CXCL12/SDF-1 and Hematopoiesis

Encyclopedia of Cell Biology

Volumn 3, Issue , 2016, Pages 624-631

  Capitano, M L ^a   Broxmeyer, H E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

B cells; Bone marrow niche; Chemokines; CXCL12; Hematopoietic progenitor cells; Hematopoietic stem cell; Homing; Migration; Neutrophils; Retention

Indexed keywords

EID: 85014893464     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-394447-4.30080-3     Document Type: Chapter

References (91)

1. Aggarwal S., Ghilardi N., Xie M.H., de Sauvage F.J., Gurney A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. Journal of Biological Chemistry 2003, 278:1910-1914.
2. Alvarez P., Carrillo E., Velez C., et al. Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing. BioMed Research International 2013, 2013:312656.
3. Bacon K., Baggiolini M., Broxmeyer H., et al. Chemokine/chemokine receptor nomenclature. Journal of Interferon & Cytokine Research 2002, 22:1067-1068.
4. Baggiolini M., Dewald B., Moser B. Human chemokines: An update. Annual Review of Immunology 1997, 15:675-705.
5. Bonig H., Wundes A., Chang K.H., Lucas S., Papayannopoulou T. Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab. Blood 2008, 111:3439-3441.
6. Broxmeyer H., Van Zant G., Zucali J.R., LoBue J., Gordon A.S. Mechanisms of leukocyte production and release. XII. A comparative assay of the leukocytosis-inducing factor (LIF) and the colony-stimulating factor (CSF). Proceedings of the Society for Experimental Biology and Medicine 1974, 145:1262-1267.
7. Broxmeyer H.E. Regulation of hematopoiesis by chemokine family members. International Journal of Hematology 2001, 74:9-17.
8. Broxmeyer H.E. Chemokines in hematopoiesis. Current Opinion in Hematology 2008, 15:49-58.
9. Broxmeyer H.E., Kohli L., Kim C.H., et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. Journal of Leukocyte Biology 2003, 73:630-638.
10. Broxmeyer H.E., Orschell C.M., Clapp D.W., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. Journal of Experimental Medicine 2005, 201:1307-1318.
11. Burdon P.C., Martin C., Rankin S.M. The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Blood 2005, 105:2543-2548.
12. Burdon P.C., Martin C., Rankin S.M. Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR+CXC chemokines. British Journal of Haematology 2008, 142:100-108.
13. Cai X.Y., Gommoll C.P., Justice L., Narula S.K., Fine J.S. Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17. Immunology Letters 1998, 62:51-58.
14. Chow A., Lucas D., Hidalgo A., et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. Journal of Experimental Medicine 2011, 208:261-271.
15. Christopher M.J., Link D.C. Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. Journal of Bone and Mineral Research 2008, 23:1765-1774.
16. Christopher M.J., Rao M., Liu F., Woloszynek J.R., Link D.C. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. Journal of Experimental Medicine 2011, 208:251-260.
17. Christopherson K.W., Hangoc G., Broxmeyer H.E. Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells. Journal of Immunology 2002, 169:7000-7008.
18. Christopherson K.W., Hangoc G., Mantel C.R., Broxmeyer H.E. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004, 305:1000-1003.
19. Christopherson K.W., Uralil S.E., Porecha N.K., et al. G-CSF- and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34+CD38- human cord blood hematopoietic cells. Experimental Hematology 2006, 34:1060-1068.
20. -/- mice. Experimental Hematology 2003, 31:1126-1134.
21. D'Apuzzo M., Rolink A., Loetscher M., et al. The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. European Journal of Immunology 1997, 27:1788-1793.
22. Dar A., Kollet O., Lapidot T. Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. Experimental Hematology 2006, 34:967-975.
23. Day R.B., Link D.C. Regulation of neutrophil trafficking from the bone marrow. Cellular and Molecular Life Sciences 2012, 69:1415-1423.
24. De La Luz Sierra M., Gasperini P., McCormick P.J., Zhu J., Tosato G. Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood 2007, 110:2276-2285.
25. Debnath B., Xu S., Grande F., Garofalo A., Neamati N. Small molecule inhibitors of CXCR4. Theranostics 2013, 3:47-75.
26. Ding L., Morrison S.J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 2013, 495:231-235.
27. Ding L., Saunders T.L., Enikolopov G., Morrison S.J. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012, 481:457-462.
28. Dorshkind K., Narayanan R., Landreth K.S. Regulatory cells and cytokines involved in primary B lymphocyte production. Advances in Experimental Medicine and Biology 1992, 323:119-123.
