-
1
-
-
84940447040
-
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
-
Global Burden of Disease Study. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;386:743–800.
-
(2015)
Lancet
, vol.386
, pp. 743-800
-
-
-
3
-
-
0242410368
-
Lost productive time and cost due to common pain conditions in the US workforce
-
Stewart WF, Ricci JA, Chee E, et al. Lost productive time and cost due to common pain conditions in the US workforce. JAMA 2003;290:2443–2454.
-
(2003)
JAMA
, vol.290
, pp. 2443-2454
-
-
Stewart, W.F.1
Ricci, J.A.2
Chee, E.3
-
5
-
-
76549095208
-
Current practice and future directions in the management of migraine: acute and preventive
-
Goadsby PJ, Sprenger T. Current practice and future directions in the management of migraine: acute and preventive. Lancet Neurol 2010;9:285–298.
-
(2010)
Lancet Neurol
, vol.9
, pp. 285-298
-
-
Goadsby, P.J.1
Sprenger, T.2
-
6
-
-
34247120060
-
Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study
-
Diener HC, Bussone G, Van Oene JC, et al. Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia 2007;27:814–823.
-
(2007)
Cephalalgia
, vol.27
, pp. 814-823
-
-
Diener, H.C.1
Bussone, G.2
Van Oene, J.C.3
-
7
-
-
77957922955
-
CGRP and its receptors provide new insights into migraine pathophysiology
-
Ho TW, Edvinsson L, Goadsby PJ. CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol 2010;6:573–582.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 573-582
-
-
Ho, T.W.1
Edvinsson, L.2
Goadsby, P.J.3
-
8
-
-
84947032547
-
Incredible progress in migraine for an era of better care
-
Goadsby PJ. Incredible progress in migraine for an era of better care. Nat Rev Neurol 2015;11:621–622.
-
(2015)
Nat Rev Neurol
, vol.11
, pp. 621-622
-
-
Goadsby, P.J.1
-
9
-
-
0029907006
-
Sumatriptan can inhibit trigeminal afferents by an exclusively neural mechanism
-
Hoskin KL, Kaube H, Goadsby PJ. Sumatriptan can inhibit trigeminal afferents by an exclusively neural mechanism. Brain 1996;119:1419–1428.
-
(1996)
Brain
, vol.119
, pp. 1419-1428
-
-
Hoskin, K.L.1
Kaube, H.2
Goadsby, P.J.3
-
10
-
-
0032765014
-
Stimulation of the middle meningeal artery leads to Fos expression in the trigeminocervical nucleus: a comparative study of monkey and cat
-
Hoskin KL, Zagami A, Goadsby PJ. Stimulation of the middle meningeal artery leads to Fos expression in the trigeminocervical nucleus: a comparative study of monkey and cat. J Anat 1999;194:579–588.
-
(1999)
J Anat
, vol.194
, pp. 579-588
-
-
Hoskin, K.L.1
Zagami, A.2
Goadsby, P.J.3
-
11
-
-
33748641238
-
Animal models of migraine. Looking at the component parts of a complex disorder
-
Bergerot A, Holland PR, Akerman S, et al. Animal models of migraine. Looking at the component parts of a complex disorder. Eur J Neurosci 2006;24:1517–1534.
-
(2006)
Eur J Neurosci
, vol.24
, pp. 1517-1534
-
-
Bergerot, A.1
Holland, P.R.2
Akerman, S.3
-
12
-
-
0036462446
-
Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives
-
Gasparini F, Kuhn R, Pin JP. Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives. Curr Opin Pharmacol 2002;2:43–49.
-
(2002)
Curr Opin Pharmacol
, vol.2
, pp. 43-49
-
-
Gasparini, F.1
Kuhn, R.2
Pin, J.P.3
-
13
-
-
0030995878
-
Pharmacology and functions of metabotropic glutamate receptors
-
Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 1997;37:205–237.
-
(1997)
Annu Rev Pharmacol Toxicol
, vol.37
, pp. 205-237
-
-
Conn, P.J.1
Pin, J.P.2
-
14
-
-
14944372499
-
The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons
-
Mao L, Yang L, Tang Q, et al. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci 2005;25:2741–2752.
