The effect of plasma transfusion on morbidity and mortality: A systematic review and meta-analysis

Transfusion

Volumn 50, Issue 6, 2010, Pages 1370-1383

  Murad, Mohammad Hassan ^a,b   Stubbs, James R ^a,b   Gandhi, Manish J ^a,b   Wang, Amy T ^a,b   Paul, Anu ^a,b   Erwin, Patricia J ^a,b   Montori, Victor M ^a,b   Roback, John D ^a,b  

^a MAYO CLINIC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; VITAMIN K GROUP;

ACUTE LUNG INJURY; ADULT; ANTICOAGULATION; BRAIN HEMORRHAGE; CLINICAL TRIAL; ERYTHROCYTE; HUMAN; META ANALYSIS; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; PLASMA TRANSFUSION; REVIEW; SYSTEMATIC REVIEW;

BLOOD COMPONENT TRANSFUSION; DATABASES, FACTUAL; HUMANS; INTRACRANIAL HEMORRHAGES; MALE; MULTIPLE ORGAN FAILURE; PLASMA; RISK FACTORS; WOUNDS AND INJURIES;

EID: 77953088469     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2010.02630.x     Document Type: Review

References (69)

1. AABB. The 2007 national blood collection and utilization survey report 2007. Available from: URL: http://www.aabb.org/Content/Programs-and-Services/ Data-Center/NBCUS/
2. Wallis JP, Dzik S. Is fresh frozen plasma overtransfused in the United States? [see comment]. Transfusion 2004 44 : 1674 5.
3. O'Shaughnessy DF, Atterbury C, Bolton Maggs P, Murphy M, Thomas D, Yates S, Williamson LM British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol 2004 126 : 11 28.
4. Expert Working Group. Guidelines for red blood cell and plasma transfusion for adults and children. Can Med Assoc 1997 156 (11 Suppl S1 24.
5. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology 2006 105 : 198 208.
6. Stanworth SJ, Brunskill SJ, Hyde CJ, McClelland DB, Murphy MF. Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials. Br J Haematol 2004 126 : 139 52.
7. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007 63 : 805 13.
8. Cotton B, Au B, Nunez T, Gunter O, Robertson A, Young P. Predefined massive transfusion protocols are associated with a reduction in organ failure and post-injury complications. J Trauma 2009 66 : 41 8 discussion 48-49.
9. Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA Jr., St Jacques P, Young PP. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma 2008 64 : 1177 82 discussion 1182-3.
10. Gunter O. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma 2008 65 : 527 34.
11. Holcomb JB, Wade C, Michalek J, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS. Increased plasma and platelet to RBC ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008 248 : 447 58.
12. Kashuk J. Post injury life threatening coagulopathy: is 1:1 FFP : RBC the answer? J Trauma 2008 65 : 261 71.
13. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B Working Group on Polytrauma of the German Society of Trauma Surgery (DGU). Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 2008 95 : 112 9.
14. Kleinman S, Caulfield T, Chan P, Davenport R, McFarland J, McPhedran S, Meade M, Morrison D, Pinsent T, Robillard P, Slinger P. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel [see comment]. Transfusion 2004 44 : 1774 89.
15. Gajic O, Dzik W, Toy P. Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm? Crit Care Med 2006 34 : S170 3.
16. Brien WF, Butler RJ, Inwood MJ. An audit of blood component therapy in a Canadian general teaching hospital. CMAJ 1989 140 : 812 5.
17. Mozes B, Epstein M, Ben-Bassat I, Modan B, Halkin H. Evaluation of the appropriateness of blood and blood product transfusion using preset criteria. Transfusion 1989 29 : 473 6.
18. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009 6 : e1000097.
19. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000 283 : 2008 12.
20. Szczepiorkowski ZM, Bandarenko N, Kim HC, Linenberger ML, Marques MB, Sarode R, Schwartz J, Shaz BH, Weinstein R, Wirk A, Winters JL American Society for Apheresis; Apheresis Applications Committee of the American Society for Apheresis. Guidelines on the use of therapeutic apheresis in clinical practice: evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. J Clin Apher 2007 22 : 106 75.
21. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986 7 : 177 88.
22. Higgins J, Thompson S, Deeks J, Altman D. Measuring inconsistency in meta-analyses. BMJ 2003 327 : 557 60.
23. Altman DG, Bland JM. Interaction revisited: the difference between two estimates [see comment]. BMJ 2003 326 : 219.
