The use of nanoscaffolds and dendrimers in tissue engineering

Drug Discovery Today

Volumn 22, Issue 4, 2017, Pages 652-664

  Gorain, Bapi ^a   Tekade, Muktika ^b   Kesharwani, Prashant ^c   Iyer, Arun K ^d   Kalia, Kiran ^e   Tekade, Rakesh Kumar ^e  

^a LINCOLN UNIVERSITY COLLEGE   (Malaysia)

^b Technocrats Institute of Technology Pharmacy   (India)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^d WAYNE STATE UNIVERSITY   (United States)

^e NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER AHMEDABAD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRIMER; MOLECULAR SCAFFOLD; BIOMATERIAL; NANOPARTICLE;

BIOCOMPATIBILITY; BIODEGRADABILITY; CELL ADHESION; CELL FUNCTION; CELL GROWTH; ELECTROSPINNING; FREEZE DRYING; HAIR FOLLICLE; HUMAN; LEARNING; NANOFABRICATION; NANOTECHNOLOGY; NONHUMAN; REVIEW; STEM CELL; TISSUE ENGINEERING; TISSUE REGENERATION; TUMOR MICROENVIRONMENT; ANIMAL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; PROCEDURES; REGENERATION; TISSUE SCAFFOLD;

ANIMALS; BIOCOMPATIBLE MATERIALS; DENDRIMERS; DRUG DELIVERY SYSTEMS; HUMANS; NANOPARTICLES; REGENERATION; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 85014224887     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2016.12.007     Document Type: Review

References (119)

