Characterization of 11C-GSK1482160 for Targeting the P2X7 receptor as a biomarker for neuroinflammation

Journal of Nuclear Medicine

Volumn 58, Issue 3, 2017, Pages 458-465

  Territo, Paul R ^a   Meyer, Jill A ^a   Peters, Jonathan S ^a   Riley, Amanda A ^a   McCarthy, Brian P ^a   Gao, Mingzhang ^a   Min, Wang ^a   Green, Mark A ^a   Zheng, Qi Huang ^a   Hutchins, Gary D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

11C GSK1482160; Neuroinflammation; P2X7 receptor; Purinergic; Receptors

Indexed keywords

BIOLOGICAL MARKER; GSK 1482160 C 11; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR; SODIUM CHLORIDE; TRACER; UNCLASSIFIED DRUG; AUTACOID; CARBON; N-(2-CHLORO-3-(TRIFLUOROMETHYL)BENZYL)-N-METHYL-5-OXOPYRROLIDINE-2-CARBOXAMIDE; PYROGLUTAMIC ACID; RADIOPHARMACEUTICAL AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CELL DENSITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; EMBRYO; HEK293 CELL LINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PET-CT SCANNER; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; PROTEIN EXPRESSION; ANIMAL; BRAIN; C57BL MOUSE; DIAGNOSTIC IMAGING; ENCEPHALITIS; METABOLISM; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ANIMALS; BIOMARKERS; BRAIN; CARBON RADIOISOTOPES; ENCEPHALITIS; HUMANS; INFLAMMATION MEDIATORS; MICE; MICE, INBRED C57BL; MOLECULAR IMAGING; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDONECARBOXYLIC ACID; RADIOPHARMACEUTICALS; RECEPTORS, PURINERGIC P2X7; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 85014843826     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.116.181354     Document Type: Article

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