Smooth pursuit eye movements to extraretinal motion signals: Deficits in relatives of patients with schizophrenia

Archives of General Psychiatry

Volumn 55, Issue 9, 1998, Pages 830-836

  Thaker, Gunvant K ^a   Ross, David E ^a   Cassady, Shawn L ^a   Adami, Helene M ^a   LaPorte, David ^b   Medoff, Deborah R ^a   Lahti, Adrienne ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

^b INDIANA UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DATA ANALYSIS; DEMOGRAPHY; FEMALE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; PATIENT CODING; RELATIVE; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT;

ADOLESCENT; ADULT; COMORBIDITY; FAMILY; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; MOTION PERCEPTION; PERCEPTUAL MASKING; PSYCHIATRIC STATUS RATING SCALES; PURSUIT, SMOOTH; RETINA; SCHIZOID PERSONALITY DISORDER; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; VISUAL FIELDS;

EID: 0031689938     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.55.9.830     Document Type: Article

References (47)

1. Holzman PS. Recent studies of psychophysiology in schizophrenia. Schizophr Bull. 1987;13:49-75.
2. Arolt V, Lencer R, Nolte A, Muller-Myhsok B, Purmann S, Schurmann M, Leutelt J, Pinnow M, Schwinger E. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet. 1996;67:564-579.
3. Lisberger SG, Morris EJ, Tychsen L. Visual motion processing and sensorymotor integration for smooth pursuit eye movements. Annu Rev Neurosci. 1987; 10:97-129.
4. van den Berg AV. Human smooth pursuit during transient perturbations of predictable and unpredictable target movement. Exp Brain Res. 1988;72: 95-108.
5. Barnes GR, Asselman PT. Pursuit of intermittently illuminated moving targets in the human. J Physiol. 1992;445:617-637.
6. Thaker GK, Ross DE, Buchanan RW, Adami H, Medoff D. Smooth pursuit eye movements (SPEM) to extraretinal motion signals in schizophrenia. Schizophr Res. 1997;24:245.
7. Thaker GK, Ross DE, Buchanan RW, Moran MJ, Lahti A, Kim CE, Medoff D. Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism? Psychiatry Res. 1996;59:221-237.
8. Thaker GK, Cassady S, Adami H, Moran M, Ross DE. Eye movements in spectrum personality disorders: comparison of community subjects and relatives of schizophrenic patients. Am J Psychiatry. 1996;153:362-368.
9. Clementz BA, Sweeney JA, Hirt M, Haas G, Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia. J Abnorm Psychol. 1990; 99:327-335.
10. Arolt V, Lencer R, Nolte A, Pinnow M, Schwinger E. Eye tracking dysfunction in families with multiple cases of schizophrenia. Eur Arch Psychiatry Clin Neurosci. 1996;246:175-181.
11. Keefe RS, Silverman JM, Mohs RC, Siever LJ, Harvey PD, Friedman L, Roitman SE, DuPre RL, Smith CJ, Schmeidler J, Davis KL. Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry. 1997;54:169-176.
12. Moran MJ, Thaker GK, Laporte DJ, Cassady SL, Ross DE. Covert visual attention in schizophrenia spectrum personality disordered subjects: visuospatial cuing and alerting effects. J Psychiatr Res. 1996;30:261-275.
13. Stanley MA, Turner SM, Borden JW. Schizotypal features in obsessive-compulsive disorder. Compr Psychiatry. 1990;31:511-518.
14. Mavissakalian M, Hamann MS, Jones B. Correlates of DSM-III personality disorder in obsessive-compulsive disorder. Compr Psychiatry. 1990;31: 481-489.
15. Reiss AL, Hagerman RJ, Vinogradov S, Abrams M, King RJ. Psychiatric disability in female carriers of the fragile X chromosome. Arch Gen Psychiatry. 1988; 45:25-30.
16. Sobesky WE, Hull CE, Hagerman RJ. Symptoms of schizotypal personality disorder in fragile X women. J Am Acad Child Adolesc Psychiatry. 1994;33:247-255.
17. Kerby DS, Dawson BL. Autistic features, personality, and adaptive behavior in males with the fragile X syndrome and no autism. Am J Ment Retard. 1994;98: 455-462.
18. Chapman LJ, Chapman JP, Kwapil TR, Eckblad M, Zinser MC. Putatively psychosisprone subjects 10 years later. J Abnorm Psychol. 1994;103:171-183.
19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition. Washington, DC: American Psychiatric Press; 1987.
20. Spitzer RL, Williams JBW, Gibbon M, First MB. Structured Clinical Interview for DSM III-R (SCID) PB. New York, NY: New York State Psychiatric Institute, Biometrics Research Dept; 1990.
21. Pfohl B, Blum N, Zimmerman M, Stangl D. Structured Interview for DSM-III-R Personality (SIDP-R). Iowa City: Dept of Psychiatry, University of Iowa; 1989.