1. 1 Madonna, R., et al. Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: as biomarkers and targets for new treatments. Mech. Ageing Dev. 159 (2016), 22–30.
2. 2 Raftery, R.M., et al. Delivering nucleic-acid based nanomedicines on biomaterial scaffolds for orthopedic tissue repair: challenges, progress and future perspectives. Adv. Mater. 28 (2016), 5447–5469.
3. 3 Place, E.S., et al. Complexity in biomaterials for tissue engineering. Nat. Mater. 8 (2009), 457–470.
4. 4 Spicer, P.P., et al. Evaluation of bone regeneration using the rat critical size calvarial defect. Nat. Protoc. 7 (2012), 1918–1929.
5. 5 Law, J.X., et al. Tissue-engineered trachea: A review. Int. J. Pediatr. Otorhinolaryngol 91 (2016), 55–63.
6. 6 Saxena, R., et al. Review on organ transplantation: a social medical need. J. Crit. Rev. 3 (2016), 23–29.
7. 7 O'Leary, J.G., et al. The influence of immunosuppressive agents on the risk of de novo donor-specific hla antibody production in solid organ transplant recipients. Transplantation 100 (2016), 39–53.
8. 8 Nakamura, T., et al. Rapamycin prolongs cardiac allograft survival in a mouse model by inducing myeloid-derived suppressor cells. Am. J. Transplant. 15 (2015), 2364–2377.
9. 9 Garrod, M., Chau, D.Y.S., An overview of tissue engineering as an alternative for toxicity assessment. J. Pharm. Pharm. Sci. 19 (2016), 31–71.
10. 10 Wang, Y., et al. A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA. Chem. Commun. (Camb.) 51 (2015), 16786–16789.
11. 11 Atala, A., et al. Engineering complex tissues. Sci. Transl. Med., 4, 2012, 160rv12.
12. 12 Tibbitt, M.W., Anseth, K.S., Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng. 103 (2009), 655–663.
13. 13 Sullivan, D.C., et al. Current translational challenges for tissue engineering: 3D culture, nanotechnology, and decellularized matrices. Curr. Pathobiol. Rep. 3 (2015), 99–106.
14. 14 Coury, A.J., Expediting the transition from replacement medicine to tissue engineering. Regen. Biomater. 3 (2016), 111–113.
15. 15 Wang, Y., et al. A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA. Chem. Commun. 51 (2015), 9996–10001.
16. 16 Kaigler, D., et al. Bone engineering of maxillary sinus bone deficiencies using enriched cd90+ stem cell therapy: a randomized clinical trial. J. Bone Miner. Res. 30 (2015), 1206–1216.
17. 17 Shinoka, T., Development of a tissue-engineering vascular graft for use in congenital heart surgery. EBioMedicine 1 (2014), 12–13.
18. 18 Udelsman, B.V., et al. Tissue engineering of blood vessels in cardiovascular disease: moving towards clinical translation. Heart 99 (2013), 454–460.
19. 19 Abdel-Sayed, P., et al. Anti-microbial dendrimers against multidrug-resistant P. aeruginosa enhance the angiogenic effect of biological burn-wound bandages. Sci. Rep. 6 (2016), 1857–1869.
20. 20 Caspi, O., et al. Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ. Res. 100 (2007), 263–272.
21. 21 Caplan, A.I., Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J. Cell. Physiol. 213 (2007), 341–347.
22. 22 Davies, O.G., et al. A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue, bone marrow and dental pulp. J. Bone Miner. Metab. 33 (2015), 371–382.
23. 23 Weinand, C., et al. Optimizing biomaterials for tissue engineering human bone using mesenchymal stem cells. Plast. Reconstr. Surg. 137 (2016), 854–863.
24. 24 Freiman, A., et al. Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro. Stem Cell Res. Ther. 71 (2016), 300–310.
25. 25 Guven, S., et al. Multiscale assembly for tissue engineering and regenerative medicine. Trends Biotechnol. 33 (2015), 269–279.
26. 26 Smith, B.D., Grande, D.A., The current state of scaffolds for musculoskeletal regenerative applications. Nat. Rev. Rheumatol. 11 (2015), 213–222.
27. 27 Joshi, N., Grinstaff, M., Applications of dendrimers in tissue engineering. Curr. Top. Med. Chem. 8 (2008), 1225–1236.
28. 28 Cheung, A.T.M., et al. Biomimetic scaffolds for tissue engineering biomimetic scaffolds for skin and skeletal tissue engineering. J. Biotechnol. Biomater., 5, 2015, 191.
29. 29 Cheung, A.T.M., et al. Biomimetic scaffolds for skin and skeletal tissue engineering. J. Biotechnol. Biomater., 5, 2015, 191.
30. 30 Santo, V.E., et al. Controlled release strategies for bone, cartilage, and osteochondral engineering – Part I: Recapitulation of native tissue healing and variables for the design of delivery systems. Tissue Eng. Part B: Rev. 19 (2013), 308–326.