-
(2005)
J Neurosci
, vol.25
, pp. 2741-2752
-
-
Mao, L.1
Yang, L.2
Tang, Q.3
-
15
-
-
0032955976
-
Trigeminovascular nociceptive transmission involves N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors
-
Storer RJ, Goadsby PJ. Trigeminovascular nociceptive transmission involves N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors. Neuroscience 1999;90:1371–1376.
-
(1999)
Neuroscience
, vol.90
, pp. 1371-1376
-
-
Storer, R.J.1
Goadsby, P.J.2
-
16
-
-
0035980471
-
The periaqueductal gray matter modulates trigeminovascular input: a role in migraine?
-
Knight YE, Goadsby PJ. The periaqueductal gray matter modulates trigeminovascular input: a role in migraine? Neuroscience 2001;106:793–800.
-
(2001)
Neuroscience
, vol.106
, pp. 793-800
-
-
Knight, Y.E.1
Goadsby, P.J.2
-
17
-
-
0032996425
-
Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis
-
Mitsikostas DD, Sanchez del Rio M, Waeber C, et al. Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis. Br J Pharmacol 1999;127:623–630.
-
(1999)
Br J Pharmacol
, vol.127
, pp. 623-630
-
-
Mitsikostas, D.D.1
Sanchez del Rio, M.2
Waeber, C.3
-
18
-
-
84892168474
-
Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks
-
Gomez-Mancilla B, Brand R, Jurgens TP, et al. Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks. Cephalalgia 2014;34:103–113.
-
(2014)
Cephalalgia
, vol.34
, pp. 103-113
-
-
Gomez-Mancilla, B.1
Brand, R.2
Jurgens, T.P.3
-
19
-
-
2342483183
-
LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine
-
Sang CN, Ramadan NM, Wallihan RG, et al. LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Cephalalgia 2004;24:596–602.
-
(2004)
Cephalalgia
, vol.24
, pp. 596-602
-
-
Sang, C.N.1
Ramadan, N.M.2
Wallihan, R.G.3
-
20
-
-
61849083297
-
Innovative drug development for headache disorders: glutamate
-
In, Olesen J, Ramadan N, eds., Oxford, Oxford University Press
-
Johnson KW, Nisenbaum ES, Johnson MP, et al. Innovative drug development for headache disorders: glutamate. In: Olesen J, Ramadan N, eds. Innovative drug development for headache disorders. Oxford: Oxford University Press, 2008. p. 185–194.
-
(2008)
Innovative drug development for headache disorders
, pp. 185-194
-
-
Johnson, K.W.1
Nisenbaum, E.S.2
Johnson, M.P.3
-
21
-
-
0026716350
-
Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat
-
Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J Comp Neurol 1992;322:121–135.
-
(1992)
J Comp Neurol
, vol.322
, pp. 121-135
-
-
Shigemoto, R.1
Nakanishi, S.2
Mizuno, N.3
-
22
-
-
0027378595
-
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
-
Shigemoto R, Nomura S, Ohishi H, et al. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 1993;163:53–57.
-
(1993)
Neurosci Lett
, vol.163
, pp. 53-57
-
-
Shigemoto, R.1
Nomura, S.2
Ohishi, H.3
-
23
-
-
79952787066
-
Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease
-
Zerbib F, Bruley des Varannes S, Roman S, et al. Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011;33:911–921.
-
(2011)
Aliment Pharmacol Ther
, vol.33
, pp. 911-921
-
-
Zerbib, F.1
Bruley des Varannes, S.2
Roman, S.3
-
24
-
-
77952473377
-
Glutamatergic fine tuning with ADX-10059- a novel therapeutic approach for migraine?
-
Marin JCA, Goadsby PJ. Glutamatergic fine tuning with ADX-10059- a novel therapeutic approach for migraine? Expert Opin Emerg Drugs 2010;19:555–561.
