Oculomotor Prediction: A Window into the Psychotic Mind

Trends in Cognitive Sciences

Volumn 21, Issue 5, 2017, Pages 344-356

  Thakkar, Katharine N ^a   Diwadkar, Vaibhav A ^b   Rolfs, Martin ^c  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; FORECASTING; NEUROPHYSIOLOGY; PHYSIOLOGY;

ACTION EXECUTION; CD SIGNALS; OCULOMOTOR SYSTEMS; PHYSIOLOGICAL PROCESS; SENSE OF AGENCIES; SHEDDING LIGHT;

EYE MOVEMENTS;

CORRELATION ANALYSIS; EYE MOVEMENT; HUMAN; NERVE TRACT; OCULOMOTOR SYSTEM; PHYSIOLOGICAL PROCESS; PROPRIOCEPTION; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; MOVEMENT (PHYSIOLOGY); PATHOPHYSIOLOGY; SENSATION;

EYE MOVEMENTS; HUMANS; MOVEMENT; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SENSATION;

EID: 85014784428     PISSN: 13646613     EISSN: 1879307X     Source Type: Journal    
DOI: 10.1016/j.tics.2017.02.001     Document Type: Review

References (115)

1. 1 Friston, K., The free-energy principle: a rough guide to the brain?. Trends Cogn. Sci. 13 (2009), 293–301.
2. 2 Friston, K.J., et al. Computational psychiatry: the brain as a phantastic organ. Lancet Psychiatry 1 (2014), 148–158.
3. 3 Corlett, P.R., et al. Prediction error, ketamine and psychosis: an updated model. J. Psychopharmacol. 30 (2016), 1145–1155.
4. 4 Fletcher, P.C., Frith, C.D., Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia. Nat. Rev. Neurosci. 10 (2009), 48–58.
5. 5 Hemsley, D.R., An experimental psychological model for schizophrenia. Hafner, H., et al. (eds.) Search for the Causes of Schizophrenia, 1987, Springer, 179–188.
6. 6 Pack, C.C., Eye movements as a probe of corollary discharge function in schizophrenia. ACS Chem. Neurosci. 5 (2014), 326–328.
7. 7 Diefendorf, A.R., Dodge, R., An experimental study of the ocular reactions of the insane from photographic records. Brain 31 (1908), 451–489.
8. 8 Cavanagh, P., et al. Visual stability based on remapping of attention pointers. Trends Cogn. Sci. 14 (2010), 147–153.
9. 9 Becker, W., Jürgens, R., An analysis of the saccadic system by means of double step stimuli. Vision Res. 19 (1979), 967–983.
10. 10 Hallett, P.E., Lightstone, A.D., Saccadic eye movements to flashed targets. Vision Res. 16 (1976), 107–114.
11. 11 Lisberger, S.G., et al. Visual motion processing and sensory-motor integration for smooth pursuit eye movements. Annu. Rev. Neurosci. 10 (1987), 97–129.
12. 12 Bahcall, D.O., Kowler, E., The control of saccadic adaptation: implications for the scanning of natural visual scenes. Vision Res. 40 (2000), 2779–2796.
13. 13 Duhamel, J.R., et al. The updating of the representation of visual space in parietal cortex by intended eye movements. Science 255 (1992), 90–92.
14. 14 Sommer, M.A., Wurtz, R.H., A pathway in primate brain for internal monitoring of movements. Science 296 (2002), 1480–1482.
15. 15 Sommer, M.A., Wurtz, R.H., What the brain stem tells the frontal cortex. II. Role of the SC–MD–FEF pathway in corollary discharge. J. Neurophysiol. 91 (2004), 1403–1423.
16. 16 Sommer, M.A., Wurtz, R.H., Influence of the thalamus on spatial visual processing in frontal cortex. Nature 444 (2006), 374–377.
17. 17 Thakkar, K.N., et al. Disrupted saccadic corollary discharge in schizophrenia. J. Neurosci. 35 (2015), 9935–9945.
18. 18 Levy, D.L., et al. Eye tracking dysfunction in schizophrenia: characterization and pathophysiology. Curr. Top. Behav. Neurosci. 4 (2010), 311–347.
19. 19 Hong, L.E., et al. Components of the smooth pursuit function in deficit and nondeficit schizophrenia. Schizophr. Res. 63 (2003), 39–48.
20. 20 Hong, L.E., et al. Response to unexpected target changes during sustained visual tracking in schizophrenic patients. Exp. Brain Res. 165 (2005), 125–131.
21. 21 Thaker, G.K., et al. Smooth pursuit eye movements to extra-retinal motion signals: deficits in patients with schizophrenia. Psychiatry Res. 88 (1999), 209–219.
22. 22 Hong, L.E., et al. Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched functional magnetic resonance imaging study. Biol. Psychiatry 57 (2005), 726–732.
23. 23 Hong, L.E., et al. Refining the predictive pursuit endophenotype in schizophrenia. Biol. Psychiatry 63 (2008), 458–464.
24. 24 Picard, H.J., et al. Correlates between neurological soft signs and saccadic parameters in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (2009), 676–681.