24. Cinat ME, Wallace WC, Nastanski F, West J, Sloan S, Ocariz J, Wilson SE. Improved survival following massive transfusion in patients who have undergone trauma. Arch Surg 1999 134 : 964 8 discussion 968-970.
25. Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, Balldin BC, Mckinley BA. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma 2007 62 : 112 9.
26. Mannucci PM, Franchi F, Dioguardi N. Correction of abnormal coagulation in chronic liver disease by combined use of fresh-frozen plasma and prothrombin complex concentrates. Lancet 1976 2 : 542 5.
27. Belcher P, Lennox SC. Avoidance of blood transfusion in coronary artery surgery: a trial of hydroxyethyl starch. Ann Thorac Surg 1984 37 : 365 70.
28. Boughton BJ, Simpson A, Baar S, Ala F, Casson J, Gower J. The concentration of plasma fibronectin in burns patients treated with fresh frozen plasma or plasma protein fraction. Resuscitation 1984 12 : 41 5.
29. Martinowitz U, Goor DA, Ramot B, Mohr R. Is transfusion of fresh plasma after cardiac operations indicated? J Thorac Cardiovasc Surg 1990 100 : 92 8.
30. Henriksson AE, Nilsson TK, Jansson U, Bergqvist D. Experimental haemorrhage and blood component transfusion in humans: no change in plasma concentration of thrombin-antithrombin complex and plasmin-antiplasmin complex. Thromb Res 1996 82 : 409 15.
31. Wilhelmi M, Franke U, Cohnert T, Weberc P, Kaukemüllerc J, Fischera S, Wahlersb T, Haverich A. Coronary artery bypass grafting surgery without the routine application of blood products: is it feasible? [see comment]. Eur J Cardiothorac Surg 2001 19 : 657 61. (Pubitemid 32416616)
32. Cotton B, Au B, Nunez T, Gunter O, Robertson A, Young P. Predefined massive transfusion protocols are associated with a reduction in organ failure and post-injury complications. J Trauma 2008 66 : 41 8, discussion 48-9.
33. Johansson PI, Stensballe J, Rosenberg I, Hilslov TL, Jorgensen L, Secher NH. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion 2007 47 : 593 8.
34. Scalea TM, Bochicchio KM, Lumpkins K, Hess JR, Dutton R, Pyle A, Bochicchio GV. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg 2008 248 : 578 84.
35. Dente CJ, Shaz BH, Nicholas JM, Harris RS, Wyrzykowski AD, Patel S, Shah A, Vercruysse GA, Feliciano DV, Rozycki GS, Salomone JP, Ingram WL. Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center. J Trauma 2009 66 : 1616 24.
36. Snyder CW, Weinberg JA, McGwin G Jr., Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW Kerby JD. The relationship of blood product ratio to mortality: survival benefit or survival bias? J Trauma 2009 66 : 358 62 discussion 354-362.
37. Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P. Impact of plasma transfusion in massively transfused trauma patients. J Trauma 2009 66 : 693 7.
38. Duchesne JC, Hunt JP, Wahl G, Marr AB, Wang YZ, Weintraub SE, Wright MJ, McSwain NE Jr. Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years? J Trauma 2008 65 : 272 6 discussion 276-8.
39. Gajic O, Rana R, Mendez JL, Rickman OB, Lymp JF, Hubmayr RD, Moore SB. Acute lung injury after blood transfusion in mechanically ventilated patients. Transfusion 2004 44 : 1468 74.
40. Hedstrand U, Hogman C, Zaren B, Lundkvist B. Postoperative complications after blood replacement with or without plasma. A trial in elective surgery. Acta Chir Scand 1987 153 : 501 5.
41. Massicotte L, Sassine MP, Lenis S, Seal RF, Roy A. Survival rate changes with transfusion of blood products during liver transplantation. Can J Anesth 2005 52 : 148 55.
42. Swisher SG, Holmes EC, Hunt KK, Gornbein JA, Zinner MJ, McFadden DW. Perioperative blood transfusions and decreased long-term survival in esophageal cancer. J Thorac Cardiovasc Surg 1996 112 : 341 8.
43. Jawan B, de Villa V, Luk HN, Chen YS, Chiang YC, Wang CC, Wang SH, Cheng YF, Huang TL, Eng HL, Liu PP, Chen CL. Ionized calcium changes during living-donor liver transplantation in patients with and without administration of blood-bank products. Transpl Int 2003 16 : 510 4.
44. Sano T, Shimada K, Sakamoto Y, Yamamoto J, Yamasaki S, Kosuge T. One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Ann Surg 2006 244 : 240 7.
45. Martin IR, Jarnagin WR, Fong Y, Biernacki P, Blumgart LH, DeMatteo RP. The use of fresh frozen plasma after major hepatic resection for colorectal metastasis: is there a standard for transfusion? J Am Coll Surg 2003 196 : 402 9.
