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Volumn 21, Issue 6, 2018, Pages 391-402

Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet

Author keywords

Docosahexaenoic acid; GI dysfunction; Gut brain and brain gut axis; Rotenone Parkinson's model; Uridine

Indexed keywords

ALPHA SYNUCLEIN; DOCOSAHEXAENOIC ACID; FISH OIL; NEUROTOXIN; PROTEIN ZO1; ROTENONE; URIDINE;

EID: 85014657418     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/1028415X.2017.1294555     Document Type: Article
Times cited : (67)

References (62)
  • 1
    • 33749022060 scopus 로고    scopus 로고
    • Association of olfactory dysfunction with incidental Lewy bodies
    • Ross GW, Abbott RD, Petrovitch H, Tanner CM, Davis DG, Nelson J, et al. Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 2006 Dec;21(12):2062–7. doi: 10.1002/mds.21076
    • (2006) Mov Disord , vol.21 , Issue.12 , pp. 2062-2067
    • Ross, G.W.1    Abbott, R.D.2    Petrovitch, H.3    Tanner, C.M.4    Davis, D.G.5    Nelson, J.6
  • 3
    • 0041510529 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in Parkinson's disease
    • Pfeiffer RF. Gastrointestinal dysfunction in Parkinson's disease. Lancet Neurol 2003 Feb;2(2):107–16. doi: 10.1016/S1474-4422(03)00307-7
    • (2003) Lancet Neurol , vol.2 , Issue.2 , pp. 107-116
    • Pfeiffer, R.F.1
  • 4
    • 84929308938 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in Parkinson's disease
    • Fasano A, Visanji NP, Liu LWC, Lang AE, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson's disease. Lancet Neurol 2015 Jun;14(6):625–39. doi: 10.1016/S1474-4422(15)00007-1
    • (2015) Lancet Neurol , vol.14 , Issue.6 , pp. 625-639
    • Fasano, A.1    Visanji, N.P.2    Liu, L.W.C.3    Lang, A.E.4    Pfeiffer, R.F.5
  • 5
    • 0035859865 scopus 로고    scopus 로고
    • Frequency of bowel movements and the future risk of Parkinson's disease
    • Abbott RD, Petrovitch H, White LR, Masaki KH, Tanner CM, Curb JD, et al. Frequency of bowel movements and the future risk of Parkinson's disease. Neurology 2001 Aug 14;57(3):456–62. doi: 10.1212/WNL.57.3.456
    • (2001) Neurology , vol.57 , Issue.3 , pp. 456-462
    • Abbott, R.D.1    Petrovitch, H.2    White, L.R.3    Masaki, K.H.4    Tanner, C.M.5    Curb, J.D.6
  • 6
    • 80052190509 scopus 로고    scopus 로고
    • A prospective study of bowel movement frequency and risk of Parkinson's disease
    • Gao X, Chen H, Schwarzschild MA, Ascherio A. A prospective study of bowel movement frequency and risk of Parkinson's disease. Am J Epidemiol 2011 Sep 1;174(5):546–51. doi: 10.1093/aje/kwr119
    • (2011) Am J Epidemiol , vol.174 , Issue.5 , pp. 546-551
    • Gao, X.1    Chen, H.2    Schwarzschild, M.A.3    Ascherio, A.4
  • 7
    • 84924341733 scopus 로고    scopus 로고
    • Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis
    • Chen H, Zhao EJ, Zhang W, Lu Y, Liu R, Huang X, et al. Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis. Transl Neurodegener 2015;4(1):1. doi: 10.1186/2047-9158-4-1
    • (2015) Transl Neurodegener , vol.4 , Issue.1 , pp. 1
    • Chen, H.1    Zhao, E.J.2    Zhang, W.3    Lu, Y.4    Liu, R.5    Huang, X.6
  • 8
    • 67651174600 scopus 로고    scopus 로고
    • Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study
    • Ponsen MM, Stoffers D, Twisk JWR, Wolters EC, Berendse HW. Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study. Mov Disord 2009 May 15;24(7):1060–5. doi: 10.1002/mds.22534
    • (2009) Mov Disord , vol.24 , Issue.7 , pp. 1060-1065
    • Ponsen, M.M.1    Stoffers, D.2    Twisk, J.W.R.3    Wolters, E.C.4    Berendse, H.W.5
  • 9
    • 84870769168 scopus 로고    scopus 로고
    • Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
    • Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, O'Sullivan GA, Pal A, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2012;2:898. doi: 10.1038/srep00898
    • (2012) Sci Rep , vol.2 , pp. 898
    • Pan-Montojo, F.1    Schwarz, M.2    Winkler, C.3    Arnhold, M.4    O'Sullivan, G.A.5    Pal, A.6
  • 10
  • 11
    • 84947038529 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
