Flaviviral methyltransferase/RNA interaction: Structural basis for enzyme inhibition

Antiviral Research

Volumn 83, Issue 1, 2009, Pages 28-34

  Milani, Mario ^a,b   Mastrangelo, Eloise ^a,b   Bollati, Michela ^a   Selisko, Barbara ^c   Decroly, Etienne ^c   Bouvet, Mickaël ^c   Canard, Bruno ^c   Bolognesi, Martino ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

Flavivirus; Methyltransferase inhibition; Viral methyltransferase; Viral RNA capping; Virtual docking

Indexed keywords

ANTIVIRUS AGENT; AURINTRICARBOXYLIC ACID; METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; NILUTAMIDE; PYRIDOXAL 5' PHOSPHATE 6 (2' NAPHTHYLAZO 6' NITRO 4',8' DISULFONATE) TETRASODIUM SALT; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENGUE VIRUS; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; FLAVIVIRUS; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; RNA CAPPING; RNA STABILITY; VIRUS REPLICATION;

CRYSTALLOGRAPHY, X-RAY; FLAVIVIRUS; METHYLTRANSFERASES; MODELS, MOLECULAR; PROTEIN BINDING; RNA CAPS; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS;

DENGUE VIRUS; FLAVIVIRUS;

EID: 67349093311     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.03.001     Document Type: Article

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