Brain-Wide Analysis of Functional Connectivity in First-Episode and Chronic Stages of Schizophrenia

Schizophrenia Bulletin

Volumn 43, Issue 2, 2017, Pages 436-448

  Li, Tao ^a   Wang, Qiang ^a   Zhang, Jie ^b,c   Rolls, Edmund T ^d,e   Yang, Wei ^f   Palaniyappan, Lena ^g,h   Zhang, Lu ^f   Cheng, Wei ^b   Yao, Ye ^b   Liu, Zhaowen ^b,i   Gong, Xiaohong ^b   Luo, Qiang ^b   Tang, Yanqing ^j   Crow, Timothy J ^k   Broome, Matthew R ^l,m,n   Xu, Ke ^j   Li, Chunbo ^o   Wang, Jijun ^o   Liu, Zhening ^p   Lu, Guangming ^c   Wang, Fei ^j   Feng, Jianfeng ^b,e,f   more..

^a SICHUAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF WARWICK   (United Kingdom)

^f Shanghai Center for Mathematical Sciences   (China)

^g UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^h Penticton Regional Hospital   (Canada)

ⁱ XIDIAN UNIVERSITY   (China)

^j CHINA MEDICAL UNIVERSITY   (China)

^k WARNEFORD HOSPITAL   (United Kingdom)

^l UNIVERSITY OF OXFORD   (United Kingdom)

^m OXFORD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

ⁿ UNIVERSITY OF WARWICK   (United Kingdom)

^o SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^p CENTRAL SOUTH UNIVERSITY   (China)

more..

Author keywords

Broca's area; clinical staging model; resting state fMRI; thalamus; whole brain functional connectivity analysis

Indexed keywords

ADULT; BRAIN CORTEX; CHRONIC DISEASE; CONNECTOME; DIAGNOSTIC IMAGING; DISEASE COURSE; FEMALE; HUMAN; MALE; META ANALYSIS; NERVE TRACT; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PROCEDURES; PRODROMAL SYMPTOM; RISK; SCHIZOPHRENIA; THALAMUS; YOUNG ADULT;

ADULT; CEREBRAL CORTEX; CHRONIC DISEASE; CONNECTOME; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; NEURAL PATHWAYS; PREFRONTAL CORTEX; PRODROMAL SYMPTOMS; RISK; SCHIZOPHRENIA; THALAMUS; YOUNG ADULT;

EID: 85026296906     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbw099     Document Type: Article

References (52)