    • Klingelhoefer L, Reichmann H. Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors. Nat Rev Neurol 2015 Nov;11(11):625–36. doi: 10.1038/nrneurol.2015.197
    • (2015) Nat Rev Neurol , vol.11 , Issue.11 , pp. 625-636
    • Klingelhoefer, L.1    Reichmann, H.2
  • 12
    • 84961266625 scopus 로고    scopus 로고
    • Microbiota-gut-brain signalling in Parkinson's disease: implications for non-motor symptoms
    • Felice VD, Quigley EM, Sullivan AM, O'Keeffe GW, O'Mahony SM. Microbiota-gut-brain signalling in Parkinson's disease: implications for non-motor symptoms. Parkinsonism Relat Disord 2016 Jun;27:1–8. doi: 10.1016/j.parkreldis.2016.03.012
    • (2016) Parkinsonism Relat Disord , vol.27 , pp. 1-8
    • Felice, V.D.1    Quigley, E.M.2    Sullivan, A.M.3    O'Keeffe, G.W.4    O'Mahony, S.M.5
  • 13
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    • Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012 Oct;13(10):701–12. doi: 10.1038/nrn3346
    • (2012) Nat Rev Neurosci , vol.13 , Issue.10 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 14
    • 33646422793 scopus 로고    scopus 로고
    • Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats
    • Miwa H, Kubo T, Suzuki A, Kondo T. Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats. Neurosci Lett 2006 Jun 19;401(1–2):146–9. doi: 10.1016/j.neulet.2006.03.003
    • (2006) Neurosci Lett , vol.401 , Issue.1-2 , pp. 146-149
    • Miwa, H.1    Kubo, T.2    Suzuki, A.3    Kondo, T.4
  • 15
    • 69749124032 scopus 로고    scopus 로고
    • Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
    • Drolet RE, Cannon JR, Montero L, Greenamyre JT. Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiol Dis 2009 Oct;36(1):96–102. doi: 10.1016/j.nbd.2009.06.017
    • (2009) Neurobiol Dis , vol.36 , Issue.1 , pp. 96-102
    • Drolet, R.E.1    Cannon, J.R.2    Montero, L.3    Greenamyre, J.T.4
  • 16
    • 84907598690 scopus 로고    scopus 로고
    • Neuroprotective effects of metallothionein against rotenone-induced myenteric neurodegeneration in parkinsonian mice
    • Murakami S, Miyazaki I, Sogawa N, Miyoshi K, Asanuma M. Neuroprotective effects of metallothionein against rotenone-induced myenteric neurodegeneration in parkinsonian mice. Neurotox Res 2014 Oct;26(3):285–98. doi: 10.1007/s12640-014-9480-1
    • (2014) Neurotox Res , vol.26 , Issue.3 , pp. 285-298
    • Murakami, S.1    Miyazaki, I.2    Sogawa, N.3    Miyoshi, K.4    Asanuma, M.5
  • 17
    • 77649284470 scopus 로고    scopus 로고
    • Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    • Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PloS One 2010;5(1):e8762. doi: 10.1371/journal.pone.0008762
    • (2010) PloS One , vol.5 , Issue.1
    • Pan-Montojo, F.1    Anichtchik, O.2    Dening, Y.3    Knels, L.4    Pursche, S.5    Jung, R.6
  • 18
    • 33745612296 scopus 로고    scopus 로고
    • Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system
    • Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim J-H, et al. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. Neurobiol Dis 2006 May;22(2):404–20. doi: 10.1016/j.nbd.2005.12.003
    • (2006) Neurobiol Dis , vol.22 , Issue.2 , pp. 404-420
    • Betarbet, R.1    Canet-Aviles, R.M.2    Sherer, T.B.3    Mastroberardino, P.G.4    McLendon, C.5    Kim, J.-H.6
  • 19
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer TB, Kim JH, Betarbet R, Greenamyre JT. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp Neurol 2003 Jan;179(1):9–16. doi: 10.1006/exnr.2002.8072
    • (2003) Exp Neurol , vol.179 , Issue.1 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 20
    • 84920184454 scopus 로고    scopus 로고
    • An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions
    • Jan;
    • Johnson ME, Bobrovskaya L. An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions. Neurotoxicology 2015 Jan;46:101–16. doi: 10.1016/j.neuro.2014.12.002
    • (2015) Neurotoxicology , vol.46 , pp. 101-116
    • Johnson, M.E.1    Bobrovskaya, L.2
  • 21
    • 67349122370 scopus 로고    scopus 로고
    • Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    • Greene JG, Noorian AR, Srinivasan S. Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease. Exp Neurol 2009 Jul;218(1):154–61. doi: 10.1016/j.expneurol.2009.04.023
    • (2009) Exp Neurol , vol.218 , Issue.1 , pp. 154-161
    • Greene, J.G.1    Noorian, A.R.2    Srinivasan, S.3
  • 23
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H, de Vos RAI, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006 Mar 20;396(1):67–72. doi: 10.1016/j.neulet.2005.11.012
    • (2006) Neurosci Lett , vol.396 , Issue.1 , pp. 67-72
    • Braak, H.1    de Vos, R.A.I.2    Bohl, J.3    Del Tredici, K.4
  • 24
    • 84861692236 scopus 로고    scopus 로고
    • Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
    • Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, et al. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord 2012 May;27(6):709–15. doi: 10.1002/mds.23838
    • (2012) Mov Disord , vol.27 , Issue.6 , pp. 709-715
    • Shannon, K.M.1    Keshavarzian, A.2    Mutlu, E.3    Dodiya, H.B.4    Daian, D.5    Jaglin, J.A.6
  • 25
    • 35949004474 scopus 로고    scopus 로고
    • Parkinson's disease: a dual-hit hypothesis
    • Hawkes CH, Del Tredici K, Braak H. Parkinson's disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol 2007 Dec;33(6):599–614. doi: 10.1111/j.1365-2990.2007.00874.x
    • (2007) Neuropathol Appl Neurobiol , vol.33 , Issue.6 , pp. 599-614
    • Hawkes, C.H.1    Del Tredici, K.2    Braak, H.3
  • 26
  • 27
    • 52949131866 scopus 로고    scopus 로고
    • Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease
    • Cansev M, Ulus IH, Wang L, Maher TJ, Wurtman RJ. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease. Neurosci Res 2008 Nov;62(3):206–9. doi: 10.1016/j.neures.2008.07.005
    • (2008) Neurosci Res , vol.62 , Issue.3 , pp. 206-209
    • Cansev, M.1    Ulus, I.H.2    Wang, L.3    Maher, T.J.4    Wurtman, R.J.5
  • 28
    • 43249095375 scopus 로고    scopus 로고
    • Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats
    • Holguin S, Huang Y, Liu J, Wurtman R. Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats. Behav Brain Res 2008 Aug 5;191(1):11–6. doi: 10.1016/j.bbr.2008.02.042
    • (2008) Behav Brain Res , vol.191 , Issue.1 , pp. 11-16
    • Holguin, S.1    Huang, Y.2    Liu, J.3    Wurtman, R.4
  • 30
    • 42049096538 scopus 로고    scopus 로고
    • Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease
    • Bousquet M, Saint-Pierre M, Julien C, Salem N, Cicchetti F, Calon F. Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease. FASEB J 2008 Apr;22(4):1213–25. doi: 10.1096/fj.07-9677com
    • (2008) FASEB J , vol.22 , Issue.4 , pp. 1213-1225
    • Bousquet, M.1    Saint-Pierre, M.2    Julien, C.3    Salem, N.4    Cicchetti, F.5    Calon, F.6
  • 31
    • 24644518083 scopus 로고    scopus 로고
    • Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity
    • Klivenyi P, Gardian G, Calingasan NY, Yang L, von Borstel R, Saydoff J, et al. Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular Med 2005;6(2–3):87–92. doi: 10.1385/NMM:6:2-3:087
    • (2005) Neuromolecular Med , vol.6 , Issue.2-3 , pp. 87-92
    • Klivenyi, P.1    Gardian, G.2    Calingasan, N.Y.3    Yang, L.4    von Borstel, R.5    Saydoff, J.6
  • 32
    • 77049100951 scopus 로고    scopus 로고
    • Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease
    • Delattre AM, Kiss A, Szawka RE, Anselmo-Franci JA, Bagatini PB, Xavier LL, et al. Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease. Neurosci Res 2010 Mar;66(3):256–64. doi: 10.1016/j.neures.2009.11.006
    • (2010) Neurosci Res , vol.66 , Issue.3 , pp. 256-264
    • Delattre, A.M.1    Kiss, A.2    Szawka, R.E.3    Anselmo-Franci, J.A.4    Bagatini, P.B.5    Xavier, L.L.6
  • 33
    • 0028783830 scopus 로고
    • Uridine reduces rotation induced by L-dopa and methamphetamine in 6-OHDA-treated rats
    • Myers CS, Fisher H, Wagner GC. Uridine reduces rotation induced by L-dopa and methamphetamine in 6-OHDA-treated rats. Pharmacol Biochem Behav 1995 Dec;52(4):749–53. doi: 10.1016/0091-3057(95)00169-W
