.1    Gelberg, H.J.2    Veech, R.L.3
  • 16
    • 84905822105 scopus 로고    scopus 로고
    • GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
    • Jo S., Yarishkin O., Hwang Y. J. et al. (2014) GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease. Nat. Med. 20, 886–896.
    • (2014) Nat. Med. , vol.20 , pp. 886-896
    • Jo, S.1    Yarishkin, O.2    Hwang, Y.J.3
  • 17
    • 78751566697 scopus 로고    scopus 로고
    • Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
    • Kapogiannis D. and Mattson M. P. (2011) Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol. 10, 187–198.
    • (2011) Lancet Neurol. , vol.10 , pp. 187-198
    • Kapogiannis, D.1    Mattson, M.P.2
  • 18
    • 77956201747 scopus 로고    scopus 로고
    • A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat
    • Kashiwaya Y., Pawlosky R., Markis W., King M. T., Bergman C., Srivastava S., Murray A., Clarke K. and Veech R. L. (2010) A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat. J. Biol. Chem. 285, 25950–25956.
    • (2010) J. Biol. Chem. , vol.285 , pp. 25950-25956
    • Kashiwaya, Y.1    Pawlosky, R.2    Markis, W.3    King, M.T.4    Bergman, C.5    Srivastava, S.6    Murray, A.7    Clarke, K.8    Veech, R.L.9
  • 19
    • 84875253158 scopus 로고    scopus 로고
    • A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
    • Kashiwaya Y., Bergman C., Lee J. H. et al. (2013) A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol. Aging 34, 1530–1539.
    • (2013) Neurobiol. Aging , vol.34 , pp. 1530-1539
    • Kashiwaya, Y.1    Bergman, C.2    Lee, J.H.3
  • 20
    • 84871920555 scopus 로고    scopus 로고
    • Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms
    • Kemper M. F., Zhao Y. Z., Duckles S. P. and Krause D. N. (2013) Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms. J. Cereb. Blood Flow Metab. 33, 122–128.
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 122-128
    • Kemper, M.F.1    Zhao, Y.Z.2    Duckles, S.P.3    Krause, D.N.4
  • 21
    • 84948172262 scopus 로고    scopus 로고
    • An ester of beta-hydroxybutyrate regulates cholesterol biosynthesis in rats and a cholesterol biomarker in humans
    • Kemper M. F., Srivastava S., Todd King M., Clarke K., Veech R. L. and Pawlosky R. J. (2015) An ester of beta-hydroxybutyrate regulates cholesterol biosynthesis in rats and a cholesterol biomarker in humans. Lipids 50, 1185–1193.
    • (2015) Lipids , vol.50 , pp. 1185-1193
    • Kemper, M.F.1    Srivastava, S.2    Todd King, M.3    Clarke, K.4    Veech, R.L.5    Pawlosky, R.J.6
  • 23
    • 79952106055 scopus 로고    scopus 로고
    • Differential regulation of BACE1 expression by oxidative and nitrosative signals
    • Kwak Y. D., Wang R., Li J. J., Zhang Y. W., Xu H. and Liao F. F. (2011) Differential regulation of BACE1 expression by oxidative and nitrosative signals. Mol. Neurodegener. 6, 17.
    • (2011) Mol. Neurodegener. , vol.6 , pp. 17
    • Kwak, Y.D.1    Wang, R.2    Li, J.J.3    Zhang, Y.W.4    Xu, H.5    Liao, F.F.6
  • 24
    • 0020758778 scopus 로고
    • Positron emission tomographic studies of aging and Alzheimer disease
    • de Leon M. J., Ferris S. H., George A. E. et al. (1983) Positron emission tomographic studies of aging and Alzheimer disease. AJNR Am. J. Neuroradiol. 4, 568–571.
    • (1983) AJNR Am. J. Neuroradiol. , vol.4 , pp. 568-571
    • de Leon, M.J.1    Ferris, S.H.2    George, A.E.3
  • 25
    • 0014350080 scopus 로고
    • The equilibrium constant of the isocitrate dehydrogenase reaction
    • Londesborough J. C. and Dalziel K. (1968) The equilibrium constant of the isocitrate dehydrogenase reaction. Biochem. J. 110, 217–222.
    • (1968) Biochem. J. , vol.110 , pp. 217-222
    • Londesborough, J.C.1    Dalziel, K.2
  • 26
    • 41449103942 scopus 로고    scopus 로고
    • Hippocampal n-acetylaspartate concentration and response to Riluzole in generalized anxiety disorder
    • Mathew S. J., Price R. B., Mao X., Smith E. L. P., Coplan J. D., Charney D. S. and Shungu D. C. (2008) Hippocampal n-acetylaspartate concentration and response to Riluzole in generalized anxiety disorder. Biol. Psychiatry 63, 891–898.