46. van der Werff YD, van der Houwen HK, Heijmans PJ, Duurkens VA, Leusink HA, van Heesewijk HP, de Boer A. Postpneumonectomy pulmonary edema. A retrospective analysis of incidence and possible risk factors. Chest 1997 111 : 1278 84.
47. Kasper SM, Giesecke T, Limpers P, Sabatowski R, Mehlhorn U, Diefenbach C. Failure of autologous fresh frozen plasma to reduce blood loss and transfusion requirements in coronary artery bypass surgery. Anesthesiology 2001 95 : 81 6 discussion 86A.
48. Ranucci M, Pazzaglia A, Bianchini C, Bozzetti G, Isgrò G. Body size, gender, and transfusions as determinants of outcome after coronary operations. Ann Thorac Surg 2008 85 : 481 7.
49. Kaibori M, Saito T, Matsui K, Yamaoka M, Kamiyama Y. Impact of fresh frozen plasma on hepatectomy for hepatocellular carcinoma. Anticancer Res 2008 28 : 1749 56.
50. Sjoblom L, Hardemark HG, Lindgren A, Norrving B, Fahlén M, Samuelsson M, Stigendal L, Stockelberg D, Taghavi A, Wallrup L, Wallvik J. Management and prognostic features of intracerebral hemorrhage during anticoagulant therapy: a Swedish multicenter study. Stroke 2001 32 : 2567 74.
51. Yiu KH, Siu CW, Jim MH, Tse HF, Fan K, Chau MC, Chow WH. Comparison of the efficacy and safety profiles of intravenous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves. Am J Cardiol 2006 97 : 409 11.
52. Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med 2005 33 : 2667 71.
53. Gazzard BG, Henderson JM, Williams R. Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapy. Gut 1975 16 : 617 20.
54. Leese T, Holliday M, Heath D, Hall AW, Bell PR. Multicentre clinical trial of low volume fresh frozen plasma therapy in acute pancreatitis. Br J Surg 1987 74 : 907 11.
55. Leese T, Holliday M, Watkins M, Thomas WM, Neoptolemos JP, Hall C, Attard A. A multicentre controlled clinical trial of high-volume fresh frozen plasma therapy in prognostically severe acute pancreatitis. Ann R Coll Surg Engl 1991 73 : 207 14.
56. Etemadrezaie H, Baharvahdat H, Shariati Z, Lari SM, Shakeri MT, Ganjeifar B. The effect of fresh frozen plasma in severe closed head injury. Clin Neurol Neurosurg 2007 109 : 166 71.
57. Khan H, Belsher J, Yilmaz M, Afessa B, Winters JL, Moore SB, Hubmayr RD, Gajic O. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 2007 131 : 1308 14.
58. Guven M, Sungur M, Eser B, Sari I, Altuntas F. The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning. J Toxicol Clin Toxicol 2004 42 : 617 23.
59. Abdel-Wahab OI, Healy B, Dzik WH. Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities [see comment]. Transfusion 2006 46 : 1279 85.
60. Chowdhury P, Saayman AG, Paulus U, Findlay GP, Collins PW. Efficacy of standard dose and 30 mL/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 2004 125 : 69 73.
61. Holland LL, Brooks JP. Toward rational fresh frozen plasma transfusion: the effect of plasma transfusion on coagulation test results. Am J Clin Pathol 2006 126 : 133 9.
62. Lau J, Ioannidis JP, Terrin N, Schmid CH, Olkin I. The case of the misleading funnel plot. BMJ 2006 333 : 597 600.
63. Gandhi GY, Murad MH, Fujiyoshi A, Mullan RJ, Flynn DN, Elamin MB, Swiglo BA, Isley WL, Guyatt GH, Montori VM. Patient-important outcomes in registered diabetes trials. JAMA 2008 299 : 2543 9.
64. Dzik W, Rao A. Why do physicians request fresh frozen plasma? Transfusion 2004 44 : 1393 4.
65. Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR, Tripodi A, Sanyal AJ Coagulation in Liver Disease Group. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006 44 : 1039 46.
66. Bellest L, Eschwege V, Poupon R, Chazouilleres O, Robert A. A modified international normalized ratio as an effective way of prothrombin time standardization in hepatology [see comment]. Hepatology 2007 46 : 528 34.
67. Trotter JF, Brimhall B, Arjal R, Phillips C. Specific laboratory methodologies achieve higher model for endstage liver disease (MELD) scores for patients listed for liver transplantation. Liver Transpl 2004 10 : 995 1000.
68. Tripodi A, Chantarangkul V, Primignani M, Fabris F, Dell'Era A, Sei C, Mannucci PM. The international normalized ratio calibrated for cirrhosis (INR(liver)) normalizes prothrombin time results for model for end-stage liver disease calculation. Hepatology 2007 46 : 520 7.
69. Segal JB, Dzik WH Transfusion Medicine/Hemostasis Clinical Trials Network. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion 2005 45 : 1413 25.