1. Bullmore E, Frangou S, Murray R. The dysplastic net hypothesis: An integration of developmental and dysconnectivity theories of schizophrenia. Schizophr Res. 1997;28:143 156.
2. Pettersson-Yeo W, Allen P, Benetti S, McGuire P, Mechelli A. Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev. 2011;35:1110 1124.
3. Weinberger DR, Egan MF, Bertolino A, et al. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry. 2001;50:825 844.
4. Potkin S, Turner J, Brown G, et al. Working memory and DLPFC inefficiency in schizophrenia: The FBIRN study. Schizophr Bulletin. 2009;35:19 31.
5. MacDonald III AW, Carter CS, Kerns JG, et al. Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am J Psychiatry. 2005;162:475 484.
6. Snitz BE, MacDonald A III, Cohen JD, Cho RY, Becker T, Carter CS. Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-Term atypical antipsychotic treatment. Am J Psychiatry. 2005;162:2322 2329.
7. Baker JT, Holmes AJ, Masters GA, et al. Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder. JAMA Psychiatry. 2014;71:109 118.
8. Barch DM, Ceaser A. Cognition in schizophrenia: core psychological and neural mechanisms. Trends Cogn Sci. 2012;16:27 34.
9. Pol HEH, Kahn RS. What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr Bull. 2008;34:354 366.
10. Cole MW, Anticevic A, Repovs G, Barch D. Variable global dysconnectivity and individual differences in schizophrenia. Biol Psychiat. 2011;70:43 50.
11. Thermenos HW, Whitfield-Gabrieli S, Seidman LJ, et al. Altered language network activity in young people at familial high-risk for schizophrenia. Schizophr Res. 2013;151:229 237.
12. Benetti S, Mechelli A, Picchioni M, Broome M, Williams S, McGuire P. Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state. Brain. 2009;132:2426 2436.
13. Kaufmann T, Skatun KC, Alnaes D, et al. Disintegration of sensorimotor brain networks in schizophrenia. Schizophrenia Bull. 2015;41:1326 1335.
14. Crossley NA, Mechelli A, Fusar-Poli P, et al. Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Hum Brain Mapp. 2009;30:4129 4137.
15. Carter CS, MacDonald AW III, Ross LL, Stenger VA. Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: An eventrelated fMRI study. Am J Psychiatry. 2001;158:1423 1428.
16. Meyer-Lindenberg AS, Olsen RK, Kohn PD, et al. Regionally specific disturbance of dorsolateral prefrontal hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry. 2005;62:379 386.
17. Guller Y, Ferrarelli F, Shackman AJ, et al. Probing thalamic integrity in schizophrenia using concurrent transcranial magnetic stimulation and functional magnetic resonance imaging. Arch Gen Psychiatry. 2012;69:662 671.
18. Pinault D. Dysfunctional thalamus-related networks in schizophrenia. Schizophr Bull. 2011;37:238 243.
19. Cheng W, Palaniyappan L, Li M, et al. Voxel-based, brainwide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry. NPJ Schizophr. 2015;1:15016.
20. Anticevic A, Cole MW, Repovs G, et al. Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness. Cereb Cortex. 2014;24:3116 3130.
21. Woodward ND, Heckers S. Mapping thalamocortical functional connectivity in chronic and early stages of psychotic disorders. Biol Psychiatry. 2016;79:1016 1025.
22. Welsh RC, Chen AC, Taylor SF. Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in schizophrenia. Schizophr Bull. 2010;36:713 722.
23. Woodward ND, Karbasforoushan H, Heckers S. Thalamocortical dysconnectivity in schizophrenia. Am J Psychiatry. 2012;169:1092 1099.
24. Marenco S, Stein JL, Savostyanova AA, et al. Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophrenia. Neuropsychopharmacol. 2012;37:499 507.
25. Fusar-Poli P, Allen P, McGuire P. Neuroimaging studies of the early stages of psychosis: A critical review. European Psychiatry. 2008;23:237 244.
26. Wood SJ, Yung AR, McGorry PD, Pantelis C. Neuroimaging and treatment evidence for clinical staging in psychotic disorders: from the at-risk mental state to chronic schizophrenia. Biol Psychiatry. 2011;70:619 625.
27. Lin A, Reniers RL, Wood SJ. Clinical staging in severe mental disorder: evidence from neurocognition and neuroimaging. Brit J Psychiatry. 2013;202:s11 s17.
28. McGorry PD. Issues for DSM-V: clinical staging: A heuristic pathway to valid nosology and safer, more effective treatment in psychiatry. Am J Psychiatry. 2007;164:859 860.
29. Benetti S, Mechelli A, Picchioni M, Broome M, Williams S, McGuire P. Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state. Brain. 2009;132:2426 2436.
30. Allen P, Luigjes J, Howes OD, et al. Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals. Schizophr Bull. 2012;38:1268 1276.
31. Glahn DC, Laird AR, Ellison-Wright I, et al. Meta-Analysis of gray matter anomalies in schizophrenia: Application of anatomic likelihood estimation and network analysis. Biol Psychiatry. 2008;64:774 781.
32. Petrides M. Neuroanatomy of Language Regions of the Human Brain. New York, NY: Academic Press; 2014.
33. Tao H, Guo S, Ge T, Kendrick KM, Xue Z, Liu Z, Feng J. Depression uncouples brain hate circuit. Mol Psychiatry. 2013;18:101 111.
34. Cheng W, Rolls ET, Gu H, Zhang J, Feng J. Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self. Brain 2015;138:1382 1393.
35. Guo S, Kendrick KM, Yu R, Wang HL, Feng J. Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self. Hum Brain Mapp. 2014;35:123 139.
36. Mayer AR, Ruhl D, Merideth F, et al. Functional imaging of the hemodynamic sensory gating response in schizophrenia. Human Brain Mapp. 2013;34:2302 2312.
37. Guo S, Kendrick KM, Zhang J, et al. Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression. Neuroimage Clin. 2013;2:818 826.
38. Anticevic A, Tang Y, Cho YT, et al. Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia. Schizophr Bull. 2014;40:1105 1116.
39. First M, Spitzer R, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV), 1997. Washington, DC: American Psychiatric Association Press; 2007.
40. Kay SR, Flszbein A, Opfer LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261.
41. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15:273 289.
42. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage. 2012;59:2142 2154.
43. Liptak T. On the combination of independent tests. Magyar Tud Akad Mat Kutato Int Kozl. 1958;3:171 197.
44. Zhou Y, Liang M, Jiang T, et al. Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neurosci Lett. 2007;417:297 302.
45. Ren W, Lui S, Deng W, et al. Anatomical and functional brain abnormalities in drug-maive first-episode schizophrenia. Am J Psychiatry. 2013;170:1308 1316.
46. Greenlee JD, Oya H, Kawasaki H, et al. Functional connections within the human inferior frontal gyrus. J Comp Neurol. 2007;503:550 559.
47. Friederici AD. The cortical language circuit: from auditory perception to sentence comprehension. Trends Cogn Sci. 2012;16:262 268.
48. Rolls ET. Emotion and Decision-Making Explained. Oxford, UK: Oxford University Press; 2014.
49. Berlim MT, Mattevi BS, Belmonte-de-Abreu P, Crow TJ. The etiology of schizophrenia and the origin of language: overview of a theory. Compr Psychiatry. 2003;44:7 14.
50. Cronenwett WJ, Csernansky J. Thalamic pathology in schizophrenia. Behavioral Neurobiology of Schizophrenia and Its Treatment. New York, NY: Springer; 2010:509 528.
51. Anticevic A, Haut K, Murray JD, et al. Association of thalamic dysconnectivity and conversion to psychosis in youth and young adults at elevated clinical risk. JAMA Psychiatry. 2015;72:882 891.
52. Craddock RC, James GA, Holtzheimer PE, Hu XPP, Mayberg HS. A whole brain fMRI atlas generated via spatially constrained spectral clustering. Hum Brain Mapp. 2012;33:1914 1928.