29. Eash K.J., Greenbaum A.M., Gopalan P.K., Link D.C. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. Journal of Clinical Investigation 2010, 120:2423-2431.
30. Eash K.J., Means J.M., White D.W., Link D.C. CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 2009, 113:4711-4719.
31. Frenette P.S., Mayadas T.N., Rayburn H., Hynes R.O., Wagner D.D. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 1996, 84:563-574.
32. Frenette P.S., Subbarao S., Mazo I.B., von Andrian U.H., Wagner D.D. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:14423-14428.
33. Fricker S.P. Physiology and pharmacology of plerixafor. Transfusion Medicine and Hemotherapy 2013, 40:237-245.
34. Furze R.C., Rankin S.M. Neutrophil mobilization and clearance in the bone marrow. Immunology 2008, 125:281-288.
35. Furze R.C., Rankin S.M. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB Journal 2008, 22:3111-3119.
36. Glodek A.M., Honczarenko M., Le Y., Campbell J.J., Silberstein L.E. Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. Journal of Experimental Medicine 2003, 197:461-473.
37. Gordy C., Pua H., Sempowski G.D., He Y.W. Regulation of steady-state neutrophil homeostasis by macrophages. Blood 2011, 117:618-629.
38. Greenbaum A., Hsu Y.M., Day R.B., et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013, 495:227-230.
39. Hattori K., Heissig B., Tashiro K., et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 2001, 97:3354-3360.
40. Imbert A.M., Belaaloui G., Bardin F., et al. CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration. Blood 2006, 108:2578-2586.
41. Inoue S., Osmond D.G. Basement membrane of mouse bone marrow sinusoids shows distinctive structure and proteoglycan composition: A high resolution ultrastructural study. Anatomical Record 2001, 264:294-304.
42. Jacobson L.O., Marks E.K., Gaston E.O., Robson M.J., Zirkle R.E. The role of the spleen in radiation injury. Proceedings of the Society for Experimental Biology and Medicine 1949, 70:740-742.
43. Kahn J., Byk T., Jansson-Sjostrand L., et al. Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood 2004, 103:2942-2949.
44. Katayama Y., Battista M., Kao W.M., et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006, 124:407-421.
45. Kawabata K., Ujikawa M., Egawa T., et al. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:5663-5667.
46. Kim H.K., De La Luz Sierra M., Williams C.K., Gulino A.V., Tosato G. G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells. Blood 2006, 108:812-820.
47. Kincade P.W. Cell interaction molecules and cytokines which participate in B lymphopoiesis. Baillière's Clinical Haematology 1992, 5:575-598.
48. Kohler A., De Filippo K., Hasenberg M., et al. G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood 2011, 117:4349-4357.
49. Kollet O., Dar A., Shivtiel S., et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Journal home 2006, 12:657-664.
50. Kunkel E.J., Butcher E.C. Plasma-cell homing. Nature Reviews Immunology 2003, 3:822-829.
51. Le Y., Zhou Y., Iribarren P., Wang J. Chemokines and chemokine receptors: Their manifold roles in homeostasis and disease. Cellular and Molecular Immunology 2004, 1:95-104.
52. Levesque J.P., Helwani F.M., Winkler I.G. The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia 2010, 24:1979-1992.
53. Levesque J.P., Hendy J., Takamatsu Y., Simmons P.J., Bendall L.J. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. Journal of Clinical Investigation 2003, 111:187-196.
54. Levesque J.P., Hendy J., Takamatsu Y., et al. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Experimental Hematology 2002, 30:440-449.
55. Levesque J.P., Hendy J., Winkler I.G., Takamatsu Y., Simmons P.J. Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. Experimental Hematology 2003, 31:109-117.
56. Lorenz E., Uphoff D., Reid T.R., Shelton E. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. Journal of the National Cancer Institute 1951, 12:197-201.
57. Lucas D., Bruns I., Battista M., et al. Norepinephrine reuptake inhibition promotes mobilization in mice: Potential impact to rescue low stem cell yields. Blood 2012, 119:3962-3965.
58. Ma Q., Jones D., Borghesani P.R., et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:9448-9453.
59. Ma Q., Jones D., Springer T.A. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 1999, 10:463-471.
60. Martin C., Burdon P.C., Bridger G., et al. Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity 2003, 19:583-593.