    • (1995) Pharmacol Biochem Behav , vol.52 , Issue.4 , pp. 749-753
    • Myers, C.S.1    Fisher, H.2    Wagner, G.C.3
  • 35
    • 34249814605 scopus 로고    scopus 로고
    • Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone
    • Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, et al. Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem 2007 Jun;101(6):1491–504. doi: 10.1111/j.1471-4159.2006.04440.x
    • (2007) J Neurochem , vol.101 , Issue.6 , pp. 1491-1504
    • Inden, M.1    Kitamura, Y.2    Takeuchi, H.3    Yanagida, T.4    Takata, K.5    Kobayashi, Y.6
  • 36
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993 Nov;123(11):1939–51. doi: 10.1093/jn/123.11.1939
    • (1993) J Nutr , vol.123 , Issue.11 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey, G.C.3
  • 37
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West MJ, Slomianka L, Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991 Dec;231(4):482–97. doi: 10.1002/ar.1092310411
    • (1991) Anat Rec , vol.231 , Issue.4 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 38
    • 0023913503 scopus 로고
    • Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
    • Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988 May;96(5):379–94. doi: 10.1111/j.1699-0463.1988.tb05320.x
    • (1988) APMIS , vol.96 , Issue.5 , pp. 379-394
    • Gundersen, H.J.1    Bendtsen, T.F.2    Korbo, L.3    Marcussen, N.4    Møller, A.5    Nielsen, K.6
  • 39
    • 0031681261 scopus 로고    scopus 로고
    • Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine
    • Axelsson LG, Landström E, Bylund-Fellenius AC. Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine. Aliment Pharmacol Ther 1998 Sep;12(9):925–34. doi: 10.1046/j.1365-2036.1998.00357.x
    • (1998) Aliment Pharmacol Ther , vol.12 , Issue.9 , pp. 925-934
    • Axelsson, L.G.1    Landström, E.2    Bylund-Fellenius, A.C.3
  • 40
    • 68649095434 scopus 로고    scopus 로고
    • Parkinson's disease: the dual hit theory revisited
    • Hawkes CH, Del Tredici K, Braak H. Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci 2009 Jul;1170:615–22. doi: 10.1111/j.1749-6632.2009.04365.x
    • (2009) Ann N Y Acad Sci , vol.1170 , pp. 615-622
    • Hawkes, C.H.1    Del Tredici, K.2    Braak, H.3
  • 41
    • 84922092995 scopus 로고    scopus 로고
    • Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
    • Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol (Berl) 2014 Dec;128(6):805–20. doi: 10.1007/s00401-014-1343-6
    • (2014) Acta Neuropathol (Berl) , vol.128 , Issue.6 , pp. 805-820
    • Holmqvist, S.1    Chutna, O.2    Bousset, L.3    Aldrin-Kirk, P.4    Li, W.5    Björklund, T.6
  • 43
    • 82455206282 scopus 로고    scopus 로고
    • Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease
    • Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, et al. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease. PloS One 2011;6(12):e28032. doi: 10.1371/journal.pone.0028032
    • (2011) PloS One , vol.6 , Issue.12
    • Forsyth, C.B.1    Shannon, K.M.2    Kordower, J.H.3    Voigt, R.M.4    Shaikh, M.5    Jaglin, J.A.6
  • 44
    • 59549100692 scopus 로고    scopus 로고
    • Tight junctions at a glance
    • Balda MS, Matter K. Tight junctions at a glance. J Cell Sci 2008 Nov 15;121(Pt 22):3677–82. doi: 10.1242/jcs.023887
    • (2008) J Cell Sci , vol.121 , pp. 3677-3682
    • Balda, M.S.1    Matter, K.2
  • 45
    • 34247598857 scopus 로고    scopus 로고
    • Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    • Poritz LS, Garver KI, Green C, Fitzpatrick L, Ruggiero F, Koltun WA. Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis. J Surg Res 2007 Jun 1;140(1):12–9. doi: 10.1016/j.jss.2006.07.050
    • (2007) J Surg Res , vol.140 , Issue.1 , pp. 12-19
    • Poritz, L.S.1    Garver, K.I.2    Green, C.3    Fitzpatrick, L.4    Ruggiero, F.5    Koltun, W.A.6
  • 46
    • 42149093127 scopus 로고    scopus 로고
    • The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression
    • Maes M, Kubera M, Leunis J-C. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett 2008 Feb;29(1):117–24.
