Simplification of a septic shock endotyping strategy for clinical application

American Journal of Respiratory and Critical Care Medicine

Volumn 195, Issue 2, 2017, Pages 263-265

  Wong, Hector R ^a,b,c   Sweeney, Timothy E ^d   Lindsell, Christopher J ^c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID;

CHILD; CRITICALLY ILL PATIENT; DECISION TREE; DIAGNOSTIC TEST; DISEASE CLASSIFICATION; DISEASE SEVERITY; ENDOTYPING; FEMALE; GENE EXPRESSION; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; MORTALITY RISK; PREDICTIVE VALUE; PRESCHOOL CHILD; PRESCRIPTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEPTIC SHOCK; CLASSIFICATION; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOTYPE;

GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; SHOCK, SEPTIC;

EID: 85009814135     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201607-1535LE     Document Type: Letter

References (10)

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2. Wong HR, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Willson DF, Freishtat RJ, Anas N, Meyer K, Checchia PA, et al. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med 2009;7:34.
3. Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, et al. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med 2011;39:2511-2517.
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7. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K,Weiss YG, Benbenishty J, Kalenka A, Forst H, et al.; CORTICUS Study Group.Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111-124.
8. Atkinson SJ, Cvijanovich NZ, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, et al. Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis. PLoS One 2014;9:e112702.
9. Atkinson SJ, Wong HR. Identifying critically ill patients who may benefit from adjunctive corticosteroids: not as easy as we thought. Pediatr Crit Care Med 2014;15:769-771.
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