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Volumn 140, Issue 11, 2017, Pages 2545-2556

Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis

Author keywords

Apcmin + mice; deoxycholic acid; intestinal carcinogenesis; intestinal microbiota; tumor associated macrophages

Indexed keywords

APC PROTEIN; BETA CATENIN; BILE ACID; DEOXYCHOLIC ACID; WNT PROTEIN;

EID: 85014107164     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.30643     Document Type: Article
Times cited : (170)

References (53)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359–E86.
    • (2015) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3
  • 2
    • 84971619686 scopus 로고    scopus 로고
    • Gastrointestinal microbiota and colon cancer
    • Hold GL. Gastrointestinal microbiota and colon cancer. Dig Dis 2016;34:244–50.
    • (2016) Dig Dis , vol.34 , pp. 244-250
    • Hold, G.L.1
  • 3
    • 84966389294 scopus 로고    scopus 로고
    • Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer
    • Vipperla K, O'Keefe SJ. Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer. Food Funct 2016;7:1731–40.
    • (2016) Food Funct , vol.7 , pp. 1731-1740
    • Vipperla, K.1    O'Keefe, S.J.2
  • 4
    • 33745814399 scopus 로고    scopus 로고
    • Deficiency of adenomatous polyposis coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology
    • Bortlik M, Vitkova I, Papezova M, et al. Deficiency of adenomatous polyposis coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology. World J Gastroenterol 2006;12:3901–5.
    • (2006) World J Gastroenterol , vol.12 , pp. 3901-3905
    • Bortlik, M.1    Vitkova, I.2    Papezova, M.3
  • 5
    • 84964884533 scopus 로고    scopus 로고
    • Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model
    • Savari S, Chandrashekar NK, Osman J, et al. Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model. Carcinogenesis 2016;37:491–9.
    • (2016) Carcinogenesis , vol.37 , pp. 491-499
    • Savari, S.1    Chandrashekar, N.K.2    Osman, J.3
  • 6
    • 84908608590 scopus 로고    scopus 로고
    • The gut microbiota, bacterial metabolites and colorectal cancer
    • Louis P, Hold GL, Flint HJ. The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol 2014;12:661–72.
    • (2014) Nat Rev Microbiol , vol.12 , pp. 661-672
    • Louis, P.1    Hold, G.L.2    Flint, H.J.3
  • 7
    • 84896078883 scopus 로고    scopus 로고
    • Microbes, microbiota, and colon cancer
    • Sears CL, Garrett WS. Microbes, microbiota, and colon cancer. Cell Host Microbe 2014;15:317–28.
    • (2014) Cell Host Microbe , vol.15 , pp. 317-328
    • Sears, C.L.1    Garrett, W.S.2
  • 8
    • 84898793295 scopus 로고    scopus 로고
    • Gastrointestinal malignancy and the microbiome
    • E1533
    • Abreu MT, Peek RM, Jr. Gastrointestinal malignancy and the microbiome. Gastroenterology 2014;146:1534–46, E1533.
    • (2014) Gastroenterology , vol.146 , pp. 1534-1546
    • Abreu, M.T.1    Peek, R.M.2
  • 9
    • 80052739162 scopus 로고    scopus 로고
    • Carcinogenicity of deoxycholate, a secondary bile acid
    • Bernstein C, Holubec H, Bhattacharyya AK, et al. Carcinogenicity of deoxycholate, a secondary bile acid. Arch Toxicol 2011;85:863–71.
    • (2011) Arch Toxicol , vol.85 , pp. 863-871
    • Bernstein, C.1    Holubec, H.2    Bhattacharyya, A.K.3
  • 10
    • 84944060076 scopus 로고    scopus 로고
    • Secondary bile acids effects in colon pathology. Experimental mice study
    • Saracut C, Molnar C, Russu C, et al. Secondary bile acids effects in colon pathology. Experimental mice study. Acta Cir Bras 2015;30:624–31.
    • (2015) Acta Cir Bras , vol.30 , pp. 624-631
    • Saracut, C.1    Molnar, C.2    Russu, C.3
  • 11
    • 84915144172 scopus 로고
    • Production of tumors in mice by deoxycholic acid
    • Cook JW, Kennaway EL, Kennaway NM. Production of tumors in mice by deoxycholic acid. Nature 1940;145:627–9.
    • (1940) Nature , vol.145 , pp. 627-629
    • Cook, J.W.1    Kennaway, E.L.2    Kennaway, N.M.3
  • 12
    • 84901846653 scopus 로고    scopus 로고
    • Secondary bile acids: an underrecognized cause of colon cancer
    • Ajouz H, Mukherji D, Shamseddine A. Secondary bile acids: an underrecognized cause of colon cancer. World J Surg Oncol 2014;12:164–8.
    • (2014) World J Surg Oncol , vol.12 , pp. 164-168
    • Ajouz, H.1    Mukherji, D.2    Shamseddine, A.3
  • 13
    • 79956088425 scopus 로고    scopus 로고
    • Significance of fecal deoxycholic acid concentration for colorectal tumor enlargement
