Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

Immunity

Volumn 46, Issue 3, 2017, Pages 488-503

  Tan, Haiyan ^a   Yang, Kai ^a   Li, Yuxin ^a   Shaw, Timothy I ^a   Wang, Yanyan ^a   Blanco, Daniel Bastardo ^a,b   Wang, Xusheng ^a   Cho, Ji Hoon ^a   Wang, Hong ^a,b   Rankin, Sherri ^a   Guy, Cliff ^a   Peng, Junmin ^a   Chi, Hongbo ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

glycolysis; kinase; mitochondria; mTORC1; phosphoproteomics; proteomics; quiescence exit; systems biology; systems immunology; T cell

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL ENZYME; PHOSPHOPROTEOME; PHOSPHOTRANSFERASE; PROTEOME; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; COX10 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; TRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; BIOGENESIS; CHEMICAL LABELING; CONTROLLED STUDY; DATA BASE; ENZYME ACTIVATION; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; MITOCHONDRIAL RIBOSOME; MOUSE; NONHUMAN; PHOSPHOPROTEOMICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUANTITATIVE ANALYSIS; RIBOSOME; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; T LYMPHOCYTE ACTIVATION; TH1 CELL; ANIMAL; C57BL MOUSE; ENERGY METABOLISM; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; PHOSPHORYLATION; T LYMPHOCYTE;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ENERGY METABOLISM; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEOMICS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 85014720851     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.02.010     Document Type: Article

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