25. 25 Lencer, R., et al. Instability of visual error processing for sensorimotor adaptation in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci., 2016, 10.1007/s00406-016-0716-3 Published online July 21, 2016.
26. 26 Coesmans, M., et al. Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia. J. Psychiatry Neurosci. 39 (2014), E3–E11.
27. 27 McDowell, J.E., Clementz, B.A., The effect of fixation condition manipulations on antisaccade performance in schizophrenia: studies of diagnostic specificity. Exp. Brain Res. 115 (1997), 333–344.
28. 28 Mazhari, S., et al. Revisiting the suitability of antisaccade performance as an endophenotype in schizophrenia. Brain Cogn. 77 (2011), 223–230.
29. 29 Waters, F., et al. Electrophysiological brain activity and antisaccade performance in schizophrenia patients with first-rank (passivity) symptoms. Psychiatry Res. 170 (2009), 140–149.
30. 30 Brownstein, J., et al. Antisaccade performance is abnormal in schizophrenia patients but not in their biological relatives. Schizophr. Res. 63 (2003), 13–25.
31. 31 Polli, F.E., et al. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain 131 (2008), 971–986.
32. 32 Polli, F.E., et al. Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade task. Schizophr. Res. 82 (2006), 191–201.
33. 33 Reuter, B., et al. Antisaccade performance of schizophrenia patients: evidence of reduced task-set activation and impaired error detection. J. Psychiatr. Res. 40 (2006), 122–130.
34. 34 Wurtz, R.H., Neuronal mechanisms of visual stability. Vision Res. 48 (2008), 2070–2089.
35. 35 Lindner, A., et al. Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions. Curr. Biol. 15 (2005), 1119–1124.
36. 36 Spering, M., et al. Efference copy failure during smooth pursuit eye movements in schizophrenia. J. Neurosci. 33 (2013), 11779–11787.
37. 37 Deubel, H., et al. Postsaccadic target blanking prevents saccadic suppression of image displacement. Vision Res. 36 (1996), 985–996.
38. 38 Collins, T., et al. Post-saccadic location judgments reveal remapping of saccade targets to non-foveal locations. J. Vis. 9 (2009), 29.1–29.9.
39. 39 Rosler, L., et al. Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia. J. Neurophysiol. 114 (2015), 1129–1136.
40. 40 Richard, A., et al. Perisaccadic perception of visual space in people with schizophrenia. J. Neurosci. 34 (2014), 4760–4765.
41. 41 Ross, J., et al. Compression of visual space before saccades. Nature 386 (1997), 598–601.
42. 42 Pola, J., An explanation of perisaccadic compression of visual space. Vision Res. 51 (2011), 424–434.
43. 43 Zimmermann, E., et al. Perifoveal spatial compression. J. Vis., 13, 2013, 21.
44. 44 Ostendorf, F., et al. Perisaccadic mislocalization without saccadic eye movements. Neuroscience 137 (2006), 737–745.
45. 45 Ivleva, E.I., et al. Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension. Schizophr. Bull. 40 (2014), 642–652.
46. 46 Moates, A.F., et al. Predictive pursuit association with deficits in working memory in psychosis. Biol. Psychiatry 72 (2012), 752–757.
47. 47 Kattoulas, E., et al. Predictive smooth eye pursuit in a population of young men: II. Effects of schizotypy, anxiety and depression. Exp. Brain Res. 215 (2011), 219–226.
48. 48 Malassis, R., et al. Corollary discharge failure in an oculomotor task is related to delusional ideation in healthy individuals. PLoS One, 10, 2015, e0134483.
49. 49 Thaker, G.K., et al. A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype. Psychophysiology 40 (2003), 277–284.
50. 50 Thaker, G.K., et al. Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia. Arch. Gen. Psychiatry 55 (1998), 830–836.
51. 51 Cannon, T.D., et al. Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch. Gen. Psychiatry 65 (2008), 28–37.
52. 52 Javitt, D.C., Sensory processing in schizophrenia: neither simple nor intact. Schizophr. Bull. 35 (2009), 1059–1064.
53. 53 Butler, P.D., et al. Visual perception and its impairment in schizophrenia. Biol. Psychiatry 64 (2008), 40–47.
54. 54 Nuechterlein, K.H., Reaction time and attention in schizophrenia: a critical evaluation of the data and theories. Schizophr. Bull. 3 (1977), 373–428.
55. 55 Chen, Y., et al. Motion perception in schizophrenia. Arch. Gen. Psychiatry 56 (1999), 149–154.
