Generation dependent safety and efficacy of folic acid conjugated dendrimer based anticancer drug formulations

Pharmaceutical Research

Volumn 32, Issue 4, 2015, Pages 1438-1450

  Kesharwani, Prashant ^a,b,c   Tekade, Rakesh K ^d,e   Jain, Narendra K ^a  

^a DR H S GOUR UNIVERSITY   (India)

^b WAYNE STATE UNIVERSITY   (United States)

^c Advanced Imaging Research Center   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

Author keywords

dendrimer generation; folate conjugation; toxicity; tumor targeting

Indexed keywords

AZETIDINE DERIVATIVE; DENDRIMER; DRUG CARRIER; FOLATE CONJUGATED POLYPROPYLENEIMINE DENDRIMER; FOLIC ACID; FOLIC ACID DERIVATIVE; MELPHALAN; UNCLASSIFIED DRUG; ALKYLATING AGENT; POLY(PROPYLENEIMINE); POLYPROPYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL DESTRUCTION; CANCER SURVIVAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG RELEASE; DRUG SAFETY; ELIMINATION RATE CONSTANT; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME; TREATMENT OUTCOME; UPTAKE ASSAY; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; DRUG STABILITY; ERYTHROCYTE; HEMOLYSIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL LINE, TUMOR; CELL SURVIVAL; DENDRIMERS; DRUG CARRIERS; DRUG LIBERATION; DRUG STABILITY; ERYTHROCYTES; FEMALE; FOLIC ACID; HEMOLYSIS; HUMANS; MELPHALAN; MICE, INBRED BALB C; POLYPROPYLENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84925510347     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1549-2     Document Type: Article

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