Intensive care medicine in 2050: precision medicine

Intensive Care Medicine

Volumn 43, Issue 10, 2017, Pages 1507-1509

  Wong, Hector R ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ADULT RESPIRATORY DISTRESS SYNDROME; CARDIOGENIC SHOCK; CRITICAL ILLNESS; EDITORIAL; GENETIC VARIABILITY; HUMAN; INTENSIVE CARE; MALIGNANT NEOPLASM; PERSONALIZED MEDICINE; PHARMACOGENOMICS; PRACTICE GUIDELINE; SEPSIS; SEPTIC SHOCK; TRANSCRIPTOMICS; FORECASTING; MOLECULAR MEDICINE; NEOPLASM; PROCEDURES; TRENDS;

CRITICAL CARE; FORECASTING; HUMANS; MOLECULAR MEDICINE; NEOPLASMS; PRECISION MEDICINE; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS;

EID: 85013852123     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-017-4727-y     Document Type: Editorial

References (15)

1. Dickmann LJ, Ware JA (2016) Pharmacogenomics in the age of personalized medicine. Drug Discov Today Technol 21(22):11–16
2. Collins FS, Varmus H (2015) A new initiative on precision medicine. N Engl J Med 372:793–795
3. Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ (2016) Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Crit Care Med 44:e1000–e1003
4. Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF (2013) An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med 5:195ra95
5. Wong HR, Salisbury S, Xiao Q, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Sen A, Nowak J, Quasney M, Henricksen JW, Chopra A, Banschbach S, Beckman E, Harmon K, Lahni P, Lindsell CJ (2012) The pediatric sepsis biomarker risk model. Crit Care 16:R174
6. Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart TC, Nguyen TC, Lindsell CJ (2016) PERSEVERE II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype. Crit Care Med 44:2010–2017
7. Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Kingsmore SF, Woods CW, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ (2016) Mortality prediction in sepsis via gene expression analysis: a community approach. bioRxiv. doi:10.1101/095489
8. Meyer NJ, Feng R, Li M, Zhao Y, Sheu CC, Tejera P, Gallop R, Bellamy S, Rushefski M, Lanken PN, Aplenc R, O’Keefe GE, Wurfel MM, Christiani DC, Christie JD (2013) IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist. Am J Respir Crit Care Med 187:950–959
9. Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP (2014) A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock. Am J Respir Crit Care Med 190:656–664
10. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA (2014) Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2:611–620
11. Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS (2016) ARDS subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med 195:331–338
12. Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AV, Hinds CJ, Knight JC (2016) Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 4:259–271
13. Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AV, Hinds CJ, Knight JC (2016) Shared and distinct aspects of the sepsis transcriptomic response to fecal peritonitis and pneumonia. Am J Respir Crit Care Med. doi:10.1164/rccm.201608-1685OC
14. Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Shanley TP, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Shekhar RS, Gertz S, Dawson E, Howard K, Harmon K, Beckman E, Frank E, Lindsell CJ (2015) Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med 191:309–315
15. Wong HR, Sweeney TE, Lindsell CJ (2017) Simplification of a septic shock endotyping strategy for clinical application. Am J Respir Crit Care Med 195:263–265