Postinjury life threatening coagulopathy: Is 1:1 fresh frozen plasma: Packed red blood cells the answer?

Journal of Trauma - Injury, Infection and Critical Care

Volumn 65, Issue 2, 2008, Pages 261-270

  Kashuk, Jeffry L ^a,b   Moore, Ernest E ^a   Johnson, Jeffrey L ^a   Haenel, James ^a   Wilson, Michael ^a   Moore, John B ^a   Cothren, C Clay ^a   Biffl, Walter L ^a   Banerjee, Anirban ^a   Sauaia, Angela ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b DENVER HEALTH MEDICAL CENTER   (United States)

Author keywords

Coagulopathy; Plasma; Postinjury; Transfusion

Indexed keywords

FRESH FROZEN PLASMA;

ADULT; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD PH; BODY TEMPERATURE; CONFIDENCE INTERVAL; CRYSTALLOID; EMERGENCY WARD; ENVIRONMENTAL TEMPERATURE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MORTALITY; OPERATING ROOM; PARTIAL THROMBOPLASTIN TIME; PLASMA TRANSFUSION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SURVIVAL; THROMBOCYTE TRANSFUSION; TIME SERIES ANALYSIS; BLOOD COMPONENT THERAPY; FEMALE; INJURY; MALE; METHODOLOGY; PLASMA; RETROSPECTIVE STUDY; RISK; STATISTICAL MODEL;

ADULT; BLOOD COAGULATION DISORDERS; BLOOD COMPONENT TRANSFUSION; BLOOD LOSS, SURGICAL; ERYTHROCYTE TRANSFUSION; FEMALE; HUMANS; LOGISTIC MODELS; MALE; ODDS RATIO; PLASMA; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; WOUNDS AND INJURIES;

EID: 67649233456     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31817de3e1     Document Type: Article

References (68)

