Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering

Regenerative Therapy

Volumn 1, Issue , 2015, Pages 109-118

  Monteiro, Nelson ^a   Martins, Albino ^a   Reis, Rui L ^a   Neves, Nuno M ^a  

^a UNIVERSITY OF MINHO   (Portugal)

Author keywords

Bioactive agents; Delivery systems; Mesenchymal stem cells; Nanoparticles; Scaffolds

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR; LIPOSOME; MACROGOL; NANOPARTICLE; POLYCAPROLACTONE; POLYGLACTIN; POLYLACTIC ACID; POLYLACTIDE; SOMATOMEDIN C; TRANSCRIPTION FACTOR RUNX2;

BIOCOMPATIBILITY; BIODEGRADABILITY; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTROSPINNING; IMMOBILIZATION; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; REVIEW; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE SCAFFOLD; TREATMENT OUTCOME;

EID: 84970919073     PISSN: None     EISSN: 23523204     Source Type: Journal    
DOI: 10.1016/j.reth.2015.05.004     Document Type: Review

References (152)

1. Santo V.E., Gomes M.E., Mano J.F., Reis R.L. From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering. Nanomed 2012, 7:1045-1066.
2. Liao S., Chan C.K., Ramakrishna S. Stem cells and biomimetic materials strategies for tissue engineering. Mater Sci Eng C Biomimetic Supramol Syst 2008, 28:1189-1202.
3. Chung B.G., Kang L., Khademhosseini A. Micro- and nanoscale technologies for tissue engineering and drug discovery applications. Expert Opin Drug Discov 2007, 2:1653-1668.
4. Dvir T., Timko B.P., Kohane D.S., Langer R. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol 2011, 6:13-22.
5. Ma P.X. Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 2008, 60:184-198.
6. Quaglia F. Bioinspired tissue engineering: the great promise of protein delivery technologies. Int J Pharm 2008, 364:281-297.
7. Stevens M.M., George J.H. Exploring and engineering the cell surface interface. Science 2005, 310:1135-1138.
8. Santo V.E., Sato K., Ratanavaraporn J., Gomes M.E., Mano J.F., Reis R.L., et al. Enhanced orthotopic bone regeneration promoted by intracellular delivery of dexamethasone. J Tissue Eng Regen Med 2012, 6:330.
9. Santo V.E., Duarte A.R.C., Popa E.G., Gomes M.E., Mano J.F., Reis R.L. Enhancement of osteogenic differentiation of human adipose derived stem cells by the controlled release of platelet lysates from hybrid scaffolds produced by supercritical fluid foaming. J Control Release 2012, 162:19-27.
10. Kim B.Y.S., Rutka J.T., Chan W.C.W. Nanomedicine. N Engl J Med 2010, 363:2434-2443.
11. Hillaireau H., Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell Mol Life Sci 2009, 66:2873-2896.
12. Shi J., Votruba A.R., Farokhzad O.C., Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 2010, 10:3223-3230.
13. Liu Z., Jiao Y., Wang Y., Zhou C., Zhang Z. Polysaccharides-based nanoparticles as drug delivery systems. Adv Drug Deliv Rev 2008, 60:1650-1662.
14. Zhang S.F., Uludag H. Nanoparticulate systems for growth factor delivery. Pharm Res 2009, 26:1561-1580.
15. Banerjee R. Liposomes: applications in medicine. J Biomater Appl 2001, 16:3-21.
16. Monteiro N., Martins A., Reis R.L., Neves N.M. Liposomes in tissue engineering and regenerative medicine. J R Soc Interface 2014, 11. [ahead of print].
17. Mozafari M.R. Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett 2005, 10:711-719.
18. Matuschek E., Brown D.F.J., Kahlmeter G. Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories. Clin Microbiol Infect 2014, 20:O255-O266.
19. Yang L., Webster T.J. Nanotechnology controlled drug delivery for treating bone diseases. Expert Opin Drug Deliv 2009, 6:851-864.
20. Pinto Reis C., Neufeld R.J., Ribeiro A.J., Veiga F., Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnol Biol Med 2006, 2:8-21.
21. Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., Rudzinski W.E. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001, 70:1-20.