    • (2008) Biol. Psychiatry , vol.63 , pp. 891-898
    • Mathew, S.J.1    Price, R.B.2    Mao, X.3    Smith, E.L.P.4    Coplan, J.D.5    Charney, D.S.6    Shungu, D.C.7
  • 27
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson M. P. (2004) Pathways towards and away from Alzheimer's disease. Nature 430, 631–639.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 28
    • 84928238678 scopus 로고    scopus 로고
    • The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer
    • Meidenbauer J. J., Mukherjee P. and Seyfried T. N. (2015) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr. Metab. 12, 12.
    • (2015) Nutr. Metab. , vol.12 , pp. 12
    • Meidenbauer, J.J.1    Mukherjee, P.2    Seyfried, T.N.3
  • 29
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    • Mosconi L., Pupi A. and De Leon M. J. (2008) Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann. N. Y. Acad. Sci. 1147, 180–195.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    De Leon, M.J.3
  • 30
    • 85002322997 scopus 로고    scopus 로고
    • Novel ketone diet enhances physical and cognitive performance
    • Murray A. J., Knight N. S., Cole M. A. et al. (2016) Novel ketone diet enhances physical and cognitive performance. FASEB J. 12, 4021–4032.
    • (2016) FASEB J. , vol.12 , pp. 4021-4032
    • Murray, A.J.1    Knight, N.S.2    Cole, M.A.3
  • 31
    • 84922709891 scopus 로고    scopus 로고
    • A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease
    • Newport M. T., VanItallie T. B., Kashiwaya Y., King M. T. and Veech R. L. (2015) A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease. Alzheimers Dement. 11, 99–103.
    • (2015) Alzheimers Dement. , vol.11 , pp. 99-103
    • Newport, M.T.1    VanItallie, T.B.2    Kashiwaya, Y.3    King, M.T.4    Veech, R.L.5
  • 33
    • 37549064016 scopus 로고    scopus 로고
    • Cerebral metabolic adaptation and ketone metabolism after brain injury
    • Prins M. L. (2008) Cerebral metabolic adaptation and ketone metabolism after brain injury. J. Cereb. Blood Flow Metab. 28, 1–16.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 1-16
    • Prins, M.L.1
  • 35
    • 84868657591 scopus 로고    scopus 로고
    • Microwave irradiation decreases ATP, increases free [Mg(2)(+)], and alters in vivo intracellular reactions in rat brain
    • Srivastava S., Kashiwaya Y., Chen X., Geiger J. D., Pawlosky R. and Veech R. L. (2012a) Microwave irradiation decreases ATP, increases free [Mg(2)(+)], and alters in vivo intracellular reactions in rat brain. J. Neurochem. 123, 668–675.
    • (2012) J. Neurochem. , vol.123 , pp. 668-675
    • Srivastava, S.1    Kashiwaya, Y.2    Chen, X.3    Geiger, J.D.4    Pawlosky, R.5    Veech, R.L.6
  • 36
    • 84861764348 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet
    • Srivastava S., Kashiwaya Y., King M. T., Baxa U., Tam J., Niu G., Chen X., Clarke K. and Veech R. L. (2012b) Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. FASEB J. 26, 2351–2362.
    • (2012) FASEB J. , vol.26 , pp. 2351-2362
    • Srivastava, S.1    Kashiwaya, Y.2    King, M.T.3    Baxa, U.4    Tam, J.5    Niu, G.6    Chen, X.7    Clarke, K.8    Veech, R.L.9
  • 37
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech R. L. (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fatty Acids 70, 309–319.
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 38
    • 85016713176 scopus 로고    scopus 로고
    • Alzheimer's Disease Causes and Treatment
    • in, Masino S., ed.), Oxford University Press, USA
    • Veech R. L. and King M. T. (2016) Alzheimer's Disease Causes and Treatment, in Ketogenic Diet and Metabolic therapies (Masino S., ed.), pp. 241–253. Oxford University Press, USA.
    • (2016) Ketogenic Diet and Metabolic therapies , pp. 241-253
    • Veech, R.L.1    King, M.T.2
  • 39
    • 0014621744 scopus 로고
    • The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
    • Veech R. L., Eggleston L. V. and Krebs H. A. (1969) The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem. J. 115, 609–619.
    • (1969) Biochem. J. , vol.115 , pp. 609-619
    • Veech, R.L.1    Eggleston, L.V.2    Krebs, H.A.3
  • 41
    • 0014082605 scopus 로고
    • The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
    • Williamson D. H., Lund P. and Krebs H. A. (1967) The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem. J. 103, 514–527.
    • (1967) Biochem. J. , vol.103 , pp. 514-527
    • Williamson, D.H.1    Lund, P.2    Krebs, H.A.3
  • 42
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao J., Irwin R. W., Zhao L., Nilsen J., Hamilton R. T. and Brinton R. D. (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 106, 14670–14675.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 43
    • 79959802475 scopus 로고    scopus 로고
    • 2-Deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease
    • Yao J., Chen S., Mao Z., Cadenas E. and Brinton R. D. (2011) 2-Deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS ONE 6, e21788.
    • (2011) PLoS ONE , vol.6
    • Yao, J.1    Chen, S.2    Mao, Z.3    Cadenas, E.4    Brinton, R.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.