1. Borgman M, Spinella P, Perkins M, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J. Trauma. 2007;63: 805-813.
2. Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion. 2006;46:685- 686.
3. Hess JR, Lawson JH. The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma. 2006;60(suppl 6):S12-S19.
4. Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62:307-310.
5. Holcomb JB, McMullin N, Pearse L, et al. Causes of death in U.S. special operations forces in the global war on terrorism: 2001-2004. Ann Surg. 2007;245:986 -991.
6. Gonzalez EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma. 2007;62:112-119.
7. Kashuk J, Moore EE, Milikan JS, Moore JB. Major abdominal vascular trauma-a unified approach. J Trauma. 1982;22:672-679.
8. Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B. Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. J Trauma. 1997;42:857- 861.
9. Brohi K, Singh J, Heron M, Coats T. Acute Traumatic coagulopathy. J Trauma. 2003;54:1127-1130.
10. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion. Ann Surg. 2007;245:812- 818.
11. Johnson J, Moore EE, Kashuk J, et al. Early transfusion of FFP is independently associated with post-injury MOF. Arch Surg. In press.
12. Moore FA, Moore EE, Sauaia A. Blood transfusion: an independent risk factor for postinjury multiple organ failure. Arch Surg. 1997; 132:620-625.
13. Zallen G, Offner PJ, Moore EE, et al. Age of transfused blood is an independent risk factor for post-injury multiple organ failure. Am J Surg. 1999;178:570 -572.
14. Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR. Blood transfusion rates in the care of acute trauma. Transfusion. 2004; 44:809-813.
15. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma. 2003;54:898 -905.
16. Basran S, Frumento RJ, Cohen A, et al. The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesth Analg. 2006; 103:15-20.
17. Ho J, Sibbald WJ, Chin-Yee IH. Effects of storage on efficacy of red cell transfusion: when is it not safe? Crit Care Med. 2003; 31:S687-S697.
18. Tinmouth A, Fergusson D, Yee IC, Hebert PC. Clinical consequences of red cell storage in the critically ill. Transfusion. 2006;46:2014 -2027.
19. MacLennan S, Williamson LM. Risks of fresh frozen plasma and platelets. J Trauma. 2006;60(suppl 6):S46 -S50.
20. Stanworth SJ, Brunskill SJ, Hyde CJ, Murphy MF, McClelland DB. Is fresh frozen plasma clinically effective: a systematic review of randomized controlled trials. Br J Haematol. 2004; 126:139 -152.
21. Khan H, Belsher J, Yilmaz M, et al. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest. 2007; 131:1308 -1314.
22. Blajchman MA, Vamvakas EC. The continuing risk of transfusion transmitted infections. N Engl J Med. 2006;355:1303-1305.
23. Vincent JL, Baron JF, Reinhart K, et al. Anemia and blood transfusion in critically ill patients. JAMA. 2002;288:1499 -507.
24. Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med. 2005;33:2667-2671.
25. Spahn DR, Rossaint, R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth. 2005;95:130 -139.
26. Faringer PD, Mullins RJ, Johnson RL, Trunkey DD. Blood component supplementation during massive transfusion of AS-1 red cells in trauma patients. J Trauma. 1993;34:481.
27. Mitchell KJ, Moncure KE, Onyeije C, Rao MS, Siram S. Evaluation of massive volume replacement in the penetrating trauma patient. J Natl Med Assoc. 1994;86:926 -929.
28. Ho AM, Karmakar MK, Dion PW. are we giving enough coagulation factors during major trauma resuscitation? Am J Surg. 2005;190:479-484.
29. Ketchum L, Hess JR, Hiippala S. Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma. J Trauma. 2006;60(suppl 6):S51-S58.
30. Hosmer DW, Lemeshow S. Applied Logistic Regression. New York: John Wiley & Sons; 1989.
31. Biffl WL, Smith WR, Moore EE, et al. Evolution of a multidisciplinary clinical pathway for the management of unstable patients with pelvic fractures. Ann Surg. 2001;223:843- 850.
32. Malone DL, Hess JR, Fingerhut A. Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol. J Trauma. 2006;60(suppl 6):S91-S96.
33. Repine TB, Perkins JG, Kauvar DS, Blackborne L. The use of fresh whole blood in massive transfusion. J Trauma. 2006;60 (suppl 6):S59 -S69.
34. Lucas CE, Ledgerwood AM. Clinical significance of altered coagulation tests after massive transfusion for trauma. Am Surg. 1981;47:125-130.
35. Ledgerwood AM, Lucas CE. A review of studies on the effects of hemorrhagic shock and resuscitation on the coagulation profile. J Trauma. 2003;54(suppl 5):S68 -S74.
36. Moore EE. Staged laparotomy for the hypothermia, acidosis, and coagulopathy syndrome. Am J Surg. 1996;172:405- 410.
37. Cinat ME, Wallace WC, Nastanski F, et al. Improved survival following massive transfusion in patients who have undergone trauma. Arch Surg. 1999;134:964 -970.
38. Kluger Y, Kashuk J, Mayo A. Terror bombing-mechanisms, consequences and implications. Scand J Surg. 2004;93:11-14.
39. Kluger Y, Peleg K, Daniel-Aharonson L, Mayo A; Israeli Trauma Group. The special injury pattern in terrorist bombings. J Am Coll Surg. 2004;199:875- 879.
40. Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med. 2005;33:2667-2671.
41. Schofield WN, Rubin GL, Dean MG. Appropriateness of platelet, fresh frozen plasma and cryoprecipitate transfusion in New South Wales, public hospitals. Med J Aust. 2003;178:117-121.
42. Hui CH, Williams I, Davis K. Clinical audit of the use of freshfrozen plasma and platelets in a tertiary teaching hospital and the impact of a new transfusion request form. Intern Med J. 2005; 35:283-288.
43. Wallis JP, Dzik S. Is fresh frozen plasma over-transfused in the United States? Transfusion. 2004;44:1674 -1675.
44. Stanworth SJ, Brunskill SJ, Hyde CJ, McClelland DB, Murphy MF. Is fresh frozen plasma clinically effective? a systematic review of randomized controlled trials. Br J Haematol. 2004; 126:139 -152.
45. O'Shaughnessy DF, Atterbury C, Bolton Maggs P, et al. Guidelines for the use of fresh-frozen plasma, Cryoprecipitate and Cryosupernatant. Br J Haematol. 2004;126:11-28.
46. Spahn D, Cerny V, Coats T. Management of bleeding following major trauma: a European guideline. Crit Care. 2007;11:R17.
47. Rossaint R, Cerny V, Coats T, et al. Key issues in advanced bleeding care in trauma. Shock. 2006;26:322-331.
48. Rossaint R, Duranteau J, Stahel P. Nonsurgical Treatment of major bleeding. Anesthesiol Clin. 2007;25:35- 48.
49. Toy P, Popovsky MA, Abraham E, et al. Transfusion-related acute lung injury: definition and review. Crit Care Med. 2005;33:721-726.
50. Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury (TRALI). Blood. 2005;105:2266 -2273.
51. Popovsky MA, Moore SB. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion. 1985;25:573-577.
52. Kleinman S, Caulfield T, Chan P, et al. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion. 2004;44:1774 -1789.
53. Gajic O, Dzik WH, Toy P. Fresh frozen plasma and platelet transfusion for non-bleeding patients in the intensive care unit: benefit or harm? Crit Care Med. 2006;34:S170 -S173.
54. Marik PE, Sibbald WJ. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA. 1993;269:3024 -3029.
55. Napolitano LM, Corwin HL. Efficacy of red blood cell transfusion in the critically ill. Crit Care Clin. 2004;20:255-268.
56. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, ontrolled clinical trial of transfusion requirements in critical care transfusion requirements in critical care investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340:409-417.
57. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006;116:1615-1623.
58. Seeger W, Schneider U, Kreusler B, et al. Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood. 1990;76:1438 -1444.
59. Sachs UJ, Hattar K, Weissmann N, et al. Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood. 2006;107:1217-1219.
60. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55: 39-44.
61. Ganter MT, Brohi K, Cohen MJ, et al. Role of the alternative pathway in the early complement activation following major trauma. Shock. 2007;28:29 -34.
62. Dzik WH. Predicting hemorrhage using pre-operative coagulation screening assays. Curr Haematol. 2004;3:324 -330.
63. Kaufmann C, Dwyer K, Crews J, Dols SJ, Trask AL. Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma. 1997;42:716 -722.
64. Schreiber MA, Differding J, Thorberg P, Schreiber MA, Differding J, Thorberg P. Hypercoagulability is most prevalent early after injury and in female patients. J Trauma. 2004;58:475- 481.
65. Rugeri L, Levrat A, Delecroix E. Diagnosis of early coagulation abnormalities in trauma patients by rotation thromboelastography. J Thromb Haemost. 2006;5:289 -295.
66. Engstrom M, Schott U, Romner B, Reinstrup P. Acidosis impairs the coagulation: a Thromboelastographic Study. J Trauma. 2006; 61(3):624-628.
67. Hansen MK, Jensen MK, Andersen C. Uncontrollable bleeding in a patient with head trauma treated with blood component therapy guided by thromboelastography. Ugeskr Laeger. 2006;168: 3535-3536.
68. Grashey R, Mathonia P, Mutschler W, Heindl B. Perioperative coagulation management controlled by thromboelastography. clinical implementation illustrated by reference to a case of acquired coagulopathy following aortic stab injury. Unfallchirug. 2007; 110:259 -263.