22. Adams M.L., Lavasanifar A., Kwon G.S. Amphiphilic block copolymers for drug delivery. J Pharm Sci 2003, 92:1343-1355.
23. Gillies E.R., Fréchet J.M.J. Dendrimers and dendritic polymers in drug delivery. Drug Discov Today 2005, 10:35-43.
24. Lee C.C., MacKay J.A., Frechet J.M.J., Szoka F.C. Designing dendrimers for biological applications. Nat Biotechnol 2005, 23:1517-1526.
25. Adler A.F., Leong K.W. Emerging links between surface nanotechnology and endocytosis: Impact on nonviral gene delivery. Nano Today 2010, 5:553-569.
26. Wang G., Uludag H. Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles. Expert Opin Drug Deliv 2008, 5:499-515.
27. Fang J., Nakamura H., Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev 2011, 63:136-151.
28. Bertrand N., Wu J., Xu X., Kamaly N., Farokhzad O.C. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev 2014, 66:2-25.
29. Yin H., Liao L., Fang J. Enhanced permeability and retention (EPR) effect based tumor targeting: the concept, application and prospect. JSM Clin Oncol Res 2014, 2.
30. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46:6387-6392.
31. Rothenfluh D.A., Bermudez H., O'Neil C.P., Hubbell J.A. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater 2008, 7:248-254.
32. Garnier B., Tan S., Gounou C., Brisson A.R., Laroche-Traineau J., Jacobin-Valat M.-J., et al. Development of a platform of antibody-presenting liposomes. Biointerphases 2012, 7:11.
33. Gomes-da-Silva L.C., Fonseca N.A., Moura V., de Lima M.C.P., Simoes S., Moreira J.N. Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges. Accounts Chem Res 2012, 45:1163-1171.
34. Motornov M., Roiter Y., Tokarev I., Minko S. Stimuli-responsive nanoparticles, nanogels and capsules for integrated multifunctional intelligent systems. Prog Polym Sci 2010, 35:174-211.
35. Ganta S., Devalapally H., Shahiwala A., Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Release 2008, 126:187-204.
36. Moura V., Lacerda M., Figueiredo P., Corvo M.L., Cruz M.E.M., Soares R., et al. Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer. Breast Cancer Res Treat 2012, 133:61-73.
37. Bessa P.C., Machado R., Nurnberger S., Dopler D., Banerjee A., Cunha A.M., et al. Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs. J Control Release 2010, 142:312-318.
38. Herbst S.M., Klegerman M.E., Kim H., Qi J., Shelat H., Wassler M., et al. Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1. Mol Pharm 2009, 7:3-11.
39. Tanaka H., Sugita T., Yasunaga Y., Shimose S., Deie M., Kubo T., et al. Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model. J Biomed Mater Res A 2005, 73:255-263.
40. Matsuo T., Sugita T., Kubo T., Yasunaga Y., Ochi M., Murakami T. Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. J Biomed Mater Res A 2003, 66:747-754.
41. Dai Y.-Q., Qin G., Geng S.-Y., Yang B., Xu Q., Wang J.-Y. Photo-responsive release of ascorbic acid and catalase in CDBA-liposome for commercial application as a sunscreen cosmetic. RSC Adv 2012, 2:3340-3346.
42. Zhang J., Wu L., Chan H.-K., Watanabe W. Formation, characterization, and fate of inhaled drug nanoparticles. Adv Drug Deliv Rev 2011, 63:441-455.
43. Wu L., Zhang J., Watanabe W. Physical and chemical stability of drug nanoparticles. Adv Drug Deliv Rev 2011, 63:456-469.
44. Sohaebuddin S.K., Thevenot P.T., Baker D., Eaton J.W., Tang L. Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol 2010, 7.
45. Fischer H.C., Chan W.C.W. Nanotoxicity: the growing need for in vivo study. Curr Opin Biotechnol 2007, 18:565-571.
46. Monopoli M.P., Aberg C., Salvati A., Dawson K.A. Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol 2012, 7:779-786.