61. Mazo I.B., Gutierrez-Ramos J.C., Frenette P.S., et al. Hematopoietic progenitor cell rolling in bone marrow microvessels: Parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Journal of Experimental Medicine 1998, 188:465-474.
62. Mendelson A., Frenette P.S. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Journal home 2014, 20:833-846.
63. Mendez-Ferrer S., Michurina T.V., Ferraro F., et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010, 466:829-834.
64. Miyake K., Medina K., Ishihara K., et al. A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. Journal of Cell Biology 1991, 114:557-565.
65. Moll N.M., Ransohoff R.M. CXCL12 and CXCR4 in bone marrow physiology. Expert Review of Hematology 2010, 3:315-322.
66. Muller W.A. How endothelial cells regulate transmigration of leukocytes in the inflammatory response. American Journal of Pathology 2014, 184:886-896.
67. Murphy P.M. Chemokine receptors: Structure, function and role in microbial pathogenesis. Cytokine & Growth Factor Reviews 1996, 7:47-64.
68. Nagaoka H., Gonzalez-Aseguinolaza G., Tsuji M., Nussenzweig M.C. Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production. Journal of Experimental Medicine 2000, 191:2113-2120.
69. Nagasawa T., Hirota S., Tachibana K., et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996, 382:635-638.
70. Nagase H., Miyamasu M., Yamaguchi M., et al. Cytokine-mediated regulation of CXCR4 expression in human neutrophils. Journal of Leukocyte Biology 2002, 71:711-717.
71. O'Leary H., Ou X., Broxmeyer H.E. The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation. Current Opinion in Hematology 2013, 20:314-319.
72. Omatsu Y., Sugiyama T., Kohara H., et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity 2010, 33:387-399.
73. Ou X., O'Leary H.A., Broxmeyer H.E. Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types. Blood 2013, 122:161-169.
74. Papayannopoulou T., Craddock C., Nakamoto B., Priestley G.V., Wolf N.S. The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proceedings of the National Academy of Sciences of the United States of America 1995, 92:9647-9651.
75. Peled A., Petit I., Kollet O., et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999, 283:845-848.
76. Pelus L.M., Bian H., Fukuda S., et al. The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor. Experimental Hematology 2005, 33:295-307.
77. Petit I., Goichberg P., Spiegel A., et al. Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. Journal of Clinical Investigation 2005, 115:168-176.
78. Richardson R.M., Tokunaga K., Marjoram R., Sata T., Snyderman R. Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization. Journal of Biological Chemistry 2003, 278:15867-15873.
79. Semerad C.L., Christopher M.J., Liu F., et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 2005, 106:3020-3027.
80. Semerad C.L., Liu F., Gregory A.D., Stumpf K., Link D.C. G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 2002, 17:413-423.
81. Stein J.V., Nombela-Arrieta C. Chemokine control of lymphocyte trafficking: A general overview. Immunology 2005, 116:1-12.
82. Suratt B.T., Petty J.M., Young S.K., et al. Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood 2004, 104:565-571.
83. Suratt B.T., Young S.K., Lieber J., et al. Neutrophil maturation and activation determine anatomic site of clearance from circulation. American Journal of Physiology: Lung Cellular and Molecular Physiology 2001, 281:L913-921.
84. Thakur M.L., Lavender J.P., Arnot R.N., Silvester D.J., Segal A.W. Indium-111-labeled autologous leukocytes in man. Journal of Nuclear Medicine 1977, 18:1014-1021.
85. Ueda Y., Kondo M., Kelsoe G. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. Journal of Experimental Medicine 2005, 201:1771-1780.
86. Ueda Y., Yang K., Foster S.J., Kondo M., Kelsoe G. Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. Journal of Experimental Medicine 2004, 199:47-58.
87. Vagima Y., Lapid K., Kollet O., et al. Pathways implicated in stem cell migration: The SDF-1/CXCR4 axis. Methods in Molecular Biology 2011, 750:277-289.
88. Wengner A.M., Pitchford S.C., Furze R.C., Rankin S.M. The coordinated action of G-CSF and ELR+CXC chemokines in neutrophil mobilization during acute inflammation. Blood 2008, 111:42-49.
89. Winkler I.G., Sims N.A., Pettit A.R., et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood 2010, 116:4815-4828.
90. Yong K.L., Watts M., Shaun Thomas N., et al. Transmigration of CD34+ cells across specialized and nonspecialized endothelium requires prior activation by growth factors and is mediated by PECAM-1 (CD31). Blood 1998, 91:1196-1205.
91. Zou Y.R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998, 393:595-599.