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Volumn 127, Issue 2, 2017, Pages 564-568

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

C MER TYROSINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; LDLR PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN RECEPTOR; MERTK PROTEIN, HUMAN; MERTK PROTEIN, MOUSE; ONCOPROTEIN;

EID: 85014120850     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI90520     Document Type: Article
Times cited : (164)

References (38)
  • 1
    • 0034019601 scopus 로고    scopus 로고
    • Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions
    • Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262-1275.
    • (2000) Arterioscler Thromb Vasc Biol. , vol.20 , Issue.5 , pp. 1262-1275
    • Virmani, R.1    Kolodgie, F.D.2    Burke, A.P.3    Farb, A.4    Schwartz, S.M.5
  • 3
    • 27644537437 scopus 로고    scopus 로고
    • Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: The importance of lesion stage and phagocytic efficiency
    • Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: The importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol. 2005;25(11):2255-2264.
    • (2005) Arterioscler Thromb Vasc Biol. , vol.25 , Issue.11 , pp. 2255-2264
    • Tabas, I.1
  • 4
    • 54049137639 scopus 로고    scopus 로고
    • Atherosclerosis: Evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    • Merched AJ, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008;22(10):3595-3606.
    • (2008) FASEB J. , vol.22 , Issue.10 , pp. 3595-3606
    • Merched, A.J.1    Ko, K.2    Gotlinger, K.H.3    Serhan, C.N.4    Chan, L.5
  • 5
    • 72949116358 scopus 로고    scopus 로고
    • Macrophage death and defective inflammation resolution in atherosclerosis
    • Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol. 2010;10(1):36-46.
    • (2010) Nat Rev Immunol. , vol.10 , Issue.1 , pp. 36-46
    • Tabas, I.1
  • 6
    • 34250357688 scopus 로고    scopus 로고
    • Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    • Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007;447(7146):869-874.
    • (2007) Nature. , vol.447 , Issue.7146 , pp. 869-874
    • Schwab, J.M.1    Chiang, N.2    Arita, M.3    Serhan, C.N.4
  • 7
    • 18544378668 scopus 로고    scopus 로고
    • Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: Stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo
    • Mitchell S, et al. Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. J Am Soc Nephrol. 2002;13(10):2497-2507.
    • (2002) J Am Soc Nephrol. , vol.13 , Issue.10 , pp. 2497-2507
    • Mitchell, S.1
  • 8
    • 84973397896 scopus 로고    scopus 로고
    • MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
    • Cai B, et al. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A. 2016;113(23):6526-6531.
    • (2016) Proc Natl Acad Sci U S A. , vol.113 , Issue.23 , pp. 6526-6531
    • Cai, B.1
  • 9
    • 52449109523 scopus 로고    scopus 로고
    • Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/-mice
    • Thorp E, Cui D, Schrijvers DM, Kuriakose G, Tabas I. Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/-mice. Arterioscler Thromb Vasc Biol. 2008;28(8):1421-1428.
    • (2008) Arterioscler Thromb Vasc Biol. , vol.28 , Issue.8 , pp. 1421-1428
    • Thorp, E.1    Cui, D.2    Schrijvers, D.M.3    Kuriakose, G.4    Tabas, I.5
  • 10
    • 52449097275 scopus 로고    scopus 로고
    • Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis
    • Ait-Oufella H, et al. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28(8):1429-1431.
    • (2008) Arterioscler Thromb Vasc Biol. , vol.28 , Issue.8 , pp. 1429-1431
    • Ait-Oufella, H.1
  • 11
    • 33846872571 scopus 로고    scopus 로고
    • A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    • Sather S, et al. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood. 2007;109(3):1026-1033.
    • (2007) Blood. , vol.109 , Issue.3 , pp. 1026-1033
    • Sather, S.1
  • 12
    • 80053030745 scopus 로고    scopus 로고
    • Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK)
    • Thorp E, Vaisar T, Subramanian M, Mautner L, Blobel C, Tabas I. Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK). J Biol Chem. 2011;286(38):33335-33344.
    • (2011) J Biol Chem. , vol.286 , Issue.38 , pp. 33335-33344