47. Pighinelli L., Kucharska M. Chitosan-hydroxyapatite composites. Carbohydr Polym 2013, 93:256-262.
48. Kataoka K., Harada A., Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 2001, 47:113-131.
49. Baoum A., Dhillon N., Buch S., Berkland C. Cationic surface modification of PLC nanoparticles offers sustained gene delivery to pulmonary epithelial cells. J Pharm Sci 2010, 99:2413-2422.
50. Gonçalves M.C., Mertins O., Pohlmann A.R., Silveira N.P., Guterres S.S. Chitosan coated liposomes as an innovative nanocarrier for drugs. J Biomed Nanotechnol 2012, 8:240-250.
51. Monopoli M.P., Pitek A.S., Lynch I., Dawson K.A. Formation and characterization of the nanoparticle-protein corona. Methods Mol Biol (Clifton, NJ) 2013, 1025:137-155.
52. Vetten M.A., Yah C.S., Singh T., Gulumian M. Challenges facing sterilization and depyrogenation of nanoparticles: effects on structural stability and biomedical applications. Nanomed 2014, 10:1391-1399.
53. Rabanel J.M., Aoun V., Elkin I., Mokhtar M., Hildgen P. Drug-loaded nanocarriers: passive targeting and crossing of biological barriers. Curr Med Chem 2012, 19:3070-3102.
54. Lee J.S., Bae J.W., Joung Y.K., Lee S.J., Han D.K., Park K.D. Controlled dual release of basic fibroblast growth factor and indomethacin from heparin-conjugated polymeric micelle. Int J Pharm 2008, 346:57-63.
55. Oliveira J.M., Kotobuki N., Tadokoro M., Hirose M., Mano J.F., Reis R.L., et al. Ex vivo culturing of stromal cells with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles promotes ectopic bone formation. Bone 2010, 46:1424-1435.
56. Oliveira J.M., Sousa R.A., Kotobuki N., Tadokoro M., Hirose M., Mano J.F., et al. The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles. Biomaterials 2009, 30:804-813.
57. Oliveira J.M., Kotobuki N., Marques A.P., Pirraco R.P., Benesch J., Hirose M., et al. Surface engineered carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles for intracellular targeting. Adv Funct Mater 2008, 18:1840-1853.
58. Zaki N.M., Tirelli N. Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting. Expert Opin Drug Deliv 2010, 7:895-913.
59. Sahay G., Alakhova D.Y., Kabanov A.V. Endocytosis of nanomedicines. J Control Release 2010, 145:182-195.
60. Dash B.C., Rethore G., Monaghan M., Fitzgerald K., Gallagher W., Pandit A. The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility. Biomaterials 2010, 31:8188-8197.
61. Ge Y., Zhang Y., Xia J., Ma M., He S., Nie F., et al. Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro. Colloid Surf B Biointerfaces 2009, 73:294-301.
62. Patil S., Sandberg A., Heckert E., Self W., Seal S. Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential. Biomaterials 2007, 28:4600-4607.
63. Harush-Frenkel O., Debotton N., Benita S., Altschuler Y. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. Biochem Biophys Res Commun 2007, 353:26-32.
64. Roger E., Lagarce F., Garcion E., Benoit J.P. Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. J Control Release 2009, 140:174-181.
65. Kulkarni M., Greiser U., O'Brien T., Pandit A. Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends Biotechnol 2010, 28:28-36.
66. Chung H.J., Park T.G. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Adv Drug Deliv Rev 2007, 59:249-262.
67. Dawson E., Mapili G., Erickson K., Taqvi S., Roy K. Biomaterials for stem cell differentiation. Adv Drug Deliv Rev 2008, 60:215-228.
68. Fu J., Wang Y.-K., Yang M.T., Desai R.A., Yu X., Liu Z., et al. Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods 2010, 7. 733-U95.
69. Evans N.D., Minelli C., Gentleman E., LaPointe V., Patankar S.N., Kallivretaki M., et al. Substrate stiffness affects early differentiation events in embryonic stem cells. Eur Cell Mater 2009, 18:1-13. [discussion-4].
70. Kawano T., Nakamichi Y., Fujinami S., Nakajima K., Yabu H., Shimomura M. Mechanical regulation of cellular adhesion onto honeycomb-patterned porous scaffolds by altering the elasticity of material surfaces. Biomacromolecules 2013, 14:1208-1213.