56. 56 Chen, Y., et al. Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit. Proc. Natl. Acad. Sci. U. S. A. 96 (1999), 4724–4729.
57. 57 Deubel, H., et al. Landmarks facilitate visual space constancy across saccades and during fixation. Vision Res. 50 (2010), 249–259.
58. 58 Deubel, H., Localization of targets across saccades: role of landmark objects. Vis. Cogn. 11 (2004), 173–202.
59. 59 Barch, D.M., Ceaser, A., Cognition in schizophrenia: core psychological and neural mechanisms. Trends Cogn. Sci. 16 (2012), 27–34.
60. 60 Lee, J., Park, S., Working memory impairments in schizophrenia: a meta-analysis. J. Abnorm. Psychol. 114 (2005), 599–611.
61. 61 Ohl, S., Rolfs, M., Saccadic eye movements impose a natural bottleneck on visual short-term memory. J. Exp. Psychol. Learn. Mem. Cogn., 2016, 10.1037/xlm0000338 Published online October 20, 2016.
62. 62 Bellebaum, C., et al. The role of the human thalamus in processing corollary discharge. Brain 128 (2005), 1139–1154.
63. 63 Gaymard, B., et al. Impairment of extraretinal eye position signals after central thalamic lesions in humans. Exp. Brain Res. 102 (1994), 1–9.
64. 64 Ostendorf, F., et al. Human thalamus contributes to perceptual stability across eye movements. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 1229–1234.
65. 65 Cavanaugh, J., et al. Saccadic corollary discharge underlies stable visual perception. J. Neurosci. 36 (2016), 31–42.
66. 66 Rolfs, M., et al. Predictive remapping of attention across eye movements. Nat. Neurosci. 14 (2011), 252–256.
67. 67 Rolfs, M., Szinte, M., Remapping attention pointers: linking physiology and behavior. Trends Cogn. Sci. 20 (2016), 399–401.
68. 68 Hall, N.J., Colby, C.L., Remapping for visual stability. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 366 (2011), 528–539.
69. 69 Zirnsak, M., et al. Visual space is compressed in prefrontal cortex before eye movements. Nature 507 (2014), 504–507.
70. 70 Neupane, S., et al. Two distinct types of remapping in primate cortical area V4. Nat. Commun., 7, 2016, 10402.
71. 71 Rao, H.M., et al. Circuits for presaccadic visual remapping. J. Neurophysiol. 116 (2016), 2624–2636.
72. 72 Tanaka, M., Involvement of the central thalamus in the control of smooth pursuit eye movements. J. Neurosci. 25 (2005), 5866–5876.
73. 73 Stone, L.S., Lisberger, S.G., Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. I. Simple spikes. J. Neurophysiol. 63 (1990), 1241–1261.
74. 74 Newsome, W.T., et al. Relation of cortical areas MT and MST to pursuit eye movements. II. Differentiation of retinal from extraretinal inputs. J. Neurophysiol. 60 (1988), 604–620.
75. 75 Mustari, M.J., et al. Signal processing and distribution in cortical-brainstem pathways for smooth pursuit eye movements. Ann. N. Y. Acad. Sci. 1164 (2009), 147–154.
76. 76 Berman, R.A., Wurtz, R.H., Functional identification of a pulvinar path from superior colliculus to cortical area MT. J. Neurosci. 30 (2010), 6342–6354.
77. 77 Berman, R.A., Wurtz, R.H., Signals conveyed in the pulvinar pathway from superior colliculus to cortical area MT. J. Neurosci. 31 (2011), 373–384.
78. 78 Krauzlis, R.J., Recasting the smooth pursuit eye movement system. J. Neurophysiol. 91 (2004), 591–603.
79. 79 Modha, D.S., Singh, R., Network architecture of the long-distance pathways in the macaque brain. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 13485–13490.
80. 80 Douglas, R.J., Martin, K.A., Mapping the matrix: the ways of neocortex. Neuron 56 (2007), 226–238.
81. 81 Logothetis, N.K., et al. How not to study spontaneous activity. Neuroimage 45 (2009), 1080–1089.
82. 82 Sherman, S.M., Guillery, R.W., The role of the thalamus in the flow of information to the cortex. Philos. Trans. R. Soc. Lond. B Biol. Sci. 357 (2002), 1695–1708.
83. 83 Sherman, S.M., The thalamus is more than just a relay. Curr. Opin. Neurobiol. 17 (2007), 417–422.
84. 84 Andreasen, N.C., A unitary model of schizophrenia: Bleuler's “fragmented phrene” as schizencephaly. Arch. Gen. Psychiatry 56 (1999), 781–787.
85. 85 Glahn, D.C., et al. Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol. Psychiatry 64 (2008), 774–781.
86. 86 Tu, P.C., et al. Neural correlates of antisaccade deficits in schizophrenia, an fMRI study. J. Psychiatr. Res. 40 (2006), 606–612.