    • Kawano A, Ishikawa H, Kamano T, et al. Significance of fecal deoxycholic acid concentration for colorectal tumor enlargement. Asian Pac J Cancer Prev 2010;11:1541–6.
    • (2010) Asian Pac J Cancer Prev , vol.11 , pp. 1541-1546
    • Kawano, A.1    Ishikawa, H.2    Kamano, T.3
  • 14
    • 0027400031 scopus 로고
    • Increased serum deoxycholic acid levels in men with colorectal adenomas
    • Bayerdörffer E, Mannes GA, Richter WO, et al. Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology 1993;104:145–51.
    • (1993) Gastroenterology , vol.104 , pp. 145-151
    • Bayerdörffer, E.1    Mannes, G.A.2    Richter, W.O.3
  • 15
    • 84910031461 scopus 로고    scopus 로고
    • Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer
    • Tsuei J, Chau T, Mills D, et al. Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer. Exp Biol Med (Maywood) 2014;239:1489–504.
    • (2014) Exp Biol Med (Maywood) , vol.239 , pp. 1489-1504
    • Tsuei, J.1    Chau, T.2    Mills, D.3
  • 16
    • 84937511480 scopus 로고    scopus 로고
    • The secondary bile acid, deoxycholate accelerates intestinal adenoma–adenocarcinoma sequence in Apc (min/+) mice through enhancing Wnt signaling
    • Cao H, Luo S, Xu M, et al. The secondary bile acid, deoxycholate accelerates intestinal adenoma–adenocarcinoma sequence in Apc (min/+) mice through enhancing Wnt signaling. Fam Cancer 2014;13:563–71.
    • (2014) Fam Cancer , vol.13 , pp. 563-571
    • Cao, H.1    Luo, S.2    Xu, M.3
  • 17
    • 84959882996 scopus 로고    scopus 로고
    • Bile acid modifications at the microbe-host interface: potential for nutraceutical and pharmaceutical interventions in host health
    • Joyce SA, Gahan CG. Bile acid modifications at the microbe-host interface: potential for nutraceutical and pharmaceutical interventions in host health. Annu Rev Food Sci Technol 2016;7:313–33.
    • (2016) Annu Rev Food Sci Technol , vol.7 , pp. 313-333
    • Joyce, S.A.1    Gahan, C.G.2
  • 18
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie CG, Bucci V, Stein RR, et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 2015;517:205–8.
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1    Bucci, V.2    Stein, R.R.3
  • 19
    • 80054862011 scopus 로고    scopus 로고
    • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats
    • Islam KB, Fukiya S, Hagio M, et al. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011;141:1773–81.
    • (2011) Gastroenterology , vol.141 , pp. 1773-1781
    • Islam, K.B.1    Fukiya, S.2    Hagio, M.3
  • 21
    • 84928175356 scopus 로고    scopus 로고
    • Distinct commensals induce interleukin-1beta via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury
    • Seo SU, Kamada N, Muñoz-Planillo R, et al. Distinct commensals induce interleukin-1beta via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury. Immunity 2015;42:744–55.
    • (2015) Immunity , vol.42 , pp. 744-755
    • Seo, S.U.1    Kamada, N.2    Muñoz-Planillo, R.3
  • 22
    • 84894105226 scopus 로고    scopus 로고
    • Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection
    • Weingarden AR, Chen C, Bobr A, et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am J Physiol Gastrointest Liver Physiol 2014;306:G310–G19.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , pp. G310-G319
    • Weingarden, A.R.1    Chen, C.2    Bobr, A.3
  • 23
    • 84897921392 scopus 로고    scopus 로고
    • Fecal transplantation does not transfer either susceptibility or resistance to food borne listeriosis in C57BL/6 and BALB/c/By mice
    • Myers-Morales T, Bussell KM, D'Orazio SE. Fecal transplantation does not transfer either susceptibility or resistance to food borne listeriosis in C57BL/6 and BALB/c/By mice. F1000Res 2013;2:177.
    • (2013) F1000Res , vol.2 , pp. 177
    • Myers-Morales, T.1    Bussell, K.M.2    D'Orazio, S.E.3
  • 24
    • 84946854837 scopus 로고    scopus 로고
    • The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
    • Schuijt TJ, Lankelma JM, Scicluna BP, et al. The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut 2016;65:575–83.
    • (2016) Gut , vol.65 , pp. 575-583
    • Schuijt, T.J.1    Lankelma, J.M.2    Scicluna, B.P.3
  • 25
    • 84910684500 scopus 로고    scopus 로고
    • DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice
    • Grill JI, Neumann J, Herbst A, et al. DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice. Mol Cancer Res 2014;12:1655–62.
    • (2014) Mol Cancer Res , vol.12 , pp. 1655-1662
    • Grill, J.I.1    Neumann, J.2    Herbst, A.3
  • 26
    • 84893013094 scopus 로고    scopus 로고
    • High-fat diet alters gut microbiota physiology in mice