    • (2008) Neuro Endocrinol Lett , vol.29 , Issue.1 , pp. 117-124
    • Maes, M.1    Kubera, M.2    Leunis, J.-C.3
  • 47
    • 84973616612 scopus 로고    scopus 로고
    • Alteration of colonic excitatory tachykinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration
    • Pellegrini C, Fornai M, Colucci R, Tirotta E, Blandini F, Levandis G, et al. Alteration of colonic excitatory tachykinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration. J Neuroinflammation 2016;13(1):735. doi: 10.1186/s12974-016-0608-5
    • (2016) J Neuroinflammation , vol.13 , Issue.1 , pp. 735
    • Pellegrini, C.1    Fornai, M.2    Colucci, R.3    Tirotta, E.4    Blandini, F.5    Levandis, G.6
  • 48
    • 79953709369 scopus 로고    scopus 로고
    • Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone
    • Mulcahy P, Walsh S, Paucard A, Rea K, Dowd E. Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone. Neuroscience 2011 May 5;181:234–42. doi: 10.1016/j.neuroscience.2011.01.038
    • (2011) Neuroscience , vol.181 , pp. 234-242
    • Mulcahy, P.1    Walsh, S.2    Paucard, A.3    Rea, K.4    Dowd, E.5
  • 49
    • 84897084346 scopus 로고    scopus 로고
    • Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease
    • Carriere CH, Kang NH, Niles LP. Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience 2014 May 16;267:114–21. doi: 10.1016/j.neuroscience.2014.02.028
    • (2014) Neuroscience , vol.267 , pp. 114-121
    • Carriere, C.H.1    Kang, N.H.2    Niles, L.P.3
  • 50
    • 84883194902 scopus 로고    scopus 로고
    • Effect of a single intrastriatal rotenone injection on oxidative stress and neurodegeneration in the rat brain
    • Abdel-Salam OE, Khadrawy Y, Youness E, Mohammed N, Abdel-Rahman R, Hussein J, et al. Effect of a single intrastriatal rotenone injection on oxidative stress and neurodegeneration in the rat brain. Comp Clin Pathol 2014;23(5):1457–67. doi: 10.1007/s00580-013-1807-4
    • (2014) Comp Clin Pathol , vol.23 , Issue.5 , pp. 1457-1467
    • Abdel-Salam, O.E.1    Khadrawy, Y.2    Youness, E.3    Mohammed, N.4    Abdel-Rahman, R.5    Hussein, J.6
  • 51
    • 84934955012 scopus 로고    scopus 로고
    • Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
    • Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol Dis 2015 Oct;82:185–99. doi: 10.1016/j.nbd.2015.06.003
    • (2015) Neurobiol Dis , vol.82 , pp. 185-199
    • Paumier, K.L.1    Luk, K.C.2    Manfredsson, F.P.3    Kanaan, N.M.4    Lipton, J.W.5    Collier, T.J.6
  • 52
    • 80955181036 scopus 로고    scopus 로고
    • The importance of non-motor disturbances to quality of life in Parkinson's disease
    • Martinez-Martin P. The importance of non-motor disturbances to quality of life in Parkinson's disease. J Neurol Sci 2011 Nov 15;310(1–2):12–6. doi: 10.1016/j.jns.2011.05.006
    • (2011) J Neurol Sci , vol.310 , Issue.1-2 , pp. 12-16
    • Martinez-Martin, P.1
  • 53
    • 34748814532 scopus 로고    scopus 로고
    • Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients
    • Martinez-Martin P, Schapira AHV, Stocchi F, Sethi K, Odin P, MacPhee G, et al. Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients. Movement Disorders 2007 Aug 15;22(11):1623–9. doi: 10.1002/mds.21586
    • (2007) Movement Disorders , vol.22 , Issue.11 , pp. 1623-1629
    • Martinez-Martin, P.1    Schapira, A.H.V.2    Stocchi, F.3    Sethi, K.4    Odin, P.5    MacPhee, G.6
  • 54
    • 78651096332 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in Parkinson's disease
