Neural correlates of antisaccade deficits in schizophrenia, an fMRI study

Journal of Psychiatric Research

Volumn 40, Issue 7, 2006, Pages 606-612

  Tu, P C ^a,c   Yang, T H ^b   Kuo, W J ^b   Hsieh, J C ^b   Su, T P ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c TAIPEI MUNICIPAL GAN DAU HOSPITAL   (Taiwan)

Author keywords

Antisaccade; fMRI; Frontal eye field; Inferior frontal gyrus; Lentiform nucleus; Schizophrenia; Supplementary eye field; Thalamus

Indexed keywords

ADULT; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; EYE MOVEMENT; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; PARAMETRIC TEST; PARIETAL LOBE; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; TASK PERFORMANCE; THALAMUS; VISUAL CORTEX;

ADULT; BRAIN; BRAIN MAPPING; CUES; DOMINANCE, CEREBRAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MALE; MOTION PERCEPTION; NERVE NET; ORIENTATION; PATTERN RECOGNITION, VISUAL; SACCADES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 33748325796     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.05.012     Document Type: Article

References (32)

1. Alexander G.E., DeLong M.R., and Strick P.L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience 9 (1986) 357-381
2. Anderson T.J., Jenkins I.H., Brooks D.J., Hawken M.B., Frackowiak R.S., and Kennard C. Cortical control of saccades and fixation in man. A PET study. Brain 117 (1994) 1073-1084
3. Corbetta M., Akbudak E., Conturo T.E., Snyder A.Z., et al. A common network of functional areas for attention and eye movements. Neuron 21 (1998) 761-773
4. Cornelissen F.W., Kimmig H., Schira M., Rutschmann R.M., et al. Event-related fMRI responses in the human frontal eye fields in a randomized pro- and anti-saccade task. Experimental Brain Research 145 2 (2002) 270-274
5. Crawford T.J., Haeger B., Kennard C., Reveley M.A., and Henderson L. Saccadic abnormalities in psychotic patients. I. Neuroleptic-free psychotic patients. Psychological Medicine 25 (1995) 461-471
6. Crawford T.J., Puri B.K., Nijran K.S., Jones B., Kennard C., and Lewis S.W. Abnormal saccadic distractibility in patients with schizophrenia: a 99mTc-HMPAO SPET study. Psychological Medicine 26 (1996) 265-277
7. Curtis C.E., and D'Esposito M. Success and failure suppressing reflexive behavior. Journal of Cognitive Neuroscience 15 3 (2003) 409-418
8. Doricchi F., Perani D., Incoccia C., Grassi F., Cappa S.F., Bettinardi V., et al. Neural control of fast-regular saccades and antisaccades: an investigation using positron emission tomography. Experimental Brain Research 116 1 (1997) 50-62
9. Fukushima J., Fukushima K., Chiba T., Tanaka S., Yamashita I., and Kato M. Disturbances of voluntary control of saccadic eye movements in schizophrenic patients. Biological Psychiatry 23 7 (1988) 670-677
10. Fukushima J., Fukushima K., Miyasaka K., and Yamashita I. Voluntary control of saccadic eye movement in patients with frontal cortical lesions and parkinsonian patients in comparison with that in schizophrenics. Biological Psychiatry 36 1 (1994) 21-30
11. Gaymard B., Ploner C.J., Rivaud S., Vermersch A.I., and Pierrot-Deseilligny C. Cortical control of saccades. Experimental Brain Research 123 (1998) 159-163
12. Guitton D., Buchtal H.A., and Douglas R.M. Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal directed saccades. Experimental Brain Research 58 (1985) 455-474
13. Holzman P.S., Proctor L.R., Levy D.L., Yasillo N.J., Meltzer H.Y., and Hurt S.W. Eye-tracking dysfunctions in schizophrenic patients and their relatives. Archive of General Psychiatry 31 (1974) 143-151
