Activation of the A 2A adenosine G-protein-coupled receptor by conformational selection

Nature

Volumn 533, Issue , 2016, Pages 265-268

  Ye, Libin ^a,b   Van Eps, Ned ^b   Zimmer, Marco ^b,c   Ernst, Oliver P ^b   Scott Prosser, R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF STUTTGART   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2A RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; LUF 5834; PARTIAL AGONIST; UNCLASSIFIED DRUG; ADENOSINE A2 RECEPTOR AGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LIGAND;

DISEASE; DRUG; HEALTH STATUS; LIGAND; NUCLEAR MAGNETIC RESONANCE; PROTEIN; RESONANCE;

ARTICLE; ENZYME ACTIVATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; ISOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY; ALLOSTERISM; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; HUMAN; INVERSE AGONISM; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PARTIAL AGONISM; PH; THERMODYNAMICS;

ADENOSINE A2 RECEPTOR AGONISTS; ALLOSTERIC REGULATION; DRUG INVERSE AGONISM; DRUG PARTIAL AGONISM; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, BIOLOGICAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RECEPTOR, ADENOSINE A2A; RECEPTORS, ADRENERGIC, BETA-2; THERMODYNAMICS;

EID: 84968547343     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17668     Document Type: Article

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