71. Engler A.J., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126:677-689.
72. Peyton S.R., Raub C.B., Keschrumrus V.P., Putnam A.J. The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells. Biomaterials 2006, 27:4881-4893.
73. Santo V.E., Gomes M.E., Mano J.F., Reis R.L. Controlled release strategies for bone, cartilage and osteochondral engineering. Part I: recapitulation of tissue healing and variables for the design of delivery systems. Tissue Eng Part B Rev 2012, 19(4):308-326.
74. Habraken W.J.E.M., Wolke J.G.C., Jansen J.A. Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev 2007, 59:234-248.
75. Luz G.M., Mano J.F. Chitosan/bioactive glass nanoparticles composites for biomedical applications. Biomed Mater 2012, 7.
76. Martins A., Reis R.L., Neves N.M. Electrospinning: processing technique for tissue engineering scaffolding. Int Mater Rev 2008, 53:257-274.
77. Hutmacher D.W., Goh J.C.H., Teoh S.H. An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singap 2001, 30:183-191.
78. Martins A., Chung S., Pedro A.J., Sousa R.A., Marques A.P., Reis R.L., et al. Hierarchical starch-based fibrous scaffold for bone tissue engineering applications. J Tissue Eng Regen Med 2009, 3:37-42.
79. Gloria A., Causa F., Russo T., Battista E., Della Moglie R., Zeppetelli S., et al. Three-dimensional poly(epsilon-caprolactone) bioactive scaffolds with controlled structural and surface properties. Biomacromolecules 2012, 13:3510-3521.
80. Gillette B.M., Rossen N.S., Das N., Leong D., Wang M.X., Dugar A., et al. Engineering extracellular matrix structure in 3D multiphase tissues. Biomaterials 2011, 32:8067-8076.
81. Kelleher C.M., Vacanti J.P. Engineering extracellular matrix through nanotechnology. J R Soc Interface 2010, 7:S717-S729.
82. Alexander C. Stimuli-responsive hydrogels - drugs take control. Nat Mater 2008, 7:767-768.
83. Ulijn R.V., Bibi N., Jayawarna V., Thornton P.D., Todd S.J., Mart R.J., et al. Bioresponsive hydrogels. Mater Today 2007, 10:40-48.
84. Kim T.G., Park T.G. Surface functionalized electrospun biodegradable nanofibers for immobilization of bioactive molecules. Biotechnol Prog 2006, 22:1108-1113.
85. Yoo H.S., Kim T.G., Park T.G. Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv Drug Deliv Rev 2009, 61:1033-1042.
86. Martins A., Pinho E.D., Faria S., Pashkuleva I., Marques A.P., Reis R.L., et al. Surface modification of electrospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance. Small 2009, 5:1195-1206.
87. Darain F., Chan W.Y., Chian K.S. Performance of surface-modified polycaprolactone on growth factor binding, release, and proliferation of smooth muscle cells. Soft Mater 2011, 9:64-78.
88. Pashkuleva I., Marques A., Vaz F., Reis R. Surface modification of starch based biomaterials by oxygen plasma or UV-irradiation. J Mater Sci Mater Med 2010, 21:21-32.
89. Mattanavee W., Suwantong O., Puthong S., Bunaprasert T., Hoven V.P., Supaphol P. Immobilization of biomolecules on the surface of electrospun polycaprolactone fibrous scaffolds for tissue engineering. ACS Appl Mater Interfaces 2009, 1:1076-1085.
90. Mori M., Uyama Y., Ikada Y. Surface modification of polyethylene fiber by graft-poymerization. J Polym Sci Part A Polymer Chem 1994, 32:1683-1690.
91. He W., Yong T., Teo W.E., Ma Z.W., Ramakrishna S. Fabrication and endothelialization of collagen-blended biodegradable polymer nanofibers: potential vascular graft for blood vessel tissue engineering. Tissue Eng 2005, 11:1574-1588.
92. Malynych S., Luzinov I., Chumanov G. Poly(vinyl pyridine) as a universal surface modifier for immobilization of nanoparticles. J Phys Chem B 2002, 106:1280-1285.