    • Thorp, E.1    Vaisar, T.2    Subramanian, M.3    Mautner, L.4    Blobel, C.5    Tabas, I.6
  • 13
    • 84871813033 scopus 로고    scopus 로고
    • Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: A role for oxidized polyunsaturated fatty acids?
    • Garbin U, et al. Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: A role for oxidized polyunsaturated fatty acids? Cardiovasc Res. 2013;97(1):125-133.
    • (2013) Cardiovasc Res. , vol.97 , Issue.1 , pp. 125-133
    • Garbin, U.1
  • 14
    • 0028345073 scopus 로고
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    • Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest. 1994;93(5):1885-1893.
    • (1994) J Clin Invest. , vol.93 , Issue.5 , pp. 1885-1893
    • Ishibashi, S.1    Goldstein, J.L.2    Brown, M.S.3    Herz, J.4    Burns, D.K.5
  • 15
    • 84923087134 scopus 로고    scopus 로고
    • Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice
    • Fredman G, et al. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med. 2015;7(275):275ra20.
    • (2015) Sci Transl Med. , vol.7 , Issue.275 , pp. 275ra20
    • Fredman, G.1
  • 16
    • 84921489456 scopus 로고    scopus 로고
    • Cutting edge: Maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation
    • Krishnamoorthy N, et al. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol. 2015;194(3):863-867.
    • (2015) J Immunol. , vol.194 , Issue.3 , pp. 863-867
    • Krishnamoorthy, N.1
  • 17
    • 84929955331 scopus 로고    scopus 로고
    • Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
    • Gagliani N, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 2015;523(7559):221-225.
    • (2015) Nature. , vol.523 , Issue.7559 , pp. 221-225
    • Gagliani, N.1
  • 18
    • 84881653086 scopus 로고    scopus 로고
    • Decreased numbers of regulatory T cells are associated with human atherosclerotic lesion vulnerability and inversely correlate with infiltrated mature dendritic cells
    • Dietel B, Cicha I, Voskens CJ, Verhoeven E, Achenbach S, Garlichs CD. Decreased numbers of regulatory T cells are associated with human atherosclerotic lesion vulnerability and inversely correlate with infiltrated mature dendritic cells. Atherosclerosis. 2013;230(1):92-99.
    • (2013) Atherosclerosis. , vol.230 , Issue.1 , pp. 92-99
    • Dietel, B.1    Cicha, I.2    Voskens, C.J.3    Verhoeven, E.4    Achenbach, S.5    Garlichs, C.D.6
  • 19
    • 80052261509 scopus 로고    scopus 로고
    • Differential effects of regulatory T cells on the initiation and regression of atherosclerosis
    • Foks AC, et al. Differential effects of regulatory T cells on the initiation and regression of atherosclerosis. Atherosclerosis. 2011;218(1):53-60.
    • (2011) Atherosclerosis. , vol.218 , Issue.1 , pp. 53-60
    • Foks, A.C.1
  • 20
    • 84988603167 scopus 로고    scopus 로고
    • An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
    • Fredman G, et al. An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nat Commun. 2016;7:12859.
    • (2016) Nat Commun. , vol.7 , pp. 12859
    • Fredman, G.1
  • 21
    • 84984710527 scopus 로고    scopus 로고
    • Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice
    • Viola JR, et al. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ Res. 2016;119(9):1030-1038.
    • (2016) Circ Res. , vol.119 , Issue.9 , pp. 1030-1038
    • Viola, J.R.1
  • 22
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
    • Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008;8(5):349-361.
    • (2008) Nat Rev Immunol. , vol.8 , Issue.5 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 23
  • 24
    • 84857752617 scopus 로고    scopus 로고
    • Transcriptional regulation of the human FPR2/ALX gene: Evidence of a heritable genetic variant that impairs promoter activity
    • Simiele F, et al. Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity. FASEB J. 2012;26(3):1323-1333.
    • (2012) FASEB J. , vol.26 , Issue.3 , pp. 1323-1333
    • Simiele, F.1
  • 25
    • 84919702335 scopus 로고    scopus 로고
    • Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway
    • Fredman G, et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. Proc Natl Acad Sci U S A. 2014;111(40):14530-14535.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , Issue.40 , pp. 14530-14535