-
(2010)
Expert Opin Emerg Drugs
, vol.19
, pp. 555-561
-
-
Marin, J.C.A.1
Goadsby, P.J.2
-
25
-
-
84883731858
-
Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and ‘triptan’ receptors: implications in migraine
-
Akerman S, Holland PR, Lasalandra M, Goadsby PJ. Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and ‘triptan’ receptors: implications in migraine. J Neurosci 2013;33:14869–14877.
-
(2013)
J Neurosci
, vol.33
, pp. 14869-14877
-
-
Akerman, S.1
Holland, P.R.2
Lasalandra, M.3
Goadsby, P.J.4
-
26
-
-
84868151004
-
Acid-sensing ion channel-1: a novel therapeutic target for migraine with aura
-
Holland PR, Akerman S, Andreou AP, et al. Acid-sensing ion channel-1: a novel therapeutic target for migraine with aura. Ann Neurol 2012;72:559–563.
-
(2012)
Ann Neurol
, vol.72
, pp. 559-563
-
-
Holland, P.R.1
Akerman, S.2
Andreou, A.P.3
-
27
-
-
0345671971
-
The International Classification of Headache Disorders (second edition)
-
Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders (second edition). Cephalalgia 2004;24(Suppl 1):1–160.
-
(2004)
Cephalalgia
, vol.24
, pp. 1-160
-
-
-
28
-
-
85046235609
-
-
ed., Geneva, International Conference on Harmonisation
-
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. European Medicines Agency, ed. Statistical principles for clinical trials. Geneva: International Conference on Harmonisation, 1998.
-
(1998)
Statistical principles for clinical trials
-
-
-
29
-
-
0033758569
-
Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
-
Walker K, Bowes M, Panesar M, et al. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. Neuropharmacology 2001;40:1–9.
-
(2001)
Neuropharmacology
, vol.40
, pp. 1-9
-
-
Walker, K.1
Bowes, M.2
Panesar, M.3
-
30
-
-
4644312225
-
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
-
Kawasaki Y, Kohno T, Zhuang ZY, et al. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 2004;24:8310–8321.
-
(2004)
J Neurosci
, vol.24
, pp. 8310-8321
-
-
Kawasaki, Y.1
Kohno, T.2
Zhuang, Z.Y.3
-
31
-
-
84885953432
-
Peripheral metabotropic glutamate receptor subtype 5 contributes to inflammation-induced hypersensitivity of the rat temporomandibular joint
-
Li B, Lu L, Tan X, et al. Peripheral metabotropic glutamate receptor subtype 5 contributes to inflammation-induced hypersensitivity of the rat temporomandibular joint. J Mol Neurosci 2013;51:710–718.
-
(2013)
J Mol Neurosci
, vol.51
, pp. 710-718
-
-
Li, B.1
Lu, L.2
Tan, X.3
-
32
-
-
0035094199
-
Peripheral group I metabotropic glutamate receptors modulate nociception in mice
-
Bhave G, Karim F, Carlton SM, Gereau RW IV. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 2001;4:417–423.
-
(2001)
Nat Neurosci
, vol.4
, pp. 417-423
-
-
Bhave, G.1
Karim, F.2
Carlton, S.M.3
Gereau, R.W.4
-
33
-
-
84859812075
-
Efficacy and tolerability of lasmiditan, an oral 5-HT(1F) receptor agonist, for the acute treatment of migraine: a phase 2 randomised, placebo-controlled, parallel-group, dose-ranging study
-
Farkkila M, Diener HC, Geraud G, et al. Efficacy and tolerability of lasmiditan, an oral 5-HT(1F) receptor agonist, for the acute treatment of migraine: a phase 2 randomised, placebo-controlled, parallel-group, dose-ranging study. Lancet Neurol 2012;11:405–413.
-
(2012)
Lancet Neurol
, vol.11
, pp. 405-413
-
-
Farkkila, M.1
Diener, H.C.2
Geraud, G.3
-
34
-
-
57649233374
-
Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial
-
Ho TW, Ferrari MD, Dodick DW, et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 2008;372:2115–2123.
-
(2008)
Lancet
, vol.372
, pp. 2115-2123
-
-
Ho, T.W.1
Ferrari, M.D.2
Dodick, D.W.3
-
35
-
-
0035074009
-
Substance P receptor antagonists in the therapy of migraine
-
May A, Goadsby PJ. Substance P receptor antagonists in the therapy of migraine. Expert Opin Investig Drugs 2001;10:1–6.