31. 31 Glowacki, J., Mizuno, S., Collagen scaffolds for tissue engineering. Biopolymers [Internet] 89 (2008), 338–344.
32. 32 Monteiro, N., et al. Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering. Regen. Ther. 1 (2015), 109–118.
33. ® composite tubular foam scaffolds for tissue engineering applications. Mater. Sci. Eng. C 25 (2005), 23–31.
34. 34 Habraken, W.J.E.M., et al. Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 59 (2007), 234–248.
35. 35 Luz, G.M., Mano, J.F., Chitosan/bioactive glass nanoparticles composites for biomedical applications. Biomed. Mater., 7, 2012, 054104.
36. 36 Salinas, A.J., et al. A tissue engineering approach based on the use of bioceramics for bone repair. Biomater. Sci., 1, 2012 686–651.
37. 37 Yang, S., et al. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng. 7 (2001), 679–689.
38. 38 Silva, M.M.C.G., et al. The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds. Biomaterials 27 (2006), 5909–5917.
39. 39 Loh, Q.L., Choong, C., Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size. Tissue Eng. Part B: Rev. 19 (2013), 485–502.
40. 40 Rose, F.R., et al. In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel. Biomaterials 25 (2004), 5507–5514.
41. 41 Quaglia, F., Bioinspired tissue engineering: the great promise of protein delivery technologies. Int. J. Pharm. 364 (2008), 281–297.
42. 42 Stevens, M.M., George, J.H., Exploring and engineering the cell surface interface. Science 310 (2005), 1135–1138.
43. 43 Kulkarni, M., et al. Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends Biotechnol. 28 (2010), 28–36.
44. 44 Abbah, S.A., et al. Harnessing hierarchical nano- and micro-fabrication technologies for musculoskeletal tissue engineering. Adv. Healthc. Mater. 4 (2015), 2488–2499.
45. 45 Jakab, K., et al. Tissue engineering by self-assembly and bio-printing of living cells. Biofabrication, 2, 2010, 022001.
46. 46 Wang, M.C., et al. Collagen fibres with improved strength for the repair of soft tissue injuries. Biomaterials 15 (1994), 507–512.
47. 47 Zeugolis, D.I., et al. Extruded collagen-polyethylene glycol fibers for tissue engineering applications. J. Biomed. Mater. Res. B: Appl. Biomater. 85 (2008), 343–352.
48. 48 Alfredo Uquillas, J., et al. Genipin crosslinking elevates the strength of electrochemically aligned collagen to the level of tendons. J. Mech. Behav. Biomed. Mater. 15 (2012), 176–189.
49. 49 Torbet, J., Ronzière, M.C., Magnetic alignment of collagen during self-assembly. Biochem. J. 219 (1984), 1057–1059.
50. 50 Caliari, S.R., Harley, B.A.C., Structural and biochemical modification of a collagen scaffold to selectively enhance msc tenogenic, chondrogenic, and osteogenic differentiation. Adv. Healthc. Mater. 3 (2014), 1086–1096.
51. 51 Wu, X., et al. Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method. Acta Biomater. 6 (2010), 1167–1177.
52. 52 Hutmacher, D.W., et al. Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol. 22 (2004), 354–362.
53. 53 Mota, C., et al. Additive manufacturing techniques for the production of tissue engineering constructs. J. Tissue Eng. Regen. Med. 9 (2015), 174–190.
54. 54 Townsend-Nicholson, A., Jayasinghe, S.N., Cell electrospinning: a unique biotechnique for encapsulating living organisms for generating active biological microthreads/scaffolds. Biomacromolecules 7 (2006), 3364–3369.
55. 55 Jayasinghe, S.N., et al. Electrohydrodynamic jet processing: an advanced electric-field-driven jetting phenomenon for processing living cells. Small 2 (2006), 216–219.
56. 56 Lannutti, J., et al. Electrospinning for tissue engineering scaffolds. Mater. Sci. Eng. C 27 (2007), 504–509.
57. 57 Jayasinghe, S.N., Cell electrospinning: a novel tool for functionalising fibres, scaffolds and membranes with living cells and other advanced materials for regenerative biology and medicine. Analyst 138 (2013), 2215–2223.
58. 58 Jayasinghe, S.N., Bio-electrosprays: from bio-analytics to a generic tool for the health sciences. Analyst 136 (2011), 878–890.
59. 59 Liu, H., et al. Electrospinning of nanofibers for tissue engineering applications. J. Nanomater. 2013 (2013), 1–11.
60. 60 Liu, S., et al. Tendon healing and anti-adhesion properties of electrospun fibrous membranes containing bFGF loaded nanoparticles. Biomaterials 34 (2013), 4690–4701.
61. 61 English, A., et al. Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions. J. Mater. Sci. Mater. Med. 23 (2012), 137–148.