    • Daniel H, Moghaddas Gholami A, Berry D, et al. High-fat diet alters gut microbiota physiology in mice. ISME J 2014;8:295–308.
    • (2014) ISME J , vol.8 , pp. 295-308
    • Daniel, H.1    Moghaddas Gholami, A.2    Berry, D.3
  • 27
    • 84938917629 scopus 로고    scopus 로고
    • Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon
    • Ijssennagger N, Belzer C, Hooiveld GJ, et al. Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon. Proc Natl Acad Sci U S A 2015;112:10038–43.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 10038-10043
    • Ijssennagger, N.1    Belzer, C.2    Hooiveld, G.J.3
  • 28
    • 83355173006 scopus 로고    scopus 로고
    • Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    • Schloss PD, Gevers D, Westcott SL. Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies. PLoS One 2011;6:e27310.
    • (2011) PLoS One , vol.6
    • Schloss, P.D.1    Gevers, D.2    Westcott, S.L.3
  • 29
    • 72949107142 scopus 로고    scopus 로고
    • Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    • Schloss PD, Westcott SL, Ryabin T, et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 2009;75:7537–41.
    • (2009) Appl Environ Microbiol , vol.75 , pp. 7537-7541
    • Schloss, P.D.1    Westcott, S.L.2    Ryabin, T.3
  • 30
    • 34548293679 scopus 로고    scopus 로고
    • Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy
    • Wang Q, Garrity Tiedje JM, Cole JR. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 2007;73:5261–7.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 5261-5267
    • Wang, Q.1    Garrity Tiedje, J.M.2    Cole, J.R.3
  • 31
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 2013;110:9066–71.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 9066-9071
    • Everard, A.1    Belzer, C.2    Geurts, L.3
  • 32
    • 84898789502 scopus 로고    scopus 로고
    • Regulation of the immune system by the resident intestinal bacteria
    • Kamada N, Nunez G. Regulation of the immune system by the resident intestinal bacteria. Gastroenterology 2014;146:1477–88.
    • (2014) Gastroenterology , vol.146 , pp. 1477-1488
    • Kamada, N.1    Nunez, G.2
  • 33
    • 84879000385 scopus 로고    scopus 로고
    • IFN-gamma selectively exerts pro-apoptotic effects on tumor-initiating label-retaining colon cancer cells
    • Ni C, Wu P, Zhu X, et al. IFN-gamma selectively exerts pro-apoptotic effects on tumor-initiating label-retaining colon cancer cells. Cancer Lett 2013;336:174–84.
    • (2013) Cancer Lett , vol.336 , pp. 174-184
    • Ni, C.1    Wu, P.2    Zhu, X.3
  • 34
    • 66149172257 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 (MCP-1): an overview
    • Deshmane SL, Kremlev S, Amini S, et al. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 2009;29:313–26.
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 313-326
    • Deshmane, S.L.1    Kremlev, S.2    Amini, S.3
  • 35
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    • Sica A, Schioppa T, Mantovani A, et al. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 2006;42:717–27.
    • (2006) Eur J Cancer , vol.42 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3
  • 36
    • 84923068676 scopus 로고    scopus 로고
    • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
    • Zhou W, Ke SQ, Huang Z, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol 2015;17:170–82.
    • (2015) Nat Cell Biol , vol.17 , pp. 170-182
    • Zhou, W.1    Ke, S.Q.2    Huang, Z.3
  • 37
    • 84882334105 scopus 로고    scopus 로고
    • Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin
    • Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 2013;14:195–206.
    • (2013) Cell Host Microbe , vol.14 , pp. 195-206
    • Rubinstein, M.R.1    Wang, X.2    Liu, W.3
  • 38
    • 84947552418 scopus 로고    scopus 로고
    • Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks
    • Morgun A, Dzutsev A, Dong X, et al. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut 2015;64:1732–43.
    • (2015) Gut , vol.64 , pp. 1732-1743
    • Morgun, A.1    Dzutsev, A.2    Dong, X.3
  • 39
    • 84888049920 scopus 로고    scopus 로고
    • Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    • Iida N, Dzutsev A, Stewart CA, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 2013;342:967–70.
    • (2013) Science , vol.342 , pp. 967-970
    • Iida, N.1    Dzutsev, A.2    Stewart, C.A.3
  • 40
    • 33751306998 scopus 로고    scopus 로고
    • Multistep carcinogenesis of the colon in Apc(Min/+) mouse
    • Yamada Y, Mori H. Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci 2007;98:6–10.
