Erratum: A nontoxic pain killer designed by modeling of pathological receptor conformations (Science (966) DOI: 10.1126/science.aai8636);A nontoxic pain killer designed by modeling of pathological receptor conformations

Science

Volumn 355, Issue 6328, 2017, Pages 966-969

  Spahn, V ^a   Del Vecchio, G ^a   Labuz, D ^a   Rodriguez Gaztelumendi, A ^a   Massaly, N ^a,c   Temp, J ^a   Durmaz, V ^b   Sabri, P ^b   Reidelbach, M ^b   Machelska, H ^a   Weber, M ^b   Stein, C ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ZUSE INSTITUTE BERLIN   (Germany)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALOXONE; ANALGESIC AGENT; CYCLIC AMP; FENTANYL; FLUORINE; FREUND ADJUVANT; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROGEN; MU OPIATE RECEPTOR AGONIST; N (3 FLUORO 1 PHENETHYLPIPERIDIN 4 YL) N PHENYL PROPIONAMIDE; NALOXONE; PERTUSSIS TOXIN; UNCLASSIFIED DRUG; ADENOSINE PHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LIGAND; MU OPIATE RECEPTOR; N-(3-FLUORO-1-PHENETHYLPIPERIDINE-4-YL)-N-PHENYLPROPIONAMIDE; NARCOTIC ANALGESIC AGENT; PIPERIDINE DERIVATIVE; PROTEIN BINDING;

COMPUTER SIMULATION; FLUORESCENCE; INHIBITION; INJURY; LIGAND; PATHOLOGY; PHYSIOLOGY; PROTEIN;

ACID DISSOCIATION CONSTANT; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; COMPUTER SIMULATION; CONDITIONED PLACE PREFERENCE TEST; DOSE RESPONSE; DRUG EFFICACY; EMBRYO; FLUORESCENCE RESONANCE ENERGY TRANSFER; FREUND ADJUVANT-INDUCED INFLAMMATION; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC50; INFLAMMATORY PAIN; INHIBITION CONSTANT; NONHUMAN; PAIN THRESHOLD; PH; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; SIMULATION; SYNTHESIS; ACUTE PAIN; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; CONSTIPATION; DRUG DESIGN; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; RESPIRATORY FAILURE;

RATTUS;

ACUTE PAIN; ADENOSINE MONOPHOSPHATE; ANALGESIA; ANALGESICS, OPIOID; ANIMALS; COMPUTER SIMULATION; CONSTIPATION; DRUG DESIGN; FENTANYL; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, MOLECULAR; PAIN MANAGEMENT; PIPERIDINES; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RECEPTORS, OPIOID, MU; RESPIRATORY INSUFFICIENCY; TRANSFECTION;

EID: 85014627129     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aao0278     Document Type: Erratum

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