62. 62 Bettinger, C.J., et al. Enhancement of in vitro capillary tube formation by substrate nanotopography. Adv. Mater. 20 (2008), 99–103.
63. 63 Oh, S., et al. Stem cell fate dictated solely by altered nanotube dimension. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 2130–2135.
64. 64 Chen, F.-M., Liu, X., Advancing biomaterials of human origin for tissue engineering. Prog. Polym. Sci. 53 (2016), 86–168.
65. 65 Goldberg, M., et al. Nanostructured materials for applications in drug delivery and tissue engineering. J. Biomater. Sci. Polym. Ed. 18 (2007), 241–268.
66. 66 Murugan, R., Ramakrishna, S., Development of nanocomposites for bone grafting. Compos. Sci. Technol. 65 (2005), 2385–2406.
67. 67 Edwards, S.L., et al. Carbon nanotubes in scaffolds for tissue engineering. Expert Rev. Med. Devices 6 (2009), 499–505.
68. 68 Seunarine, K., et al. Biodegradable polymer tubes with lithographically controlled 3D micro- and nanotopography. Microelectron. Eng. 85 (2008), 1350–1354.
69. 69 Lee, J.S., et al. Controlled dual release of basic fibroblast growth factor and indomethacin from heparin-conjugated polymeric micelle. Int. J. Pharm. 346 (2008), 57–63.
70. 70 Park, J.S., et al. In vitro and in vivo chondrogenesis of rabbit bone marrow-derived stromal cells in fibrin matrix mixed with growth factor loaded in nanoparticles. Tissue Eng. Part A 15 (2009), 2163–2175.
71. 71 Jain, N.K., Tekade, R.K., Dendrimers for enhanced drug solubilization. Douroumis, Dionysios, Fahr, Alfred, (eds.) Drug Delivery Strategies for Poorly Water-Soluble Drugs, 2013, John Wiley & Sons, 373–409.
72. 72 Ghanghoria, R., et al. Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel. Nanomedicine (Lond.) 11 (2016), 797–816.
73. 73 Sharma, P.A., et al. Nanomaterial based approaches for the diagnosis and therapy of cardiovascular diseases. Curr. Pharm. Des. 21 (2015), 4465–4478.
74. 74 Dwivedi, P., et al. Nanoparticulate carrier mediated intranasal delivery of insulin for the restoration of memory signaling in Alzheimer's disease. Curr. Nanosci. 9 (2013), 46–55.
75. 75 Soni, N., et al. Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. J. Colloid Interface Sci. 481 (2016), 107–116.
76. 76 Wahajuddin, A.S., Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int. J. Nanomedicine 7 (2012), 3445–3471.
77. 77 Moeendarbari, S., et al. Theranostic nanoseeds for efficacious internal radiation therapy of unresectable solid tumors. Sci. Rep. 6 (2016), 97–118.
78. 78 Choudhury, H., et al. Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform. Int. J. Pharm. 460 (2014), 131–143.
79. 79 Youngren, S.R., et al. STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells. Biomed Res. Int., 2013, 1–13.
80. 80 Chopdey, P.K., et al. Glycyrrhizin conjugated dendrimer and multi-walled carbon nanotubes for liver specific delivery of doxorubicin. J. Nanosci. Nanotechnol. 15 (2015), 1088–1100.
81. 81 Fernández-Urrusuno, R., et al. Effect of polymeric nanoparticle administration on the clearance activity of the mononuclear phagocyte system in mice. J. Biomed. Mater. Res. 31 (1996), 401–408.
82. 82 Rolland, A., et al. Blood clearance and organ distribution of intravenously administered polymethacrylic nanoparticles in mice. J. Pharm. Sci. 78 (1989), 481–484.
83. 83 Goenka, S., et al. Graphene-based nanomaterials for drug delivery and tissue engineering. J. Control. Release 173 (2014), 75–88.
84. 84 Kaga, S., et al. Dendrimers and dendrons as versatile building blocks for the fabrication of functional hydrogels. Molecules, 21, 2016, 497.
85. 85 Wang, Y., et al. A novel poly(amido amine)-dendrimer-based hydrogel as a mimic for the extracellular matrix. Adv. Mater. 26 (2014), 4163–4167.
86. 86 Maheshwari, R., et al. Nanocarriers assisted sirna gene therapy for the management of cardiovascular disorders. Curr. Pharm. Des. 21 (2015), 4427–4440.
87. 87 Tekade, R.K., et al. Abstract 3680: albumin–chitosan hybrid onconase nanocarriers for mesothelioma therapy. Cancer Res., 75, 2015, 3680.
88. 88 Tekade, R.K., et al. RNAi-combined nano-chemotherapeutics to tackle resistant tumors. Drug Discov. Today 21 (2016), 1761–1774.
89. 89 Kesharwani, P., et al. Evaluation of dendrimer safety and efficacy through cell line studies. Curr. Drug Targets 12 (2011), 1478–1497.
90. 90 Kesharwani, P., et al. Cancer targeting potential of some ligand-anchored poly(propylene imine) dendrimers: a comparison. Nanomedicine 7 (2011), 295–304.
91. 91 Kesharwani, P., et al. Dendrimer generational nomenclature: the need to harmonize. Drug Discov. Today 20 (2015), 497–499.