-
(2001)
Expert Opin Investig Drugs
, vol.10
, pp. 1-6
-
-
May, A.1
Goadsby, P.J.2
-
36
-
-
61849094474
-
A randomised, single-blind, placebo-controlled, adaptive clinical trial of GW274150, a selective iNOS inhibitor, in the treatment of acute migraine
-
Palmer JE, Guillard FL, Laurijssens BE, et al. A randomised, single-blind, placebo-controlled, adaptive clinical trial of GW274150, a selective iNOS inhibitor, in the treatment of acute migraine. Cephalalgia 2009;29:124.
-
(2009)
Cephalalgia
, vol.29
, pp. 124
-
-
Palmer, J.E.1
Guillard, F.L.2
Laurijssens, B.E.3
-
37
-
-
84907964596
-
Randomized, double-blind, placebo-controlled, phase II trial of ALD403, an anti-CGRP peptide antibody in the prevention of frequent episodic migraine
-
Dodick DW, Goadsby PJ, Silberstein SD, et al. Randomized, double-blind, placebo-controlled, phase II trial of ALD403, an anti-CGRP peptide antibody in the prevention of frequent episodic migraine. Lancet Neurol 2014;13:1100–1107.
-
(2014)
Lancet Neurol
, vol.13
, pp. 1100-1107
-
-
Dodick, D.W.1
Goadsby, P.J.2
Silberstein, S.D.3
-
38
-
-
84906262129
-
CGRP monoclonal antibody LY2951742 for the prevention of migraine: a phase 2, randomized, double-blind, placebo-controlled study
-
Dodick DW, Goadsby PJ, Spierings ELH, et al. CGRP monoclonal antibody LY2951742 for the prevention of migraine: a phase 2, randomized, double-blind, placebo-controlled study. Lancet Neurol 2014;13:885–892.
-
(2014)
Lancet Neurol
, vol.13
, pp. 885-892
-
-
Dodick, D.W.1
Goadsby, P.J.2
Spierings, E.L.H.3
-
39
-
-
84944059855
-
Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study
-
Bigal ME, Dodick DW, Rapoport AM, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol 2015;14:1081–1090.
-
(2015)
Lancet Neurol
, vol.14
, pp. 1081-1090
-
-
Bigal, M.E.1
Dodick, D.W.2
Rapoport, A.M.3
-
40
-
-
84944039741
-
Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study
-
Bigal ME, Edvinsson L, Rapoport AM, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol 2015;14:1091–1100.
-
(2015)
Lancet Neurol
, vol.14
, pp. 1091-1100
-
-
Bigal, M.E.1
Edvinsson, L.2
Rapoport, A.M.3
-
41
-
-
84960476959
-
Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial
-
Sun H, Dodick DW, Silberstein S, et al. Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 2016;15:382–390.
-
(2016)
Lancet Neurol
, vol.15
, pp. 382-390
-
-
Sun, H.1
Dodick, D.W.2
Silberstein, S.3
-
42
-
-
84906314912
-
Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias
-
Rascol O, Fox S, Gasparini F, et al. Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias. Parkinsonism Relat Disord 2014;20:947–956.
-
(2014)
Parkinsonism Relat Disord
, vol.20
, pp. 947-956
-
-
Rascol, O.1
Fox, S.2
Gasparini, F.3
-
43
-
-
0031862305
-
Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat
-
Simmons RM, Li DL, Hoo KH, et al. Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat. Neuropharmacology 1998;37:25–36.
-
(1998)
Neuropharmacology
, vol.37
, pp. 25-36
-
-
Simmons, R.M.1
Li, D.L.2
Hoo, K.H.3
-
44
-
-
0031771639
-
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans
-
Sang CN, Hostetter MP, Gracely RH, et al. AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology 1998;89:1060–1067.
-
(1998)
Anesthesiology
, vol.89
, pp. 1060-1067
-
-
Sang, C.N.1
Hostetter, M.P.2
Gracely, R.H.3
|