14. Hoptman M.J., Ardekani B.A., Butler P.D., Nierenberg J., Javitt D.C., and Lim K.O. DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis. Neuroreport 15 16 (2004) 2467-2470
15. Konishi S., Nakajima K., Uchida I., Sekihara K., Miyashita Y., et al. No-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging. European Journal of Neuroscience 10 (1998) 1209-1213
16. Konishi S., Nakajima K., Uchida I., Kikyo H., Kameyama M., and Miyashita Y. Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related fMRI. Brain 122 (1999) 981-991
17. Law I., Svarer C., Holm S., and Paulson O.B. The activation pattern in normal humans during suppression, imagination and performance of saccadic eye movements. Acta Physiologica Scandinavica 161 3 (1997) 419-434
18. Maruff P., Danckert J., Pantelis C., and Currie J. Saccadic and attentional abnormalities in patients with schizophrenia. Psychological Medicine 28 5 (1998) 1091-1100
19. Matsuda T., Matsuura M., Ohkubo T., Ohkubo H., Matsushima E., Inoue K., et al. Functional MRI mapping of brain activation during visually guided saccades and antisaccades: cortical and subcortical networks. Psychiatry Research 131 2 (2004) 147-155
20. Matsue Y., Okuma T., Saito H., Aneha S., Ueno T., Chiba H., et al. Saccadic eye movements in tracking, fixation, and rest in schizophrenic and normal subjects. Biological Psychiatry 21 4 (1986) 382-389
21. McDowell J.E., and Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree biological relatives. Journal of Abnormal Psychology 103 2 (1994) 277-287
22. McDowell J.E., Brown G.G., Paulus M., Martinez A., et al. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biological Psychiatry 51 3 (2002) 216-223
23. Menon V., Adleman N.E., White C.D., and Glover G.H. Error-related brain activation during a go/no-go response inhibition task. Human Brain Mapping 12 (2001) 131-143
24. Muri R.M., Iba-Zizen M.T., Derosier C., Cabanis E.A., and Pierrot-Deseilligny. Location of the human posterior eye field with functional magnetic resonance imaging. Journal of Neurology, Neurosurgery, and Psychiatry 60 (1996) 445-448
25. Muri R.M., Heid O., Nirkko A.C., Ozdoba C., et al. Functional organization of saccades and antisaccades in the frontal lobe in humans: a study with echo planar functional magnetic resonance imaging. Journal of Neurology, Neurosurgery, and Psychiatry 65 (1998) 374-377
26. O'Driscoll G.A., Alpert N.M., Matthysse S.W., Levy D.L., Rauch S.L., and Holzman P.S. Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proceedings of the National Academy of Sciences of the USA 92 (1995) 925-929
27. O'Driscoll G.A., Lenzenweger M.F., and Holzman P.S. Antisaccades and smooth pursuit eye tracking and schizotypy. Archive of General Psychiatry 55 9 (1998) 837-843
28. Petit L., Orssaud C., Tzourio N., Crivello F., Berthoz A., and Mazoyer B. Functional anatomy of a prelearned sequence of horizontal saccades in humans. Journal of Neuroscience 16 (1996) 3714-3726
29. Pierrot-Deseilligny C., et al. Saccade and smooth pursuit impairment after cerebral hemispheric lesions. European Neurology 34 (1994) 121-134
30. Raemaekers M., Jansma J.M., Cahn W., Van der Geest J.N., Van der Linden J.A., Kahn R.S., et al. Neural substrate of the saccadic inhibition deficit in schizophrenia investigated with three-dimensional event-related functional magnetic resonance imaging. Archives of General Psychiatry 59 (2002) 313-320
31. Sereno A.B., and Holzman P.S. Antisaccades and smooth pursuit eye movements in schizophrenia. Biological Psychiatry 37 (1995) 394-401
32. Sweeney J.A., Mintun M.A., Kwee S., Wiseman M.B., and Brown D.L. Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. Journal of Neurophysiology 75 1 (1996) 454-468