93. Zhu Y., Gao C., Liu X., He T., Shen J. Immobilization of biomacromolecules onto aminolyzed poly(L-lactic acid) toward acceleration of endothelium regeneration. Tissue Eng 2004, 10:53-61.
94. Mourtas S., Kastellorizios M., Klepetsanis P., Farsari E., Amanatides E., Mataras D., et al. Covalent immobilization of liposomes on plasma functionalized metallic surfaces. Colloid Surf B Biointerfaces 2011, 84:214-220.
95. Yoon J.J., Song S.H., Lee D.S., Park T.G. Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. Biomaterials 2004, 25:5613-5620.
96. Curran J.M., Chen R., Hunt J.A. The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Biomaterials 2006, 27:4783-4793.
97. Bengali Z., Shea L.D. Gene delivery by immobilization to cell-adhesive substrates. MRS Bull 2005, 30(9):659-662.
98. Andersen M.O., Nygaard J.V., Burns J.S., Raarup M.K., Nyengaard J.R., Bunger C., et al. siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Mol Ther 2010, 18:2018-2027.
99. De Laporte L., Shea L.D. Matrices and scaffolds for DNA delivery in tissue engineering. Adv Drug Deliv Rev 2007, 59:292-307.
100. Yamauchi F., Kato K., Iwata H. Layer-by-layer assembly of poly(ethyleneimine) and plasmid DNA onto transparent indium-tin oxide electrodes for temporally and spatially specific gene transfer. Langmuir 2005, 21:8360-8367.
101. Chan C.K., Liao S., Li B., Lareu R.R., Larrick J.W., Ramakrishna S., et al. Early adhesive behavior of bone-marrow-derived mesenchymal stem cells on collagen electrospun fibers. Biomed Mater 2009, 4. 035006.
102. Santo V.E.G.M., Mano J.F., Reis R.L. Controlled release strategies for bone, cartilage and osteochondral engineering. Part II: challenges on the evolution from single towards multiple bioactive factor delivery. Tissue Eng Part B Rev 2012, 19(4):327-352.
103. Park J.S., Yang H.N., Woo D.G., Chung H.M., Park K.H. In vitro and in vivo chondrogenesis of rabbit bone marrow-derived stromal cells in fibrin matrix mixed with growth factor loaded in nanoparticles. Tissue Eng Part A 2009, 15:2163-2175.
104. Deng C., Dong N., Shi J., Chen S., Xu L., Shi F., et al. Application of decellularized scaffold combined with loaded nanoparticles for heart valve tissue engineering in vitro. J Huazhong Univ Sci Technol Med Sci 2011, 31:88-93.
105. Pulavendran S., Thiyagarajan G. Three-dimensional scaffold containing EGF incorporated biodegradable polymeric nanoparticles for stem cell based tissue engineering applications. Biotechnol Bioprocess Eng 2011, 16:393-399.
106. Tan Q., Tang H., Hu J.G., Hu Y.R., Zhou X.M., Tao Y.M., et al. Controlled release of chitosan/heparin nanoparticle-delivered VEGF enhances regeneration of decellularized tissue-engineered scaffolds. Int J Nanomedicine 2011, 6:929-942.
107. Wang S.S., Yang M.C., Chung T.W. Liposomes/chitosan scaffold/human fibrin gel composite systems for delivering hydrophilic drugs - release behaviors of tirofiban in vitro. Drug Deliv 2008, 15:149-157.
108. Meyenburg S., Lilie H., Panzner S., Rudolph R. Fibrin encapsulated liposomes as protein delivery system - studies on the in vitro release behavior. J Control Release 2000, 69:159-168.
109. Chung T.W., Yang M.C., Tsai W.J. A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs - influences of the surface properties of liposomes and the crosslinked fibrin network. Int J Pharm 2006, 311:122-129.
110. Wang G., Babadagli M.E., Uludag H. Bisphosphonate-derivatized liposomes to control drug release from Collagen/Hydroxyapatite scaffolds. Mol Pharm 2011, 8:1025-1034.
111. Bengali Z., Pannier A.K., Segura T., Anderson B.C., Jang J.-H., Mustoe T.A., et al. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng 2005, 90:290-302.
