Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study

Movement Disorders

Volumn 24, Issue 7, 2009, Pages 1060-1065

  Ponsen, Mirthe M ^a   Stoffers, Diederick ^a,b   Twisk, Jos W R ^b   Wolters, Erik Ch ^a   Berendse, Henk W ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Cognition; Early diagnosis; Olfaction; Parkinson's disease; Preclinical period

Indexed keywords

ADULT; ARTICLE; BRAIN DYSFUNCTION; BRAIN FUNCTION; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; HYPOSMIA; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; OLFACTORY DISCRIMINATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RISK FACTOR;

AGED; COGNITION DISORDERS; FAMILY HEALTH; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TESTS; OLFACTION DISORDERS; PARKINSON DISEASE; PREDICTIVE VALUE OF TESTS; PROBLEM SOLVING; REGRESSION ANALYSIS;

EID: 67651174600     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.22534     Document Type: Article

References (28)

1. Doty RL, Deems DA, Stellar S. Olfactory dysfunction in Parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 1988;38:1237-1244.
2. Hawkes CH, Shephard BC, Daniel SE. Olfactory dysfunction in Parkinson's disease. J Neurol Neurosurg Psychiatry 1997;62: 436-446.
3. Tissingh G, Berendse HW, Bergmans P, et al. Loss of olfaction in de novo and treated Parkinson's disease: possible implications for early diagnosis. Mov Disord 2001;16:41-46.
4. Doty RL, Stern MB, Pfeiffer C. Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1992;55:138-142.
5. Berendse HW, Booij J, Francot CM, et al. Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann Neurol 2001;50: 34-41.
6. Ponsen MM, Stoffers D, Booij J, Eck-Smit van BLF, Wolters EC, Berendse HW. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 2004;56:173-181.
7. Sommer U, Hummel T, Cormann K, et al. Detection of presymptomatic Parkinson's disease: combining smell tests, transcranial sonography, and SPECT. Mov Disord 2004;19:1196-1202.
8. Haehner A, Hummel T, Hummel C, Sommer U, Junghanns S, Reichmann H. Olfactory loss may be a first sign of idiopathic Parkinson's disease. Mov Disord 2007;22:839-842.
9. Ross GW, Petrovitch H, Abbott RD, et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 2008;63:167-173.
10. Lotsch J, Reichmann H, Hummel T. Different odor tests contribute differently to the evaluation of olfactory loss. Chem Senses 2008;33:17-21.
11. Brown RG, Marsden CD. Cognitive function in Parkinson's disease: from description to theory. Trends Neurosci 1990;13: 21-29.
12. Stoffers D, Berendse HW, Deijen JB, Wolters EC. Deficits on Corsi's block-tapping task in early stage Parkinson's disease. Parkinsonism Relat Disord 2003;10:107-111.
13. Stoffers D, Berendse HW, Deijen JB, Wolters EC. Motor perseveration is an early sign of Parkinson's disease. Neurology 2001;57:2111-2113.
14. Foltynie T, Brayne CE, Robbins TW, Barker RA. The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study. Brain 2004;127:550-560.
15. Schneider JS, Pope-Coleman A. Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey. Neurodegeneration 1995;4:245-255.
16. Dujardin K, Duhamel A, Becquet E, Grunberg C, Defebvre L, Destee A. Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson's disease. J Neurol Neurosurg Psychiatry 1999;67:323-328.
17. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745-752.
18. Doty RL, Gregor TP, Settle G. Influence of intertrial interval and sniff-bottle volume on phenyl ethyl alcohol odor detection tresholds. Chem Senses 1986;11:265-282.
19. Hulshoff Pol HE, Hijman R, Baare WF, van Eekelen S, van Ree JM. Odor discrimination and task duration in young and older adults. Chem Senses 2000;25:461-464.
20. Doty RL, Marcus A, Lee WW. Development of the 12-item cross-cultural smell identification test (CC- SIT). Laryngoscope 1996;106:353-356.
21. Markopoulou K, Larsen KW, Wszolek EK, et al. Olfactory dysfunction in familial parkinsonism. Neurology 1997;49:1262-1267.
22. Montgomery EB, Jr, Baker KB, Lyons K, Koller WC. Abnormal performance on the PD test battery by asymptomatic first- degree relatives. Neurology 1999;52:757-762.
23. Ross GW, Abbott RD, Petrovitch H, et al. Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 2006; 21:2062-2067.
24. Marras C, Goldman S, Smith A, et al. Smell identification ability in twin pairs discordant for Parkinson's disease. Mov Disord 2005;20:687-693.
25. Doty RL, Smith R, McKeown DA, Raj J. Tests of human olfactory function: principal components analysis suggests that most measure a common source of variance. Percept Psychophys 1994;56:701-707.
26. Kareken DA, Mosnik DM, Doty RL, Dzemidzic M, Hutchins GD. Functional anatomy of human odor sensation, discrimination, and identification in health and aging. Neuropsychology 2003;17:482-495.
27. Savic I, Gulyas B, Larsson M, Roland P. Olfactory functions are mediated by parallel and hierarchical processing. Neuron 2000; 26:735-745.
28. Boesveldt S, Verbaan D, Knol DL, et al. A comparative study of odor identification and odor discrimination deficits in Parkinson's disease. Mov Disord 2008;23:1984-1990.