22. Kendler KS, Lieberman JA, Walsh D. The Structured Interview for Schizotypy (SIS): a preliminary report. Schizophr Bull. 1989;15:559-571.
23. Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT. The Schedule for the Deficit Syndrome: an instrument for research in schizophrenia. Psychiatry Res. 1989;30:119-123.
24. Andreasen NC, Rice J, Endicott J, Reich T, Coryell W. The family history approach to diagnosis: how useful is it? Arch Gen Psychiatry. 1986;43:421-429.
25. Becker W, Fuchs AF. Prediction in the oculomotor system: smooth pursuit during transient disappearance of a visual target. Exp Brain Res. 1985;57:562-575.
26. Battaglia M, Cavallini MC, Macciardi F, Bellodi L. The structure of DSM-III-R schizotypal personality disorder diagnosed by direct interviews. Schizophr Bull. 1997; 23:83-92.
27. Hollingshead A, Redlich S. Social Class and Mental Illness: A Community Study. New York, NY: John Wiley & Sons; 1988.
28. Newsome WT, Wurtz RH, Dursteler MR, Mikami A. Deficits in visual motion processing following ibotenic acid lesions of the middle temporal visual area of the macaque monkey. J Neurosci. 1985;5:825-840.
29. Ferrera VP, Rudolph KK, Maunsell JH, Fleming K, Goldberg TE, Gold JM, Weinberger DR. Responses of neurons in the parietal and temporal visual pathways during a motion task: verbal working memory dysfunction in schizophrenia: use of a Brown-Peterson paradigm. J Neurosci. 1995;56:155-161.
30. Komatsu H, Wurtz RH. Modulation of pursuit eye movements by stimulation of cortical areas MT and MST. J Neurophysiol. 1989;62:31-47.
31. Brothers L, Ring B. Mesial temporal neurons in the macaque monkey with responses selective for aspects of social stimuli. Behav Brain Res. 1993;57: 53-61.
32. Radant AD, Hommer DW. A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking: a comparison of schizophrenics with normals and substance abusing controls. Schizophr Res 1992;6: 225-235.
33. Clementz BA. Saccades to moving targets in schizophrenia: evidence for normal posterior cortex functioning. Psychophysiology. 1996;33:650-654.
34. Newsome WT, Wurtz RH, Komatsu H. Relation of cortical areas MT and MST to pursuit eye movements, II: differentiation of retinal from extraretinal inputs. J Neurophysiol. 1988;60:604-620.
35. Tootell RB, Reppas JB, Kwong KK, Malach R, Born RT, Brady TJ, Rosen BR, Belliveau JW. Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging. J Neurosci. 1995;15:3215-3230.
36. Boussaoud D, Ungerleider LG, Desimone R. Pathways for motion analysis: cortical connections of the medial superior temporal and fundus of the superior temporal visual areas in the macaque. J Comp Neurol. 1990;296:462-495.
37. Boussaoud D, Desimone R, Ungerleider LG. Subcortical connections of visual areas MST and FST in macaques. Vis Neurosci. 1992;9:291-302.
38. Assad JA, Maunsell JH. Neuronal correlates of inferred motion in primate posterior parietal cortex. Nature. 1995;373:518-521.
39. Huerta MF, Krubitzer LA, Kaas JH. Frontal eye field as defined by intracortical microstimulation in squirrel monkeys, owl monkeys, and macaque monkeys, II: cortical connections. J Comp Neurol. 1987;265:332-361.
40. MacAvoy MG, Gottlieb JP, Bruce CJ. Smooth-pursuit eye movement representation in the primate frontal eye field. Cereb Cortex. 1991;1:95-102.
41. Braun DI, Boman DK, Hotson JR. Anticipatory smooth eye movements and predictive pursuit after unilateral lesions in human brain. Exp Brain Res. 1996;110: 111-116.
42. Clementz BA, Reid SA, McDowell JE, Cadenhead KS. Abnormality of smooth pursuit eye movement initiation: specificity to the schizophrenia spectrum? Psychophysiology. 1995;32:130-134.
43. Ross DE, Thaker GK, Buchanan RW, Lahti AC, Medoff D, Bartko JJ, Moran M, Hartley J. Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients. Am J Psychiatry. 1996;153:1158-1165.
44. Ross DE, Thaker GK, Holcomb HH, Cascella NG, Medoff DR, Tamminga CA. Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res. 1995;58:53-67.
45. Goldman-Rakic PS. Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci. 1994;6:348-357.
46. Park S, Holzman PS, Goldman-Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry. 1995;52:821-828.
47. Malaspina D, Wray AD, Friedman JH, Amador X, Yale S, Hasan A, Gorman JM, Kaufmann CA. Odor discrimination deficits in schizophrenia: association with eye movement dysfunction. J Neuropsychiatry Clin Neurosci. 1994;6:273-278.