112. Abrams M.T., Koser M.L., Seitzer J., Williams S.C., DiPietro M.A., Wang W.M., et al. Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment. Mol Ther 2010, 18:171-180.
113. Bengali Z., Rea J.C., Gibly R.F., Shea L.D. Efficacy of immobilized polyplexes and lipoplexes for substrate-mediated gene delivery. Biotechnol Bioeng 2009, 102:1679-1691.
114. De Laporte L., Yan A.L., Shea L.D. Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury. Biomaterials 2009, 30:2361-2368.
115. He C.X., Li N., Hu Y.L., Zhu X.M., Li H.J., Han M., et al. Effective gene delivery to mesenchymal stem cells based on the reverse transfection and three-dimensional cell culture system. Pharm Res 2011, 28:1577-1590.
116. Wei G., Jin Q., Giannobile W.V., Ma P.X. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007, 28:2087-2096.
117. Xing M., Zhong W., Xu X., Thomson D. Adhesion force studies of nanofibers and nanoparticles. Langmuir 2010, 26:11809-11814.
118. Yilgor P., Sousa R.A., Reis R.L., Hasirci N., Hasirci V. Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration. J Mater Sci Mater Med 2010, 21:2999-3008.
119. Jung Y., Chung Y.I., Kim S.H., Tae G., Kim Y.H., Rhie J.W. In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-beta(1) loaded fibrin-poly(lactide-caprolactone) nanoparticulate complex. Biomaterials 2009, 30:4657-4664.
120. Chen F.M., Zhang M., Wu Z.F. Toward delivery of multiple growth factors in tissue engineering. Biomaterials 2010, 31:6279-6308.
121. Gurkan U.A., Gargac J., Akkus O. The sequential production profiles of growth factors and their relations to bone volume in ossifying bone marrow explants. Tissue Eng Part A 2010, 16:2295-2306.
122. Biondi M., Ungaro F., Quaglia F., Netti P.A. Controlled drug delivery in tissue engineering. Adv Drug Deliv Rev 2008, 60:229-242.
123. Guldberg R.E. Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration. J Bone Min Res 2009, 24:1507-1511.
124. Kulkarni M., Breen A., Greiser U., O'Brien T., Pandit A. Fibrin-lipoplex system for controlled Topical delivery of multiple genes. Biomacromolecules 2009, 10:1650-1654.
125. Houchin-Ray T., Huang A., West E.R., Zelivyanskaya M., Shea L.D. Spatially patterned gene expression for guided neurite extension. J Neurosci Res 2009, 87:844-856.
126. Lim S.M., Oh S.H., Lee H.H., Yuk S.H., Im G.I., Lee J.H. Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering. J Mater Sci Mater Med 2010, 21:2593-2600.
127. Guo-ping W., Xiao-chuan H., Zhi-hui Y., Li G. Influence on the osteogenic activity of the human bone marrow mesenchymal stem cells transfected by liposome-mediated recombinant plasmid pIRES-hBMP2-hVEGF165 in vitro. Ann Plast Surg 2010, 65:80-84.
128. da Silva M.A., Martins A., Teixeira A.A., Reis R.L., Neves N.M. Impact of biological agents and tissue engineering approaches on the treatment of rheumatic diseases. Tissue Eng Part B-Rev 2010, 16:331-339.
129. Puppi D., Chiellini F., Piras A.M., Chiellini E. Polymeric materials for bone and cartilage repair. Prog Polym Sci 2010, 35:403-440.
130. Chung Y.-I., Ahn K.-M., Jeon S.-H., Lee S.-Y., Lee J.-H., Tae G. Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. J Control Release 2007, 121:91-99.
131. Nie H., Wang C.-H. Fabrication and characterization of PLGA/HAp scaffolds for delivery of BMP-2 plasmid composite DNA. J Control Release 2007, 120:111-121.
132. Hosseinkhani H., Hosseinkhani M., Gabrielson N.P., Pack D.W., Khademhosseini A., Kobayashi H. DNA nanoparticles encapsulated in 3D tissue-engineered scaffolds enhance osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res Part A 2008, 85A:47-60.