92. 92 Jain, S., et al. One platform comparison of solubilization potential of dendrimer with some solubilizing agents. Drug Dev. Ind. Pharm. 41 (2015), 722–727.
93. 93 Tekade, R.K., et al. Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics. J. Microencapsul. 26 (2009), 287–296.
94. 94 Tekade, R.K., et al. Dendrimer-stabilized smart-nanoparticle (DSSN) platform for targeted delivery of hydrophobic antitumor therapeutics. Pharm. Res. 32 (2015), 910–928.
95. 95 Kesharwani, P., et al. Generation dependent safety and efficacy of folic acid conjugated dendrimer based anticancer drug formulations. Pharm. Res. 32 (2015), 1438–1450.
96. 96 Mody, N., et al. Dendrimer, liposomes, carbon nanotubes and PLGA nanoparticles: one platform assessment of drug delivery potential. AAPS PharmSciTech, 15, 2014, 388.
97. 97 Prajapati, R.N., et al. Dendimer-mediated solubilization, formulation development and in vitro–in vivo assessment of piroxicam. Mol. Pharm. 6 (2009), 940–950.
98. 98 Nanjwade, B.K., et al. Dendrimers: emerging polymers for drug-delivery systems. Eur. J. Pharm. Sci. 38 (2009), 185–196.
99. 99 Kesharwani, P., et al. Formulation development and in vitro–in vivo assessment of the fourth-generation PPI dendrimer as a cancer-targeting vector. Nanomedicine (Lond.) 9 (2014), 2291–2308.
100. 100 Kesharwani, P., et al. Generation dependent cancer targeting potential of poly(propyleneimine) dendrimer. Biomaterials 35 (2014), 5539–5548.
101. 101 Gajbhiye, V., et al. Dendrimers as therapeutic agents: a systematic review. J. Pharm. Pharmacol. 61 (2009), 989–1003.
102. 102 Tekade, R.K., Editorial: contemporary siRNA therapeutics and the current state-of-art. Curr. Pharm. Des. 21 (2015), 4527–4528.
103. 103 Gajbhiye, V., et al. PEGylated PPI dendritic architectures for sustained delivery of H2 receptor antagonist. Eur. J. Med. Chem. 44 (2009), 1155–1166.
104. 104 Ghobril, C., et al. Recent advances in dendritic macromonomers for hydrogel formation and their medical applications. Biomacromolecules 17 (2016), 1235–1252.
105. 105 Dhakad, R.S., et al. Cancer targeting potential of folate targeted nanocarrier under comparative influence of tretinoin and dexamethasone. Curr. Drug Deliv. 10 (2013), 477–491.
106. 106 Desai, P.N., et al. Synthesis and characterization of photocurable polyamidoamine dendrimer hydrogels as a versatile platform for tissue engineering and drug delivery. Biomacromolecules 11 (2010), 666–673.
107. 107 Ren, X., et al. Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications. Chem. Soc. Rev. 44 (2015), 3754–3772.
108. 108 Jiang, L., et al. The effects of an RGD-PAMAM dendrimer conjugate in 3D spheroid culture on cell proliferation, expression and aggregation. Biomaterials 34 (2013), 2665–2673.
109. 109 Oliveira, J.M., et al. The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles. Biomaterials 30 (2009), 804–813.
110. 110 Murugan, E., et al. New dendrimer functionalized multi-walled carbon nanotube hybrids for bone tissue engineering. RSC Adv. 4 (2014), 242–243.
111. 111 Church, D., et al. Burn wound infections. Clin. Microbiol. Rev. 19 (2006), 403–434.
112. 112 Duan, X., Sheardown, H., Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. Biomaterials 27 (2006), 4608–4617.
113. 113 Alldredge, O.C., Krachmer, J.H., Clinical types of corneal transplant rejection. Their manifestations, frequency, preoperative correlates, and treatment. Arch. Ophthalmol. 99 (1981), 599–604.
114. 114 Oliva, N., et al. Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia. Sci. Transl. Med., 7, 2015, 272ra11.
115. 115 Kwon, M.J., et al. Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer. J. Gene Med. 14 (2012), 272–278.
116. 116 Fernandes, E.G.R., et al. Antithrombogenic properties of bioconjugate streptokinase-polyglycerol dendrimers. J. Mater. Sci. Mater. Med. 17 (2006), 105–111.
117. 117 Feng, G., et al. Elastic light tunable tissue adhesive dendrimers. Macromol. Biosci. 16 (2016), 1072–1082.
118. 118 Zhong, Q., et al. Conjugation to poly (amidoamine) dendrimers and pulmonary delivery reduce cardiac accumulation and enhance antitumor activity of doxorubicin in lung metastasis. Mol. Pharm. 13 (2016), 2363–2375.
119. [119] Tekade, R.K., Dutta, T., Tyagi, A., Bharti, A.C., Das, B.C., Jain, N.K., Surface engineered dendrimers for dual drug delivery: A receptor up-regulation and enhanced cancer targeting strategy. J. Drug Targeting 16 (2008), 758–772.