    • (2007) Cancer Sci , vol.98 , pp. 6-10
    • Yamada, Y.1    Mori, H.2
  • 41
    • 84944056844 scopus 로고    scopus 로고
    • Novel diet-related mouse model of colon cancer parallels human colon cancer
    • Prasad AR, Prasad S, Nguyen H, et al. Novel diet-related mouse model of colon cancer parallels human colon cancer. World J Gastrointest Oncol 2014;6:225–43.
    • (2014) World J Gastrointest Oncol , vol.6 , pp. 225-243
    • Prasad, A.R.1    Prasad, S.2    Nguyen, H.3
  • 42
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    • De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A 2010;107:14691–6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14691-14696
    • De Filippo, C.1    Cavalieri, D.2    Di Paola, M.3
  • 43
    • 84889681706 scopus 로고    scopus 로고
    • Western diet induces dysbiosis with increased E. coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
    • Martinez-Medina M, Denizot J, Dreux N, et al. Western diet induces dysbiosis with increased E. coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut 2014;63:116–24.
    • (2014) Gut , vol.63 , pp. 116-124
    • Martinez-Medina, M.1    Denizot, J.2    Dreux, N.3
  • 44
    • 0010612265 scopus 로고
    • Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid
    • Stacey M, Webb M. Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid. Proc R Soc Lond B 1947;134:523–37.
    • (1947) Proc R Soc Lond B , vol.134 , pp. 523-537
    • Stacey, M.1    Webb, M.2
  • 45
    • 33644752102 scopus 로고    scopus 로고
    • Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria
    • Kurdi P, Kawanishi K, Mizutani K, et al. Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria. J Bacteriol 2006;188:1979–86.
    • (2006) J Bacteriol , vol.188 , pp. 1979-1986
    • Kurdi, P.1    Kawanishi, K.2    Mizutani, K.3
  • 46
    • 0015446049 scopus 로고
    • The effect of bile acids on intestinal microflora
    • Floch MH, Binder HJ, Filburn B, et al. The effect of bile acids on intestinal microflora. Am J Clin Nutr 1972;25:1418–26.
    • (1972) Am J Clin Nutr , vol.25 , pp. 1418-1426
    • Floch, M.H.1    Binder, H.J.2    Filburn, B.3
  • 47
    • 33744960773 scopus 로고    scopus 로고
    • Deoxycholic acid induces intracellular signaling through membrane perturbations
    • Jean-Louis S, Akare S, Ali MA, et al. Deoxycholic acid induces intracellular signaling through membrane perturbations. J Biol Chem 2006;281:14948–60.
    • (2006) J Biol Chem , vol.281 , pp. 14948-14960
    • Jean-Louis, S.1    Akare, S.2    Ali, M.A.3
  • 48
    • 80054870683 scopus 로고    scopus 로고
    • Bile acid stress in lactic acid bacteria and bifidobacteria
    • In, Sonomoto K, Yokota A, eds., Norfolk, VA, Caister Academic Press
    • Margolles A, Yokota A. Bile acid stress in lactic acid bacteria and bifidobacteria. In: Sonomoto K, Yokota A, eds. Lactic acid bacteria and bifidobacteria: current progress in advanced research. Norfolk, VA: Caister Academic Press, 2011. 111–142.
    • (2011) Lactic acid bacteria and bifidobacteria: current progress in advanced research , pp. 111-142
    • Margolles, A.1    Yokota, A.2
  • 49
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008;57:1470–81.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3
  • 50
    • 84883552728 scopus 로고    scopus 로고
    • Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer
    • Day SD, Enos RT, McClellan JL, et al. Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer. Cytokine 2013;64:454–62.
    • (2013) Cytokine , vol.64 , pp. 454-462
    • Day, S.D.1    Enos, R.T.2    McClellan, J.L.3
  • 51
    • 84928941368 scopus 로고    scopus 로고
    • Application of the Apc(Min/+) mouse model for studying inflammation-associated intestinal tumor
    • Wang L, Zhang Q. Application of the Apc(Min/+) mouse model for studying inflammation-associated intestinal tumor. Biomed Pharmacother 2015;71:216–21.
    • (2015) Biomed Pharmacother , vol.71 , pp. 216-221
    • Wang, L.1    Zhang, Q.2
  • 52
    • 84958231592 scopus 로고    scopus 로고
    • A breakthrough: macrophage-directed cancer immunotherapy
    • Mills CD, Lenz LL, Harris RA. A breakthrough: macrophage-directed cancer immunotherapy. Cancer Res 2016;76:513–6.
    • (2016) Cancer Res , vol.76 , pp. 513-516
    • Mills, C.D.1    Lenz, L.L.2    Harris, R.A.3
  • 53
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin PJ, Sparks AB, Korinek V, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787–90.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3


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