    • Fredman, G.1
  • 26
    • 84902131678 scopus 로고    scopus 로고
    • Mechanisms of plaque formation and rupture
    • Bentzon JF, Otsuka F, Virmani R, Falk E. Mechanisms of plaque formation and rupture. Circ Res. 2014;114(12):1852-1866.
    • (2014) Circ Res. , vol.114 , Issue.12 , pp. 1852-1866
    • Bentzon, J.F.1    Otsuka, F.2    Virmani, R.3    Falk, E.4
  • 27
    • 84873152891 scopus 로고    scopus 로고
    • A role of RIP3-mediated macrophage necrosis in atherosclerosis development
    • Lin J, et al. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep. 2013;3(1):200-210.
    • (2013) Cell Rep. , vol.3 , Issue.1 , pp. 200-210
    • Lin, J.1
  • 28
    • 85006622606 scopus 로고    scopus 로고
    • Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
    • Karunakaran D, et al. Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv. 2016;2(7):e1600224.
    • (2016) Sci Adv. , vol.2 , Issue.7 , pp. e1600224
    • Karunakaran, D.1
  • 29
    • 84982806125 scopus 로고    scopus 로고
    • CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
    • Kojima Y, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536(7614):86-90.
    • (2016) Nature. , vol.536 , Issue.7614 , pp. 86-90
    • Kojima, Y.1
  • 30
    • 41249092199 scopus 로고    scopus 로고
    • Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation
    • Tibrewal N, et al. Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation. J Biol Chem. 2008;283(6):3618-3627.
    • (2008) J Biol Chem. , vol.283 , Issue.6 , pp. 3618-3627
    • Tibrewal, N.1
  • 31
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007;131(6):1124-1136.
    • (2007) Cell. , vol.131 , Issue.6 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 32
    • 33846025798 scopus 로고    scopus 로고
    • Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages
    • Freire-de-Lima CG, Xiao YQ, Gardai SJ, Bratton DL, Schiemann WP, Henson PM. Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem. 2006;281(50):38376-38384.
    • (2006) J Biol Chem. , vol.281 , Issue.50 , pp. 38376-38384
    • Freire-De-Lima, C.G.1    Xiao, Y.Q.2    Gardai, S.J.3    Bratton, D.L.4    Schiemann, W.P.5    Henson, P.M.6
  • 33
    • 84887552725 scopus 로고    scopus 로고
    • Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators
    • Li Y, Dalli J, Chiang N, Baron RM, Quintana C, Serhan CN. Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. Immunity. 2013;39(5):885-898.
    • (2013) Immunity. , vol.39 , Issue.5 , pp. 885-898
    • Li, Y.1    Dalli, J.2    Chiang, N.3    Baron, R.M.4    Quintana, C.5    Serhan, C.N.6
  • 34
    • 30044449982 scopus 로고    scopus 로고
    • Resolution of inflammation: The beginning programs the end
    • Serhan CN, Savill J. Resolution of inflammation: The beginning programs the end. Nat Immunol. 2005;6(12):1191-1197.
    • (2005) Nat Immunol. , vol.6 , Issue.12 , pp. 1191-1197
    • Serhan, C.N.1    Savill, J.2
  • 35
    • 0035837323 scopus 로고    scopus 로고
    • Phagocytosis and clearance of apoptotic cells is mediated by MER
    • Scott RS, et al. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature. 2001;411(6834):207-211.
    • (2001) Nature. , vol.411 , Issue.6834 , pp. 207-211
    • Scott, R.S.1
  • 36
    • 79955100531 scopus 로고    scopus 로고
    • Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
    • Wu J, et al. Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis. Arthritis Res Ther. 2011;13(2):R62.
    • (2011) Arthritis Res Ther. , vol.13 , Issue.2 , pp. R62
    • Wu, J.1
  • 37
    • 84891418230 scopus 로고    scopus 로고
    • Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity
    • Zizzo G, Guerrieri J, Dittman LM, Merrill JT, Cohen PL. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther. 2013;15(6):R212.
    • (2013) Arthritis Res Ther. , vol.15 , Issue.6 , pp. R212
    • Zizzo, G.1    Guerrieri, J.2    Dittman, L.M.3    Merrill, J.T.4    Cohen, P.L.5
  • 38
    • 84937521801 scopus 로고    scopus 로고
    • The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome
    • Qin B, et al. The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome. Joint Bone Spine. 2015;82(4):258-263.
    • (2015) Joint Bone Spine. , vol.82 , Issue.4 , pp. 258-263
    • Qin, B.1


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