Activation-Associated accelerated apoptosis of memory B cells in critically III patients with sepsis

Critical Care Medicine

Volumn 45, Issue 5, 2017, Pages 875-882

  Shankar Hari, Manu ^a,b   Fear, David ^a,c   Lavender, Paul ^a,c   Mare, Tracey ^b   Beale, Richard ^a,b   Swanson, Chad ^a   Singer, Mervyn ^d   Spencer, Jo ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; B cells; Immune memory; Immunosuppression; Sepsis

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; LIPOCORTIN 5;

ADULT; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HOSPITAL ADMISSION; HOSPITAL MORTALITY; HUMAN; HUMORAL IMMUNE DEFICIENCY; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; MIDDLE AGED; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPSIS; AGED; B LYMPHOCYTE; B LYMPHOCYTE SUBPOPULATION; BLOOD; CRITICAL ILLNESS; IMMUNOLOGY; INTENSIVE CARE UNIT; LYMPHOPENIA; METABOLISM; PHYSIOLOGY; TISSUE MICROARRAY; UNIVERSITY HOSPITAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANNEXIN A5; APOPTOSIS; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CRITICAL ILLNESS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION; HOSPITALS, UNIVERSITY; HUMANS; INTENSIVE CARE UNITS; LYMPHOPENIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RNA, MESSENGER; SEPSIS; TISSUE ARRAY ANALYSIS;

EID: 85015240972     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000002380     Document Type: Article

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