87. 87 Dauvermann, M.R., et al. The application of nonlinear dynamic causal modelling for fMRI in subjects at high genetic risk of schizophrenia. Neuroimage 73 (2013), 16–29.
88. 88 Li, T., et al. Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia. Schizophr. Bull., 2016, 10.1093/schbul/sbw099 Published online July 21, 2016.
89. 89 Woodward, N.D., et al. Thalamocortical dysconnectivity in schizophrenia. Am. J. Psychiatry 169 (2012), 1092–1099.
90. 90 Frith, C.D., The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychol. Med. 17 (1987), 631–648.
91. 91 Feinberg, I., Efference copy and corollary discharge: implications for thinking and its disorders. Schizophr. Bull. 4 (1978), 636–640.
92. 92 Feinberg, I., Guazzelli, M., Schizophrenia – a disorder of the corollary discharge systems that integrate the motor systems of thought with the sensory systems of consciousness. Br. J. Psychiatry 174 (1999), 196–204.
93. 93 Wolpert, D.M., Ghahramani, Z., Computational principles of movement neuroscience. Nat. Neurosci. 3:Suppl (2000), 1212–1217.
94. 94 Graybiel, A.M., The basal ganglia and cognitive pattern generators. Schizophr. Bull. 23 (1997), 459–469.
95. 95 Pynn, L.K., DeSouza, J.F., The function of efference copy signals: implications for symptoms of schizophrenia. Vision Res. 76 (2013), 124–133.
96. 96 Ford, J.M., Mathalon, D.H., Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking. J. Psychiatr. Res. 38 (2004), 37–46.
97. 97 Ford, J.M., et al. Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging. Arch. Gen. Psychiatry 61 (2004), 119–129.
98. 98 Ford, J.M., et al. Cortical responsiveness during inner speech in schizophrenia: an event-related potential study. Am. J. Psychiatry 158 (2001), 1914–1916.
99. 99 Ford, J.M., et al. Cortical responsiveness during talking and listening in schizophrenia: an event-related brain potential study. Biol. Psychiatry 50 (2001), 540–549.
100. 100 Ford, J.M., et al. Neurophysiological evidence of corollary discharge dysfunction in schizophrenia. Am. J. Psychiatry 158 (2001), 2069–2071.
101. 101 Leudar, I., et al. Self-monitoring in speech production: effects of verbal hallucinations and negative symptoms. Psychol. Med. 24 (1994), 749–761.
102. 102 Blakemore, S.J., et al. Why can't you tickle yourself?. Neuroreport 11 (2000), R11–R16.
103. 103 Blakemore, S.J., et al. The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: evidence for a breakdown in self-monitoring. Psychol. Med. 30 (2000), 1131–1139.
104. 104 Shergill, S.S., et al. Two eyes for an eye: the neuroscience of force escalation. Science, 301, 2003, 187.
105. 105 Shergill, S.S., et al. Evidence for sensory prediction deficits in schizophrenia. Am. J. Psychiatry 162 (2005), 2384–2386.
106. 106 Malenka, R.C., et al. Impaired central error-correcting behavior in schizophrenia. Arch. Gen. Psychiatry 39 (1982), 101–107.
107. 107 Malenka, R.C., et al. Central error-correcting behavior in schizophrenia and depression. Biol. Psychiatry 21 (1986), 263–273.
108. 108 Wegner, D.M., Who is the controller of controlled processes?. Hassin, R., et al. (eds.) In The New Unconscious, 2005, Oxford University Press, 19–36.
109. 109 van der Weiden, A., Self-other integration and distinction in schizophrenia: a theoretical analysis and a review of the evidence. Neurosci. Biobehav. Rev. 57 (2015), 220–237.
110. 110 Becker, W., Fuchs, A.F., Prediction in the oculomotor system: smooth pursuit during transient disappearance of a visual target. Exp. Brain Res. 57 (1985), 562–575.
111. 111 Murthy, A., et al. Frontal eye field contributions to rapid corrective saccades. J. Neurophysiol. 97 (2007), 1457–1469.
112. 112 Ethier, V., et al. Changes in control of saccades during gain adaptation. J. Neurosci. 28 (2008), 13929–13937.
113. 113 Chen-Harris, H., et al. Adaptive control of saccades via internal feedback. J. Neurosci. 28 (2008), 2804–2813.
114. 114 Rolfs, M., Carrasco, M., Rapid simultaneous enhancement of visual sensitivity and perceived contrast during saccade preparation. J. Neurosci. 32 (2012), 13744–13752.
115. 115 Deubel, H., Schneider, W.X., Saccade target selection and object recognition: evidence for a common attentional mechanism. Vision Res. 36 (1996), 1827–1837.