133. Park K.H., Kim H., Moon S., Na K. Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering. J Biosci Bioeng 2009, 108:530-537.
134. Yilgor P., Tuzlakoglu K., Reis R.L., Hasirci N., Hasirci V. Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials 2009, 30:3551-3559.
135. Zhang S., Doschak M.R., Uludag H. Pharmacokinetics and bone formation by BMP-2 entrapped in polyethylenimine-coated albumin nanoparticles. Biomaterials 2009, 30:5143-5155.
136. Zhang S., Kucharski C., Doschak M.R., Sebald W., Uludag H. Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery. Biomaterials 2010, 31:952-963.
137. Ratanavaraporn J., Furuya H., Tabata Y. Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration. Biomaterials 2012, 33:304-316.
138. Eibl H., Kaufmann-Kolle P. Medical application of synthetic phospholipids as liposomes and drugs. J Liposome Res 1995, 5:131-148.
139. Monteiro N., Martins A., Pires R., Faria S., Fonseca N.A., Moreira J.N., et al. Immobilization of bioactive factor-loaded liposomes at the surface of electrospun nanofibers targeting tissue engineering. Biomater Sci 2014, 2:1195-1209.
140. Monteiro N., Ribeiro D., Martins A., Faria S., Fonseca N.A., Moreira J.N., et al. Instructive nanofibrous scaffold comprising runt-related transcription factor 2 gene delivery for bone tissue engineering. ACS Nano 2014, 8:8082-8094.
141. Park J.S., Park K., Woo D.G., Yang H.N., Chung H.-M., Park K.-H. PLGA microsphere construct coated with TGF-beta 3 loaded nanoparticles for neocartilage formation. Biomacromolecules 2008, 9:2162-2169.
142. Mickova A., Buzgo M., Benada O., Rampichova M., Fisar Z., Filova E., et al. Core/Shell nanofibers with embedded liposomes as a drug delivery system. Biomacromolecules 2012, 13:952-962.
143. Cao X., Deng W.W., Wei Y., Yang Y., Su W.Y., Wei Y.W., et al. Incorporating ptgf-beta 1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells for chondrogenic differentiation. Eur Cell Mater 2012, 23:81-93.
144. Ertan A.B., Yilgor P., Bayyurt B., Calikoglu A.C., Kaspar C., Kok F.N., et al. Effect of double growth factor release on cartilage tissue engineering. J Tissue Eng Regen Med 2013, 7:149-160.
145. Shi J., Zhang X., Zhu J., Pi Y., Hu X., Zhou C., et al. Nanoparticle delivery of the bone morphogenetic protein 4 gene to adipose-derived stem cells promotes articular cartilage repair in vitro and in Vivo. Arthrosc 2013, 29. 2001-U182.
146. Lu H., Lv L., Dai Y., Wu G., Zhao H., Zhang F. Porous chitosan scaffolds with embedded hyaluronic acid/chitosan/plasmid-DNA nanoparticles encoding TGF-beta 1 induce DNA controlled release, transfected chondrocytes, and promoted cell proliferation. PLoS One 2013, 8.
147. Kim S., Jeon O., Lee J., Bae M., Chun H.-J., Moon S.-H., et al. Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells. J Biomed Sci 2008, 15:771-777.
148. Bakhshandeh B., Soleimani M., Ghaemi N., Shabani I. Effective combination of aligned nanocomposite nanofibers and human unrestricted somatic stem cells for bone tissue engineering. Acta Pharmacol Sin 2011, 32:626-636.
149. Pathi S.P., Lin D.D.W., Dorvee J.R., Estroff L.A., Fischbach C. Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis. Biomaterials 2011, 32:5112-5122.
150. Bonadio J., Smiley E., Patil P., Goldstein S. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 1999, 5:753-759.
151. Oliveira J.T., Reis R.L. Polysaccharide-based materials for cartilage tissue engineering applications. J Tissue Eng Regen Med 2011, 5:421-436.
152. Park J.S., Yang H.N., Woo D.G., Jeon S.Y., Park K.-H. Chondrogenesis of human mesenchymal stem cells in fibrin constructs evaluated in vitro and in nude mouse and rabbit defects models. Biomaterials 2011, 32:1495-1507.