    • Pfeiffer RF. Gastrointestinal dysfunction in Parkinson's disease. Parkinsonism Relat Disord 2011 Jan;17(1):10–5. doi: 10.1016/j.parkreldis.2010.08.003
    • (2011) Parkinsonism Relat Disord , vol.17 , Issue.1 , pp. 10-15
    • Pfeiffer, R.F.1
  • 55
    • 78649436932 scopus 로고    scopus 로고
    • Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses
    • Wurtman RJ, Cansev M, Sakamoto T, Ulus I. Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. Nutr Rev 2010 Dec;68(Suppl 2):S88–S101. doi: 10.1111/j.1753-4887.2010.00344.x
    • (2010) Nutr Rev , vol.68 , pp. S88-S101
    • Wurtman, R.J.1    Cansev, M.2    Sakamoto, T.3    Ulus, I.4
  • 56
    • 36049020643 scopus 로고    scopus 로고
    • Oral supplementation with docosahexaenoic acid and uridine-5′-monophosphate increases dendritic spine density in adult gerbil hippocampus
    • Sakamoto T, Cansev M, Wurtman RJ. Oral supplementation with docosahexaenoic acid and uridine-5′-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res 2007 Nov 28;1182:50–9. doi: 10.1016/j.brainres.2007.08.089
    • (2007) Brain Res , vol.1182 , pp. 50-59
    • Sakamoto, T.1    Cansev, M.2    Wurtman, R.J.3
  • 57
    • 84920609364 scopus 로고    scopus 로고
    • A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats
    • Cansev M, van Wijk N, Turkyilmaz M, Orhan F, Sijben JWC, Broersen LM. A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats. Neurobiol Aging 2015 Jan;36(1):344–51. doi: 10.1016/j.neurobiolaging.2014.07.021
    • (2015) Neurobiol Aging , vol.36 , Issue.1 , pp. 344-351
    • Cansev, M.1    van Wijk, N.2    Turkyilmaz, M.3    Orhan, F.4    Sijben, J.W.C.5    Broersen, L.M.6
  • 59
    • 84889581933 scopus 로고    scopus 로고
    • Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease
    • Zerbi V, Jansen D, Wiesmann M, Fang X, Broersen LM, Veltien A, et al. Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease. Neurobiol Aging 2014 Mar;35(3):600–13. doi: 10.1016/j.neurobiolaging.2013.09.038
    • (2014) Neurobiol Aging , vol.35 , Issue.3 , pp. 600-613
    • Zerbi, V.1    Jansen, D.2    Wiesmann, M.3    Fang, X.4    Broersen, L.M.5    Veltien, A.6
  • 60
    • 84962070978 scopus 로고    scopus 로고
    • A dietary treatment improves cerebral blood flow and brain connectivity in aging apoE4 Mice
    • Wiesmann M, Zerbi V, Jansen D, Haast R, Lütjohann D, Broersen LM, et al. A dietary treatment improves cerebral blood flow and brain connectivity in aging apoE4 Mice. Neural Plast 2016;2016:6846721. doi: 10.1155/2016/6846721
    • (2016) Neural Plast , vol.2016 , pp. 6846721
    • Wiesmann, M.1    Zerbi, V.2    Jansen, D.3    Haast, R.4    Lütjohann, D.5    Broersen, L.M.6
  • 61
    • 58149466868 scopus 로고    scopus 로고
    • Oxidative and inflammatory pathways in Parkinson's disease
    • Miller RL, James-Kracke M, Sun GY, Sun AY. Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res 2009 Jan;34(1):55–65. doi: 10.1007/s11064-008-9656-2
    • (2009) Neurochem Res , vol.34 , Issue.1 , pp. 55-65
    • Miller, R.L.1    James-Kracke, M.2    Sun, G.Y.3    Sun, A.Y.4
  • 62
    • 84855614914 scopus 로고    scopus 로고
    • Autonomic involvement in Parkinson's disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers
    • Cersosimo MG, Benarroch EE. Autonomic involvement in Parkinson's disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers. J Neurol Sci 2012 Feb 15;313(1–2):57–63. doi: 10.1016/j.jns.2011.09.030
    • (2012) J Neurol Sci , vol.313 , Issue.1-2 , pp. 57-63
    • Cersosimo, M.G.1    Benarroch, E.E.2


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