A randomized, phase 2 study investigating TRV130, a biased ligand of the -opioid receptor, for the intravenous treatment of acute pain

Pain

Volumn 157, Issue 1, 2016, Pages 264-272

  Viscusi, Eugene R ^a   Webster, Lynn ^b   Kuss, Michael ^c   Daniels, Stephen ^c   Bolognese, James A ^d   Zuckerman, Seth ^d   Soergel, David G ^e   Subach, Ruth Ann ^e   Cook, Emily ^e   Skobieranda, Franck ^e  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b PRA HEALTH SCIENCES   (United States)

^c Premier Research   (United States)

^d Cytel Incorporated   (United States)

^e TREVENA INC   (United States)

Author keywords

Acute pain; Biased ligand; Bunionectomy; Opioid; TRV130

Indexed keywords

MORPHINE; OLICERIDINE; PLACEBO; ((3-METHOXYTHIOPHEN-2-YL)METHYL)((2-(9-(PYRIDIN-2-YL)-6-OXASPIRO(4.5)DECAN-9-YL)ETHYL))AMINE; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; SPIRO COMPOUND; THIOPHENE DERIVATIVE;

ADULT; AGED; ANALGESIA; ARTICLE; BODY MASS; BUNIONECTOMY; COMORBIDITY; DEPRESSED BLOOD PRESSURE; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ELECTROCARDIOGRAPHY; FEMALE; HEADACHE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NAUSEA; OSTEOSYNTHESIS; OSTEOTOMY; OXYGEN SATURATION; PAIN INTENSITY; PHASE 2 CLINICAL TRIAL; PHYSICAL EXAMINATION; PILOT STUDY; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PREVALENCE; PRIORITY JOURNAL; RATING SCALE; REGIONAL ANESTHESIA; SURGICAL PATIENT; TACHYCARDIA; TREATMENT DURATION; VOMITING; ACUTE PAIN; ADOLESCENT; ADVERSE EFFECTS; AGONISTS; CLINICAL TRIAL; CONTROLLED STUDY; HALLUX VALGUS; MIDDLE AGED; ORTHOPEDIC SURGERY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; YOUNG ADULT;

ACUTE PAIN; ADOLESCENT; ADULT; AGED; ANALGESICS, OPIOID; DOUBLE-BLIND METHOD; FEMALE; HALLUX VALGUS; HUMANS; MALE; MIDDLE AGED; MORPHINE; ORTHOPEDIC PROCEDURES; RECEPTORS, OPIOID, MU; SPIRO COMPOUNDS; THIOPHENES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84953716366     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000363     Document Type: Article

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