Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma

Journal of Trauma and Acute Care Surgery

Volumn 82, Issue 3, 2017, Pages 605-617

  Cannon, Jeremy W ^a   Khan, Mansoor A ^b   Raja, Ali S ^c,d   Cohen, Mitchell J ^e   Como, John J ^f   Cotton, Bryan A ^g   Dubose, Joseph J ^h   Fox, Erin E ^g   Inaba, Kenji ⁱ   Rodriguez, Carlos J ^j   Holcomb, John B ^g   Duchesne, Juan C ^k  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e DENVER HEALTH MEDICAL CENTER   (United States)

^f METROHEALTH MEDICAL CENTER   (United States)

^g UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^h DAVID GRANT MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^j Walter Reed Medical Center   (United States)

^k Division of Trauma Critical Care North Oaks Shock Trauma Center   (United States)

more..

Author keywords

coagulopathy of trauma; Damage control resuscitation; massive transfusion protocol; recombinant factor VIIa; tranexamic acid

Indexed keywords

AMINOCAPROIC ACID; BLOOD CLOTTING FACTOR 7; FIBRINOGEN; HEMOSTATIC AGENT; RECOMBINANT ACTIVATED FACTOR VII; TRANEXAMIC ACID; UNCLASSIFIED DRUG; ANTIFIBRINOLYTIC AGENT; BLOOD CLOTTING FACTOR 7A; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ABDOMINAL COMPARTMENT SYNDROME; BLEEDING; BLOOD TRANSFUSION; CONFERENCE PAPER; CRYSTALLOID; DAMAGE CONTROL RESUSCITATION; DISEASE SEVERITY; ERYTHROCYTE; GLASGOW COMA SCALE; GUNSHOT INJURY; HEMORRHAGIC SHOCK; HOSPITAL MORTALITY; HUMAN; INJURY SEVERITY; MULTIPLE ORGAN FAILURE; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RESUSCITATION; SURVIVAL; THROMBOEMBOLISM; TRAUMATIC HEMORRHAGE; BLOOD CELL COUNT; HEMORRHAGE; INJURY SCALE; MORTALITY; PROCEDURES; WOUNDS AND INJURIES;

ANTIFIBRINOLYTIC AGENTS; BLOOD CELL COUNT; BLOOD TRANSFUSION; FACTOR VIIA; HEMORRHAGE; HUMANS; RECOMBINANT PROTEINS; RESUSCITATION; TRANEXAMIC ACID; TRAUMA SEVERITY INDICES; WOUNDS AND INJURIES;

EID: 85014569842     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000001333     Document Type: Conference Paper

References (96)

1. Gentilello LM, Jurkovich GJ, Stark MS, Hassantash SA, O'Keefe GE. Is hypothermia in the victim of major trauma protective or harmful? A randomized, prospective study. Ann Surg. 1997;226(4):439-447.
2. Shafi S, Elliott AC, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma. 2005;59(5): 1081-1085.
3. Kragh JF Jr, Walters TJ, Baer DG, Fox CJ, Wade CE, Salinas J, Holcomb JB. Survival with emergency tourniquet use to stop bleeding in major limb trauma. Ann Surg. 2009;249(1):1-7.
4. Schroll R, Smith A, McSwain NE Jr, Myers J, Rocchi K, Inaba K, Siboni S, Vercruysse GA, Ibrahim-zada I, Sperry JL, et al. A multi-institutional analysis of prehospital tourniquet use. J Trauma Acute Care Surg. 2015;79(1): 10-14.
5. Inaba K, Siboni S, Resnick S, Zhu J, Wong MD, Haltmeier T, Benjamin E, Demetriades D. Tourniquet use for civilian extremity trauma. J Trauma Acute Care Surg. 2015;79(2):232-237; quiz 332-3.
6. Leonard J, Zietlow J, Morris D, Berns K, Eyer S, Martinson K, Jenkins D, Zietlow S. A multi-institutional study of hemostatic gauze and tourniquets in rural civilian trauma. J Trauma Acute Care Surg. 2016;81(3):441-444.
7. Yong E, Vasireddy A, Pavitt A, Davies GE, Lockey DJ. Pre-hospital pelvic girdle injury: improving diagnostic accuracy in a physician-led trauma service. Injury. 2016;47(2):383-388.
8. DuBose JJ, Scalea TM, Brenner M, Skiada D, Inaba K, Cannon J, Moore L, Holcomb J, Turay D, Arbabi CN, et al. The AAST prospective Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) registry: data on contemporary utilization and outcomes of aortic occlusion and resuscitative balloon occlusion of the aorta (REBOA). J Trauma Acute Care Surg. 2016;81(3):409-419.
9. Bickell WH, Wall MJ, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl JMed. 1994;331(17):1105-1109.
10. Dutton RP, Mackenzie CF, Scalea TM. Hypotensive resuscitation during active hemorrhage: impact on in-hospitalmortality. J Trauma Acute Care Surg. 2002;52(6):1141-1146.
11. Duchesne JC, Heaney J, Guidry C, McSwain N Jr, Meade P, Cohen M, Schreiber M, Inaba K, Skiada D, Demetriades D, et al. Diluting the benefits of hemostatic resuscitation: a multi-institutional analysis. J Trauma Acute Care Surg. 2013;75(1):76-82.
12. Schreiber MA, Meier EN, Tisherman SA, Kerby JD, Newgard CD, Brasel K, Egan D, Witham W, Williams C, Daya M, et al. Acontrolled resuscitation strategy is feasible and safe in hypotensive trauma patients: results of a prospective randomized pilot trial. J Trauma Acute Care Surg. 2015;78(4):687-695.
13. O'Keeffe T, Refaai M, Tchorz K, Forestner JE, Sarode R. A massive transfusion protocol to decrease blood component use and costs. Arch Surg. 2008; 143(7):686-690.
14. Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66(1):41-48.
15. Meizoso JP, Ray JJ, Karcutskie CA, Allen CJ, Zakrison TL, Pust GD, Koru-Sengul T, Ginzburg E, Pizano LR, Schulman CI, et al. Effect of time to operation on mortality for hypotensive patients with gunshot wounds to the torso: the golden 10 minutes. J Trauma Acute Care Surg. 2016;81(4): 685-691.
16. Schwartz DA, Medina M, Cotton BA, Rahbar E, Wade CE, Cohen AM, Beeler AM, Burgess AR, Holcomb JB. Are we delivering two standards of care for pelvic trauma? Availability of angioembolization after hours and on weekends increases time to therapeutic intervention. J Trauma Acute Care Surg. 2014;76(1):134-139.
17. Tesoriero RB, Bruns BR, Narayan M, Dubose J, Guliani SS, Brenner ML, Boswell S, Stein DM, Scalea TM. Angiographic embolization for hemorrhage following pelvic fracture: is it "time" for a paradigm shift? J Trauma Acute Care Surg. 2017;82(1):18-26.
18. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63(4):805-813.
19. Holcomb JB, del Junco DJ, Fox EE, Wade CE, Cohen MJ, Schreiber MA, Alarcon LH, Bai Y, Brasel KJ, Bulger EM, et al. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 2013;148(2):127.
20. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471-482.
21. Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, et al. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg. 2016;263(6):1051-1059.
22. Tapia NM, Chang A, Norman M, Welsh F, Scott B, Wall MJ Jr, Mattox KL, Suliburk J. TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients. J Trauma Acute Care Surg. 2013;74(2):378-385; discussion 385-6.
23. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23-32.
24. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study. Arch Surg. 2012;147(2):113-119.
25. Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent J-L, Tortella BJ, et al. Results of the CONTROL trial: efficacy and safety of recombinant activated factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010;69(3):489-500.
26. Hodgetts TJ, Mahoney PF, Kirkman E. Damage control resuscitation. J R Army Med Corps. 2007;153(4):299-300.
27. Hodgetts TJ, Mahoney PF, Russell MQ, Byers M. ABC to < C > ABC: redefining the military trauma paradigm. Emerg Med J. 2006;23(10):745-746.
28. Moore EE, Burch JM, Franciose RJ, Offner PJ, Biffl WL. Staged physiologic restoration and damage control surgery. World J Surg. 1998;22(12):1184-1190; discussion 1190-1.
29. Holcomb JB. The 2004 Fitts lecture: current perspective on combat casualty care. J Trauma. 2005;59(4):990-1002.
30. Rasmussen TE, Gross KR, Baer DG. Where do we go from here? Preface. US Military Health System Research Symposium, August 2013. J Trauma Acute Care Surg. 2013;75(2 Suppl 2):S105-S106.
31. Duchesne JC, McSwain NE, Cotton BA, Hunt JP, Dellavolpe J, Lafaro K, Marr AB, Gonzalez EA, Phelan HA, Bilski T, et al. Damage control resuscitation: the new face of damage control. J Trauma. 2010;69(4):976-990.
32. Kerwin AJ, Haut ER, Burns JB, Como JJ, Haider A, Stassen N, Dahm P, Eastern Association for the Surgery of Trauma Practice Management Guidelines Ad Hoc Committee. The Eastern Association of the Surgery of Trauma approach to practice management guideline development using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. J Trauma Acute Care Surg. 2012;73(5 Suppl 4):S283-S287.
33. Cinat ME, Wallace WC, Nastanski F, West J, Sloan S, Ocariz J, Wilson SE. Improved survival followingmassive transfusion in patientswho have undergone trauma. Arch Surg. 1999;134(9):964-968; discussion 968-70.
34. Inaba K, Lustenberger T, Rhee P, Holcomb JB, Blackbourne LH, Shulman I, Nelson J, Talving P, Demetriades D. The impact of platelet transfusion in massively transfused trauma patients. JAmColl Surg. 2010;211(5):573-579.
35. Cotton BA, Reddy N, Hatch QM, LeFebvre E, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Holcomb JB. Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients. Ann Surg. 2011;254 (4):598-605.
36. Khan S, Allard S, Weaver A, Barber C, Davenport R, Brohi K. A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury. 2013;44(5):587-592.
37. Nascimento B, Callum J, Tien H, Rubenfeld G, Pinto R, Lin Y, Rizoli S. Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-resultsguided transfusion in patients with severe trauma: a randomized feasibility trial. CMAJ. 2013;185(12):E583-E589.
38. Campion EM, Pritts TA, Dorlac WC, Nguyen AQ, Fraley SM, Hanseman D, Robinson BR. Implementation of a military-derived damage-control resuscitation strategy in a civilian trauma center decreases acute hypoxia in massively transfused patients. J Trauma Acute Care Surg. 2013;75(2 Suppl 2): S221-S227.
39. Duchesne JC, Kimonis K, Marr AB, Rennie KV, Wahl G, Wells JE, Islam TM, Meade P, Stuke L, Barbeau JM, et al. Damage control resuscitation in combination with damage control laparotomy: a survival advantage. J Trauma. 2010;69(1):46-52.
40. Riskin DJ, Tsai TC, Riskin L, Hernandez-Boussard T, Purtill M, Maggio PM, Spain DA, Brundage SI. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg. 2009;209(2):198-205.
41. Shaz BH, Dente CJ, Nicholas J, MacLeod JB, Young AN, Easley K, Ling Q, Harris RS, Hillyer CD. Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion. 2010;50(2):493-500.
42. Fox CJ, Gillespie DL, Cox ED, Mehta SG, Kragh JF Jr, Salinas J, Holcomb JB. The effectiveness of a damage control resuscitation strategy for vascular injury in a combat support hospital: results of a case control study. J Trauma. 2008;64(Suppl 2):S99-S106.
43. Kutcher ME, Kornblith LZ, Vilardi RF, Redick BJ, Nelson MF, Cohen MJ. The natural history and effect of resuscitation ratio on coagulation after trauma: a prospective cohort study. Ann Surg. 2014;260(6):1103-1111.
44. Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, et al. An FFP: PRBC transfusion ratio ≥1:1.5 is associated with a lower risk ofmortality after massive transfusion. J Trauma. 2008;65(5):986-993.
45. Duchesne JC, Islam TM, Stuke L, Timmer JR, Barbeau JM, Marr AB, Hunt JP, Dellavolpe JD, Wahl G, Greiffenstein P, et al. Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy. J Trauma. 2009;67(1):33-37.
46. Halmin M, Boström F, Brattström O, Lundahl J, Wikman A, Östlund A, Edgren G. Effect of plasma-to-rbc ratios in trauma patients: a cohort study with time-dependent data. Crit Care Med. 2013;41(8):1905-1914.
47. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248(3):447-458.
48. Kim Y, Lee K, Kim J, Kim J, Heo Y, Wang H, Lee K, Jung K. Application of damage control resuscitation strategies to patients with severe traumatic hemorrhage: review of plasma to packed red blood cell ratios at a single institution. J Korean Med Sci. 2014;29(7):1007-1011.
49. Magnotti LJ, Zarzaur BL, Fischer PE, Williams RF, Myers AL, Bradburn EH, Fabian TC, Croce MA. Improved survival after hemostatic resuscitation: does the emperor have no clothes? J Trauma. 2011;70(1):97-102.
50. Mitra B, Mori A, Cameron PA, Fitzgerald M, Paul E, Street A. Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury. 2010;41(1):35-39.
51. Peiniger S, Nienaber U, Lefering R, Braun M, Wafaisade A, Wutzler S, Borgmann M, Spinella PC, Maegele M. Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury. Crit Care. 2011;15(1):1.
52. Snyder CW, Weinberg JA, McGwin G Jr, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW 3rd, Kerby JD. The relationship of blood product ratio to mortality: survival benefit or survival bias? J Trauma. 2009;66(2):358-364.
53. Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P. Impact of plasma transfusion inmassively transfused trauma patients. J Trauma. 2009;66(3):693-697.
54. Guidry C, DellaVope J, Simms E, Heaney JB, Guice J, McSwain N Jr, Meade P, Duchesne JC. Impact of inverse ratios on patientswith exsanguinating vascular injuries: shouldmore be the new paradigm? J Trauma Acute Care Surg. 2013;74(2):403-410.
55. Perkins JG, Cap AP, Spinella PC, Blackbourne LH, Grathwohl KW, Repine TB, Ketchum L, Waterman P, Lee RE, Beekley AC, et al. An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J Trauma. 2009;66(Suppl 4):S77-S84.
56. Boffard KD, Riou B, Warren B, Choong PI, Rizoli S, Rossaint R, Axelsen M, Kluger Y. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebocontrolled, double-blind clinical trials. J Trauma. 2005;59(1):8-15.
57. Harrison TD, Laskosky J, Jazaeri O, Pasquale MD, Cipolle M. "Low-dose" recombinant activated factor vii results in less blood and blood product use in traumatic hemorrhage. J Trauma. 2005;59(1):150-154.
58. Rizoli SB, Nascimento B, Osman F, Netto FS, Kiss A, Callum J, Brenneman FD, Tremblay L, Tien HC. Recombinant activated coagulation factor VII and bleeding trauma patients. J Trauma. 2006;61(6):1419-1425.
59. Spinella PC, Perkins JG, McLaughlin DF, Niles SE, Grathwohl KW, Beekley AC, Salinas J, Mehta S, Wade CE, Holcomb JB. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma. 2008;64(2):286-294.
60. Cole E, Davenport R, Willett K, Brohi K. Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study. Ann Surg. 2015;261(2):390-394.
61. Morrison JJ, Ross JD, Dubose JJ, Jansen JO, Midwinter MJ, Rasmussen TE. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II study. JAMA Surg. 2013;148(3):218-225.
62. Schöchl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care. 2010;14(2):R55.
63. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016;20:100.
64. Wafaisade A, Lefering R, Maegele M, Brockamp T, Mutschler M, Lendemans S, Banerjee M, Bouillon B, Probst CTrauma Registry of DGU. Administration of fibrinogen concentrate in exsanguinating trauma patients is associatedwith improved survival at 6 hours but not at discharge. J Trauma Acute Care Surg. 2013;74(2):387-383; discussion 393-5.
65. Singh S, Haut ER, Brotman DJ, Sharma R, Chelladurai Y, Shermock KM, Kebede S, Stevens KA, Prakasa KR, Shihab HM, et al. Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations. Rockville, MD: Agency for Healthcare Research and Quality; 2013.
66. Hewson JR, Neame PB, Kumar N, Ayrton A, Gregor P, Davis C, Shragge BW. Coagulopathy related to dilution and hypotension during massive transfusion. Crit Care Med. 1985;13(5):387-391.
67. Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007; 62(2):307-310.
68. Holcomb JB, McMullin NR, Pearse L, Caruso J, Wade CE, Oetjen-Gerdes L, Champion HR, Lawnick M, Farr W, Rodriguez S, et al. Causes of death in U.S. special operations forces in the globalwar on terrorism: 2001-2004. Ann Surg. 2007;245(6):986-991.
69. Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion. 2006;46(5):685-686.
70. Biffl WL, Smith WR, Moore EE, Gonzalez RJ, Morgan SJ, Hennessey T, Offner PJ, Ray CE, Franciose RJ, Burch JM. Evolution of amultidisciplinary clinical pathway for the management of unstable patients with pelvic fractures. Ann Surg. 2001;233(6):843-850.
71. Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, Balldin BC, McKinley BA. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma. 2007;62 (1):112-119.
72. Novak DJ, Bai Y, Cooke RK, Marques MB, Fontaine MJ, Gottschall JL, Carey PM, Scanlan RM, Fiebig EW, Shulman IA, et al. Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial. Transfusion. 2015;55(6):1331-1339.
73. Callcut RA, Cotton BA, Muskat P, Fox EE, Wade CE, Holcomb JB, Schreiber MA, Rahbar MH, Cohen MJ, Knudson MM, et al. Defining when to initiatemassive transfusion: a validation study of individualmassive transfusion triggers in PROMMTT patients. J Trauma Acute Care Surg. 2013; 74(1):59-65; 67-8; discussion 66-7.
74. Cotton BA, Dossett LA, Au BK, Nunez TC, Robertson AM, Young PP. Room for (performance) improvement: provider-related factors associated with poor outcomes in massive transfusion. J Trauma. 2009;67(5): 1004-1012.
75. Wilson RF, Mammen E, Walt AJ. Eight years of experience with massive blood transfusions. J Trauma. 1971;11(4):275-285.
76. Holcomb JB. Optimal use of blood products in severely injured trauma patients. Hematology Am Soc Hematol Educ Program. 2010;2010:465-469.
77. Murad MH, Stubbs JR, Gandhi MJ, Wang AT, Paul A, Erwin PJ, Montori VM, Roback JD. The effect of plasma transfusion onmorbidity andmortality: a systematic review and meta-analysis. Transfusion. 2010;50(6):1370-1383.
78. Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A. Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? J Trauma. 2008;65(2):261-270.
79. Scalea TM, Bochicchio KM, Lumpkins K, Hess JR, Dutton R, Pyle A, Bochicchio GV. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg. 2008;248 (4):578-584.
80. Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, et al. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma. 2011; 71(2 Suppl 3):S318-S328.
81. Pidcoke HF, Aden JK, Mora AG, Borgman MA, Spinella PC, Dubick MA, Blackbourne LH, Cap AP. Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival. J Trauma Acute Care Surg. 2012; 73:S445-S452.
82. del Junco DJ, Holcomb JB, Fox EE, Brasel KJ, Phelan HA, Bulger EM, Schreiber MA, Muskat P, Alarcon LH, Cohen MJ, et al. Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S24-S30.
83. Ho AM, Dion PW, Yeung JH, Holcomb JB, Critchley LA, Ng CS, Karmakar MK, Cheung CW, Rainer TH. Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiringmassive transfusion. Anesthesiology. 2012;116(3):716-728.
84. Kornblith LZ, Howard BM, Cheung CK, Dayter Y, Pandey S, Busch MP, Pati S, Callcut RA, Vilardi RF, Redick BJ, et al. The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants. J Trauma Acute Care Surg. 2014;77(6):818-827.
85. Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB. Warm freshwhole blood is independently associatedwith improved survival for patients with combat-related traumatic injuries. J Trauma. 2009;66(Suppl 4): S69-S76.
86. Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev. 2003;17(3):223-231.
87. Kenet G, Walden R, Eldad A, Martinowitz U. Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1999;354(9193):1879.
88. Stein DM, Dutton RP, Hess JR, Scalea TM. Low-dose recombinant factor VIIa for trauma patients with coagulopathy. Injury. 2008;39(9):1054-1061.
89. Levi M, Levy JH, Andersen HF, Truloff D. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med. 2010;363(19): 1791-1800.
90. Cohen MJ. Towards hemostatic resuscitation: the changing understanding of acute traumatic biology, massive bleeding, and damage-control resuscitation. Surg Clin North Am. 2012;92(4):877-891, viii.
91. Pusateri AE, Weiskopf RB, Bebarta V, Butler F, Cestero RF, Chaudry IH, Deal V, Dorlac WC, Gerhardt RT, Given MB, et al. Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock. 2013;39(2):121-126.
92. Harvin JA, Peirce CA, Mims MM, Hudson JA, Podbielski JM, Wade CE, Holcomb JB, Cotton BA. The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis. J Trauma Acute Care Surg. 2015; 78(5):905-909; discussion 909-11.
93. CRASH-2 collaborators Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771): 1096-1101, 1101.e1-2.
94. Rotondo MF, Cribari C, Smith RS. Resources for optimal care of the injured patient. Chicago, IL: American College of Surgeons; 2014.
95. ACS TQIP guidelines, massive transfusion in trauma. Available at: https://www.facs.org/quality-programs/trauma/tqip/best-practice. Accessed May 7, 2016.
96. National Institute for Health and Care Excellence (NICE) guidelines, major trauma, assessment and initial management. Available at: https://www.nice. org.uk/guidance/ng39. Accessed May 7, 2016.